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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
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Articles 18 Documents
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Search results for , issue "Vol 12, No 2 (2025)" : 18 Documents clear
Urea Reduction Ratio for CKD Stage 5 Hemodialysis Patients at Dr Pirngadi Hospital Medan Dasopang, Eva Sartika; Hasanah, Fenny; Handayani, Salmah; Daya, Verawati L.; Thaharah, Yelda R.; Sandika, Thalita
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.50702

Abstract

Stage 5 CKD is a severe form of kidney disease with a GFR value of <15 mL/min/1.73 m2. Haemodialysis is a replacement therapy that removes metabolic waste, including urea. The text discusses a study conducted at Dr. Pirngadi Hospital in Medan City to compare pre- and post-urea values and URR (urea reduction ratio) in patients with stage 5 chronic kidney disease (CKD) undergoing haemodialysis. The study used retrospective data from CKD stage 5 patients with complete medical records and pre- and post-urea laboratory results. The results of the study revealed that the haemodialysis process was effective, with a significant difference in pre- and post-urea values (p<0.05). The average pre-urea value was 114.29 mg/dL, while the average post-haemodialysis urea value was 37.85 mg/dL. The URR was found to be 67.46%. However, it was concluded that adequate haemodialysis in stage 5 CKD patients at Dr. Pirngadi Hospital had not reached 100%.
Preliminary Study of Physical and Chemical Stability of Polyherbal Suspensions by UV-Vis Spectrophotometry Nining, Nining; Nursal, Fith Khaira
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.45338

Abstract

Allicin, the main bioactive compound in garlic, contributes to its pharmacological effects. Monitoring the physical and chemical stability of herbal preparations is essential for ensuring product quality. This study aimed to evaluate the stability of a polyherbal suspension containing garlic, lemon, red ginger, honey, and apple cider vinegar. The suspension was assessed for physical properties (pH, viscosity, specific gravity, and particle dispersion) and chemical stability, focusing on thiosulfinate (TS) content. Measurements were taken over a period of five weeks under three different storage temperatures. TS levels were analyzed spectrophotometrically. The suspension had a specific gravity of 1.114 ± 0.002 g/mL and a pH of 3.74 ± 0.03. Both storage time and temperature significantly influenced pH, viscosity, and TS content (p<0.05), though all remained within acceptable pharmaceutical limits. TS degradation followed second-order kinetics. The polyherbal suspension demonstrated good physical stability over a five-week period. However, TS levels declined over time at all storage temperatures, indicating a trend toward reduced chemical stability.
Self Nanoemulsifying Drug Delivery System (SNEDDS) Grapeseed Oil Formulation Using Tween 20 And Cremophor Rh40 As Surfactant Andjani, Nathania Humaira; Wahyudi S, Made Dwi Pradipta; Somatirta, I Gede; Anggraini, Jessica Sanchez
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.49526

Abstract

Grape seeds (Vitis vinivera) oil is not only known to have antioxidant activity, but also known to have solubility and bioavailability problems. One way that can be used to overcome this problem is to formulate it into a Self-Nanoemulsifying Drug Delivery System (SNEDDS). SNEDDS is a system that consists of oil phase and surfactants mixture that will form nanoemulsions when stirred in water. The aim of the study was to optimize the oil phase and surfactant mixture composition, since it has been known to affect the SNEDDS characteristics. SNEDDS grapeseed oil was made with a mixture of surfactant tween 20 and cremophor RH40 which was optimized using the simplex lattice design approach with Design Expert 13.0.10. This study provided that the SNEDDS optimum formula consists of 5.73% grapeseed oil, 10% cremophor RH40, and 84.26% tween 20. The system could be emulsified in 5.32 seconds, with a transmittance of 99.435%, a droplet size of 13.5 nm, a PDI of 0.476, and a zeta potential of -21.0mV. Based on the stability test results, the resulting system was observed to be stable against dilution, freeze thaw, and centrifugation, which make the system acceptable as SNEDDS.
Formulation and Physical Evaluation of Biocellulose Sheet Mask Loaded Mulberry (Morus alba) Root Essence as Antioxidant as Cosmetic Preparation Alishlah, Tanfidz; Ulfah, Evi Umayah
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.54728

