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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
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Articles 14 Documents
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Search results for , issue "Suppl. 5, No. 1 (2023)" : 14 Documents clear
Formulation and Physical Stability Test Peel Off Mask from Kokang Leaf Extract ( Lepisanthes amoena (Haask) Leenh) as an Antioxidant Jati Pratiwi; Ika Ayu Mentari
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 5, No. 1 (2023)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v0i0.47320

Abstract

Free radicals are substances that can damage skin cell membranes and damage skin cells resulting in melanogenesis which is the main defense of the skin. So that antioxidants are needed as an antidote to free radicals that can inhibit or neutralize the bad effects of free radicals and are formulated in the form of peel-off masks to remove dirt and dead skin cells. Kokang leaves (Lepisanthes amoena (Haask) Leenh) is a plant rich in antioxidants originating from East Kalimantan which contains alkaloids, flavonoids, saponins and tannins. This study aims to determine the characteristics and physical stability as well as determine the antioxidant activity of peel off mask preparations of kokang leaf extract (Lepisanthes amoena (Haask) Leenh), experimentally using the DPPH method with a UV-Vis spectrophotometer. The results and conclusions obtained were that kokang leaf extract (Lepisanthes amoena (Haask) Leenh) peel off mask preparations 1 (0%), 2 (1%), 3 (2.5) and 4 (5%) had physical characteristics and stability good tests (meet standard requirements) including organoleptic tests, pH, homogeneity, spreadability, adhesion, drying time and viscosity. Testing the antioxidant activity using a concentration of 5%. Kokang leaf extract contains strong antioxidant activity with a value of 59,707 ppm, while kokang leaf extract peel off mask contains medium category antioxidant activity with an IC50 value of 102,945 ppm. 
Formulation and Antioxidant Activity of Lip Balm Containing Banana Peel (Musa paradisiaca var. Sapientum) Methanol Extract Jastria Pusmarani Pusmarani
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 5, No. 1 (2023)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v0i0.46009

Abstract

Banana peel (Musa paradisiaca var. Sapientum) contains flavonoid, phenolic and tannin compounds as high source of antioxidant that can inhibit free radical reaction. Antioxidant were exhibited to hydrate, soften, and reduce dryness of the skin, and it can be potentially used as a lip balm formulation. This study investigated the stability of lip balm formulation contains banana peel methanol extract include pH test, homogeneity test, hedonic test, and evaluated antioxidant activity with DPPH method. This study used experiment laboratory method with banana peel methanol extract concentrations of 5%, 7.5%, and 10%, respectively. According to the results of this study, banana peel was made in form lip balm formulation, and it has homogeneous with suitable pH (5-6), no irritation and stable in storage at temperatures room (250). The hedonic test showed that lip balm contains banana peel with concentration of 7.5% and 10% were the most preferred by panelist. The antioxidant activity was exhibited an inhibition concentration of 50% (IC50). Lip balm of banana peel methanol extract of 5%, 7.5% and 10% were showed antioxidant activity with IC50 value of 44.910 ppm, 10.887 ppm and 61.930 ppm, respectively. Antioxidant activity of lip balm contains banana peel formulation with concentration of 5% and 7.5% were classified as very strong antioxidants. Lip balm containing banana peel formulation concentrations of 10% was categorized as a strong antioxidant. In this study, all lip balm formulation can be declared stable. In addition, lip balm contains banana peel methanol extract exhibited antioxidant properties and it can be made into a natural cosmetic formulation such as a lip balm.
Formulation and Test of Physical Characteristics of Ethanol Extract Capsules of Red Atai Tuber (Angiopteris ferox Copel) Andi Nur Aisyah; Nur Khairi; Syamsu Nur; Amriani Amriani; Megawati Megawati; Lukman Lukman; Ikbal Ikbal; Marwati Marwati; Maulita Indrisari; Madinatul munawwarah
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 5, No. 1 (2023)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v0i0.46179

