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INDONESIA
Majalah Kedokteran Gigi Indonesia
Published by Universitas Gadjah Mada
ISSN : 24600164     EISSN : 24422576     DOI : https://doi.org/10.22146/majkedgiind.36959
Core Subject : Health,
Dentistry
Arjuna Subject : -
Articles 556 Documents
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The impact of varying concentrations of hyaluronic acid gel on the enhancement of VEGF and angiogenesis expression Fauzia, Malianawati; Kumala, Ega Lucida Chandra; Aufani, Maulida; Syalisha, Addini Zoya; Wahyu, Adellia; Mukhlis, Muhammad Maulana Zikrullah
Majalah Kedokteran Gigi Indonesia Vol 11, No 2 (2025): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.104632

Abstract

Periodontal dressings can contribute to plaque accumulation, which in turn may cause inflammation, irritation of healing tissues, bacteremia, and difficulties in eating. Advances in knowledge and technology have improved the materials used in these dressings, aiming to enhance effectiveness and minimize complications. High-molecular-weight hyaluronic acid (HMW-HA) is a promising dressing material because of its anti-inflammatory properties and its ability to promote epithelial regeneration. This study aimed to determine whether different concentrations of HMW-HA gel influence vascular endothelial growth factor (VEGF) expression and angiogenesis during gingival wound healing in white rats (Rattus norvegicus) of the Wistar strain. A total of 42 rats were divided into seven groups: a negative control group (K1), a positive control group (K2) treated with 0.2% Gengigel®, and five treatment groups (P1–P5) receiving HMW-HA gel at concentrations of 0.2%, 0.4%, 0.6%, 0.8%, and 1%, respectively. Standardized 2 mm wounds were created with a punch biopsy on the lower anterior jaw of each rat. Treatments were administered twice daily for seven days. VEGF expression and angiogenesis were evaluated using immunohistochemical and hematoxylin–eosin staining. The group treated with 1% HA gel (P5) showed the highest average VEGF expression and angiogenesis compared with the negative control and lower-concentration treatment groups. These findings suggest that topical application of HMW-HA gel may enhance gingival wound healing in periodontal surgery by promoting angiogenesis and increasing VEGF expression.
The effect of activated charcoal and bentonite toothpaste on extrinsic tooth discoloration Melaniwati, Melaniwati; Putri, Naura Belinda; Ratnasari, Dina; Dwisaptarini, Ade Prijanti
Majalah Kedokteran Gigi Indonesia Vol 11, No 2 (2025): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.104679

Abstract

Tooth discoloration is categorized into intrinsic and extrinsic types, with the latter caused by external staining agents such as pigmented beverages (e.g., black tea). Whitening toothpastes are commonly used to address extrinsic discoloration, though chemical-based formulations may lead to side effects. Consequently, natural alternatives, including activated charcoal and bentonite, are gaining attention as whitening agents. This study aimed to evaluate the effects of activated charcoal and bentonite toothpaste on extrinsic tooth discoloration. A control group pretest-posttest design was employed, involving 48 premolar teeth divided into four groups. Samples were stained by immersion in a black tea solution (400 mL water, 4 tea bags) for 4 hours daily over 13 days, simulating 7 months of tea consumption. Color measurements were conducted using a spectrophotometer before and after brushing. Brushing was carried out using an electric toothbrush with 0.5 g of toothpaste and 1 mL of distilled water for 2 minutes, twice daily, over 10 days. Repeated ANOVA analysis revealed significant differences in ΔE, ΔL, and ΔC values (p < 0.05). Activated charcoal toothpaste produced a marked lightening effect and increased color intensity, although no change was observed at the cervical region of the teeth. These findings suggest that activated charcoal may serve as an effective natural agent for managing extrinsic discoloration while further research is needed to clarify its long-term effects and clinical applications.
Effectiveness of Catharanthus roseus L. extract gel on TNF-α and IL-1β in the healing process of oral lesions Dewi, Tri Purnami; Canisca Putri, Ni Putu Ayu Mas Mitha; Mertayasa, Dewa Kadek
Majalah Kedokteran Gigi Indonesia Vol 11, No 2 (2025): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.105363

Abstract

The global incidence of oral lesions ranges from 5% to 66%, with an average of 20%. To date, no scientific research has investigated the effects of Catharanthus roseus L. (tapak dara) leaf extract on the expression of proinflammatory cytokines in oral lesion healing. This study aimed to evaluate the effectiveness of tapak dara leaf extract gel in reducing the expression of the proinflammatory cytokines TNF-α and IL-1β during oral lesion healing. A total of 30 mice (Mus musculus) were divided into five groups: four treatment groups and one control group, each housed separately. The gel formulation was prepared by mixing diluted extract solutions (5%, 10%, and 20%) into a 2% CMC-Na solution, heated and stirred for 10 minutes, and then cooled to achieve a gel consistency. Phytochemical screening was performed to qualitatively identify flavonoids, tannins, saponins, phenolics, alkaloids, steroids, and terpenoids. Expression levels of TNF-α and IL-1β were measured using an ELISA kit. ANOVA results showed that tapak dara leaf extract gel at 5%, 10%, and 20% significantly reduced TNF-α and IL-1β expression (p = 0.001). Tukey’s post hoc test indicated that the positive control (K+) group had the lowest expression of both TNF-α and IL-1β compared to other groups (p = 0.001). In conclusion, tapak dara leaf extract gel effectively reduces TNF-α and IL-1β expression, supporting its potential role in the healing process of oral lesions.
Orthodontic management of angle Class III malocclusion with severe anterior crowding Retyoningrum, Gita; Paskalin, Zenith; Sayuti, Elih; Laviana, Avi; Evangelina, Ida Ayu; Mardiati, Endah
Majalah Kedokteran Gigi Indonesia Vol 11, No 2 (2025): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.105794

