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The Journal of Pure and Applied Chemistry Research

jpacr
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Published by Universitas Brawijaya

ISSN : 23024690 EISSN : 25410733 DOI : http://dx.doi.org/10.21776/ub.jpacr

Core Subject : Health, Science, Engineering,

Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology Medicine & Pharmacology

The Journal of Pure and Applied Chemistry Research focuses in publishing research articles in the field of Chemistry and Applied Chemistry. The target is in exploring, investigating, and developing chemicals sources from local and/or Indonesian to increase the value. Scope of the journal is organic chemistry, analytical chemistry, inorganic chemistry, biochemistry, and physical chemistry. Included the topic also organic chemistry natural product, theoretical and computational chemistry.

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 306 Documents

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Polymeric Switch on Lysozyme Activity: Role of Hydrophobic and Electrostatic Interactions Dr. Sumon Ganguli; Md. Bellal Hossain
The Journal of Pure and Applied Chemistry Research Vol 2, No 3 (2013)
Publisher : Chemistry Department, The University of Brawijaya

Enzymes have attracted potential applications in both medicine and biotechnology. In our present study, we show a strategy for switching the enzymatic activity of lysozyme by the complex formation with a cationic smart copolymer. PAMA-g-PEG graft copolymers suppressed the enzymatic activity of lysozyme without any conformational change, indicating the formation of complex and covering the active site of lysozyme by copolymers. The addition of polyanion, poly(acrylic acid) (PAAc), recovered the suppressed enzymatic activity of the lysozyme/polymer complex efficiently. These finding suggest that that hydrophobic interaction coupled with electrostatic interactions has a great role for the complexation and decomplexation of the lysozyme/polymer complex. Circular dichroism (CD) spectral analysis indicated that the conformation of the enzymes maintained largely during the course of the complexation.

A Study on Brown Seaweed Therapy ( Sargassum sp.) toward MDA Levels and Histological Improvement on Rat Foot Suffering Rheumatoid Arthritis Fauziah Fauziah; Aulanni'am Aulanni'am; Chanif Mahdi
The Journal of Pure and Applied Chemistry Research Vol 2, No 3 (2013)
Publisher : Chemistry Department, The University of Brawijaya

Rheumatoid arthritis (AR), an autoimun disease, is characterized by the inflammation in the joint area caused an excessive of free radicals. An excessive of free radicals in the body cause oxidative stress, that increasing levels of malondialdehyde (MDA) as an indicator of lipid peroxidation and the decreasing levels of anti-oxidants. The treated with extract of brown seaweed (Sargassum sp.) intended to find out the MDA levels in serum and the histological of the foot joints rheumatoid arthritis rats. Malondialdehyde levels are determined through a TBA test (Thio Barbituric acid), meanwhile the histological of the rat foot joints was determined by Hematoxylen-Eosin staining (HE). The results showed the brown seaweed extract therapy (Sargassum sp.) was significantly (p <0.01) reduce levels of malondialdehyde (MDA) in the serum of 21,24% and improving histological foot joints rheumatoid arthritis rats.

Adsorption of Cadmium By Silica Chitosan Moftah Ali; Ani Mulyasuryani; Akhmad Sabarudin
The Journal of Pure and Applied Chemistry Research Vol 2, No 2 (2013)
Publisher : Chemistry Department, The University of Brawijaya

The adsorption process depends on initial concentration of Cd2+ and ratio of chitosan in adsorbent. The present study deals with the competitive adsorption of Cd2+ ion onto silica graft with chitosan. Batch adsorption experiments were performed at five different initial Cd2+ concentrations (5, 10, 15, 20 and 25 ppm), on five different proportion from silica to chitosan (100%, 95%, 85%, 75% and 65%) as adsorbent at pH 5. In the recovery process, the high recovery at 0.5 mg and observed the recovery decrease with increasing the initial concentration of Cd2+, and the low recovery at 0.25 mg from Cd2+. In this study, the adsorption capacity of Cd2+ in regard to the ratio of silica and chitosan hybrid adsorbents are examined in detail. The aim of this study to explore effects of initial concentrations of Cd2+, and the ratio of silica to chitosan on the adsorption and recovery of Cd2+.

