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WMJ (Warmadewa Medical Journal)
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Published by Universitas Warmadewa
ISSN : 25274627     EISSN : 25799010     DOI : doi.org/10.22225/wmj
Core Subject : Health,
Health Professions Medicine & Pharmacology
WMJ (Warmadewa Medical Journal) is the Journal of Medicine & Health, contains scientific articles (Original/ Research Articles, Review Articles, Case Reports) by academic community of the Faculty of Medicine and Health Sciences Warmadewa University, other Faculties of Medicine and Health Sciences and other related Institutions. It is the medium for hardskill and softskills development as an integral part of the Tri Dharma Perguruan Tinggi (Education, Research, Public Service) and health services in the forms of media of communication, information, scientific education, as a subsystem of Medicine and Health holistic and comprehensive services.
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Articles 104 Documents
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The benefits of aerobic training for improving quality of life: A Critical Review of Study Agung Wahyu Permadi
WMJ (Warmadewa Medical Journal) Vol 4 No 2 (2019): November 2019
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.4.2.1016.57-60

Abstract

Aerobic exercise is currently the safest sport for both young and old people. This is because aerobic training provides tiered and targeted training and acts specifically on several muscles. The general purpose of aerobic exercise isto train the body to exercise without stress and excessive psychological disturbances. Then, aerobic exercise is also done in stages such as stretching, strength, and balance of various types of muscle and joint flexibility exercises. This is very useful for the elderly to avoid injury during aerobic training and is able to reduce the psychological disorders that are often experienced by the elderly. In this review, we conclude that aerobic exercise can have a good impact especially on stress levels on quality of life in the elderly.
Role of Adolescents’ Reproductive Health Information and Counselling Program towards Knowledge and Attitude in Pregnancy Planning among Adolescent Female in Malang City Dini Eka Pripuspitasari
WMJ (Warmadewa Medical Journal) Vol 3 No 2 (2018): November 2018
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.3.2.687.43-52

Abstract

Abstract Each adolescent will experience changes related to reproductive health problems. The growth and sexual maturity drive happens earlier in women rather than in men. KPAI survey data in 2017 states that 97% of adolescents in Indonesia have watched pornographic films and 93.7% have ever done kissing, petting, and oral sex. Malang City Health Office noted in 2014, 139 teenagers aged less than 18 years have been pregnant and increased to 176 cases in 2015. This condition implies that adolescent in Malang city has a big risk of experiencing morbidity and mortality related to the condition of maternal pathology. Following this kind of problem, BKKBN established the Reproductive Health Information and Counselling Program (PIK-KRR) as a platform for young people to prepare for a family life. Through that program, each adolescent female will receive support to understand the substance of pregnancy planning, which includes the physical, psycho-social, and social economy aspects. The main objective is that each adolescent female will postpone the age of marriage and pregnancy before they are able to fulfill those essential aspects. The aim of this research is to understand the role of the Reproductive Health Information and Counselling Program in its relation to the knowledge and the attitude of adolescent females towards pregnancy planning in Malang city. This research applies the comparative observational design by using a proportional sampling technique for 350 students of selected high schools who provide such program and 350 students of selected high schools who do not provide such program. The instrument used for data collection is the questionnaire that has gone through validity and reliability tests. The research data are then analyzed and interpreted by SPSS window release computer program version 23. The results of the knowledge scoring with the category of lack of knowledge in the high school without PIK-KRR group showed the biggest difference compared to that of in the high school group with PIK-KRR. This proves that PIK-KRR contributes meaningfully to the knowledge of high school students. Likewise in the high school groups that have the PIK-KRR, the category of female students with a positive attitude is greater than that of high schools that do not have PIK-KRR. This proves that the presence of PIK-KRR has a significant influence on attitudes in pregnancy planning in adolescents in Malang City. This study shows that there is a significant difference in knowledge and attitude (p=0,00
Akurasi Total Hitung Leukosit dan Durasi Simtom sebagai Prediktor Perforasi Apendisitis pada Penderita Apendisitis Akut I Ketut Tangking Widarsa; Cokorda Istri Padmi
WMJ (Warmadewa Medical Journal) Vol 2 No 2 (2017): November 2017
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.2.2.446.71-76