Abstract

AbstractBiocellulose (BC), a natural polymer from bacteria fermentation, is one of the new delivery systems in cosmetic applications with its advantages such as biodegradability, compatibility, and high skin permeability. Due to their antioxidant activity, Mulberry (Morus alba) roots containing oxyresveratrol have the potential as an anti-aging agent. This research aims to know the formulation of BC sheet mask loaded Morus alba essence extracted with NADES-UAE method, physical evaluation, and antioxidant activity. Morus alba root extract was formulated into three formulas of essence preparation with different concentrations of gel base CMC Na (0.5; 1; 1.5%) and evaluated based on their physical properties. BC sheet mask produced from Acetobacter xylinum was formulated with different concentrations of sucrose, acetic acid glacial, and ammonium sulfate. The best BC formula was loaded with essence and physically evaluated. Antioxidant activity was tested in vitro using the DPPH method. The results showed that BC formulated as a facial sheet mask had good physical properties: thickness of 0.51-1.48 mm, water hold capacity of 64.77%, pH of 7.19, and swelling capacity of 168%. Morus alba essence formula of F2 provides the best physical evaluation: viscosity 800 mPas, pH 6.45, spreadability 7.4 cm, and good homogeneity. The essence also showed no physical changes on stability testing. Antioxidant activity testing of Morus alba roots extract and essence formulation shows the inhibition of free radicals. BC-loaded Morus alba roots essence extracted NADES method can be applied as an antioxidant agent for promising cosmetics in the future. Key words: antioxidant, biocellulose, Morus alba, NADES-UAE, sheet mask Formulasi dan Evaluasi Fisik Sheet Mask Bioselulosa Mengandung Essence Mulberry (Morus alba) sebagai Kosmetika Antioksidan AbstrakBioselulosa adalah polimer alam yang didapatkan dari fermentasi bakteri merupakan teknologi penghantaran kosmetik baru untuk sheet mask. Sheet Mask bioselulosa lebih ramah lingkungan, kompatibel dan memiliki permeabilitas yang baik pada kulit. Akar Morus alba telah diteliti mengandung senyawa yang memiliki aktivitas antioksidan dan menjadi kandidat bahan aktif alami dalam suatu sediaan kosmetik. Penelitian ini bertujuan untuk mengetahui formulasi dan evaluasi fisik sheet mask bioselulosa yang mengandung essence ekstrak Morus alba, serta aktivitas antioksidannya. Serbuk akar Morus alba yang diekstraksi dengan metode NADES-UAE diformulasikan menjadi tiga formula sediaan essence dengan konsentrasi basis gel CMC Na yang berbeda (0,5; 1; 1,5%). Sheet mask bioselulosa yang dihasilkan dari Acetobacter xylinum diformulasikan dengan konsentrasi sukrosa, asam asetat glasial, dan amonium sulfat yang berbeda dan dilakukan evaluasi fisik. Aktivitas antioksidan sediaan diuji secara in vitro menggunakan metode DPPH. Hasil penelitian menunjukkan bahwa sheet mask bioselulosa yang diformulasikan mempunyai sifat fisik yang baik: ketebalan 0,51-1,48 mm, kapasitas menahan air 64,77%, pH 7,19, dan kapasitas pengembangan 168%. Formula essence ekstrak akar Morus alba F2 memberikan hasil evaluasi fisik terbaik: viskositas 800 mPas, pH 6,45, daya sebar 7,4 cm, dan homogenitas yang baik. Sediaan essence juga tidak menunjukkan perubahan fisik pada pengujian stabilitas. Uji aktivitas antioksidan sediaan menunjukkan adanya penghambatan terhadap radikal bebas. Sheet mask bioselulosa mengandung essence ekstrak akar Morus alba yang diekstraksi dengan metode NADES dapat diterapkan sebagai agen antioksidan untuk kosmetik yang menjanjikan di masa depan. Kata kunci: antioksidan, bioselulosa, Morus alba, NADES-UAE, sheet mask
Effects of pH on the Stability of Monascus purpureus Red Yeast IR-64 Rice (MpRYR) Extract Shaleha, Resha Resmawati; Yuliana, Anna; amin, Saeful; Sumiwi, Sri Adi; Levita, Jutti
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.59599

Abstract

Monascus purpureus red yeast rice (MpRYR), popularly known as angkak, is a Chinese fermented rice health product. The red pigments and monacolin K contained in MpRYR are sensitive to various factors, including acidity, temperature, oxidation, and light; thus, MpRYR is unstable and susceptible to damage during storage and processing. It was reported that monacolin K in red yeast rice solution was easily degraded under thermal treatment at 85–121°C, and the absorbance of MpRYR extract increased at an alkaline pH. This work aimed to study the effects of pH on the stability of pigment extract  MpRYR. MPRYR was purchased from Raja Godhong herbal supplier and extracted with 70% ethanol for 3 × 24 h. The resulting MpRYR extracts were subjected to various pH conditions, and the pH and absorbance were measured, and the degradation rate of MpRYR extracts was calculated. The initial pH of MpRYR extract is 5.75, which increased to 5.97 (+3.82%) at 3 h. The MpRYR extract was more stable in an acidic medium with a degradation rate of 3.80% at 3 h. Research results suggest that acidic conditions are preferable for storing and formulating MpRYR-based products to preserve their functional efficacy.
Antioxidant Activity of VCO-Clove Topical Oil and Predictive Interaction toward Prostaglandin-endoperoxide Synthase 2 Pramitha, Dewa Ayu Ika; Wibawa, Agung Ari Chandra; Adrianta, Ketut Agus; Samidya, Ni Wayan Rias
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.48983

