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MEDISAINS
Published by Universitas Muhammadiyah Purwokerto
ISSN : 16937309     EISSN : 26212366     DOI : -
Core Subject : Health,
Medicine & Pharmacology Nursing Public Health
MEDISAINS: Jurnal Ilmiah Ilmu-ilmu kesehatan merupakan sarana penyebarluasan ilmu pengetahuan, riset, teknologi dan inovasi dibidang kesehatan yang diterbitkan tiga kali dalam setahun (April, Agustus dan Desember). Jurnal Medisains adalah jurnal peer reviewed dan Open-Access yang dikelola oleh Fakultas Ilmu Kesehatan Universitas Muhammadiyah Purwokerto dan di terbitkan dibawah Lembaga Publikasi Ilmiah dan Penerbitan (LPIP) Universitas Muhammadiyah Purwokerto.
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Articles 19 Documents
 1   2 
Search results for , issue "Early Release" : 19 Documents clear
In vitro study: thymoquinone inhibits the proliferation and migration of keloid fibroblasts and increases their apoptosis Hadi, Restu Syamsul; Juniarti, Juniarti
MEDISAINS Early Release
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v0i0.23975

Abstract

Background: No treatment can eliminate keloids. Thymoquinone (TQ) is hypothesized to play a pivotal role in treating keloids by modulating cellular processes such as proliferation, migration, and apoptosis. However, the existing studies investigating its effects on these mechanisms in keloid fibroblasts are limited and require further exploration.Objective: This study aims to investigate the effects of TQ on the proliferation, migration, and apoptosis of keloid fibroblasts in vitro.Methods: This experimental study was conducted using keloid fibroblast cultured in vitro. Cells were seeded in a 96-well plate at a density of about 5x103 cells per well with 100 μl of culture medium, and cells were cultured for 24, 48, and 72 hr for each concentration of TQ. Cell proliferation was assessed using a CCK-8 Kit, measuring optical density with a microplate reader. Apoptosis was measured using the TUNEL assay. Cell migration following TQ treatment was evaluated using the Scratch assay. The statistical test used a one-way analysis of variance (ANOVA) followed by the least significant difference (LSD) test. Results: TQ inhibited the proliferation of keloid fibroblasts at a dose of 5 µM after 48 hours of incubation and 10 µM after 24 hours of incubation. The inhibitory effect of TQ on fibroblast proliferation increased in a dose- and time-dependent manner. Treatment at 5 and 10 µM doses increased apoptosis in keloid fibroblast cultures. The TQ5 µM group achieved 60% closure, while the 10 µM group showed 55% closure. Migration was significantly inhibited in the 25 µM and 50 µM groups, with only 30% and 10% closure, respectively, at 72 hours.Conclusion: Thymoquinone inhibits the proliferation and migration of keloid fibroblast cells while promoting apoptosis. These properties suggest that TQ could be developed as a potential treatment for keloid-related skin issues.
Prevalence human papillomavirus type 6 and type 11 in pregnant women Haruna, Nadyah; Hatta, Mochammad; Hamid, Firdaus; Sultan, Andi Rofian; Safri, Safri; Farid, Monika Fitria; Lestari, Esa
MEDISAINS Early Release
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v0i0.23103

Abstract

Background: Pregnancy reduces the effectiveness of cell-mediated immunity, making the body more vulnerable to Human Papilloma Virus (HPV) infection. HPV comes in multiple variants, including non-pro-oncogenic varieties like 6 and 11. Less research has been done on low-risk HPV infections than on high-risk HPV since they are more frequently linked to genital warts and rarely result in cancer. Examples of these infections are types 6 and 11. It is necessary to conduct this study to ascertain whether asymptomatic pregnant women have been exposed to HPV types 6 and 11.Purpose: This study aims to determine prevalence HPV types 6 and 11 in pregnant women.Methods: A descriptive cross-sectional survey was carried out in Makassar in May 2023. The study Population consisted of pregnant women who underwent antenatal care at Tajuddin Chalid Hospital Makassar during the specified research period. After providing clarification and obtaining consent from eligible mothers, we collected a swab from the vaginal area. A PCR examination was conducted on the 167 maternal swabs that were received. Statistical analyses included frequency distribution using SPSS.Results: According to the study, 121 (72.5%) of the 167 samples tested positive for HPV type 6 DNA, while 46 (27.5%) tested negative. Meanwhile, 67% of 167 patients tested positive for HPV type 11 but were negative for the virus. Only 21 respondents with negative identification were found to be harboring both low-risk Human Papillomavirus types. In addition, 78 respondents received positive results for HPV types 6 and 11.Conclusion: Pregnant women can be infected with HPV types 6 and 11 even if they are asymptomatic. The high percentage of positive results suggests that routine maternal screening is recommended, especially during pregnancy.
Postural exercise impaction on the development of vertebral curves and functional deformity for adolescent idiopathic scoliosis Romadhoni, Dea Linia; Ramadhani, Alinda Nur
MEDISAINS Early Release
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v0i0.23017

