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Efek Lignan Terhadap Resiko Kanker Mammae Kumala, Meilani
Indonesian Journal of Cancer Vol 2, No 1 (2008): Jan - Mar 2008
Publisher : "Dharmais" Cancer Center Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1595.44 KB)

Lignan merupakan metabolit sekunder dari tumbuh-tumbuhan dan termasuk kelompok fitoestrogen. Secoisolariciresinol (SECO) dan Matairesinol (MAT) merupakan prekursor mammalian lignan yang utama dan pertama diidentifikasi. Kedua prekursor tersebut banyak terdapat pada bahan makanan asal tumbuh-tumbuhan terutama yang kaya akan serat seperti biji-bijian, padi-padian, sayuran dan buah-buahan. Flaxseed merupakan bahan makanan sumber yang mempunyai kandungan lignan paling tinggi. Dalam saluran cerna kedua prekursor tersebut mengalami serangkaian metabolisme dan dengan bantuan mikronora dikonversi menghasilkan mammalian lignan yang mempunyai struktur menyerupai estrogen endrogen. Enterolignan mempunyai berbagai aktivitas biologik meliputi menghambat ikatan estrogen dengan reseptornya, menstimulasi produksi sex hormone-binding globulin, menghambat pembentukan enzim aromatase dan meningkatkan rasio 2-OHEl:16a-OHEl. Penelitan pada hewan dan manusia menunjukkan enterolignan mempunyai efek protektif terhadap kanker mammae. Aktivitas biologik enterolignan diduga berperan dalam mekanisme protektif terhadap risiko kanker mammae.Kata kunci: lignan, mammalian lignan, enterolignan, enterolakton, enterodiol, kanker mammae

HUBUNGAN STATUS GIZI, LINGKAR PINGGANG, DAN PROFIL LIPID TERHADAP HIPERTENSI PADA USIA PRODUKTIF BERPENGHASILAN RENDAH Kumala, Meilani; Lontoh, Susy Olivia; Novendy, Novendy
Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan Vol 5, No 1 (2021): Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan
Publisher : Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/jmstkik.v5i1.9930