Abstract

Umbi paku atai merah (Angiopteris ferox Copel) merupakan tumbuhan paku yang berasal dari suku Dayak yang digunakan sebagai obat tradisional yang berpotensi sebagai antioksidan karena memiliki kandungan senyawa metabolit sekunder meliputii alkaloid, steroid, flavanoid, tanin serta saponin. Penggunaan umbi paku atai merah di masyarakat masih menggunakan cara tradisional yaitu diseduh dengan air panas, diminum air rebusannya dan meninggalkan rasa yang tidak enak, sehingga tujuan dari penelitian ini yaitu untuk memformulasi sediaan kapsul ekstrak etanol umbi paku atai merah yang memenuhi karakteristik fisik. Penelitian ini dilakukan pembuatan sediaan kapsul yang berisi granul dengan variasi konsentrasi aerosil FI 5%, FII 7% dan FIII 9%. Granul dibuat dengan metode granulasi basah, lalu dilakukan evaluasi karakteristik fisik granul dan kapsul. Hasil yang diperoleh dari ketiga granul tersebut memenuhi karakteristik fisik granul dengan parameter uji organoleptik, kandungan lembab, susut pengeringan, kecepatan alir, sudut istirahat, Bj sejati, Bj nyata, Bj mampat dan porositas. Sedangkan untuk kapsul FI dan FII merupakan sediaan yang memenuhi karakteristik fisik kapsul dengan parameter uji keseragaman bobot, waktu hancur dan higroskopis.
Flavonoids from Basil Leave as a Potential Inhibitor of SARS-COV-2 Main Protease: an In Silico Approach Meilinda setya praceka; Farhan Firmansyah; Hafadhoh Arvyna; Gilang F. Dzikrillah; Wa O.I. Fitriah
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 5, No. 1 (2023)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v0i0.45864

Abstract

SARS-COV-2 a virus which caused the global pandemic Coronavirus-2019 (COVID-19) has infected about 659,108,952 among, with 6,684,756 deaths in the world as stated by WHO on December 23 2022. Basil leaves have antiviral potential, especially in groups flavonoids. People who are exposed to the COVID-19 virus are given many drugs that cause many side effects. Therefore, it is advisable to consume drugs from natural ingredients that are low in side effects such as basil leaves. This study aims to predict flavonoid derivative compounds from basil leaves that have the potential as an anti-viral drug for COVID- 19 by in silico, which has high affinity with low side effects. The method used is molecular docking for target analysis, prediction of ADME, and prediction of toxicity. The results of this study, there is a naringenin compound that has the highest potential to become an antiviral for COVID-19 with a ∆Gibbs value of -4.04 kcal/mol and an KI of 1.09 mM. These flavonoid derived compounds comply with Lipinski rules, so that the flavonoid content in basil leaves can help treat COVID-19 as a drug derived from natural ingredients that has antiviral potential with low side effects.
Kajian In Silico Senyawa Aktif Kayu Jawa (Lannea Coromadelica) Sebagai Antiinflamasi Melalui Penghambatan Mediator TNF-alpha Dan COX-2 Sukmawati Syarif; Andi Muflihunna
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 5, No. 1 (2023)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v0i0.46074

Abstract

Kayu jawa (Lannea coromandelica) merupakan salah satu tanaman yang banyak digunakan secara empiris oleh masyarakat di Sulawesi Selatan sebagai obat tradisional karena memiliki efek farmakologis seperti antiinflamasi yang merupakan respon protektif normal terhadap berbagai proses fisiologis di dalam tubuh serta memiliki efek biologis yang dapat bekerja pada target molekul. Inflamasi adalah respon perlindungan normal terhadap cedera jaringan yang disebabkan oleh trauma fisik, bahan kimia berbahaya, atau agen mikrobiologi. Tujuan penelitian ini adalah untuk mengetahui senyawa kimia apakah pada tanaman Kayu jawa (Lannea coromandelica) yang berpotensi sebagai antiinflamasi dengan mekanisme penghambatan reseptor TNF-α dan COX-2. Metode penelitian ini adalah  in silico menggunakan metode molecular docking dengan perangkat lunak Autodock. Tahapan penelitian antara lain simulasi doking reseptor dengan ligan uji kemudian di validasi, setelah itu di visualisasi menggunakan  discovery studio, kemudian dilanjutkan pada tahapan data analisis serta prediksi ADME. Adapun hasil penelitian Senyawa 3-hydroxy-4’,5,7-trimethoxyflavanone terhadap COX-2 dan senyawa uji morin terhadap TNF-α berpotensi sebagai antiinflamasi dengan kemampuan lebih rendah dibandingkan dengan liga alami untuk berkatan dengan sisi aktif pda reseptor target. Selanjutnya penelitian ini diharapkan menjadi pilot project produksi sediaan obat antiinflamasi yang dapat digunakan oleh masyarakat luas
Antipyretic And Antiinflammatory Activities Of Bopot Leaf Extract From Kutai Kartanegara District Chaerul Fadly Mochtar; Novia Misnawati Aisyiyah; Qur’anni Akhwatun Husna; Hasyrul Hamzah; Muh Irham Bakhtiar; Reni Selviana Devi; Fathiah Putri Varizza; Ayu Faradillah; Elva Hafidzah; Suriati Suriati; Nur Lutfiah Damis
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 5, No. 1 (2023)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v0i0.46188