Carbon Nanotube Covalently Attached Laccase Biocathode for Biofuel Cell Rizmahardian Ashari Kurniawan; Aulani Aulanni'am; Fa-Kuen Shieh; Peter Po-Jhen Chu
The Journal of Pure and Applied Chemistry Research Vol 2, No 2 (2013)
Publisher : Chemistry Department, The University of Brawijaya

Biocathode for biofuel cell was prepared by covalently immobilizedLaccaseon CNT (CNT-Laccase) using glutaraldehyde as conjugates. Successful laccase immobilization was confirmed by Fourier Transform Infrared (FTIR) Spectrophotometry, Surface Electron Microscopy (SEM) and Thermogravimetric Analysis (TGA). Immobilization affected Laccase enzymatic activity where it boosts the stability at high temperature and neutral pH. At temperature 65ºC, free Laccase completely loss its activity, while CNT-Laccase still retaining 57.12% of its activity at 45ºC. The activity of CNT-Laccase at pH 7 was 7.04% of activity at pH 5 which was higher than that of free Laccase. CNT-Laccase was able to perform oxygen electroreduction with addition ABTS (2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) as mediator. Performance of oxygen electroreduction activity was also determined by type and composition of binding polymer. Nafion was able to provide better environment for oxygen electroreduction activity compare to polyvinyl alcohol (PVA). Current density resulted in using Nafion in ratio 1:10 to buffer volume was 1.31 mA/cm2, which was higher than that of PVA (1.01 mA/cm2). Increasing binding polymer ratio into 1:2 and 1:1 undermined oxygen electroreduction activity.

Effect Of Methyl Mercury towards Number of Microglia Cells and Expression of iNOS On The Brain in Rats (Rattus norvegicus) Yuli Kusuma Dewi; Aulanni'am Aulanni'am; Chanif Mahdi
The Journal of Pure and Applied Chemistry Research Vol 3, No 1 (2014)
Publisher : Chemistry Department, The University of Brawijaya

Methyl mercury (MeHg) has the highest toxicity among the derivative of the organic mercury compounds. Rate of accumulation of MeHg in the body is very high because it is soluble in lipids. The ability of methyl mercury binds to proteins in the body causing MeHg to penetrate the blood-brain barrier easily, so that it can quickly disrupt the central nervous system and speed up nerve cell damage. This paper reported the effect of methyl mercury on the number of microglia cells and expression of iNOS in the brains of Rattus norvegicus. In this study, rats were divided into two groups: a control group with no exposure of MeHg and groups of rats exposed with MeHg at a dose of 0.6 mg/kg BW/day given orally for 21 days. Number of microglia cells is investigated using silver nitrate staining method and iNOS expression is determined by immunohistochemistry methods. The results showed that exposure with MeHg in a dose of 0.6 mg/kgBW can increase the number of microglia cells and iNOS expression respectively as mush as 151.63% and 918.08% . Keyword: Methyl mercury, microglia, brain, iNOS, immunohistochemistry

Mild and Efficient Reagents for Oxidation of Alcohols: [MeOCH2(Ph)3P]+[CrO3X]ֿ, (X=F, Cl) Amir Lashgari; Shahriar Ghamami
The Journal of Pure and Applied Chemistry Research Vol 4, No 1 (2015)
Publisher : Chemistry Department, The University of Brawijaya

Two fast, mild, and reasonable oxidizing agents, Methoxymethyltriphenylphosphonium Halochromates (VI), [MeOCH2(Ph)3P]+ [CrO3X]ֿ (MMTriPPXC) are synthesized. The preparations of Methoxymethyltriphenylphosphonium Halochromates are new and efficient reagents for the oxidation of primary and secondary alcohols to their corresponding carbonyl compounds in dichloromethane at ambient temperature. These are obtained with relatively short reaction times. The oxidants/substrates ratios of 1:1 are employed.

Adsorption of Iron by Fly Ash Adsorbent of Coal Irawan, Candra; Atikah, Atikah; Rumhayati, Barlah
The Journal of Pure and Applied Chemistry Research Vol. 3 No. 3 (2014)
Publisher : Chemistry Department, The University of Brawijaya

This research has investigated adsorption of Fe with using fly ash adsorbent. Phases of adsorption of Fe isactivatedwithH2SO4afterthat thefly ashwere characterizedby usingXRF, FTIRandSEM. Determination ofoptimum conditionsonthe adsorptionof Fewithadsorbentmassvariations, variations incontact time, pHvariationandvariationconcentration andadsorptionisothermstudy. Resulth showthat theadsorptionof Fein optimum conditionoccurs inadsorbentmass of2.5g, for 60minutescontact timewithpH4at a concentration of20ppm. The results alsoable toadsorpup to94% Fe. The adsorption of Fe with using fly ashadsorbentwas more fitted to theLangmuirmodel than to Freundlich model <w:LsdException Locked="false" Priority=