Abstract

Abstract Komplikasi perforasi pada penderita apendisitis akut cukup tinggi, yang ditandai dengan demam yang tinggi dan peningkatan leukosit. Tujuan penelitian ini adalah untuk mengetahui akurasi total leucocyte count (TLC) dan symptom duration (SD) sebagai prediktor perforasi pada penderita apendisitis akut. Penelitian cross-sectional retrospektive dilakukan terhadap 96 pasien apendisitis akut, yang dipilih secara konsekutif dari register rawat inap pasien apandisitis akut di RSUD Sanjiwani Gianyar tahun 2014-2015. Identitas, SD,TLC dikumpulkan dari catatan medis sampel. Penegakan diagnose perforasi didasarkan kepada hasil pemeriksanan patogi anatomi. Uji chi-square dan regresi Poisson dipakai menganalisis hubungan TLC dan SD dengan kejadian perforasi, sedangkan kemampuan prediksi dinilai dari nilai duga positif (PPV) dan negatif (NPV). Dari hasil penelitian didapatkan Risiko Relatif (RR) dari TLC (>18.000/ml:≤18.000/ml) adalah 2,9 (1,2 – 6,7) dan SD (>24jam:≤24jam) adalah 2,3 (1,1 – 4,9). PPV/NPV dari TLC, SD dan kombinasi TLC&SD adalah 59,4/93,8; 52,9/91,9; dan 82,4/88,4 secara berurutan. Dari penelitian ini disimpulkan bahwa kombinasi TLC&SD mempunyai tingkat prediksi yang baik sebagai prediktor kejadian perforasi pada penderita apendisitis akut. Kata kunci: Apendisitis perforasi, Total Leucocyte Count, Time Duration Abstract Perforation is frequently observed among acute appendicitis patients, which characterized by high fever and increased leucocyte level. The aim of this study is to determine the accuracy of total leucocyte count (TLC) and symptom duration (SD) as predictors of perforation in acute appendicitis patients. A retrospective cross sectional study was conducted and 96 acute appendicitis patients were enrolled in the study. The subjects were selected based on consecutive method taken from inpatient register of 2014 -2015 of Sanjiwani Hospital at Gianyar. Demographic data, SD and TLC were collected from medical record. Perforation was diagnosed based on the result of pathology and anatomy examinations. Chi square test and Poisson regression method were performed to analyze the association between TLC, SD and incidence of perforation. Positive predictive value (PPV) and Negative predictive value (NPV) were also calculated to measure the level of accuracy of the predictors. Results show that Relative Risk (RR) of TLC (>18.000/ml:≤18.000/ml) was 2.9 (1.2 – 6.7) whereas RR of SD (>24hours:≤24hours) was 2.3 (1.1 – 4.9). PPV/NPV of TLC, SD and TLC&SD combination were 59.4/93.8; 52.9/91.9; and 82.4/88.4, respectively. As conclusion, TLC&SD combined has high accuracy as predictor of perforation in acute appendicitis patients. Key word: Apendisitis perforation, Total Leucocyte Count, Time Duration
Perkiraan Tinggi Badan Berdasarkan Tulang Panjang Usia 17-22 Tahun I Gusti Ngurah Putu Sana; Dewa Ayu Agung Alit Suka Astini; I Ketut Tangking Widarsa; I Nyoman Sueta; I Wayan Suwitra; Komang Trisna Sumadewi
WMJ (Warmadewa Medical Journal) Vol 1 No 2 (2016): November 2016
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.1.2.29.66-70