Background: The prevalence of hypertension in the world today increases year by year. Monitoring data of non communicable diseases (NCD), 2017 shows that the number and risk of death for Indonesian people in productive age is quite high. Research on the relationship between risk factors and hypertension in low-income productive age communities in Indonesia has not been widely studied. Objective: This study aims to determine the relationship between nutritional status, waist circumference (WC) and lipid profile with hypertension in people of low income productive age. Methods: The design of this study was cross sectional. Identity data were collected through interview, blood pressure, anthropometry, waist circumference data were obtained by measuring and blood lipid profile, fasting blood sugar data were carried out by laboratory test. The data that had been obtained were tested using Fisher’s exact test. Results: As many as 50% of 62 subjects had hypetension, 38.7% of subjects had overweight, 33,87% of subjects had obesity and 61.9% of subjects had WC above normal or including central obesity. As many as 37.1% of subjects had hypercholesterolemia, 90.3% had low density lipoproteinemia (LDL) above normal, 16.1% of subjects had high density lipoproteinemia (HDL) below normal and 22.6% of subjects had hypertriglyceridemia. The results of Fisher's exact test showed that there was no relationship between nutritional status, WC and lipid profiles with hypertension. The prevalence odds ratio (POR) showed that subjects with over nutrition and obesity have a 1.63 times risk of developing hypertension; subjects with central obesity had a 1.73 times risk of developing hypertension; subjects with hypercholesterolemia had a 2.7-fold risk of developing hypertension and subjects with high LDL had 2.15 times the risk of developing hypertension, while POR of HDL and triglycerides showed a neutral value or not a risk factor for hypertension. Conclusion: Nutritional status, WC, lipid profile have no relationship with hypertension in low-income productive age people in Indonesia. Based on the POR, it was found that obesity, WC, cholesterol and LDL were risk factors for hypertension, whereas triglycerides and HDL did not affect the incidence of hypertension Keywords: nutritional status; waist circumferences; lipid profile; productive age; low income AbstrakLatar Belakang: Pevalensi hipertensi di dunia dewasa ini meningkat dari tahun ke tahun. Data monitor kemajuan penyakit tidak menular (PTM), 2017 menunjukkan bahwa angka dan risiko kematian masyarakat dengan usia produktif di Indonesia cukup tinggi.Penelitian hubungan faktor risiko terhadap hipertensi pada masyarakat usia produktif berpenghasilan rendah di Indonesia belum banyak dikaji lebih dalam. Tujuan: Penelitian yang dilakukan untuk mengetahui hubungan status gizi, lingkar pinggang (Lpi) dan profil lipid dengan hipertensi pada masyarakat usia produktif berpenghasilan rendah. Metode: Desain penelitian ini adalah potong lintang. Data identitas dikumpulkan melalui wawancara, data tekanan darah, antropometri, lingkar pinggang diperoleh dengan melakukan pengukuran dan data profil lipid darah, gula darah puasa dilakukan dengan pemeriksaan laboratorium. Data yang telah diperoleh, diuji menggunakan uji Fisher’s exact. Hasil: Sebanyak 50% dari 62 subjek mengalami hipertensi, 38,7% subjek mempunyai status gizi berlebih, 33,9% subjek termasuk obesitas dan 61,9% subjek mempunyai Lpi di atas normal atau obesitas sentral. Sebanyak 37,1% subjek mengalami hiperkolesterolemia, 90,3% mempunyai low density lipoproteinemia (LDL) di atas normal, 16,1% subjek mempunyai high density lipoproteinemia (HDL) dibawah normal dan 22,6% subjek mengalami hipertrigliseridemia. Hasil uji Fisher’s exact menunjukkan tidak terdapat hubungan antara status gizi, Lpi dan profil lipid dengan hipertensi. Prevalence odds ratio menunjukkan subjek dengan status gizi berlebih dan obesitas mempunyai risiko 1,63 kali mengalami hipertensi; subjek dengan obesitas sentral mempunyai risiko 1,73 kali mengalami hipertensi; subjek dengan hiperkolesterolemia mempunyai risiko 2,7 kali mengalami hipertensi dan subjek dengan LDL yang tinggi mempunyai risiko 2,15 kali mengalami hipertensi, sedangkan POR HDL dan trigliserida memperlihatkan tidak merupakan faktor risiko hipertensi. Kesimpulan: Status gizi, Lpi, profil lemak darah tidak mempunyai hubungan dengan kejadian hipertensi pada masyarakat usia produktif berpenghasilan rendah. Gizi lebih dan obesitas, Lpi, kolesterol dan LDL merupakan faktor risiko kejadian hipertensi sedangkan, triglieserida dan HDL tidak memengaruhi kejadian hipertensi.

GAMBARAN TINGKAT AKTIFITAS FISIK PADA MASYARAKAT KELURAHAN TOMANG JAKARTA BARAT Lontoh, Susy Olivia; Kumala, Meilani; Novendy, Novendy
Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan Vol 4, No 2 (2020): Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan
Publisher : Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/jmstkik.v4i2.8728

