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Nexus Kedokteran Klinik
Published by Universitas Sebelas Maret
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
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Articles 334 Documents
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Perbedaan Pemberian Asam Valproat dan Fenobarbital terhadap Kadar Kalsium Darah Pasien Epilepsi Anak di RSUD Dr. Moewardi Friska Kusumaningtyas; Fadhilah Tia Nur; Dyah Ratna Budiani
Nexus Kedokteran Klinik Vol 2, No 3 (2013): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background : Antiepileptic drugs have different mechanisms. Meanwhile valproate acid and phenobarbital have similar mechanism, inactivation of voltage gated Ca2+ channels, Na+ channels, and increased activity of GABAergic inhibitory. However, the mechanism of phenobarbital also induces cytochrome P450 (CYP450) enzymes that affect the metabolism of vitamin D. The aim of this study was to examine the differences between valproic acid and phenobarbital on blood calcium levels of pediatric epilepsy. Methods : The cross sectional study was conducted by 24 pediatric epilepsy in the pediatric neurology clinic of RSUD Dr. Moewardi who met the inclusion criteria. Calcium ion levels in blood serum obtained from the medical records of pediatric patients who had been done routine laboratory tests about the side effects of antiepileptic drugs. Data normality was tested by Shapiro-Wilk. The differences of giving valproic acid and phenobarbital on calcium ion level of blood serum were analyzed by the Mann-Whitney test. The correlation between long term drug use and calcium ion levels in blood serum were analyzed by Spearman test. Results : The analysis results show that there is no difference between calcium ion levels in blood serum of valproic acid and phenobarbital of pediatric epilepsy in RSUD Dr. Moewardi with p = 0.881 (p > 0.05). Correlation analyze show that there is no correlation between duration of drug intake and calcium ion levels in blood serum levels with p = 0.191 (p > 0.05), 35.7% of subjects had a negative correlation for valproic acid and p = 0.548 (p > 0.05), 23.2% of subjects had a negative correlation for phenobarbital. Conclusion : There is no significant difference between calcium ion levels in blood serum of valproic acid and phenobarbital in pediatric epilepsy in RSUD Dr. Moewardi. As well as, there is a weak correlation between duration of drug intake and calcium ion in blood serum. Keywords : epilepsy, antiepileptic drug, valproic acid, phenobarbital, calcium ion
Hubungan antara Usia Menarke dengan Tinggi Badan dan Panjang Kaki Saat Dewasa Anindita Putri Hapsari; Tri Budi Wiryanto; . Sumardiyono
Nexus Kedokteran Klinik Vol 3, No 2 (2014): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Menarche happens when estrogen activity at the peak, that is showed with high level estrogen. In other words, age at menarche is the first onset of high level estrogen. Estrogen not just has important role in reproduction system but also in bone growth. Low level estrogen, or estrogen level when estrogen activity has not at peak yet during puberty time, can stimulate bone growth with growth hormone stimulation mechanism while high level estrogen, or estrogen level when estrogen activity at the peak, can accelerate the closure of epiphysial growth disks so the bone growth will stop in stages. Based on that theory, there is correlation between age at menarche with adult height and leg length. But there are still pros and cons about the result of correlation between age at menarche with final height and leg length from researchers in different places. Therefore, research about age at menarche in relation with adult height and leg length is needed. Methods: This research is analytic observational cross sectional. The data about age at menarche, height and leg length is gained from interview and measurement with 60 medical students of Sebelas Maret University. The data gained from the research is analyzed statistically using t test and Pearson Correlation test. Results: The average of age at menarche is 12.42 years old. In t test, there is no significant average difference of height (p = 0.612) and leg length (p = 0.341) between later age at menarche (higher than the average) group with early age at menarche (lower than the average) group. In Pearson Correlation test, there is no correlation between age at menarche with adult height (p = 0.985) and leg length (p = 0.443). Conclusions: In conclusion, there is no correlation between age at menarche with adult height and leg length. Keywords: age at menarche, height, leg length
Perbedaan Kecenderungan Somatisasi Antara Mahasiswa Semester IV yang Memiliki Tingkat Kecemasan Tinggi dan Rendah di Fakultas Kedokteran Universitas Sebelas Maret Surakarta . Arifa; Djoko Suwito; Diffah Hanim
Nexus Kedokteran Klinik Vol 3, No 3 (2014): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Somatization disorder is the presence of somatic complaints (physic) which can not be found the adequate medical explanation. Anxiety is a feeling disorder which characterized by a feeling of fear or concern that deep and sustained. Anxiety can occur in the fourth semester students. This research aims to find out is there any difference of the somatization tendencies between semester IV students who have high and low levels of anxiety in Medical Faculty of Sebelas Maret University Surakarta. Methods: This was an analytic observational research with case-control design. The subject were fourth semester students in Medical Faculty of Sebelas Maret University who meet established criteria. The sampling technique using total sampling of a large population of 237 people. The data analysed by using SPSS for Windows version 17.0 programme with the normality test by Shapiro-Wilk continued by Mann-Whitney because the data that taken was not normal distribution. Results: Students with high anxiety level was obtained an average IRS score of 15.75 and SD 6.883. Students with low anxiety level was obtained an average IRS score of 5.33 and SD 3.467. The difference of somatization tendencies between semester IV students who had high and low levels of anxiety generate significant value (p = 0.000) Conclusions: There were difference of somatization tendencies which statistically significant betweet semester IV students who had high and low levels of anxiety. Students who had high level of anxiety are more likely to experience somatization compared to students who had low level of anxiety. Keywords: Level of anxiety, somatization tendencies, medical students.