Abstract

Fever, a condition where the body temperature is above normal (> 37°C) can occur due to inflammation, an immune system response from harmful stimuli such as pathogens. Bopot leaves (Tabernaemontana divaricata) contain flavonoids, tannins, saponins and alkaloids which are thought to play a role in inhibiting prostaglandin synthesis (PGE2). This research was conducted to determine the antipyretic and anti-inflammatory activity of Bopot leaves. In vivo testing was used in mice (Mus musculus). The antipyretic test used peptone induction and rectal temperature was measured using a digital thermometer, while the anti-inflammatory test was carrageenin induced and the volume of edema was measured using a plethysmometer. Measurements were made before and after induction with an interval of 30 minutes for 2 hours. Results were analyzed by ANOVA using SPSS. The antipyretic test showed that the dose of 200 mg/Kg BW had the best antipyretic activity with an antipyretic power of 90.20% and the best anti-inflammatory activity at a dose of 250 mg/Kg BW. Bopot leaves contain flavanoid compounds which have antipyretic and anti-inflammatory effects by inhibiting cyclooxygenase (COX) which triggers prostaglandins that cause an increase in body temperature and inflammation. It was concluded that Bopot leaf extract has antipyretic and anti-inflammatory activity.
Comparison of Extraction Solvents Towards Anti-Propionibacterium acnes activity of Alphitonia incana (Roxb). Teijsm. & Binn. ex Kurz Leaves Hafiz Ramadhan; Rahmi Muthia; Sari Wahyunita; Dyera Forestryana; Sherly Mar'atu Soleha; Lihimi Lihimi
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 5, No. 1 (2023)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v0i0.45897

Abstract

Alphitonia incana (Roxb.) Teijsm. & Binn. ex Kurz locally known as Balik Angin in Borneo Island is one of the endemic plants that have the potential to be an alternative antibacterial agent. Balik Angin leaves contain secondary metabolites that have to play a role to inhibit the growth of Gram-positive bacteria. This study aimed to compare the different extraction solvents which are methanol and ethanol on the maceration of Balik Angin leaves in producing antibacterial activity against Propionibacterium acnes. The leaves were macerated using methanol and ethanol respectively. Antibacterial assay was carried out by the Well diffusion method. The results showed minimum inhibitory concentration (MIC) of ethanol extract which is 3.2% has a diameter of clear zone of 9.475±0.311 mm. Meanwhile, the methanolic extract with a similar MIC has a lower diameter of clear zone of 2.55±0.85 mm. The results correlate with the number of secondary metabolites groups that were identified based on phytochemical screening in ethanol extract containing alkaloid, phenolic, flavonoid, tannin, saponin, and phytosteroid, however, methanol extract not containing alkaloid. The conclusion of this study is ethanol solvent more effective to extract secondary metabolites from Balik Angin leaves compare to methanol solvent, so that can produce more powerful anti-Propionibacterium acnes activity.
Physical Stability of Guava Leaves Extract at Different Storage Temperature Nadya Ambarwati; Amanda Safithri Sinulingga; Ira Purbosari
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 5, No. 1 (2023)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v0i0.46076

Abstract

Guava (Psidium guajava L.) has been widely used by Indonesian people as traditional medicine. Guava leaves have been studied and show various pharmacological activities including antidiarrheal, antioxidant, anti-inflammatory, analgesic, antimutagenic, anti-cough, antibacterial, antifungal, antiplaque, suppresses cardiac muscle inotropism, antidiabetic, antihypertensive, hepatoprotective and anticoagulant. In Indonesia, guava leaves have been formulated into several dosage forms. The guava leaves extract, as raw material of traditional medicine, should perform stability during storage period. This study aims to test the physical stability of guava leaves extract, which includes organoleptic, pH, and viscosity at different storage temperature and time susceptibility. Extraction was carried out by maceration method using ethanol 96% as solvent. Extraction is done until a thick extract is obtained. The extract was stored at 8oC (refrigerator temperature), 27oC (room temperature), and 70oC (oven temperature). Physical stability test was performed before storage period and at 1st, 2nd, 3rd week of storage period. Stability test results showed that ethanolic extract of guava leaves was stable at different storage temperatures. The results showed no differences on organoleptic, pH and viscosity test before storage period and at 1st, 2nd, 3rd week of storage period.  Key words: Physical stability, Guava leaves, Ethanolic extract
FORMULATION AND TEST OF ANTIOXIDANT ACTIVITY OF GEL MASK PEEL OFF FROM SURIAN (Toona Sinensis) LEAF ETHANOL EXTRACT IN VITRO Uce Lestari; Muhaimin Muhaimin; Yuliawati Yuliawati
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 5, No. 1 (2023)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v0i0.46456

