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INDONESIA
Berkala Ilmu Kesehatan Kulit dan Kelamin
Published by Universitas Airlangga
ISSN : 19784279     EISSN : 25494082     DOI : 10.20473
Core Subject : Health, Science,
Immunology & microbiology Public Health
Arjuna Subject : -
Articles 12 Documents
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Search results for , issue "Vol. 34 No. 1 (2022): APRIL" : 12 Documents clear
Secukinumab Therapy in Psoriasis Management Ira Yunita; Sylvia Anggraeni
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 1 (2022): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.1.2022.59-65

Abstract

Background : In recent years, use of biological therapy in psoriasis has increased as a result of advances in understanding the pathophysiology of psoriasis disease. Biological agents currently approved for the treatment of moderate to severe plaque psoriasis including inhibitor TNF-α (adalimumab, etanercept, infliximab), inhibitor IL-17 (ixekizumab, brodalumab, secukinumab), inhibitor IL-12/IL-23 (ustekinumab), and inhibitor IL-23 (guselkumab, tildrakizumab). Secukinumab is a human monoclonal antibody that selectively neutralizes IL-17A, a cytokine involved in the development of psoriasis. Review: Psoriasis is a chronic skin inflammation with the characteristic form of erythematous plaque firmly, thick scale, layered, and silvery-white. The trigger factors cause damage to the skin and produce cytokines IFN-γ, TNF-α, IL-17, and IL-22. This proinflammatory cytokine induces the proliferation of keratinocytes and subsequently causes skin inflammation, leading to plaque psoriasis formation. Biologic agents are utilized to block those cytokines. There are three main classes of biological agents in the treatment of psoriasis: inhibitor TNFα, inhibitor IL-17, and inhibitor IL-23. Secukinumab is a fully human antibody that selectively binds and neutralizes IL-17A. Conclusion: Biological agents targeting IL-17 receptors are more effective and safer than biological agents that target TNF-α and IL-23 receptors for moderate to severe plaque psoriasis treatment. Secukinumab has been approved for plaque psoriasis therapy in adults, psoriasis arthritis (PsA), and ankylosing spondylitis.
A Case Report of Tinea Capitis in Children: Utility of Trichoscopy Harningtyas, Citra Dwi; Ervianti, Evy; Astari, Linda; Anggraeni, Sylvia; Yuri Widia
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 1 (2022): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.1.2022.66-72

Abstract

Background: Tinea capitis (TC) is the most prevalent pediatric superficial dermatophyte infection. Scalp dermoscopy or "trichoscopy” represents a valuable, noninvasive technique for the evaluation of patients with hair loss due to TC. Purpose: To characterize trichoscopic findings in children with clinical findings suggestive of TC. Case:  A 13-year-old boy was presented with a scaled plaque on his scalp that had appeared 1 month earlier. A physical examination revealed a scaly, nonerythematous, rounded lesion in the parietal area of the head. Wood's lamp yielded a blue fluorescence. Microscopic morphology from fungal culture found the typical spindle-shaped macroconidia of Microsporum canis. Trichoscopy showed mainly comma hair, corkscrew hair, morse code hair, bent hair, and zig zag hair. The patient was started on oral griseofulvin 20 mg/kg/day and antifungal shampoo for 8 weeks. The patient was cured after two months of treatment and trichoscopy returned to normal. Discussion: Fungal culture remains the gold standard in TC diagnosis, but it needs time. Trichoscopy can be an additional tool to help evaluate the diagnosis, aetiology, and follow up of this disorder. The presence of characteristic trichoscopic features (comma hairs, corkscrew hairs, Morse code-like hairs, zigzag hairs, bent hairs, block hairs, and i-hairs) is predictive of TC. The present analysis confirmed that trichoscopy is a useful method in differentiating between Microsporum and Trichophyton TC, which is important from the perspective of a different therapeutic approach. Conclusion: Trichoscopy is not only of value in the diagnosis of TC but also for the etiologic agent and follow-up after treatment in this case.
Recurrent Verruca Vulgaris Treated with Combination of 80% Trichloroacetate and Electrosurgery: a Case Report Nyoman Yoga Maya Pramita; Ketut Kwartantaya Winaya; I Gusti Nyoman Darmaputra
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 1 (2022): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.1.2022.73-76