Hubungan Indeks Massa Tubuh Overweight dengan Gambaran Fatty Liver pada USG Abdomen di RSUD dr. Moewardi Charismatika Syintia Dewi
Nexus Kedokteran Klinik Vol 1, No 2 (2012): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Overweight increasing in the world is one result of the modernization of lifestyles, the increasing caloric intake and limited physical activity. Overweight is more realized to become of a person's risk for metabolism chronic disease. Fatty liver is increasingly recognized condition that also develop into chronic liver disease. This study aims to examine the relationship between overweight body mass index and fatty liver picture on USG Abdomen in RSUD dr. Moewardi. The study is expected to assist in diagnosis and treatment is more adequate and the prevention of fatty liver early on. Methods: This research is an analytical observational research with cross-sectional approach. Subjects were patients undergoing abdominal ultrasound Radiology Installation in RSUD dr. Moewardi in June 2012. Sampling was done after a fixed exposure sampling were selected based on inclusion and exclusion criteria of the sample. The obtained data were as many as 40 samples, taken immediately to see the results of focused abdominal ultrasound examination of heart and with a body mass index calculation derived from measurements of height and weight. Then samples were analyzed by Chi Square test and Odds Ratio test using the Statistical Product and Service Solution (SPSS ) 17.0 for Windows. Result: The data link overweight with a body mass index picture of fatty liver on abdominal ultrasound in RSUD dr. Moewardi was tested by Chi Square test bivariate analysis, obtained p = 0,011. Odds Ratio test was then performed to determine the strength of a causal relationship with OR = 5,571. Conclusion: There is a significant association between overweight body mass index with images of fatty liver on abdominal ultrasound (p = 0,011), where an overweight have a risk for developing fatty liver 5,571 times that of a normoweight or underweight. Keywords: fatty liver, body mass index, overweight, ultrasound
The Difference in Level of Depression between Chronic and Non-Chronic Hospitalized Child Syarifah Aini Khairunisa; Suci Murti Karini; Mohammad Fanani
Nexus Kedokteran Klinik Vol 4, No 3 (2015): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Health problems, either chronic or non-chronic, could possibly cause a depression. Depression in people with health problems often be seen as a normal reaction. In children, most of the time, depression is underdiagnosed or undertreated. This is possibly because children can hardly express their negative thoughts or feels, and they have unspecified somatization. Hence, this study is conducted to find information whether there is any difference in level of depression between chronic and non-chronic hospitalized child. Methods: This is an analytical descriptive study with cross sectional approach using purposive sampling. Data taken from medical records and patients-and-parents interviews using Skala Penilaian Depresi Anak as instrument for measuring the level of depression. The study conducted in 10 weeks, from November 2014 to February 2015. The subjects are 8 to 18 years old Hospitalized Child in RSUD Dr Moewardi Surakarta, as much as 102 patients, consists of 68 chronic patients and 34 non-chronic patients. The data was then analysed using Kolmogorov Smirnov test with a significance value of p < 0.05 in SPSS 20.0 for Windows. Results: The result of Kolmogorov Smirnov test shows the asymptotic significance value of 0.970 (p > 0.05), which means there is no significant difference in level of depression between chronic and non-chronic hospitalized child. Conclusions: There is no significant difference in level of depression between chronic and non-chronic hospitalized child. There should be conducted any further study about depression in hospitalized children including more influential factors that could possibly cause depression. Keywords: Chronic Disease, Non-Chronic Disease, Depression, Hospitalized Child.
