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INDONESIA
Jurnal Ilmiah Farmasi
Published by Universitas Islam Indonesia
ISSN : 16938666     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JIF merupakan jurnal yang dikelola oleh Prodi Farmasi Universitas Islam Indonesia, dan diterbitkan dua kali dalam setahun. Jurnal ini dirancang sebagai sarana publikasi penelitian yang mencakup secara rinci sejumlah topik dalam bidang farmasi yang berkaitan dengan farmasi sains dan teknologi serta klinik dan komunitas. Jurnal ini menyediakan sebuah forum sebagai sarana pertukaran gagasan dan dan informasi antar peneliti, akademisi dan praktisi sehingga diharapkan mampu mendukung dan menginisiasi berbagai penelitian terkini yang terkait dengan ilmu kefarmasian. Hasil penelitian yang disajikan dalam jurnal ini diharapkan dapat memberikan kontribusi bagi perkembangan ilmu di bidang farmasi dan kesehatan.
Arjuna Subject : -
Articles 269 Documents
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ISOLASI DAN IDENTIFIKASI SENYAWA GOLONGAN XANTON DARI KULIT BUAH MANGGIS ( Garcinia mangostana L.) Ivan Surya Pradipta; Titi W Nikodemus; Yasmiwar Susilawati
Jurnal Ilmiah Farmasi Vol. 4 No. 2 (2007)
Publisher : Universitas Islam Indonesia

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ABSTRACTA research on the isolation and identification of xanthone from the fruit rind of mangosteen(Garcinia mangostana L.) was carried out. Extraction was done using maceration with methanol –water solvent and fractionation with n-hexane and ethyl acetate solvent. Column chromatographywith silica gel as the stationary phase and n-hexane – ethyl acetate (7 : 3) as the mobile phase wasused for the isolation. From the ethyl acetate fraction was obtained GM II-1 isolate (Rf 0,61 ; nhexane– ethyl acetate 7 : 3 as mobile phase) which showed a colour change from reddish brown toyellow under UV light 366 nm after spraying with AlCl3. Identification of the isolate with UVspectrophotometry gave maximum absorptions at wavelengths 241,5, 257,5, 317, 364,5 nm. GC -MS indicated that GM II-1 isolate had a molecular weight of 259, the isolate was presumed to be axanthone.Keywords: xanthone, Garcinia mangostana L., mangosteen, isolation, identification
BAHAN ALAM (NATURAL PRODUCTS) SEBAGAI AGEN KEMOPREVENTIV DAN KEMOTERAPI KANKER Asih Triastuti
Jurnal Ilmiah Farmasi Vol. 1 No. 2 (2004)
Publisher : Universitas Islam Indonesia

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ABSTRACTMedicinal plant has formed the basis of sophisticated traditional medicine systems that havebeen existed for thousands of years. Many advances in the chemistry of novel bioactive naturalproducts are reported. This article looks at potential chemotherapeutic and chemopreventive ofsome natural products such as curcumin, polyphenol, and dietary phytochemicals. Apparently, themedicinal plants will be continue to be important source of lead compounds for the new drugdiscovery and development in the future especially for the new anti cancer drug.Key word: bahan alam, kemopreventiv, kemoterapi, kanker
SINTESIS DIASETIL GAMAVUTON-0 DENGAN MENGGUNAKAN ASETIL KLORIDA SEBAGAI ACYLATING AGENT Ridho Nugroho Zendrato; Supardjan Amir Margono
Jurnal Ilmiah Farmasi Vol. 2 No. 2 (2005)
Publisher : Universitas Islam Indonesia