Abstract

Background: Adolescent idiopathic scoliosis (AIS) is a common spinal deformity affecting children aged 10–18 years. Various treatment approaches, including specific exercises, bracing, surgery, traction, casting, and biofeedback, have been implemented to manage AIS. However, posture correction exercises remain a non-invasive rehabilitation strategy with the potential to prevent scoliosis progression and improve functional outcomes.Purpose: This study aimed to evaluate the effectiveness of posture correction exercises in reducing vertebral curvature deformity and improving functional abilities in adolescents with idiopathic scoliosis.Methods: This quasi-experimental study employed a one-group pretest-posttest design involving 30 students aged 10–15 years diagnosed with AIS. Participants underwent a four-week supervised posture correction exercise program. The primary outcome, vertebral curvature deformity, was assessed using the Adam’s Forward Bending Test, while changes in vertebral inclination angle were measured using a Scoliometer. All data were documented through structured questionnaires.Results: The findings revealed a statistically significant reduction in vertebral inclination angle following the intervention (p<0.001), indicating the effectiveness of posture correction exercises as part of scoliosis-specific rehabilitation programs.Conclusion: Posture correction exercises significantly reduce vertebral curvature deformity and enhance functional capabilities in adolescents with AIS. These findings support their integration into physiotherapy programs as a non-invasive rehabilitative and preventive approach for scoliosis management.
In vivo study of Centella asiatica leaf extract cream for Matrix Metalloproteinase-1 inhibition and collagen enhancement to prevent photoaging Purmawanti, Sri; W, Joko Wahyu; Sumarawati, Titiek
MEDISAINS Early Release
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v0i0.24719

Abstract

Background: Ultraviolet B (UVB) exposure accelerates skin aging, causing wrinkles and increasing matrix metalloproteinase-1 (MMP-1) activity, which degrades collagen. Centella asiatica (CA) has well-documented anti-inflammatory and antioxidant properties that may counteract UVB-induced photoaging. However, studies on its topical formulation for MMP-1 inhibition and collagen enhancement remain limited.Purpose: This study aims to determine the effect of CA leaf extract cream on inhibiting MMP-1 and increasing collagen in skin tissue exposed to UVB rays.Methods: This experimental study used a post-test only control group design. The sample population of BALB/c mice was 24, divided into four groups: healthy control group (KN), negative control group (K-), Treatment 1 (P1): 10% CA extract cream dosage, and Treatment 2 (P2): 20% CA extract cream dosage. Skin tissue samples were measured for MMP-1 expression using immunohistochemistry (IHC) staining, and collagen density using Sirius Red staining. Data analysis on MMP-1 expression using One-way ANOVA test and collagen density using Kruskal Wallis test.Results: MMP-1 expression was highest in the K2 group (UVB exposure + cream base) and decreased in the P1 and P2 groups (10% CA cream), with the lowest expression in the K1 group (healthy control). However, One-Way ANOVA showed no significant differences among groups (p=0.053). Collagen density analysis using the Kruskal-Wallis test showed significant differences (p = 0.04), with a decrease in the K2 group and an increase in the K3 and K4 groups.Conclusion: Application of CA extract cream affects MMP-1 expression and collagen density in skin tissue exposed to UVB rays.
Potential of turmeric cream (curcuma caesia roxb.) extract in incision wounds Udayani, Ni Nyoman Wahyu; Adrianta, I Ketut Agus; Wiguna, I Putu Bagus Artha; Yowani, Anak Agung Sagung Iswarani
MEDISAINS Early Release
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v0i0.23731