Hubungan Indeks Massa Tubuh (IMT) dengan Derajat Keparahan Stroke Iskemik pada Pasien di Unit Penyakit Saraf RSUD Dr. Moewardi Aga Suganda; . Suroto; Siti Utari
Nexus Kedokteran Klinik Vol 2, No 3 (2013): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Stroke is the third leading cause of death in the world. Approximately 80% of strokes are ischemic strokes. One of the significant prognostic factors causing morbidity of stroke patients is the Body Mass Index (BMI). National Institutes of Health Stroke Scale (NIHSS) is a systematic examination to determine the severity stroke. The aim of this study is to determine the relationship of body mass index (BMI) with ischemic stroke severity in patients at Neurology Ward Dr. Moewardi Hospital. Methods: This was an observational study with cross sectional analytic. A total of 32 subjects were selected by purposive sampling, they were ischemic stroke patients in the Neurology Ward Dr. Moewardi Hospital. Data were collected by direct interview, direct measurement of weight and height also examination of severity stroke patient by using NIHSS score. Data analysis used multiple logistic regression models and were processed with Statistical Product and Service Solutions (SPSS) 17.00 for Windows. Results: Multiple logistic regression showed OR = 17,690; CI 95% 1,190 263,039; and p = 0,037. These results have been earned by controlled the confounding variables of age, blood pressure, blood sugar levels, cholesterol levels and smoking history. Conclusions: Ischemic stroke patients with high BMI score has risk of ischemic stroke severity 17.690 times higher than whose normal BMI score.There is a strong relationship between body mass index (BMI) with the severity of ischemic stroke patients at Neurology Ward of Dr. Moewardi Hospital, the relationship is statistically significant in this study. Keywords:BMI, Stroke Severity, Ischemic Stroke
Hubungan Hiperglikemia Dengan Kejadian Stroke Hemoragik Pada Pemeriksaan Multislice CT-Scan Kepala Tanpa Kontras Di RSUD DR. Moewardi Surakarta Fernando Feliz Christyan; . Widiastuti; Jarot Subandono
Nexus Kedokteran Klinik Vol 3, No 1 (2014): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Stroke is the third most common cause of death in the world, with a high prevalence of death in low-and middle-income countries. Hyperglycemia has been associated with atherosclerotic lession resulting in cerebral aneurysm which can lead to hemorrhagic stroke. CT-Scan is considered sufficiently sensitive for detecting acute hemorrhage, as well as detecting mass lessions. The aim of this study was to determine the correlation between hyperglycemia and hemorrhagic stroke incident on noncontrast multislice CT-Scan of the head examination. Methods: This study was an observational study with the analytical approach to the subject of cross-sectional study. 70 subjects were selected by fixed- disease sampling methods. These subjects have been performed a noncontrast multislice CT-Scan of the head examination. Data was collected by reading the result of blood glucose level and CT-Scan of the head examination on patients medical record. Data were processed with Statistical Product and Service Solution (SPSS) 17.00 for Windows Results: Chi-Square models showed that X2 = 7,19 with 5% significancy. OR (Odds Ratio) in hemorrhagic stroke was 4,26 (CI 95% = 1,43-12,74). Patient with hyperglycemia increases the risk of getting hemorrhagic stroke 4,26 (4) times than patient without hyperglycemia. Conclusion: There is a correlation between hyperglycemia and hemorrhagic stroke incident. Keywords: hyperglycemia, hemorrhagic stroke, noncontrast head CT-Scan
Hubungan Endometriosis dengan Infertilitas pada Pasien Poliklinik Obstetri Ginekologi dan Klinik Fertilitas Sekar RSUD Dr. Moewardi Surakarta Irsalina Nur Shabrina; Tedja Danudjo Oepomo; Yulia Sari .