Lack of physical activity is a risk factor for increased incidence of coronary heart disease (CHD), type 2 diabetes mellitus (T2DM), breast cancer, colon cancer and reduced life expectancy. Regular and adequate levels of physical activity are essential to reduce the risk of non-communicable diseases. Kelurahan Tomang has an urban area and is an urban area and tends to be a sedentary life style. Data regarding the description of physical activity in the Tomang Village, West Jakarta is still limited. This study aims to determine the level of physical activity in the community of Tomang Village, West Jakarta. This research is an observational analytic study with a cross-sectional design. The study was conducted on 181 subjects and subject taking was done by consecutive sampling. Subjects in this study were aged from 20 years - 45 years with an average age of 35.1 ± 6.79 years, the majority were women as much as 55.8% and 78.5% of the subjects were married. Judging from the level of education, dominated by high school education / equivalent, the average monthly income of 42.9% of the subjects earned Rp. 3,000,001,-Rp. 4,000,000, - and most of the subjects worked as housewives and 43.1 % of subjects who did not exercise. The results of the measurement of the subject's physical activity level showed that 59.7% of subjects who had light activity and sex and type of work had an effect on the lack of physical activity Keywords: physical activity, sedentary life style ABSTRAKAktifitas fisik yang kurang menjadi faktor risiko untuk peningkatan kejadian penyakit jantung koroner (PJK), diabetes mellitus tipe 2 (T2DM), kanker payudara, kanker usus besar dan mengurangi harapan hidup. Tingkat aktifitas fisik yang teratur dan memadai sangat penting untuk mengurangi risiko penyakit tidak menular. Kelurahan Tomang berwilayah diperkotaan serta merupakan daerah urban dan cenderung sedentary life style. Data mengenai gambaran aktifitas fisik di lingkungan Kelurahan Tomang Jakarta Barat masih terbatas. Penelitian ini bertujuan untuk mengetahui gambaran tingkat aktifitas fisik pada masyarakat kelurahan Tomang Jakarta Barat. Penelitian yang dilakukan merupakan penelitian analitik observational dengan disain potong lintang. Penelitian dilakukan pada 181 subyek dan pengambilan subjek dilakukan secara consecutive sampling. Subjek dalam penelitian ini berusia mulai dari 20 tahun - 45 tahun dengan usia rata-rata adalah 35.1 ± 6,79 tahun, mayoritas adalah perempuan sebanyak 55,8 % dan 78,5 % subjek menikah. Dilihat dari jenjang pendidikan, didominasi dengan pendidikan SMA/sederajat, rata-rata penghasilan perbulan 42,9 % subjek berpenghasilan Rp.3.000.001,-Rp.4.000.000,- dan sebagian besar subjek bekerja sebagai ibu rumah tangga serta 43,1%subjek yang tidak melakukan olahraga. Hasil pengukuran tingkat aktifitas fisik subjek terlihat bahwa 59,7 % subjek yang memiliki aktifitas ringan dan jenis kelamin dan jenis pekerjaan berpengaruh terhadap kurangnya aktifitas fisik.

Efek Lignan Terhadap Resiko Kanker Mammae Meilani Kumala
Indonesian Journal of Cancer Vol 2, No 1 (2008): Jan - Mar 2008
Publisher : National Cancer Center - Dharmais Cancer Hospital

Lignan merupakan metabolit sekunder dari tumbuh-tumbuhan dan termasuk kelompok fitoestrogen. Secoisolariciresinol (SECO) dan Matairesinol (MAT) merupakan prekursor mammalian lignan yang utama dan pertama diidentifikasi. Kedua prekursor tersebut banyak terdapat pada bahan makanan asal tumbuh-tumbuhan terutama yang kaya akan serat seperti biji-bijian, padi-padian, sayuran dan buah-buahan. Flaxseed merupakan bahan makanan sumber yang mempunyai kandungan lignan paling tinggi. Dalam saluran cerna kedua prekursor tersebut mengalami serangkaian metabolisme dan dengan bantuan mikronora dikonversi menghasilkan mammalian lignan yang mempunyai struktur menyerupai estrogen endrogen. Enterolignan mempunyai berbagai aktivitas biologik meliputi menghambat ikatan estrogen dengan reseptornya, menstimulasi produksi sex hormone-binding globulin, menghambat pembentukan enzim aromatase dan meningkatkan rasio 2-OHEl:16a-OHEl. Penelitan pada hewan dan manusia menunjukkan enterolignan mempunyai efek protektif terhadap kanker mammae. Aktivitas biologik enterolignan diduga berperan dalam mekanisme protektif terhadap risiko kanker mammae.Kata kunci: lignan, mammalian lignan, enterolignan, enterolakton, enterodiol, kanker mammae

Relationship of Caffeinated Beverage Intake with Sleep Quality of 2020 Students' Faculty of Medicine Tarumanagara University Wendy Tan; Meilani Kumala
Budapest International Research and Critics Institute-Journal (BIRCI-Journal) Vol 5, No 3 (2022): Budapest International Research and Critics Institute August
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birci.v5i3.6470

Sleep is a condition in which a person becomes less aware of something. Short rest periods (<7 hours) can increase the risk of death and have been considered a major risk factor for damaging the endocrine system, immune system, nervous system, and cardiovascular system. Many factors affect sleep duration and sleep quality in adults and children, including the use of caffeinated beverages. The purpose of this study was to determine whether there was a relationship between the intake of caffeinated beverages and the sleep quality of the 2020 students of the Faculty of Medicine, Tarumanagara University. The research is a descriptive-analytic cross-sectional study. Data was collected by distributing g-form to respondents. The collected data were inputted and analyzed using SPSS with Chi-Square and Fisher's Exact as an alternative analysis for cells with an expected of less than five. The results of this study showed that 41.3% of respondents had good sleep quality, and 58.7% of respondents had poor sleep quality. There is a significant relationship between coffee intake and sleep quality (p-value = 0.044), and there is no significant relationship between intake of tea, chocolate drinks, soft drinks, and energy drinks with sleep quality. The value of the prevalence ratio of caffeinated beverages intake with sleep quality is greater than one, which indicates caffeinated beverages are a risk for poor sleep quality.

