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MEDISAINS
Published by Universitas Muhammadiyah Purwokerto
ISSN : 16937309     EISSN : 26212366     DOI : -
Core Subject : Health,
Medicine & Pharmacology Nursing Public Health
MEDISAINS: Jurnal Ilmiah Ilmu-ilmu kesehatan merupakan sarana penyebarluasan ilmu pengetahuan, riset, teknologi dan inovasi dibidang kesehatan yang diterbitkan tiga kali dalam setahun (April, Agustus dan Desember). Jurnal Medisains adalah jurnal peer reviewed dan Open-Access yang dikelola oleh Fakultas Ilmu Kesehatan Universitas Muhammadiyah Purwokerto dan di terbitkan dibawah Lembaga Publikasi Ilmiah dan Penerbitan (LPIP) Universitas Muhammadiyah Purwokerto.
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Articles 11 Documents
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Search results for , issue "Vol. 23 No. 3 (2025)" : 11 Documents clear
Poundfit exercise and cardiometabolic health in women: a quasi-experimental study Sucipto, Adi; Rahmadani , Irianti Fitri; Afriani, Yuni; Sari, Siska Puspita; Boru, Dhelsiana Rambu Desi; Nabila , Dinda Rambu; Puspaningtyas, Desty Ervira
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 23 No. 3 (2025)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v23i3.24480

Abstract

Background: Poundfit is a rhythmic, music-driven aerobic exercise that integrates cardiovascular movement and strength-based activities. Despite its growing popularity, evidence regarding its effects on cardiometabolic parameters in healthy adults remains limited. Objective: This study aimed to evaluate the effects of a short-term Poundfit exercise program on blood pressure and blood glucose levels in healthy adult women. Methods: A quasi-experimental one-group pretest–posttest design was conducted among 22 women aged 19–50 years. Participants attended Poundfit exercise sessions twice weekly for two weeks, with each session lasting 60 minutes. Blood pressure and blood glucose levels were measured before and after the intervention. Pretest–posttest comparisons were analyzed using the Wilcoxon signed-rank test. Results: Following the two-week intervention, systolic and diastolic blood pressure showed slight reductions, while blood glucose levels showed a slight increase; however, none of these changes were statistically significant (p = 0.122 for systolic blood pressure, p = 0.933 for diastolic blood pressure, and p = 0.220 for blood glucose). Conclusion: A two-week Poundfit exercise program did not result in statistically significant changes in blood pressure or blood glucose levels in healthy adult women. These findings suggest that short-term Poundfit training may be insufficient to produce measurable cardiometabolic improvements in normotensive individuals, highlighting the need for longer or more intensive exercise interventions in future studies.
In vivo study on the effect of noni leaf extract cream (Morinda Citrifolia L) on PDGF and TNF-α levels in cut wounds Sari, Shintia Devi Arum; Mulyani, Sri Priyantini; Putra, Agung; Setiawan , Eko
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 23 No. 3 (2025)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v23i3.25252

Abstract

ABSTRACT Background: Skin wounds damage the structure and epithelial tissue, resulting in scar tissue formation. Prolonged wound healing or excessive body response will inhibit the normal process and produce unaesthetic scar tissue. Many plant extracts and their active components can accelerate the wound healing process, Noni leaf extract has antioxidant activity and accelerates wound healing. Objective: This study aims to determine the effect of noni leaf extract cream (Morinda Citrifolia L) on TNF-α and PDGF levels in Wistar rats with incised wounds. Method: A laboratory experimental study with a post-test only control group design. Consisting of five treatment groups, namely the healthy rat group (KS), Negative group (KN) rats with incised wounds without treatment, positive group (KP) rats with incised wounds that were smeared with povidone-iodine cream, treatment group 1 (P1) rats that were smeared with 20% noni leaf extract cream, and treatment group 2 (P2) rats that were smeared with 40% noni leaf extract cream, treatment for 3 days then examined the levels of TNF-α and PDGF skin tissue using the ELISA method. Results: The average TNF-α levels showed a significant difference between groups p of 0.000 (p <0.05) with the One way anova test, the highest average in group (KN) 220.68 pg / mL, there was a decrease in all treatment groups with the lowest TNF-α levels in group (KP) 76.59 pg / mL. The average results of TNF-α levels showed a significant difference of p 0.000 (<0.05) with the One-way ANOVA test, the group without intervention (KP) had the lowest PDGF levels while the group (P2) experienced the highest increase in PDGF levels. Conclusion: Administration of noni leaf extract cream with doses of 20% and 40% had an effect on reducing TNF-α levels and increasing PDGF levels in Wistar rats with incised wounds.
Kelakai serum reduces UVB-induced vascular endothelial growth factor and interleukin-6: in vivo study Ulfadhina, Nedya; Hussaana, Atina; Suparmi, Suparmi
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 23 No. 3 (2025)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v23i3.25906