Nexus Kedokteran Klinik Vol 3, No 2 (2014): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Women with endometriosis have a difficult pregnancy. Nowadays, infertility becoming a difficult problem towards married persons, especially for the wife, from this research would known the fact is it true that endometriosis is a disease that is often found in infertil woman. This study aims is to determine the relationship between endometriosis and infertility among the patients at RSUD Dr. Moewardi Surakarta. Methods: This study was an observational analytic studies, with case-control approach. Data were taken from female patients who had been hospitalized on the Obstetrics Gynecology Clinic and Sekar Fertility Clinic of RSUD Dr. Moewardi from January 2012 to July 2013, interviews were conducted with a questionnaire to find out the history of parity. Data were analyzed by chi-square statistical test (? = 0.05). Results: Based on the research towards 44 sampels, consisted of 22 samples of cases and 22 samples of controls were identified that there were 16 infertile women with endometriosis, 2 fertile women who have endometriosis, 6 infertile women without endometriosis, and 20 fertile women without endometriosis. Chi Square statistical test results showed a significant relationship between endometriosis with infertility with p = 0.00 (p <0.05). Conclusions: There is a statistically significant relationship between endometriosis with infertility (p = 0.00) among the patients of RSUD Dr. Moewardi Surakarta. Keywords: endometriosis, infertility
Hubungan Kualitas Tidur dengan Ansietas pada Penderita Asma Bronkiale Dhiandra Dwi Hapsari; Harsini .; Hartono .
Nexus Kedokteran Klinik Vol 1, No 2 (2012): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Asthma is chronic inflammatory disease. Anxiety is psychiatric condition that is often found in many aspect of health one of which is asthma. Sleep disorders commonly found in patients with known asthma nocturnal. This study aimed to determine the relationship between sleep quality and anxiety of asthma patient. Methods: This study was observational by using cross-sectional design. The sample was selected by fixed exposure sampling from out patients who visited Pulmonology Clinics, RSUD Dr. Moewardi Surakarta. This research was held on April - May 2012. The data was collected by interview and some datas taken from the medical records. The data was analyzed using Chi-Square model, run on Statistical Product and Service Solution (SPSS) 18.00 for Windows. Results: Samples sizes were 30 asthma patients with anxiety and 30 asthma patient without anxiety. The results of this study showed that there is difference of sleep quality between asthma patient with anxiety and without anxiety. Asthma patient who were anxiety had 0.13 times higher risk for experiencing poor sleep quality than those who were without anxiety (OR = 0.13; p < 0.05). Conclusions: There is relationship between the sleep quality with anxiety of asthma patient. It is a strong association and statistically significant. The higher the level of anxiety, the higher the risk for poor quality sleep. Keywords: Asthma bronchiale, anxiety, sleep quality.
The Differences of Schizoid Personality Score on Medical Students of Sebelas Maret University Years 2013 with High and Low Emotional Quotient Ivonny Rembulan Zilmi; Aris Sudiyanto; Diffah Hanim
Nexus Kedokteran Klinik Vol 4, No 2 (2015): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background : Emotional quotient is needed to control emotional changes during teenager. Teenager is also known with personality finding. Personality is a combination of emotional, attitudes, and behavior patterns of individuals. Some teenagers may have a personality disorder. Schizoid personality is one of the exsample of personality disorder. Someone with schizoid personality is tilted to be alone, over introspection, do not have best friend (only one friend) and do not want to have a relation like that and also not sensitive with rules or social habit. This research aims to see the differences of schizoid personality score on medical students of Sebelas Maret University years 2013 with emotional quotient high and low. Methods : This is an observational analytic research with case control studies approach. The research was done in Faculty of Medicine Sebelas Maret University Surakarta. Sample used are medical students years 2013 who are 18-21 years old. The sampling method used was purposive sampling after inclusive and exclusive selection based on research criteria. Dependent variable is schizoid personality, and independent variable is emotional quotient. Research subject completed (1) informed consent, (2) L-MMPI questionnaire, (3) emotional quotient questionnaire, (4) schizoid personality questionnaire. As much as 72 data were collected and analyzed using Mann Whitney. Result : There are 72 samples who 18 years old (30.6 %), 19 years old (53.8 %), 20 years old (11.1 %) and girls (68.1 %). Students with high emotional quotient have schizoid personality score lower, and vice verca. The averages of schizoid personality score on high emotional quotient is 62.19 and on low emotional quotient is 69.83 (p = 0.000). Conclusion : Statistically, there is a significant differences of schizoid personality score on medical students of Sebelas Maret University years 2013 with high and low emotional quotient. Keywords : schizoid personality, emotional quotient

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