Abstract

Background: Incisional wounds are the most common wounds in the community. Improper handling of incision wounds can worsen wounds and cause infection. The content of secondary metabolites in black turmeric rhizomes can act as anti-inflammatory and antimicrobial in the healing process of incision wounds. However, its effectiveness in healing incision wounds has not been widely studied, so further research is needed.Purpose: This study was conducted to determine the potential of black turmeric cream as an herbal medicine to heal incision wounds.Methods: This study was an invivo experimental research study with a randomized post-test control group design. The samples used were 20 male rats that were made to have a 2 cm incision wound on the back area, consisting of a negative control, a positive control, and three black turmeric extract groups (5%, 10%, and 15%). The data obtained were analyzed by an ANOVA (Analysis of Variance) parametric statistical test.Result: The results showed that the highest decrease in incision wound length was found in the black turmeric rhizome cream Formula III group and the lowest in the negative control group. On day 14, the incision wound area of the Formula III black turmeric rhizome cream group had closed or healed (0.00 cm), while the negative control group had the slowest incision wound closure (0.39 cm).Conclusion: Black turmeric rhizome cream can heal and prevent infection of the incision wound. This shows the potential of black turmeric rhizome as an anti-inflammatory and antimicrobial.
Sociodemographic and psychological factors associated with depression among nursing home elders Widyasari, Eka; Ariani, Tutu April; Aini, Nur; Marta, Ollyvia Freeska Dwi; Mashfufa, Erma Wahyu
MEDISAINS Early Release
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v0i0.25830

Abstract

Introduction: Depression in the elderly is shaped by sociodemographic and psychological factors. Depression generally affects older adults and is associated with a poor life, with sociodemographic and psychological factors such as social support and loneliness playing a role in the onset of depression. However, the relationship between these factors and depression in the elderly is still rarely explored.Purpose: This study aims to explore the relationship between psychological and sociodemographic factors on the level of depression in the elderly living in nursing homes, with a focus on social support, level of loneliness, and cognitive impairment.Methods: This study used a descriptive cross-sectional design and involved 72 older adults living in four East Java, Indonesia nursing homes. Data were collected through questionnaires using the Multidimensional Scale of Perceived Social Support (MSPSS), UCLA Loneliness Scale, Mini-Mental State Examination (MMSE), and Beck Depression Inventory-II (BDI-II), which were translated into Bahasa Indonesia. Multiple logistic regression was used to understand the relationship between sociodemographic and psychological factors and the level of depression in the elderly.Results: Marital status (AOR 0.177, p = 0.030) and social support (AOR 0.950, p = 0.040) are significantly associated with depression in the elderly.Conclusion: Marital status and level of social support have the potential to cause depression in the elderly living in nursing homes.
The effect of consuming rosella flower-infused water on control blood pressure in pregnant women with hypertension amin, dewita rahmatul; Sugiarti, Rosi Kurnia
MEDISAINS Early Release
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v0i0.24075

Abstract

Background: Hypertension during pregnancy is one of the leading causes of maternal morbidity and mortality. Rosella flower infused-water, rich in bioactive compounds such as flavonoids and polyphenols, have been shown to lower blood pressure safely. Although previous studies have highlighted the antihypertensive effects of rosella in the general population, research specifically focusing on its use in pregnant women with hypertension is still limited.Objective: This study aims to investigate the effect of rosella flower-infused water on control blood pressure reduction in pregnant women with hypertension.Method: The research design used is quasi-experimental with a pre-test and post-test approach involving 100 pregnant women with hypertension in Desa Karangraharja. The intervention group received 200 ml of rosella flower-infused water for 14 days in conjunction with nifedipine 10 mg, while the control group only received nifedipine 10 mg. The blood pressure of the control and intervention groups was measured using the Mann-Whitney Test.Results: The rosella flower-infused water effectively reduced systolic blood pressure in the intervention group by 24.92 mmHg compared to the control group by 18.78 mmHg (p=0.000). Diastolic blood pressure in the intervention group decreased by three mmHg, although this was not statistically significant compared to the control group's decrease of 3.6 mmHg (p=0.715).Conclusion: The 200 ml rosella flower-infused water for 14 consecutive days reduced systolic blood pressure in pregnant women with hypertension.
Antihyperglicemic effect of Musa paradisiaca extract in vivo Hujjatusnaini, Noor; Nirmalasari, Ridha
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Early Release
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v0i0.18814

