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Journal of Biomedicine and Translational Research
Published by Universitas Diponegoro
ISSN : -     EISSN : 25032178     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Journal of Biomedicine and Translational Research (JBTR) is an open access, international peer-reviewed journal that considers articles on: clinical medicine, molecular medicine, tropical medicine, infectious diseases, cardiovascular medicine, molecular biology, genetics, immunology, microbiology, biochemistry, and pharmacotherapy with particular interest on the link between clinical and basic research called translational research.
Arjuna Subject : -
Articles 5 Documents
 1 
Search results for , issue "Vol 11, No 1 (2025): April 2025" : 5 Documents clear
Effects of Vitamin C Supplementation on Histology of Callus Diameter and Osteoblast Number in Male Wistar Rats With Complete Femur Bone Fracture Rambe, Syahrul Ramadan; Putra, Reza Mahruzza; Rahmadhany, Heru
Journal of Biomedicine and Translational Research Vol 11, No 1 (2025): April 2025
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v11i1.25888

Abstract

Background: The role of nutritional factors, particularly vitamin C, in bone repair has been extensively studied. However, despite this research, the specific impact of vitamin C on bone fracture healing remains unclear. While some studies suggest that vitamin C supplementation may enhance bone repair, others report no significant benefits.Objective: This study aimed to investigate the effects of different doses of vitamin C on callus formation and osteoblast proliferation in a rat femur fracture model.Methods: A post-test-only control group design was employed in this study, involving 27 male Wistar rats that were randomly divided into three groups. The first and second groups received daily intramuscular injections of vitamin C at doses of 200 mg/kg body weight (BW) and 500 mg/kg BW, respectively, following femur bone fracture and fixation. The control group did not receive vitamin C and underwent no fixation. After 14 days, all rats were euthanized, and their femur bones were histologically examined for callus diameter and osteoblast count.Results: Vitamin C supplementation significantly increased the callus diameter in rats with complete femoral fractures. Both the 200 mg and 500 mg doses proved effective, demonstrating a clear dose-response relationship. Additionally, Vitamin C significantly elevated the number of osteoblasts, which play a crucial role in bone formation. However, there was no statistically significant difference in osteoblast count between the 200 mg and 500 mg doses.Conclusion: In conclusion, vitamin C supplementation has been shown to positively influence bone fracture healing in rats by promoting an increase in callus diameter and enhancing osteoblast proliferation. This study indicates that vitamin C could serve as a beneficial adjunct therapy for facilitating bone fracture healing, particularly by improving callus formation. Physicians should consider integrating vitamin C into treatment plans for patients with fractures, using doses similar to those applied in this study, adjusted appropriately for human use.
Relationship between MC4R rs17782313 Polymorphism and Body Mass Index and Appetite Regulation in Young Adults in Indonesia Sidarta, Erick; Kumala, Meilani
Journal of Biomedicine and Translational Research Vol 11, No 1 (2025): April 2025
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v11i1.26018

Abstract

Background: Obesity is an increasing public health problem, including among young adults in Indonesia. Genetic, environmental, and behavioral factors contribute to obesity. One of the genetic variants associated with obesity is the MC4R rs17782313 polymorphism, which plays a role in appetite regulation and energy balance.Objective: This study aims to determine the relationship between the MC4R rs17782313 polymorphism and Body Mass Index (BMI) in young adults in Indonesia and to evaluate its effect on feelings of hunger, satiety and eating satisfaction.Method: We conducted a cross-sectional study involving 152 young adults at Universitas Tarumanagara. Genotyping was done using the real-time PCR method with the KASP™ system. To evaluate hunger, satiety, and eating satisfaction, we used the Visual Analog Scale (VAS; 0–100 mm, where lower scores indicate intense sensations of hunger, satiety, and satisfaction) before and after meals and calculated the difference scores. We analyzed the data using R software.Results: The results showed no significant relationship between the MC4R rs17782313 polymorphism and BMI (p = 0.7). However, there was a significant difference in hunger scores between the TT and TC genotypes (p = 0.024), where individuals with the TT genotype experienced a greater reduction in hunger after eating than individuals with the TC genotype. In addition, we also found a significant difference in BMI based on gender in our young adult population (p = 0.0032).Conclusion: This study found that MC4R rs17782313 was not significantly associated with BMI in this population. However, the variant may influence appetite regulation, as individuals with the TT genotype showed a smaller reduction in hunger after eating. A significant BMI difference between sexes was also observed; these findings suggest a role for MC4R in eating behavior, warranting further investigation in larger, diverse populations.
Effect of Moringa Oleifera on Tumor Necrosis Factor-Alpha and Extracellular Matrix Trabecular Meshwork of Glaucoma Model Wistar Rats Maharani, Maharani; Astuti, Ratih Kusuma; Rahmi, Fifin Luthfia; Prihatningtias, Riski; Istiadi, Hermawan; Wildan, Arief
Journal of Biomedicine and Translational Research Vol 11, No 1 (2025): April 2025
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v11i1.24127