Abstract

Dental malocclusion Class III is a challenging condition characterized by a Class III molar relationship, and it has a specific anterior condition according to Dewey classification. In some cases, Class III dental malocclusion with skeletal Class I may present with a convex rather than a concave profile. Several methods are available to correct a convex profile, including extraction, full arch distalization using TADs, intermaxillary elastic Class II, anterior segment retraction, and others. Combining more than one of these methods can be effective in correcting a convex profile. An 18 year-old woman presented to RSGM Universitas Padjadjaran with a diagnosis of Angle Class III dental malocclusion, skeletal Class I with a convex profile, normal maxillary incisor inclination, asymmetric profile, severe anterior crowding in both arches, minimal overjet, anterior crossbite, upper midline shift, clockwise rotation and high-angle mandible, and lingual inclination of the mandibular incisors. The patient was treated with a Roth prescription fixed orthodontic appliance. Maxillary and mandibular first premolars were extracted to create space, and lacebacks were applied to the canines to correct severe anterior crowding]. Bilateral intermaxillary Class III elastics were used to maintain the facial profile and prevent it from becoming concave. Treatment was completed in 18 months, achieving a Class I molar relationship, midline correction, optimal overbite and overjet, and preservation of the facial profile. This case report presents the orthodontic management of Angle Class III malocclusion with skeletal Class I and severe anterior crowding, successfully treated with first premolar extractions while maintaining a convex profile.
The prevalence of the stylohyoid ligament ossification in Surabaya, Indonesia: an incidental finding study in panoramic radiographs Savitri, Yunita; Wahyuni, Otty Ratna; Zulfikar, Cut Zahra
Majalah Kedokteran Gigi Indonesia Vol 11, No 2 (2025): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.108073

Abstract

Stylohyoid ligament ossification is a growth disorder that is often detected as an incidental finding on panoramic radiography. Its etiology and pathogenesis are still not fully understood. Eagle's Syndrome is related to stylohyoid ligament ossification, but this syndrome is often misdiagnosed or even undiagnosed so that the patients experience losses due to undergoing various unnecessary treatments. The appearance of stylohyoid ligament ossification on panoramic radiography can help to confirm the diagnosis of Eagle's Syndrome. Until now there has been no research regarding stylohyoid ligament ossification at RSGMP UNAIR. This study amied  to determine the incidence of stylohyoid ligament ossification that is observed through panoramic radiography at RSGMP UNAIR. This research is a descriptive observational study. The data used is secondary data from soft file panoramic radiographs of RSGMP UNAIR patients in the period May 2019-May 2023 which is in accordance with the sample inclusion criteria, as well as reading results by a dental radiology specialist. The data was then grouped based on gender, age, and morphology (unilateral/bilateral) and analyzed using the Cohen's Kappa Coefficient reliability statistical test. The results showed that 416 patients (9.09%) experienced stylohyoid ligament ossification. The highest distribution occurred in female with 260 patients (62.5%), the 25-64 years age group with 274 patients (65.86%) and the bilateral type with 341 patients (82%). From this study, the distribution data of stylohyoid ligament ossification based on gender, age, and morphology (unilateral/bilateral) were obtained.
Accuracy of digital image processing in radiographic early caries detection Priaminiarti, Menik; Atmadja, Giovanni; Saraswati, Inka; Iskandar, Hanna Huzaima Bachtiar
Majalah Kedokteran Gigi Indonesia Vol 11, No 2 (2025): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.108937

Abstract

Tooth surface with early caries lesion can remineralize into sound tooth surface with early intervention. However, early caries lesion is difficult to detect and frequently goes unnoticed during clinical or radiographic examinations. Image quality enhancement through imaging tools such as filters has the potential to increase the accuracy of early caries lesion detection. To compare the accuracy of original radiographic images to enhanced images with filters on digital dental x-ray for detection of early caries lesions. Five working models were utilized, containing 42 sound tooth surfaces, and 36 surfaces with early caries lesions. Radiographic images were takenusing Vistascan storage phosphor plate system (Dürr Dental, Germany) and enhanced with Fine, Caries 1, Caries 2, and High Diagnostic (HD) filters. Original and enhanced radiographic images were assessed by three observers to record the presence or absence of early caries lesions. Sensitivity, specificity, and overall accuracy were calculated. Sensitivity of HD and Fine filter images were significantly higher (p < 0.05), but Caries 1 and Caries 2 images did not differ significantly from the original images (p > 0.05). There was no significant difference between the specificity of original filter images and filter enhanced images. The overall accuracy of original filter images and filter enhanced images increased significantly only on HD filter (p < 0.05). HD filter had significantly higher overall accuracy than the original images.In addition, it showed the highest sensitivity, specificity, and overall accuracy. Therefore, some filters may be used to enhance early caries lesion detection.

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