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INDONESIA
Nexus Kedokteran Klinik
Published by Universitas Sebelas Maret
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Arjuna Subject : -
Articles 334 Documents
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Pengaruh Usia terhadap Cervical Intraepithelial Neoplasia (CIN) pada Wanita dengan Infeksi Saluran Reproduksi Berbasis Pemeriksaan Papsmear Dewi Okta Anggraini; Paramasari Dirgahayu; Brian Wasita
Nexus Kedokteran Klinik Vol 2, No 1 (2013): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background: Cervical Intraepithelial Neoplasia (CIN) is a dysplasia of cervical squamous cells posibbly turn into cervical cancer if not treated immediately. The established cause of CIN is Human Papillomavirus (HPV). Several studies showed correlation between Reproductive Tract Infection (RTI) with CIN. But, it is still controversial. Age is one of predicted factor which can influence CIN. Through some mechanisms, age can change the cervical cells. Methods: This study was cross-sectional approach. Samples were taken from medical record, papsmears form result and papsmear preparation in the Pathology Anatomy Laboratory, Faculty of Medicine, Sebelas Maret University from 2009-2012. Total of 410 samples were divided into two groups: control and case group. Control group contain sample without RTI while case group contain sample with RTI. Each group consisted of 205 women who subsequently divided into two subgroup, aged <40 years and ? 40 years. In this study, HPV infection is uncontrolled. Data were taken including name, age, clinical symptoms, ISR and CIN. These data are analyzed using Fisher test from SPSS version 19 for windows. Results: Total CIN were found: 5 samples (<40 years) and 3 samples (?40 years) from positive RTI; 20 samples (<40 years) and 53 samples (?40 years) from negative RTI. Fisher test results showed that age has correlation with CIN (p=0,001) and there is a significant difference risk between the age distribution with CIN [RD= -12.3%, 95%CI=(-19.8)-(-4798)]. In the negative RTI, there is a significant risk sample aged <40 years and aged ?40 years to get CIN [RD= -21.28%, 95% CI= (-33.91)- (-8.655)]. RTI does not have correlation with CIN (p = 0.06) Conclusion: Without HPV controlled, age distribution (<40 years and ?40 years) has an influence to the occurence of CIN and there is no correlation between RTI with CIN. Key words: Age, Cervical Intraepithelial Neoplasia (CIN), Reproduction Tract Infection (RTI)
Herbal Usage History as a Risk Factor for Delay in Treatment on Breast Cancer Patients in Surakarta Niluh Ayu Anissa Hanum; Kristanto Yuli Yarso; Riza Novierta Pesik
Nexus Kedokteran Klinik Vol 5, No 3 (2016): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Introduction: Breast cancer is a most commonly diagnosed cancer in women with an estimated 1.67 million cases diagnosed in 2012, i.e. 25% of all cancer cases. As many as 69% of breast cancer incidence was found to have reached stage III and IV, which has lower five-years survival rate. Various factors play a role in the delay of treatment, one of them is an herbal usage history. This study aims to determine whether an herbal usage history is a risk factor of delay in breast cancer patients in Surakarta. Methods: This study design was observational analytic with cross sectional approach. The samples were 45 breast cancer patients with delayed treatment and 55 breast cancer patients without delay treatment in RSUD Dr. Moewardi and RSU Kasih Ibu Surakarta. Samples were taken by fixed disease sampling, which then selected based on inclusion and exclusion criteria. The instrument used is the patient records and supplementary questionnaire. The variables studied were delays in treatment with an herbal usage history along with other confounding factors that may affect the delay of treatment. Data then analyzed using bivariate test and logistic regression. Results: The results of the bivariate analysis showed that an herbal usage history is a risk factor of delay in treatment, with p = 0.002 and OR = 3.69. While the results of the multivariate analysis showed that a low level of knowledge affect the most to delays in treatment of breast cancer with OR = 3.699. Conclusions:Herbal usage history was proved as a risk factor for delay in treatment on breast cancer patients in Surakarta. Keywords:Herbal Usage History, Delay in Treatment, Breast Cancer
Hubungan Ibu Hamil Perokok Pasif dengan Kejadian Ketuban Pecah Dini Icha Dithyana; . Soetrisno; Ruben Dharmawan
Nexus Kedokteran Klinik Vol 3, No 1 (2014): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background: Premature Rupture of Membranes (PROM) is most important issues commonly encountered. Premature rupture of membranes can cause some complications for both mother and fetus and may increase maternal morbidity and mortality. The prevalence of smoking in Indonesia increase every year and 85.4% current smokers smoke in the home where their family members live with them, thus threatening the health and safety of the environment. This research aimed to analyze the correlation between pregnant passive smoker and premature rupture of membrane. Methode : This research is observational analytic research using case control approach. Total of 60 samples were selected with a fixed - disease sampling, are all expectant mothers and maternity patients at the RSUD Dr. Moewardi. Data were collected by interview and medical record. The data which is got then analyzed by the program Statistic Products and Service Solution (SPSS) for Windows Release 17.0 with the use of statistic test Chi Square. Result: There is a significant correlation between pregnant passive smoker and premature rupture of membrane where the results obtained by using statistical test Chi Square is p = 0.02 and OR= 3.5. Conclusion: Pregnant passive smoker is 3.5 times more risky for experiencing premature rupture of membrane than non-passive smoker. Keywords: Pregnant passive smoker, Premature Rupture of Membrane (PROM)
Perbedaan Penurunan Fungsi Kognitif pada Pasien Stroke Iskemik Lesi Hemisfer Kanan dan Kiri Di RSUD Dr. Moewardi Adya Sitaresmi; FX Soetedjo Widjojo; Dhoni Akbar Ghozali
Nexus Kedokteran Klinik Vol 3, No 3 (2014): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background: Stroke is a major health problem in many parts of the world and is increasing in prevalence in line with modernization. Damage to brain cells after stroke cause cognitive function disability that affect the quality of life and independence of the patient. Decline in cognitive function relates to size and location of the lesion. This research aims to find out the differences in cognitive function loss between right and left hemisphere ischemic stroke patients. Methods: This research is observational analytic study with retrospective cohort design performed in an Outpatient Neurology Clinic at RSUD Dr. Moewardi. There are 30 patients as subject consists of 14 right hemisphere and 16 left hemisphere ischemic stroke patients. Sampling techniques is exhaustive sampling. Cognitive function of patients with ischemic stroke was measured using Indonesian version of MoCA (Montreal Cognitive Assessment) questionnaires. The data collected are presented in tabular form and analyzed using the multiple linear regression analysis through SPSS 20.00 program for Windows. Results: The location of lesions influence cognitive function score significantly (p = 0,027) and there is a difference inwhich patients with left hemisphere lesion score lower cognitive functionthan patients withright hemisphere lesion with regression coefficient (? =-4.604). Age is a confounding variable on the relationship between lesion location with cognitive function. Age has negative effect on cognitive function, where the increase of age correlates with the declining cognitive function (p = 0.040; ? = 0.228-). Conclusions: The decline of cognitive function in left hemisphere ischemic stroke patients is more severe than right hemisphere ischemic stroke patients. Keywords: Cognitive Function Decline, Right Hemisphere Ischemic Stroke, Left Hemisphere Ischemic Stroke

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