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ABSTRACTGamavuton-0 is a curcumin-like compound, which is more stable than curcumin and stillhas an antioxidant property. The objective of synthesis of diacetyl gamavuton-0 (diAcGVT-0) is toyield the product that is more lipophile than GVT-0. Synthesis of diAcGVT-0 has been done byreacting GVT-0 with acetyl chloride as an acylating agent and tertiary amines as primary bases.DiAcGVT-0 was formed as the major product of synthesis and the product was not pure. Structureelucidation using UV-Vis,1H-NMR and MS spectra showed that the main product was diAcGVT-0.Key words : diacetyl gamavuton-0, acetyl chloride, acylating agent, lipophile
PENGARUH PRA-PERLAKUAN MADU TERHADAP FARMAKOKINETIKA ELIMINASI RIFAMPISIN PADA TIKUS WISTAR JANTAN Dimas Adhi Pradana; Farida Hayati; Dian Sukma
Jurnal Ilmiah Farmasi Vol. 10 No. 1 (2013): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol10.iss1.art3

Abstract

Rifampisin merupakan salah satu obat yang dipergunakan sebagai terapi lini pertama dalam pengobatan tuberkulosis. Tujuan dari penelitian ini untuk mengetahui pengaruh pra-perlakuan pemberian madu terhadap profil farmakokinetika fase eliminasi rifampisin pada tikus Wistar Jantan.  Dalam penelitian ini hewan uji dibagi menjadi 2 kelompok, yaitu kelompok kontrol dan perlakuan.  Setiap kelompok terdiri dari 5  ekor tikus.  Kelompok kontrol diberikan rifampisin dosis tunggal 50 mg/kg tikus sedangkan kelompok perlakuan diberikan madu 7,65 ml/kg secara oral sekali sehari selama 7 hari dan pada hari ke-8 diberikan rifampisin dosis 50 mg/kg BB tikus secara per oral. Sebanyak 0,2 ml sampel darah diambil dari vena lateralis ekor  pada 0.25; 0.5, 1.0, 1.5, 2.0, 3.0; 4.0; 6.0; 8, 0; 10.0; 12.0, dan 24.0 jam.  Penetapan kadar rifampisin dalam plasma dilakukan dengan metode HPLC pada panjang gelombang 244.6 nm. Parameter farmakokinetika fase eliminasi yang ditetapkan adalah k, t ½, dan ClT. Hasil penelitian menunjukkan bahwa pemberian pra perlakuan madu tidak mempengaruhi farmakokinetika fase eliminasi dari rifampisin. 
KETOKSIKAN AKUT TABLET EFFERVESCENT DARI EKSTRAK DAUM SIRIH ( Piper betle L.) PADA TIKUS PUTIH BETINA GALUR WISTAR Farida Hayati; Retno Murwanti; Wahyu Utaminingrum
Jurnal Ilmiah Farmasi Vol. 4 No. 1 (2007)
Publisher : Universitas Islam Indonesia

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A research on acute toxicity of effervescent tablet from Piper betle leaf extractum on wistar albino female rats was done. This research aimed to determine acute toxicity potential of effervescent tablet from piper betle leaf extractum, evaluated clinical symptom that perhaps occur due to the giving of effervescent tablet, single dosage orally on 24 hours to 15 days observation. The research uses female rats, which are divided into 5 groups. Group I was negative control with aquadest. Group II was given sample with 0,38 g/kgBW dosage. Then, succesively group III with 1,03 g/kgBW dosage, group IV with 2,79 g/kgBW dosage and group V was given test sample with highest dosage, that was 7,50 g/kgBW dosage. On the basis of data analysis result having been performed both quantitively and qualitatively, it could be said that in general, the giving of effervescent tablet from Piper betle leaf extractum single dosage orally on female rats from 0,38 g/kgBW dosage to highest level (7,50 g/kgBW) or approximately 19,74 times of therapy dosage, didn't cause toxic effect which causing damage on lung, liver, kidney, heart, spleen, stomach and intestine. It didn't cause mortality on research animal. So we can determine the quasi LD^, that was bigger than 7,50 g/kgBW, according to Loomis criteria (1978), that acute toxicity potential of effervescent tablet from piper betle extractum was practically not toxic category. Thus based on ANOVA result with 95 % significance level, it could be said that the giving of effervescent tablet from piper betle leaf extractum didn't show significant differences to average body weight changes and organ weight.
PROTECTIVE EFFECTS OF ETHYL ACETATE FRACTION OF Phaleria macrocarpa (Scheff) Boerl. ON OXIDATIVE STRESS ASSOCIATED WITH ALLOXAN-INDUCED DIABETIC RATS Asih Triastuti; Jong Won Choi
Jurnal Ilmiah Farmasi Vol. 5 No. 1 (2008)
Publisher : Universitas Islam Indonesia