PROFIL ANTROPOMETRIK, VITAMIN D, B12, FOLAT, DAN FERITIN PASIEN OBES PRABEDAH BARIATRIK DI POLIKLINIK GIZI RUMAH SAKIT SUMBER WARAS Anastasia Hayuningtyas; Lady Dhita Alfara; Tjandraningrum; Victor Tambunan; Lukman Halim; Meilani Kumala; Johana Titus
IJCNP : INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN Vol 6 No 1 (2023): IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN)
Publisher : Perhimpunan Dokter Gizi Klinik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54773/ijcnp.v6i1.183

Obese patients, especially patients with severe obesity and requiring bariatric surgery, have a high prevalence of nutrient deficiencies. This study aims to determine some of the basic characteristics of patients undergoing bariatric surgery so that they can be used as supporting data for post-bariatric surgery nutrition medical therapy, particularly in the provision of food sources and micronutrient supplementation which can be deficient due to anatomic and physiological alterations after the surgery. The study was conducted on 55 preoperative bariatric patients by assessing age, gender, and degree of obesity based on body mass index (BMI), serum vitamin D and B12 levels, erythrocyte folic acid, and serum ferritin of subjects. The study is descriptive with a cross-sectional design. Subjects were taken by consecutive sampling. The results showed that the mean age of preoperative bariatric patients was 36 ± 7.1 years; most (85.5%) were women. Most subjects (34.5%) had BMI of 35–39.9 kg/m2. Vitamin D deficiency was present in most (75.6%) of the study subjects, but most had serum vitamin B12 levels, erythrocyte folic acid levels, and serum ferritin levels within normal limits. This study shows that the basic profile of patients undergoing bariatric surgery is primarily late adults, classified as severe obese and having vitamin D deficiency. Keywords: Obesity, Prebariatric, Serum Vitamin D, Serum Vitamin B12, Erythrocyte Folic Acid, and Serum Ferritin.

Relationship between MC4R rs17782313 Polymorphism and Body Mass Index and Appetite Regulation in Young Adults in Indonesia Sidarta, Erick; Kumala, Meilani
Journal of Biomedicine and Translational Research Vol 11, No 1 (2025): April 2025
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v11i1.26018

Background: Obesity is an increasing public health problem, including among young adults in Indonesia. Genetic, environmental, and behavioral factors contribute to obesity. One of the genetic variants associated with obesity is the MC4R rs17782313 polymorphism, which plays a role in appetite regulation and energy balance.Objective: This study aims to determine the relationship between the MC4R rs17782313 polymorphism and Body Mass Index (BMI) in young adults in Indonesia and to evaluate its effect on feelings of hunger, satiety and eating satisfaction.Method: We conducted a cross-sectional study involving 152 young adults at Universitas Tarumanagara. Genotyping was done using the real-time PCR method with the KASP™ system. To evaluate hunger, satiety, and eating satisfaction, we used the Visual Analog Scale (VAS; 0–100 mm, where lower scores indicate intense sensations of hunger, satiety, and satisfaction) before and after meals and calculated the difference scores. We analyzed the data using R software.Results: The results showed no significant relationship between the MC4R rs17782313 polymorphism and BMI (p = 0.7). However, there was a significant difference in hunger scores between the TT and TC genotypes (p = 0.024), where individuals with the TT genotype experienced a greater reduction in hunger after eating than individuals with the TC genotype. In addition, we also found a significant difference in BMI based on gender in our young adult population (p = 0.0032).Conclusion: This study found that MC4R rs17782313 was not significantly associated with BMI in this population. However, the variant may influence appetite regulation, as individuals with the TT genotype showed a smaller reduction in hunger after eating. A significant BMI difference between sexes was also observed; these findings suggest a role for MC4R in eating behavior, warranting further investigation in larger, diverse populations.