Abstract

Pain is a prevalent symptom of various diseases, characterized by subjective sensory and emotional experiences, often triggered by nerve irritation and pain receptor activation. Prostaglandins play a crucial role as chemical mediators in pain mechanisms. Clove oil-based liniment is commonly used for pain relief, with eugenol as its main active compound. This study investigates the antioxidant activity of VCO-clove liniment with different clove proportions using the DPPH method and evaluates the analgesic potential of eugenol through its interaction with the PTGS2 receptor through in-silico analysis. VCO-clove liniment was formulated with varying clove weight ratio (1:10, 5:10, and 10:10 w/v). Antioxidant activity was evaluated in-vitro using DPPH assay, while the interaction between eugenol and PTGS2 (PDB code: 5KIR) was predicted using molecular docking. The results demonstrated that the 10:10 ratio exhibited the highest antioxidant activity, with an IC50 value of 40.33 µg/mL and an antioxidant activity index (AAI) of 0.99, classified as moderate. In-silico analysis revealed strong binding between eugenol and PTGS2, with a binding energy of -5.22 kcal/mol, suggesting its analgesic potential. In conclusion, VCO-clove liniment shows promise as an antioxidant and analgesic agent, with the 10:10 ratio displaying optimal antioxidant properties, and eugenol contributing significantly to its analgesic effects through PTGS2 interaction.
Phytochemical Screening and Antimicrobial Activity of Combination of Piper betle and Moringa oleifera Extracts Arifin, Siti Hakimah Aprilia Garini; Firdhausi, Nirmala Fitria; Hidayati, Irul; Faizah, Hanik
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.45288

Abstract

The inappropriate use of antibiotics can lead to pathogenic bacteria developing multiple drug resistance, making infectious disease treatment crucial. Thus, the discovery of novel antibiotics from natural materials, such as plant extracts or their combinations, is critically needed. Extracts of green betel (Piper betle) and Moringa (Moringa oleifera) leaves are known to have antimicrobial activity. This study aimed to determine the chemical content and antimicrobial activity of ethanol extracts of the combination of green betel leaves and Moringa leaves against Staphylococcus aureus, Escherichia coli, and Candida albicans. Green betel and Moringa leaves were macerated in 96% ethanol to extract secondary metabolites. Secondary metabolites were analyzed using phytochemical screening. Antimicrobial activity was tested using disk diffusion using various concentrations: EF1 (25% betel leaves + 75% moringa leaves), EF2 (50% betel leaves + 50% moringa leaves), and EF3 (75% betel leaves + 25% moringa leaves). Phytochemical tests showed that the ethanol extracts of betel leaves contained flavonoids, alkaloids, tannins, and saponins, and no terpenoids, while moringa leaves contain flavonoids, tannins, saponins, and terpenoids, but no alkaloids. S. aureus and E. coli had the highest inhibition zones at EF3 (75% betel leaves + 25% moringa leaves) concentrations, with average inhibition zones of 21.72 mm and 20.98 mm, respectively, and C. albicans at EF2 (50% betel leaves + 50% moringa leaves) concentration, with an average inhibition zone of 26.52 mm, with a very strong inhibition category.
Pharmacy Student Recommendations on Self-Medication for Headaches: A Cross-Sectional Study in Surabaya Halim, Steven Victoria; Pratama, Jeffry Refananto; Karinda, Itsna Laudzy; Setiadi, Adji Prayitno; Aditama, Lisa; Wibowo, Yosi Irawati; Brata, Cecilia; Setiawan, Eko
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.53546

Abstract

Assessing students’ ability to provide appropriate recommendations for self-medication requests is key in developing course materials for future pharmacists. Until recently, the number of published articles evaluating the appropriateness of recommendation provided by pharmacy students towards headache cases, as one of the most common symptoms urging people to seek advice from professional healthcare, is still limited. This observational study with cross-sectional design aims to identify the type and appropriateness of recommendation given by pharmacy professional degree students on two types of headache cases, i.e., tension type headache and migraine due to adverse drug reaction (ADR). The students characteristic data, type, and recommendation appropriateness were analyzed descriptively. In total, 86 students were involved in this research (response rate 82.7%) with different recommendation profiles for two different headache cases. The majority of the participants recommended a pharmaceutical product for tension type headache while referral to physicians was advised for migraine due to ADR. The appropriateness analysis findings revealed that students gave more appropriate recommendations for tension type headache (89.5%) compared to migraine due to ADR (77.9%) case. Therefore, students’ ability to provide relevant recommendations for headaches due to ADR requires further improvement by giving some cases accordingly during the learning process.

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