Abstract

Background: Verruca vulgaris is one of the most common benign skin tumor caused by human papillomavirus (HPV) type  1, 2, 3, 4, 27 and 57. HPV caused infection is often recurrent leading to frustration due to loss of time and medical expenses. Monotherapy gives a varied response, and in the case of recurrence, combination therapy can be an option. Purpose: To evaluate the cause and management of recurrent verruca vulgaris. Case: This is a case report of a 33 years-old man complaining of a recurrent wart with a rough surface on his right index finger in the past three months. Initially the patient was treated with electrosurgery, but the warts came back. The patient was a smoker. The warts disappeared after electrosurgery and two sessions of 80% trichloroacetate (TCA), and at the 4th week of observation no new lesion was reported. Discussion: Recurrence of verruca vulgaris often occurs using monotherapy, thus requires other modalities. The combination of electrocautery and 80% TCA provides good clearance with low recurrence. Conclusion: Combination treatment for recurrent warts is effective for clearing the lesion and prevent recurrence.
Characteristics of Atopic Dermatitis Patients who Underwent Skin Prick Test Nugroho, Wisnu Triadi; Ervianti, Evy; Zulkarnain, Iskandar; Hidayati, Afif Nurul; Damayanti, Damayanti; Utomo, Budi; Cita Rosita Sigit Prakoeswa
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 1 (2022): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.1.2022.10-14

Abstract

Background: Skin prick test (SPT) is indicated in type I hypersensitivity reactions (rapid type), among which is Atopic Dermatitis (AD). However, the results of SPT for the tested allergens are not always accompanied by history of known allergens in AD patients. Purpose: To identify the characteristics of AD patients who underwent SPT. Methods: This was a descriptive retrospective study to determine the demographics, allergy history, SPT results, and positive and negative clinical relevance in AD patients treated at Allergy Immunology Division of Dermatology and Venerology Outpatient Clinic Dr. Soetomo General Academic Hospital Surabaya-Indonesia from January 2017 to December 2019. Results: A total of 284 AD patients were included. The adult age group (20-59 years) predominated the AD patient's visit every year with 58 patients (60.42%), 47 patients (46.08%), and 65 patients (75.58%) in 2017, 2018, and 2019, respectively. Only 60 AD patients underwent SPT, where most patients were allergic to dust with 30 patients (50.0%). House dust mite (HDM) allergen had the highest percentage of positive SPT result with 41 patients (63.3%). The greatest clinical relevance was found in cat fur allergen, where all patients (100.0%) had clinical relevance to their SPT result. Conclusion: This study shows that most AD patients were in adult age group and had a history of dust allergy. The highest percentage of positive SPT result was found in HDM allergen and the greatest clinical relevance was found in cat fur allergen.
Ceramide is More Effective than Shea Butter in Maintaining Skin Acidity Zilpa Widyastuti; Suci Widhiati
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 1 (2022): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.1.2022.5-9

Abstract

Background: Skin is the largest organ that functions as a physical barrier. Stable skin pH can maximize its function. Ceramide and shea butter cream have components that maintain the skin pH in the stratum corneum. Purpose: The aim is to compare ceramide and shea butter cream effects on skin pH. Methods: The experimental analytic study was performed on 30 respondents. The skin pH measurement was done before applying creams and 30 days after applying ceramide cream and shea butter cream. Ceramide cream was applied on the right volar and shea butter cream on the left volar. Comparative analysis with a paired t-test was used with a significant value of p<0.05. Results: The average skin pH after applying ceramide cream was 4,61±1,19, while shea butter cream was 5,30±1.07. The derivation of skin pH after ceramide cream application was 1,57±1,26, and that of shea butter cream was 0,88±1,14. The application of ceramide cream showed a lower pH than shea butter cream significantly, with p=0.025. Conclusion: The intervention using ceramide and shea butter cream for 30 days could lower the skin pH level. The derivation of skin pH with ceramide is more significant than using shea butter cream. Ceramide can be considered to maintain skin homeostasis and skin pH.
Comparison of the Efficacy of Topical Clindamycin versus Niacinamide in the Treatment of Mild to Moderate Acne Vulgaris: a Systematic Review Eden Leonita; Trisniartami Setyaningrum; Mohammad Fathul Qorib; Damayanti -
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 1 (2022): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.1.2022.15-22