Abstract

Perkiraan tinggi badan sangat penting pada antropologi forensik dalam identifikasi jenasah akan tetapi belum ada model yang baku untuk tujuan tersebut. Penelitian ini bertujuan mengembangkan model perkiraan tinggi badan dengan menggunakan tulang panjang sebagai prediktor. Metode penelitian dengan desain observasional melalui studi cross sectional dilakukan terhadap 96 sampel mahasiswa dipilih secara stratified random dari total 199 mahasiswa yang memenuhi kriteria inklusi, usia 17-22 tahun. Tinggi badan diukur menggunakan ZT-120 Health Scale dan panjang tulang humerus, radius, ulna, femur, tibia dan fibula diukur dengan menggunakan spreading caliper. Model estimasi tinggi badan menggunakan model regresi linier berganda dengan panjang tulang panjang sebagai prediktor. Untuk estimasi tinggi badan laki-laki terdapat tiga tulang sebagai prediktor yaitu tulang tibia kiri, humerus kanan, dan radius kanan dengan koefisien regresi 0,94 (±0,3), 0,82 (±0,3), dan 0,79 (±0.4) secara berurutan. Prediktor untuk tinggi perempuan adalah tulang fibula kiri, ulna kiri, dan humerus kiri dengan koefisien regresi 1,13 (±0,3), 1,20 (±0,4), dan 0,85 (±0,4) secara berurutan. Dari penelitian ini dapat disimpulkan bahwa tulang tibia kiri, humerus kanan, dan radius kanan dapat dipakai memperkirakan tinggi badan laki-laki dan tulang fibula kiri, ulna kiri, dan humerus kiri untuk tinggi badan perempuan.Kata kunci: tinggi badan, tulang panjang, tibia, fibula. [Estimated Stature Based on Long Bone Age 17-22 Years]             The estimation of stature is very important in forensic anthropology in the identification of bodies, but there is no standard model for the purpose. This study aims to develop a model estimated height, using a predictor of long bones. A total of 96 samples of randomly selected students from a total of 199 students, aged 17-22 years. Height was measured using ZT-120 Health Scale and the length of the humerus, radius, ulna, femur, tibia and fibula was measured by using a spreading caliper. Height estimation model using multiple linear regression model with long bone length as a predictor. to estimate the height of men there are three bones as predictors, the left tibia, right humerus and a right radius, with a regression coefficient of 0.94 (±0.3), 0.82 (±0.3), and 0.79 (±0.4) sequentially. Predictors for the high women are left fibula, left ulna and left humerus, with regression koefsien 1.13 (±0.3), 1.20 (±0.4), and 0.85 (±0.4) sequentially. From this study it can be concluded that the left tibia, right humerus and right radius can be used estimate the height of men, and left fibula, left ulna and left humerus can be used estimate the height of women.Keyword: stature, long bone, tibia, fibula.
Potensi Penggunaan Materi Genetik Fetus pada Sirkulasi Maternal untuk Diagnosis Prenatal Noninvasif Penyakit Genetik Anak Agung Dewi Megawati; Ita M. Nainggolan; Agung Nova Mahendra; Nanis S. Marzuki
WMJ (Warmadewa Medical Journal) Vol 1 No 1 (2016): Mei 2016
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.1.1.4.1-9