Abstract

Free radicals can cause damage to skin oxidative cells which will have an impact on aging. This can be shown by the appearance of wrinkles, dull looking skin, black spots (spots) and easily dry skin texture. Antioxidants are compounds that can overcome the bad effects of free radicals. The use of the effects of antioxidants for preparations aimed at facial skin, is better if it is made with cosmetic dosage forms for topical use compared to oral use. One example of this cosmetic preparation is the peel off gel mask. One source of antioxidants comes from the ethanol extract of surian leaves. The aim of the study was to make a gel peel off mask preparation containing antioxidants from surian leaf extract. Surian leaves were extracted by maceration using ethanol, the antioxidant test used the DPPH method. The formulation of peel off gel masks used various extract concentrations, namely 2.5%; 5% ; 7.5% and 10% . Tests for physical characteristics have met the requirements of SNI with organoleptic covering brownish clear color, characteristic aromatic odor of surian leaves, thick form. pH value (4.87-5.47), Viscosity (14088.16-44722.81 cps), spreadability (5.26-5.69 cm), adhesion power (4.08-4.56 seconds) and drying power (22.58-24.02 minutes). The peel off gel mask with the best antioxidant value is formulation 5.
The Development of Nanoparticle Formulation Fromhylocereus Polyrhizus (Hylocereuspolyrhizus) Skin Extract as a Moisturizer in Lip Balm Yulia Yesti; Mega Elfia; Budi Setiawan; Harni Sepriyani; Aulia Febriani
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 5, No. 1 (2023)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v0i0.45975

Abstract

Kulit buah naga ( Hylocereus Polyrhizus ) merupakan limbah yang masih jarang dimanfaatkan dan sering di buang padahal banyak manfaat terkandung di kulit buah naga tersebut. Kulit buah naga memiliki kandungan antioksidan yaitu falvanoid, sebagai pelembab pada sediaan  lip balm.  Tujuan penelitian sebagai studi pengembangan formulasi sediaan nanopartikel . Lip balm mengandung zat pelembab bibir dan vitamin pada bibir oleh karena itu dibuat sediaan lip balm dalam bentuk nanopartikel bertujuan untuk pengembangan formulasi tersebut agar dapat diperoleh sediaan lip balm yang lebih optimal untuk kesehatan bibir Jenis penelitian ini eksperimantal, Penelitian ini ditujukan studi pengembangan formulasi sediaan Nanopartikel dari ekstrak kulit buah naga (hylocereus polyrhizus) sebagai Pelembab Pada Sediaan lip balm untuk mengetahui uji PSA, uji organoleptis, uji pH, uji homogenitas, uji titik lebur, uji iritasi dan uji kelembapan. Waktu Penelitian april sampai juni, penelitian ini dilaksanakan di Laboratorium Farmasi Universitas Ford De kock dan Laboratorium Universitas Andalas Padang. Analisis data yang digunakan dengan pengujian statiska menggunakan uji Wilcoxon. Pengujian terhadap nanopartikel ekstrak kulit buah naga  menggunakan PSA, Hasil penelitian diperoleh ukuran nanopartikel ekstrak kulit buah naga yaitu 30-98nm. Pengujian terhadap sediaan lip balm nanopartikel ekstrak kulit buah naga semua sediaan lip balm homogen, Memiliki ph 5, titik lebur 51°C, uji iritasi dilakukan selama tiga hari dengan mcenggunakan tikus sebagai sebagai hewan coba tidak ada terjadi iritasi pada tikus, dan uji kelembaban juga menggunakan tikus memberikan efek melembabkan setelah diolesi sedian lip balm dengan F0 tanpa ekstrak kulit buah naga diperoleh kelembaban dengan kadar air 32,73%, kadar minyak 27,63%. sediaan F1pakai ekstrak nanopartikel kulit buah naga diperoleh kelembaban dengan kadar air 43,96%, kadar minyak 26,1% sediaan lip balm. Nanopartikel Ekstrak kulit buah naga berpotensi sebagai pelembab pada pembuatan sediaan lip balm Disarankan kepada penelitian selanjutnya untuk mengganti pengikat pada pembuatan nanopartikel dengan maltodekstrin, agar didapatkan hasil dri spray dryer yang diinginkan. Perlu dilakukan penelitian sediaan lip balm nanopartikel ekstrak kulit buah naga dengan memvariasikan formulanya.

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