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ABSTRACTOxidative stress resulting from the increased production of reactive oxygen species playsa key role in the development of diabetes mellitus and its complications. Phaleria macrocarpa, atraditional plant from Indonesia, has been used empirically to control cancer, arthritis, and diabetesin society. The anti-diabetic effect and antioxidant activity of ethyl acetate (EtOAc) of Phaleriamacrocarpa (PM) was investigated in alloxan-induced diabetic rats. After two weeks administrationof PM, liver antioxidant enzyme and hyperglycemic state were evaluated. The result showed thatEtOAc fraction treatments reduced blood glucose levels in diabetic rats by oral administration(P
EFEK FRAKSI LARUT AIR EKSTRAK ETANOL 50% KEMUNING (Murraya paniculata (L.) Jack) TERHADAP BERAT BADAN TIKUS BETINA DIET LEMAK TINGGI Suwijiyo Pramono; Agung Endro Nugroho; Crisna Wardhani
Jurnal Ilmiah Farmasi Vol. 1 No. 2 (2004)
Publisher : Universitas Islam Indonesia

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ABSTRACTObesity is considered as a health problem that can promote the risks of getting disease, beingnot active and death. In some developing countries, many traditional therapies are applied for somediseases, including obesity. Kemuning (Murraya paniculata (L.) Jack) has been commonly knownas slimming potion. In present, kemuning leaf is used as ingredient of traditional medicine formula,indicated as slimming potion. Former researcher mentioned that 30% ethanol-bemusing extract hadbeen able to reduce trigliserid content in the blood reduce cholesterol content in blood serum ofmale Wistar furrow white rat (Rattus norvegicus). This research is proposed to examine the effect ofwater soluble fraction of 50% ethanol-kemuning extract to female Wistar furrow white rat bodyweight which given high fat diet and to compare the effect with anorextica (mazindol). Testedanimal are divided into 6 groups, each group contain 5 rats. Group I as negative control is given0,5% CMC Na solution. Group II as positive control is given 0,27 mg/kgBody Weight mazindolsuspension. Group III is given 50% ethanol-kemuning extract suspension with 475 mg/kg BWdosage. Group IV is given watersoluble fraction suspension of kemuning extract dosage I that is145 mg/kgBW. Group V is given watersoluble fraction suspension of kemuning extract dosage IIthat is 295 mg/kgBW. Group VI is given dose III that is 585 mg/kgBW. The suspension is givenorally with repeated dosage. Data collected are the increase of body weight, woof consumption anddrinking consumption. Body weight and woof consumption increases are analyzed by one-wayAnava with 90% significancy level. Research result shows that water soluble fraction of 50%ethanol-kemuning extract with 585 mg/kgBW dosage and positive control (mazindol) are able toobstruct rat body weight increase significancy (p < 0,10) compared to negative control group.Keys word : Murraya paniculata (L.) Jack, obesity, antiobesity
HEPATOTOKSISITAS PADA PENGOBATAN TUBERKULOSIS DI RSUD TANGERANG – INDONESIA Vitarani Dwi Ananda Ningrum; Arnia Megasari,; Suci Hanifah
Jurnal Ilmiah Farmasi Vol. 7 No. 1 (2010)
Publisher : Universitas Islam Indonesia