Abstract

Background: UVB exposure increases reactive oxygen species leading to higher expression of vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6), which accelerate photoaging. Kelakai leaf (Stenochlaena palustris) contains flavonoids and phenolic compounds with antioxidant and anti-inflammatory potential, yet its efficacy in serum formulations has not been evaluated. Purpose: To determine the effect of kelakai leaf extract serum on VEGF and IL-6 expression in BALB/c mice exposed to subchronic UVB radiation. Method: This experimental post-test only control group study used 30 BALB/c mice assigned to five groups: healthy control (K1), UVB-exposed negative control (K2), UVB + 0.025% retinoid serum (K3), UVB + 2% kelakai serum (K4), and UVB + 4% kelakai serum (K5). UVB exposure (160 mJ/cm²) was given for 14 days followed by topical treatment. Skin tissues were examined using immunohistochemistry to assess VEGF and IL-6 expression. Data were analyzed using the Kruskal–Wallis test followed by Mann–Whitney. Results: VEGF and IL-6 expression were highest in K2 and lowest in K1. Both retinoid and kelakai serum significantly reduced expression levels (p<0.05). The 4% kelakai serum (K5) produced greater reductions than the 2% dose, approaching the effect of retinoid serum. Conclusion: Kelakai leaf extract serum at 4% effectively decreases VEGF and IL-6 expression in UVB-exposed mice, supporting its potential as a natural anti-photoaging agent.
Patterns and predictors of anaemia in haemodialysis patients: relationship with comorbidities and dialysis exposure time Handrean, I Gede Eka; Putra MN, I Made Mahadinata; Pratama Putra, I Gede Laksmana
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 23 No. 3 (2025)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v23i3.26063

Abstract

Background: Anaemia is a common and serious complication in patients with chronic kidney disease (CKD) undergoing haemodialysis, contributing to increased morbidity, mortality, and reduced quality of life. Its prevalence and predictors vary across populations, and evidence from Indonesian cohorts remains limited. Objective: This study aimed to investigate the prevalence, severity, and predictors of anaemia in haemodialysis patients, with a particular focus on the influence of comorbidities and dialysis duration. Methods: A cross-sectional analytic study was conducted among 71 CKD patients undergoing regular haemodialysis at Kenak Medika Ubud Hospital between July and August 2024. Data on demographics, dialysis duration, comorbidities, and laboratory parameters (Hb, BUN, SC, MCV, MCH) were extracted from medical records. Anaemia severity was classified according to WHO and KDIGO guidelines. Statistical analysis included descriptive statistics, Chi-square tests, ANOVA, correlation analysis, and multivariate linear regression. Results: The prevalence of anaemia was 70.4%, with moderate anaemia being the most common presentation (52.1%). Patients with dialysis duration >24 months had significantly lower haemoglobin levels compared to those with shorter treatment exposure (p = 0.014). Multivariate regression analysis identified hypertension (p = 0.009) and cardiovascular disease (p = 0.013) as significant predictors of haemoglobin levels, while diabetes mellitus, BUN, SC, MCV, and MCH showed no significant associations. Conclusion: Anaemia remains highly prevalent in haemodialysis patients, with dialysis duration and cardiovascular comorbidities emerging as key predictors. These findings underscore the importance of routine anaemia monitoring, individualized treatment strategies, and integrated management of cardiovascular comorbidities to optimize outcomes in haemodialysis populations.
Sub-acute toxicity evaluation of Ziziphus spina-christi and Adenanthera pavonina leaf extracts combination in rats: an in vivo study Ngibad, Khoirul; Ayu , Patricia Gaby; Fafa , Angelica Rosia; Tria , Novitasari; Farichatul , Wachda
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 23 No. 3 (2025)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v23i3.27311