Abstract

Background: Elevated intraocular pressure (IOP) induces inflammation in the trabecular meshwork (TM) through increases in tumor necrosis factor-alpha (TNF-α) expressions by activating nuclear factor kappa B (NF-κB). Mechanical injury to the TM, such as increased IOP, can cause extracellular matrix (ECM) remodeling, impacting the permanent outflow of aqueous humor. Moringa oleifera (MO) leaf extract is an anti- inflammatory agent that inhibits NF-κB activation and has been studied to have antioxidant effects.Objective: to analyze the effects of MO leaf extract on TNF- α expression and the thickness of the trabecular meshwork ECM in a Wistar rat glaucoma model. Methods: Fourteen male Wistar rats were divided into two groups (n=7): the glaucoma group received oral MO leaf extract at 300 mg/kg body weight for four weeks, and the control group. TNF-α expressions were measured by immunohistochemical stain, and the thickness of the ECM was examined with hematoxylin eosin staining. P-values of less than 0.05 were considered to represent statistical significance.Results: The mean of TNF-α expressions in the treatment group was 4.29 ± 0.76, and the control group was 5.29 ± 0.49. There was a significant difference in TNF-α expressions between the two groups (p=0.015). The mean thickness of the ECM TM experimental group and control group were 155.65 ± 28.72μm and 218.63 ± 40.85μm respectively. The extracellular matrix TM experimental group was statistically significantly thinner than the control group (p=0.006).Conclusion: MO could protect TM from damage caused by high IOP by suppressed TNF- α expression and ECM thickness in the TM Wistar glaucoma model. 
Genetic Counselling Empowers Parents of Children with Intellectual Disabilities : A Fragile X Syndrome Perspective Amir, Mentari; Aulia, Siti Farhanah; Ranakusuma, Octaviani Indrasari; Faradz, Sultana MH
Journal of Biomedicine and Translational Research Vol 11, No 1 (2025): April 2025
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v11i1.25938

Abstract

Background: Intellectual disabilities (ID) profoundly affect individuals and their families, leading to financial strain, emotional distress, and limited access to healthcare and education. Fragile X Syndrome (FXS), the most common inherited cause of ID, remains largely underdiagnosed in Indonesia due to limited awareness and resources. Objective: This study aimed to assess the impact of genetic counselling on parental empowerment. Methods: This pre-experimental study employed a before and after counselling. A total of 238 parents of children with ID from four special schools in Jakarta participated. Data were collected using the Genetic Counselling Outcome Scale-24 (GCOS-24), which assesses empowerment. Purposive sampling was applied, and data were analysed using paired t-tests and one-way ANOVA. Results: The mean GCOS-24 score increased significantly from 106.79 (SD = 16.36) before counselling to 125.11 (SD = 15.42) after counselling (p < 0.001). Only 27.3% of parents were aware of genetic disorders, reflecting their limited baseline knowledge. A one-way ANOVA analysis showed a statistically significant difference in GCOS-24 score improvements based on parental education level (F=4.035, p=0.008) with parents with primary school education showing the greatest improvement compared to those with high school (p < 0.05). Conclusions: Genetic counselling significantly enhanced parent empowerment, as evidenced by increased GCOS-24 scores. These findings emphasize the importance of expanding genetic counselling services and educational initiatives in Indonesia to improve awareness and support for families managing ID.
Successful Management of Post-Excisional Biopsy Dehisced Wound with 1% Framycetin Sulphate and Ozonated Oil Adjuvant: A Case Report Mawu, Ferra Olivia; Sondakh, O. Reymond L.; Tampi, Joan Alexandra; Christopher, Paulus Mario
Journal of Biomedicine and Translational Research Vol 11, No 1 (2025): April 2025
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v11i1.25956

Abstract

Background: Wound dehiscence is wound edges separation due to disrupted wound healing. Wound dehiscence is a complication in 8% of dermatologic surgeries. In this case, secondary infection of the wound occurred, 1% framycetin sulphate tulle was then chosen to interfere microbial protein synthesis, combined with ozonated oil as adjuvant therapy. Ozone oxidizes bacterial phospholipids and lipoproteins, promotes local tissue metabolism, stimulates fibroblast proliferation, facilitates collagen fiber formation, and supports angiogenesis. This case report described a post-excisional biopsy dehisced wound that was treated with 1% framycetin sulphate tulle and ozonated oil, and this case is the first to report a successful management of post-excisional biopsy dehisced wound with ozonated oil as adjuvant. Case Presentation: An 11-year-old female was brought with a purulent wound on her head post-excisional biopsy. Examination of the parietal region showed a solitary ulcer, 1 cm in diameter, irregular edge, granulated tissue base, serous exudate, crusting, edema, and pus. Treatment was 0.9% NaCl compress, 1% framycetin sulphate tulle, and ozonated oil once weekly. Evaluation on day 21 showed ulcer size reduction and on day 28, ulcer turned into a scar, treatment was continued with mometasone 0.1% cream. Day 86 showed secondary cicatricial alopecia. Complications of a wound in hair-bearing area can occur, in this case, secondary cicatricial alopecia.Conclusion: This paper highlights the utilization of ozonated oil as an adjuvant therapy for a favorable outcome in wound healing.

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