CALORIE INTAKE AND NUTRITIONAL STATUS AMONG STUDENTS 13-15 YEARS AT SMP NEGERI 2 TANJUNG PINANG Aulia, Amanda; Meilani Kumala
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 12 No. 3 (2025): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v12i3.724

Nutritional status among adolescents is a global and national issue. Being overweight is a condition where a person's weight exceeds normal body weight, caused by excess fat accumulation. The impact of being overweight in adolescents will be a risk factor for degenerative diseases in young adulthood and old age. The study aimed to determine the distribution of nutritional status, daily caloric intake, and the relationship between caloric intake and nutritional status among adolescents. This study was conducted in an analytical observational manner with a cross-sectional design. This study was conducted at SMP Negeri 2 Tanjung Pinang to 262 grade IX students. Results: Most respondents were male (51.9%), aged 15 (58.8%). The nutritional status of most subjects was in the normal category (44.7%), with 30.5% being underweight and 24.8% overweight or obese. The study results showed a relationship between calorie intake and nutritional status in students aged 13-15, with a p-value = <0.001 using the Chi-Square Test.

Correlation Between Body Mass Index and Calf Circumference in Assessing the Nutritional Status of the Elderly Antolin, Cecilia; Kumala, Meilani
J-Kesmas: Jurnal Fakultas Kesehatan Masyarakat (The Indonesian Journal of Public Health) Vol 12, No 2 (2025): October 2025
Publisher : Universitas Teuku Umar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35308/j-kesmas.v12i2.13527

An increase in fat mass and a decrease in muscle mass are common physiological changes in the elderly. The loss of muscle mass increases the risk of sarcopenia, which negatively affects physical function. Therefore, accurate assessment of nutritional status in the elderly is crucial. Body Mass Index (BMI) is commonly used but cannot distinguish between fat mass and muscle mass. Calf circumference serves as a simple and practical anthropometric alternative to estimate muscle mass. This study aims to determine the correlation between BMI and calf circumference in assessing the nutritional status of elderly individuals aged ≥46 years. This research employed an analytical observational design with a cross-sectional approach, conducted at three locations during the 2024–2025 period. A total of 75 respondents who met the inclusion and exclusion criteria were included. Data were obtained through measurements of height, weight, and calf circumference. The analysis showed a significant correlation between BMI and calf circumference (p < 0.05). Conclusion: Calf circumference can serve as an important additional indicator in assessing the nutritional status of the elderly. The combination of BMI and calf circumference provides more comprehensive information for evaluating the nutritional status in the elderly population.

Perbedaan Tekanan Darah Sistolik dan Diastolik Pada Kelompok Lanjut Usia Dengan Insomnia Djung Lilya Wati; Meilani Kumala; Zita Atzmardina; Fernando Nathaniel; Dean Ascha Wijaya
Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran Vol. 1 No. 3 (2023): Juli : Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/termometer.v1i3.2060

Insomnia is the most common sleep disorder experienced by the elderly, which has a significant negative effect on morbidity and mortality in the elderly group. A study from the Penn State Adult Cohort found that people who are sleep deprived with objectively short sleep duration have a higher risk of developing hypertension. This cross-sectional study aims to determine differences in systolic and diastolic blood pressure in the elderly group (³60 years) with insomnia which were selected consecutively at the Tarumanagara University COVID-19 Vaccine Center for the period March – April 2021. The Insomnia Severity Index (ISI) questionnaire was used to evaluate the severity of insomnia. Blood pressure is measured with a digital tensimeter according to standard procedures. Statistical analysis using the Mann Whitney test. Of the 119 respondents, the average age was 69.84 years and 58% of the respondents were women. The mean systolic blood pressure was 150.18 and the average diastolic blood pressure was 83.23. From all respondents, it was found that 17.6% of respondents experienced insomnia. The results of the Mann Whitney statistical test explained that there was no difference in the mean systolic and diastolic blood pressure in the group with insomnia and without insomnia (p-value > 0.05). Further clinical studies revealed that the group of elderly who had insomnia tended to have higher blood pressure than the group of elderly who did not experience insomnia (SBP: 160 vs 151; DBP: 85 vs 84). Dealing with insomnia can be an effort to lower blood pressure.

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