The Effect of KIO3 and KI Salt Towards Iodium Levels (I2) in Urine, Malondialdehyde (MDA) and The Histology of Thyroid Gland of Goitrogenic Rat Heli, Risman; Mahdi, Chanif; Prasetyawan, Sasangka
The Journal of Pure and Applied Chemistry Research Vol. 3 No. 3 (2014)
Publisher : Chemistry Department, The University of Brawijaya

Goitrogenic substances can inhibit of iodine taking by the thyroid gland. Thus iodine concentration in thyroid gland will be low, and this phenomena is indicated by inflammation in the thyroid gland. Moreover, it can cause releaseing of an excessive amount of free radicals. This radicals, in the body, causes oxidative stress and also increase the levels of malondialdehyde (MDA). This is also as an indicator for lipid peroxidation and the decreasing of urinary iodine excretion levels (EIU). The treatment with KIO3and KI salt was intended to study the level of supplementation of iodine (I2) toward level of MDA in serum and histological description of ratâ€™s thyroid gland. The MDA levels was determined through TBA test (Thio Barbituric Acid), meanwhile the histological pattern of Â rat thyroid gland was determined by Hematoxylen-Eosin staining (HE). The results indicated both of KIO3 and KI salt significantly (p<0.01) reduced MDA level in the serum. Treatment with KIO3 salt gave 33.62% while KI salt slightly higher (37,02%). In addition, both of treaments displayed an recovering effect in thyroid gland.

Adsorption of Lead and Copper Using Water Hyacinth Compost (Eichornia Crassipes) Kiky Frederika Rumapar; Barlah Rumhayati; Rachmat Triandi Tjahjanto
The Journal of Pure and Applied Chemistry Research Vol 3, No 1 (2014)
Publisher : Chemistry Department, The University of Brawijaya

Adsorption ofheavy metals Pb and Custudies have been carried out usinga compost of plant water hyacinth (Eichornia crassipes). First steps of the compostingis fermenting fresh hyacinth plants that have been enumeratedwithmolasses and water. Once formed, the compost is used as an adsorbent for the adsorption of heavy metals Pb and Cu. After that process, the water hyacinth compost have been characterized to determine the humic acid content, as well as the functional group content of heavy metals Pb and Cu. Determination of general conditions on the adsorption of Pb and Cu performed with adsorbent mass variations, variations in pH and the concentration variation and studying adsorption isotherm. The results showed that the adsorption of Pb in optimum condition occurs in adsorbentmass of 1.2 g with pH 5. As for the adsorption of Cu on the optimum conditions occur in the adsorbent mass of 0.8 g at pH 6. Results also able to adsorb up to 95.13% Pb andup to 91.42% Cu. Pb and Cu adsorption using adsorbents of water hyacinth compost more models to follow Langmuir than Freundlich models.

Chemical Potential of Benzene Fluid from Monte Carlo Simulation with Anisotropic United Atom Model Mahfuzh Huda; Siti Mariyah Ulfa; Lukman Hakim
The Journal of Pure and Applied Chemistry Research Vol 2, No 3 (2013)
Publisher : Chemistry Department, The University of Brawijaya

The profile of chemical potential of benzene fluid has been investigated using Anisotropic United Atom (AUA) model. A Monte Carlo simulation in canonical ensemble was done to obtain the isotherm of benzene fluid, from which the excess part of chemical potential was calculated. A surge of potential energy is observed during the simulation at high temperature which is related to the gas-liquid phase transition. The isotherm profile indicates the tendency of benzene to condensate due to the strong attractive interaction. The results show that the chemical potential of benzene rapidly deviates from its ideal gas counterpart even at low density.

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Masruri

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+62341-575838

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jpacr@ub.ac.id

Editorial Address
Departemen Kimia, Fakultas MIPA, Universitas Brawijaya, Jl. Veteran 65145 Malang

Location
Kota malang,

Jawa timur

INDONESIA

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Masruri

Contact Email masruri@ub.ac.id

Phone +62341-575838

Journal Mail Official jpacr@ub.ac.id

Editorial Address Departemen Kimia, Fakultas MIPA, Universitas Brawijaya, Jl. Veteran 65145 Malang

Location Kota malang, Jawa timur INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Masruri

Contact Email
masruri@ub.ac.id

Phone
+62341-575838

Journal Mail Official
jpacr@ub.ac.id

Editorial Address
Departemen Kimia, Fakultas MIPA, Universitas Brawijaya, Jl. Veteran 65145 Malang

Location
Kota malang,

Jawa timur

INDONESIA