Abstract

Background: Acne vulgaris (AV) is one of the most common skin diseases among teenagers and is treated based on its severity. Mild acne is treated with topical agents, while moderate and severe acne are treated with a combination of topical and systemic agents. Topical agents that are often used for acne are antibiotics, such as topical clindamycin. Widespread use of antibiotics to treat AV causes resistance problems. Therefore, alternative therapies are needed to prevent resistance to topical clindamycin, such as topical niacinamide, which has anti-inflammatory effects without inducing resistance problems. Purpose: To compare the efficacy of topical clindamycin and topical niacinamide in mild to moderate AV. Methods: In this systematic review, a literature search was carried out through 6 databases, following PRISMA 2020 guidelines. Inclusion criteria were written in English or Indonesian, published in 2010-2020, randomized controlled trial (RCT) study design, conducted on human samples, and discussed the efficacy comparison of topical clindamycin and niacinamide in mild to moderate AV. Studies that were not accessible in full-text and based on secondary data were excluded. Quality and risk of bias assessments were done using The Jadad Scale and Risk of Bias 2 (RoB 2). Result: Acne severity was reduced significantly in both topical clindamycin and niacinamide groups, and there was no efficacy difference between these groups. Both topical clindamycin and topical niacinamide can cause mild side effects. Conclusion: Topical niacinamide can be an alternative therapy to topical clindamycin because they are both effective in treating mild to moderate AV.
Skin Aging Profile in Tertiary Hospital: a Descriptive Study Tasya Wikassa; Damayanti Damayanti; Irfiansyah Irwadi; Trisniartami Setyaningrum; Rahmadewi Rahmadewi; Diah Mira Indramaya; Menul Ayu Umborowati
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 1 (2022): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.1.2022.36-45

Abstract

Background: Skin aging is a physiological process that involves changes in skin cells and tissues due to abnormal mechanisms and decreased tissue function caused by both intrinsic and extrinsic factors. Skin aging has different clinical manifestations in each individual, which were classified using Glogau's photoaging classification. Purpose: The objective of this descriptive observational study is to evaluate the profile of skin aging patients at Dr. Soetomo General Hospital Surabaya from January – December 2019. Methods: This study utilized a total sampling technique from data obtained from the patients' medical records, which included age, gender, occupation, anamnesis, physical examination, diagnosis, and treatment received by patients. This research has been reviewed by the Ethics Committee at Dr. Soetomo General Hospital Surabaya (0438/KEPK/XII/2021). Result: Based on data obtained from medical records, 415 samples of skin aging patients were collected. The highest number of cases occurred among patients aged 45 - < 60 years. Most patients were female, and the majority of patients’ occupations were private employees. History taking findings include the most common complaint, namely dull skin, with the most precipitating factors discovered in patients, namely exposure to sunlight and pollution. Wrinkles were the most common physical examination finding in patients, with Glogau's photoaging III being the most common diagnosis. Most patients were treated with photoprotection in the form of sunscreen. Conclusion: With the increase of public awareness about appearance, as well as human health and quality of life, skin aging is receiving adequate attention nowadays, with sun exposure being the most common precipitating factor.
The Profile of Leprosy Patients in Aceh: Retrospective Study Nanda Earlia; Sulamsih Sri Budini; Dea Silvia Ramadana; Mikyal Bulqiah; Aqil Yuliawan Tasrif; Randika Richard R; Muhammad Adji Pangestu; Annisa Raihani; Auni Batrisyia; Eva Cahyaningsih; Fanny Adlin Nurafika; Istiqomah Genepo; Nadira Sabrina Mufti
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 1 (2022): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.1.2022.46-51

Abstract

Backgrounds: Morbus Hansen or leprosy is a chronic granulomatous infectious disease caused by the obligate intracellular Mycobacterium leprae bacillus. Leprosy can cause loss of sensation in the skin with or without lesions and body dysfunction during the course of the disease. In Aceh, there were 337 new cases of leprosy in 2019 and this was the highest case in Sumatra. Purpose: To analyze the profile of leprosy patients in the Department of Dermatology and Venereology of RSUDZA Banda Aceh. Methods: Observational descriptive study with retrospective design, using medical record of leprosy patients who visited Dermatology and Venereology Outpatient Clinic RSUDZA Banda Aceh for the period of January 2017 – December 2021. Result: A total of 183 leprosy patients were obtained from the study. Most cases occured in male patients (68.3%), the majority was in the 18-40 year age group (60.1%), most patients live outside of Banda Aceh (71%). The most frequently reported type of leprosy was the multibacillary type (71.6%). Leprosy patients without disability were 35.5%, the majority did not experience a leprosy reaction (71%), the most common morphology of the lesion was erythematous (29.5%), and the highest proportion of the bacteriological and morphological index was negative (46.4% and 50.8% respectively). Conclusion: The diagnosis of leprosy was based on clinical, bacteriological, and histopathological features. Early diagnosis, patient access to treatment, early initiation of treatment and adherence to therapy would reduce the disease transmission thus would decrease the prevalence of leprosy in Aceh.
Distribution of Leprosy Patients with and without Plantaris Ulcers Cita Rosita Sigit Prakoeswa; Sari, Vida Cahlia Novita; Prajitno, Subur
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 1 (2022): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.1.2022.23-28