Abstract

Background: The safety of combined herbal extracts remains underexplored, particularly for Ziziphus spina-christi and Adenanthera pavonina, which contain bioactive compounds with potential toxic effects. Objective: To evaluate the sub-acute toxicity of combined leaf extracts on hematological, biochemical, and organ morphology parameters in Wistar rats. Method: Thirty male and female rats were randomized into five groups receiving vehicle control or extract doses of 4000, 8000, and 10,000 mg/kg BW for 21 days following OECD 407. Blood hematology, renal biomarkers, bilirubin levels, organ weight, and morphology were analyzed. Results: Mortality increased dose-dependently, reaching 20% in males and 10% in females at 10,000 mg/kg BW. Hematology and renal biomarkers showed no significant differences (p>0.05). Total bilirubin increased at the highest dose. Morphological abnormalities, including pale discoloration and dark foci, were observed in liver and kidneys at higher doses. Conclusion: The combination extract is safe up to 8000 mg/kg BW, while 10,000 mg/kg BW induces organ alterations and increased mortality.
Mobile eye-exercise matasehatku application to reduce asthenopia in office workers: a quasi-experimental study Habiba, Putri Ghanim Septia; Jaya, Akbar
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 23 No. 3 (2025)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v23i3.27494

Abstract

Background: Asthenopia is common among computer users, yet limited evidence exists regarding interventions targeting office workers. Mobile health technologies offer new opportunities to promote ocular health in technology-intensive work environments. Purpose: This study aimed to evaluate the effectiveness of the MataSehatKu mobile eye-exercise application in reducing asthenopia among office workers in the information technology sector. Method: A quasi-experimental pre-test–post-test control group design was conducted with 39 office workers (17 intervention, 22 control) selected by purposive sampling. Asthenopia levels were measured using the Digital Eye Strain Questionnaire (DES-Q) before and after a two-week intervention. Result: The intervention group showed a significant reduction in mean asthenopia scores (8.82 ± 5.13 to 2.71 ± 1.96; mean decrease = 6.11; p < 0.001), while the control group showed a significant increase (12.45 ± 9.10 to 19.82 ± 12.91; mean increase = 7.36; p < 0.001). Between-group post-test comparison revealed significantly lower scores in the intervention group (p < 0.001). Effect size analysis indicated a large impact (Cohen’s d = 1.57 within-group; d = 1.74 between-groups). Conclusion: The MataSehatKu application effectively reduced asthenopia among office workers, supporting the potential of mobile health–based eye-exercise programs as scalable occupational health strategies.
Fatigue and psychosocial factors associated with self-concept in pediatric cancer patients Pratiwi, Pramudita Hening; Hapsari, Happy Indri; Puji Utami, Ratih Dwilestari
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 23 No. 3 (2025)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v23i3.27737

Abstract

Background: Childhood cancer is a chronic disease that requires intensive treatment, such as chemotherapy and radiotherapy. While effective, these treatments often cause various side effects, with fatigue being one of the most common complaints. Fatigue not only impacts the physical health but also significantly impairs the activities, social interactions, and self-concept of children with cancer. Purpose: This study aimed to analyze the factors that influence the self-concept of children with cancer undergoing treatment at Dr. Moewardi Surakarta Regional Hospital. Method: This study used a cross-sectional design. It was conducted at Dr. Moewardi Hospital Surakarta in March 2025, involving 90 children with cancer aged 8-18 years old, selected using consecutive sampling from a population of 907 children with cancer. The research instruments used a demographic data questionnaire, the PedsQL multidimensional fatigue scale (MFS), and the self-perception profile for children (SPPC). Data were analyzed using multiple linear regression. Results: The results of this study that fatigue is the most significant and consistent predictor of various dimensions of children's self-concept, even influencing nearly all subscales measured, including academic competence, athletic competence, physical appearance, and global self-esteem. Regression analysis corroborates this finding by showing that behavioral self-concept is significantly influenced by educational status and fatigue (p<0.001, R2 =0.165), while global self-esteem is influenced by type of care and fatigue (p<0.001, R2 =0.194). Although other factors such as educational status and gender are also associated with certain dimensions, fatigue is the only factor that universally and comprehensively influences nearly every aspect of children's self-concept. Conclusions: Fatigue, child's educational status, gender, and type of treatment influence the self-concept of children with cancer.
Booklet-based menstrual hygiene education and its effect on knowledge and attitudes of women Harahap, Mustika Hana; Harahap , Afrida Sriyani; Harahap , Dewi Anggriani
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 23 No. 3 (2025)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v23i3.27923