Abstract

Background: Musa paradisiaca has  been widely studied for its antihyperglycemic effects, showing potential as an alternative natural remedy for diabetes. However, variability in genetic factors, environmental conditions, and geographical origins may influence its bioactive compound composition and efficacy. Thus, further validation through controlled studies is required to ensure consistent therapeutic effects.Purpose: : This study aimed to evaluate the antihyperglycemic effect of Musa paradisiaca stem extract in vivo, providing additional validation for its therapeutic potential and determining the optimal concentration for clinical relevance.Method: An experimental posttest-only control group design was used. Thirty-five male Balb/c strain mice were induced into hyperglycemia using alloxan. They were then randomly divided into treatment groups receiving different concentrations of Musa paradisiaca stem extract (5%, 15%, 25%, 35%, and 45%), a positive control group (metformin), and a negative control group. Blood glucose levels were measured and analyzed statistically using One-Way ANOVA.Result: Administration of the stem extract at 15% concentration showed the most significant antihyperglycemic effect, with an average blood glucose level reduction to 63.8 mg/dL, comparable to the positive control group (metformin). Conversely, the highest concentration tested (45%) exhibited minimal effectiveness, with an average glucose level of 151.8 mg/dL, indicating reduced antihyperglycemic activity.Conclusion: The optimal antihyperglycemic effect of Musa paradisiaca stem extract was achieved at a concentration of 15%, demonstrating therapeutic efficacy comparable to metformin. This extract shows promise as a natural alternative agent in diabetes treatment. Further studies, including clinical trials, are recommended to confirm these findings.
Postural exercise impaction on the development of vertebral curves and functional deformity for adolescent idiopathic scoliosis Romadhoni, Dea Linia; Ramadhani, Alinda Nur
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Early Release
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v0i0.23017

Abstract

Background: Adolescent idiopathic scoliosis (AIS) is a common spinal deformity affecting children aged 10–18 years. Various treatment approaches, including specific exercises, bracing, surgery, traction, casting, and biofeedback, have been implemented to manage AIS. However, posture correction exercises remain a non-invasive rehabilitation strategy with the potential to prevent scoliosis progression and improve functional outcomes.Purpose: This study aimed to evaluate the effectiveness of posture correction exercises in reducing vertebral curvature deformity and improving functional abilities in adolescents with idiopathic scoliosis.Methods: This quasi-experimental study employed a one-group pretest-posttest design involving 30 students aged 10–15 years diagnosed with AIS. Participants underwent a four-week supervised posture correction exercise program. The primary outcome, vertebral curvature deformity, was assessed using the Adam’s Forward Bending Test, while changes in vertebral inclination angle were measured using a Scoliometer. All data were documented through structured questionnaires.Results: The findings revealed a statistically significant reduction in vertebral inclination angle following the intervention (p<0.001), indicating the effectiveness of posture correction exercises as part of scoliosis-specific rehabilitation programs.Conclusion: Posture correction exercises significantly reduce vertebral curvature deformity and enhance functional capabilities in adolescents with AIS. These findings support their integration into physiotherapy programs as a non-invasive rehabilitative and preventive approach for scoliosis management.
Prevalence human papillomavirus type 6 and type 11 in pregnant women Haruna, Nadyah; Hatta, Mochammad; Hamid, Firdaus; Sultan, Andi Rofian; Safri, Safri; Farid, Monika Fitria; Lestari, Esa
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Early Release
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v0i0.23103

Abstract

Background: Pregnancy reduces the effectiveness of cell-mediated immunity, making the body more vulnerable to Human Papilloma Virus (HPV) infection. HPV comes in multiple variants, including non-pro-oncogenic varieties like 6 and 11. Less research has been done on low-risk HPV infections than on high-risk HPV since they are more frequently linked to genital warts and rarely result in cancer. Examples of these infections are types 6 and 11. It is necessary to conduct this study to ascertain whether asymptomatic pregnant women have been exposed to HPV types 6 and 11.Purpose: This study aims to determine prevalence HPV types 6 and 11 in pregnant women.Methods: A descriptive cross-sectional survey was carried out in Makassar in May 2023. The study Population consisted of pregnant women who underwent antenatal care at Tajuddin Chalid Hospital Makassar during the specified research period. After providing clarification and obtaining consent from eligible mothers, we collected a swab from the vaginal area. A PCR examination was conducted on the 167 maternal swabs that were received. Statistical analyses included frequency distribution using SPSS.Results: According to the study, 121 (72.5%) of the 167 samples tested positive for HPV type 6 DNA, while 46 (27.5%) tested negative. Meanwhile, 67% of 167 patients tested positive for HPV type 11 but were negative for the virus. Only 21 respondents with negative identification were found to be harboring both low-risk Human Papillomavirus types. In addition, 78 respondents received positive results for HPV types 6 and 11.Conclusion: Pregnant women can be infected with HPV types 6 and 11 even if they are asymptomatic. The high percentage of positive results suggests that routine maternal screening is recommended, especially during pregnancy.

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