Abstract

Background: Leprosy is a chronic infectious disease caused by obligate intracellular Mycobacterium leprae, impacting public health. Leprosy causes deformity, and disability can lead to ulcer disease. Nerve involvement is essential in the emergence of ulcers on the feet, including in neuropathic ulcers. Neuropathic ulcers can be found on the soles of the feet and are often called plantar ulcers. The slow healing process of the ulcer will cause the plantar ulcer to become chronic. Purpose: To evaluate the characteristics of leprosy patients with and without plantar ulcers at the Leprosy Division of Dermatology and Venereology Outpatient Clinic of Dr. Soetomo General Academic Hospital, Surabaya, 2015-2019. Methods: A retrospective study were conducted by examining medical records for five years (2015-2019) at the Leprosy Division of Dermatology and Venereology Outpatient Clinic of Dr. Soetomo General Academic Hospital Surabaya. Results: A total of 511 patients met inclusion criteria. In leprosy patients without plantar ulcers group, the characteristics were male (68%), female (32%), aged 26-35 years (25.4%), paucibacillary (8.1%) and multibacillary (91.8%), patients without leprosy reactions (58%), and patients under treatment (49%). In leprosy patients with plantar ulcers group, the characteristics were male (64.3%), female (35.7%), aged 26-35 years (31%), multibacillary (92.9%), patients without leprosy reactions (61.9%), patients in the RFT category (76%), the ulcer duration group with highest prevalence rate 1-6 months (38.1%), and the most common location of plantar ulcers was on the forefoot (95.2%). Conclusion: Leprosy without plantar ulcers was more common than leprosy with plantar ulcers, mostly in male, dominated in the 26-35 years old for patients leprosy without plantar ulcers, type MB (multibacillary) was most history of leprosy type. Leprosy without reaction was common in leprosy patients with and without plantar ulcers. Patients without plantar ulcers majority was MDTL therapy, patients with plantar ulcers was common RFT (Release From Treatment).
Validity and Reliability Test of Vitiligo Quality of Life Index (VitiQoL) Indonesian Version in Vitiligo Patients Jeffrey Giantoro; Fajar Waskito; Sunardi Radiono
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 1 (2022): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.1.2022.52-58

Abstract

Background: Vitiligo is a multifactorial skin disorder that causes depigmentation. Vitiligo can affect a patient's quality of life due to aesthetic issue. The prevalence of vitiligo in the world is 0.5 – 1.0%. An instrument for measuring the quality of life that is specific to vitiligo patients in Indonesia is required. Purpose: This study aims to translate the Vitiligo Specific Quality of Life (VitiQoL) questionnaire into Indonesian: and assess the validity and reliability of the Indonesian language VitiQoL as a quality of life instrument. Methods: An observational method with analytical survey and cross-sectional approach was conducted on 48 vitiligo patients at Sardjito General Hospital Yogyakarta in May – September 2021. The research was carried out in 3 stages. The first stage was the translation of VitiQoL into Indonesian and then back into English. The second and third stages were measuring the validity and reliability of the VitiQoL Indonesian version. Result: The validity test using Pearson product moment showed that the average correlation coefficient for each question is 0.683. Reliability test using Cronbach's alpha of 0.924 VitiQoL. VitiQoL has 3 domains, namely limited participation, stigma, and behavior. The correlation of each domain has a value range of 0.756 - 0.918 with a variation of Cronbach's alpha value per item ranging from 0.808 - 0.89. The limited participation domain (84.2%) has the largest contribution to the value of quality of life. Conclusion: The Indonesian language VitiQoL as an instrument with good validity and reliability can be used to measure the quality of life of vitiligo patients in Indonesia.

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