Abstract

Background: Menstrual hygiene is a crucial aspect of reproductive health, particularly for women of reproductive age (WRA) in correctional institutions where access to health education is often limited. Purpose: This study aimed to evaluate the effectiveness of booklet-based education in improving knowledge and attitudes of WRA regarding menstrual hygiene at the Women’s Correctional Facility in Pekanbaru City. Method: A quasi-experimental one-group pretest–posttest design was conducted involving 70 respondents selected through purposive sampling. Data were collected using validated questionnaires and analyzed with the Wilcoxon Signed-Rank Test. Results: Respondents’ knowledge increased from 68.6% to 95.7%, and positive attitudes from 71.4% to 95.7% after the intervention (p < 0.001). Conclusion: Booklet-based education significantly improved menstrual hygiene knowledge and attitudes among incarcerated women, supporting its use as a sustainable and scalable reproductive health education strategy in correctional facilities.
Smartphone-based supportive counseling to reduce pregnancy-specific stress in pregnant adolescents Ulfah, Mariah; Yusuf , Munawir
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 23 No. 3 (2025)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v23i3.27937

Abstract

Background: Adolescence is a psychologically vulnerable period, and pregnancy during this stage increases the risk of stress, particularly when pregnancies are unintended or accompanied by social stigma. Although psychosocial support is essential, evidence on supportive counseling specifically for pregnant adolescents is limited, and most interventions rely on traditional face-to-face methods. To address this gap, this study developed a smartphone-based supportive counseling model to strengthen maternal mental health among Indonesian adolescents. Purpose: To examine the effect of smartphone-based supportive counseling on pregnancy-specific stress among pregnant adolescents. Methods: A quasi-experimental pre- and post-test non-equivalent control group design was used involving 60 pregnant adolescents. Participants were assigned to an intervention group (n = 30) or a control group (n = 30) using purposive sampling. The intervention group received smartphone-based supportive counseling sessions (60–120 minutes) over three weeks, while the control group received routine antenatal care. Pregnancy-specific stress was measured before and after the intervention. Data were analyzed using paired t-tests and independent t-tests. Results: The intervention group showed a significant reduction in pregnancy-specific stress after supportive counseling (p < 0.001), whereas the control group showed no significant change (p = 0.069). Conclusion: Smartphone-based supportive counseling is effective in reducing pregnancy-specific stress among pregnant adolescents and may serve as an accessible psychosocial support model in resource-limited settings.
Maternal and perinatal risk factors associated with neonatal asphyxia: a case–control study I Gusti Agung Ayu Sriningrat; Sanjiwani , Made Indira Dianti; Suryaningsih , Putu Siska; Suryawan , I Wayan Bikin
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 23 No. 3 (2025)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v23i3.28374

Abstract

Background: Neonatal asphyxia remains a major cause of neonatal morbidity and mortality worldwide and continues to be the second leading cause of neonatal death in Indonesia. Although numerous studies have examined maternal and perinatal risk factors, contemporary evidence from Bali particularly from Wangaya General Hospital remains limited. Objective: To analyze maternal and perinatal factors associated with neonatal asphyxia among newborns delivered at Wangaya General Hospital, Denpasar. Methods: An analytical case–control study was conducted using hospital delivery records from January to November 2024. A total of 189 newborns were included, consisting of 95 asphyxia cases and 94 non-asphyxia controls selected through proportionate stratified random sampling. Maternal variables (parity, hypertensive disorders, anemia, premature rupture of membranes) and perinatal variables (mode of delivery, gestational age, birth weight) were extracted from medical records. Associations were examined using odds ratios (OR) with 95% confidence intervals, followed by multivariable logistic regression to identify independent predictors of neonatal asphyxia. Results: Low birth weight (LBW) demonstrated the strongest association with neonatal asphyxia (adjusted OR = 112.66; 95% CI: 30.84–411.60; p < 0.001). Prematurity showed a significant crude association but became attenuated after adjustment, likely due to multicollinearity with LBW. Maternal factors including parity, hypertensive disorders, anemia, and premature rupture of membranes as well as mode of delivery did not show statistically significant associations in either bivariate or multivariable analysis. Conclusion: Neonatal asphyxia at Wangaya General Hospital is predominantly associated with perinatal biological vulnerabilities, particularly low birth weight and, to a lesser extent, prematurity. Maternal factors contributed minimally in this setting, suggesting that fetal maturity and neonatal physiological readiness play a more crucial role than maternal comorbidities. Strengthening antenatal strategies to prevent fetal growth restriction and enhancing preparedness for the stabilization of LBW and preterm infants are essential to reducing asphyxia-related morbidity.

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