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Reaksi obat yang tidak dikehendaki atau yang dikenal dengan ADR (Adverse Drug Reaction) merupakan respon pasien terhadap obat yang berbahaya dan tidak diharapkan yang terjadi pada penggunaan obat dengan dosis normal untuk tujuan profilaksis, diagnosis, terapi suatu penyakit, maupun modifikasi fungsi fisiologis. Obat yang telah diketahui dapat menimbulkan hepatotoksisitas atau kerusakan fungsi hepar adalah golongan antimikobakteri yang digunakan dalam pengobatan tuberkulosis (TB) paru. Pasien tuberkulosis harus menggunakan obat secara teratur sampai periode pengobatan selesai. Penggunaan OAT (Obat Antituberkulosis) secara terus menerus dalam jangka waktu yang cukup lama dapat menimbulkan ADR. Penelitian ini bertujuan untuk mengetahui kejadian hepatotoksisitas pada pasien tuberkulosis paru serta faktor-faktor yang mempengaruhi terjadinya hepatotoksisitas. Metode penelitian dilakukan dengan menggunakan rancangan studi cross sectional. Pasien yang dilibatkan dalam penelitian ini adalah pasien yang mendapatkan regimen terapi antituberkulosis di RSUD Tangerang pada periode 2006 - Februari 2009. Penilaian kejadian hepatotoksisitas berdasarkan adanya peningkatan kadar AST/ALT serum. Hasil penelitian dari 55 pasien menunjukkan bahwa kejadian hepatotoksik sebesar 38,2%. Hasil uji statistik menggunakan analisis Regresi Binary Logistik dengan taraf kepercayaan 95% menunjukkan jenis kelamin laki-laki dan penggunaan obat hepatotoksis lain memiliki pengaruh terhadap kejadian hepatotoksik. Selain itu terdapat faktor yang dapat mengurangi kejadian hepatotoksik diantaranya penghentian obat, penggantian obat, dan pemberian curcumin. 
EVALUASI SIFAT FISIK DAN UJI IRITASI SEDIAAN SALEP MINYAK ATSIRI BUNGA CENGKEH DALAM BASIS LARUT AIR Diah Pratimasari; Nining Sugihartini; Tedjo Yuwono
Jurnal Ilmiah Farmasi Vol. 11 No. 1 (2015): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol11.iss1.art2

Abstract

Essential oil of clove (Syzygium aromaticum) (MABC) with eugenol as its main active ingredient, has been studied as anti-inflammatory agent.  Its important to develop formulation in an advanced research. This study has been conducted to develop a topical dosage form (an ointment using a water-soluble base). The physical properties of water-soluble ointment preparation of MABC and the irritation properties at various concentrations of MABC have been evaluated. Ointment preparation MABC water-soluble base created using the mixing of the PEG 400 and PEG 4000 by a fusion method. Ointment made with a various concentration of MABC (5%, 10% and 15%). Ointment with each concentration were evaluated based on its physical properties such as pH, dispersiveness and adhesion. Ointment also tested its irritative properties on the skin, using test animals guinea pigs by Draize test method. Data from those experiments analyzed by ANOVA with T-test level of 95%. The results showed that the physical properties of water-soluble ointment base with MABC concentration of 5%, 10% and 15% reach the requirements of the pH and adhesion parameter, but not for its dispersiveness. Statistical analysis of each trial did not show any significant in difference. The experimental results against irritation test showed that the water-soluble ointment base concentration of 5%, 10% and 15% did not cause irritation to the skin of guinea pigs.  
PEMANFAATAN ZAT WARNA WORTEL (Daucus carota Linn) DALAM PEMBUATAN PEWARNA BIBIR BENTUK BATANG (LIPSTIK) Yuni Andriani; Sri Soeryati; Dolih Gozali
Jurnal Ilmiah Farmasi Vol. 6 No. 1 (2009)
Publisher : Universitas Islam Indonesia

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ABSTRACTThe utilization of natural colorant in cosmetic dosage form, especially the colorant of carrot(Daucus carota Linn) in the preparation of lipstick colorant have been carried out. It can be knownfrom the research that the extract colorant of carrot had an orange color and stable during storagetimes. Lipstick formulation with various concentration of the root colorant (20, 30, and 40%),produced lipstick that had good physical stability during storage times, and it had orange up toreddish orange, safe to be used, and the formula especially with the carrot colorant of 30% wasmore favorable.Keywords: cosmetics, lipstick, natural colorant, -carotenoid, carrot

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