Abstract

Diagnosis prenatal adalah teknik diagnostik untuk menentukan kondisi fetus yang belum lahir apakah memiliki kelainan genetik ataupun kelainan lainnya. Teknik ini umumnya dilakukan pada penyakit genetik yang tidak dapat diobati di mana terminasi menjadi bahan pertimbangan. Teknik ini juga dilakukan pada kasus yang memerlukan penanganan segera pada saat prenatal dan pada kondisi yang dapat menimbulkan morbiditas atau mortalitas pada ibu. Diagnosis prenatal dapat dilakukan melalui metode invasif dan noninvasif. Metode invasif seperti amniocentesis dan biopsi villi korialis (CVS) memiliki resiko menimbulkan kecacatan bahkan kematian fetus. Pendekatan nonivasif melalui ultrasonografi belum cukup akurat untuk diagnosis penyakit genetik, sehingga masih memerlukan pengambilan sampel fetus untuk menegakkan diagnosis. Pendekatan terbaru pengambilan sampel fetus secara noninvasif dilakukan melalui pengambilan sel fetus, DNA dan mRNA fetus yang terdapat dalam sirkulasi darah maternal. Pada artikel ini dipaparkan mengenai perkembangan riset, kendala, serta potensi aplikasi klinis ketiga metode pengambilan sampel fetus tersebut.Kata kunci: diagnosis prenatal nonivasif, penyakit genetik, cell-free fetal DNA/mRNA, sel fetus.  [Potential Use of Fetal Genetic Material in Maternal Circulation for Prenatal Noninvasive Diagnosis of Genetic Disease].Prenatal diagnostic technique is used to determine whether the unborn fetus is affected with a genetic disorder or other abnormality. This technique is generally carried out for a genetic disease that is not treatable, in which the termination should be considered. This technique is also performed in cases that require immediate action during the prenatal period and in conditions that can lead to morbidity or mortality of the mother. Prenatal diagnosis can be done by invasive and noninvasive methods. Invasive methods such as amniocentesis and chorionic villus sampling (CVS) have a risk of causing disability and even death of the fetus. While noninvasive approach by ultrasound is not sufficiently accurate for the diagnosis of genetic diseases, therefore further  fetal sampling is required. Noninvasive prenatal diagnosis is a new type of genetic testing done through taking fetal cells, fetal DNA and mRNA, which are found in maternal blood circulation. In this review, we present development of research, constraints, and potential clinical applications of these three methods for noninvasive sampling of the fetus.Keywords: noninvasive prenatal diagnosis, genetic disease, cell-free fetal DNA/mRNA, fetal cell.
Risiko Kandidiasis Serviks pada Wanita Usia Subur Akseptor Kontrasepsi Hormonal Ni Wayan Armerinayanti; Desak Putu Oki Lestari
WMJ (Warmadewa Medical Journal) Vol 3 No 1 (2018): May 2018
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.3.1.640.21-26

Abstract

Abstrak Kontrasepsi Hormonal merupakan salah satu metode kontrasepsi yang paling diminati oleh Wanita Usia Subur (WUS) di Indonesia termasuk di Bali. Dewasa ini mulai timbul pro dan kontra mengenai penggunaan kontrasepsi hormonal terkait berbagai efek samping yang ditimbulkan, salah satunya dikatakan berkaitan dengan kandidiasis serviks. Tujuan penelitian ini adalah untuk mengetahui risiko kandidiasis serviks pada WUS akseptor kontrasepsi hormonal. Penelitian ini menggunakan rancangan case control yang disarangkan pada penelitian pap smear (nested case control). Kemudian akan dibandingkan seberapa besar efek paparan kontrasepsi hormonal antara kelompok kasus (kandidiasis serviks) dengan kelompok kontrol (non kandidiasis serviks) secara deskriptif analitik melalui uji statistik chi-square dengan p
Peranan Laboratorium dalam Prevention of Mother to Child Transmission (PMTCT) HIV Sri Ratna Dewi; Umi S. Intansari
WMJ (Warmadewa Medical Journal) Vol 2 No 1 (2017): Mei 2017
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.2.1.74.33-43

Abstract

Human Immunodeficiency Virus (HIV) adalah retrovirus RNA yang dapat menyebabkan penyakit klinis, yaitu Acquired Immunodeficiency Syndrome (AIDS). Transmisi virus dari ibu ke anak (mother to child transmission/MTCT) dapat terjadi melalui darah maternal, sekresi saluran genital, dan ASI. Risiko penularan HIV dari ibu ke bayi dapat ditekan hingga 2% dengan program PMTCT. Tulisan ini bertujuan untuk memaparkan tentang peran laboratorium dalam mendukung program PMTCT HIV. Dalam hal ini laboratorium memegang peranan yang penting dalam mendeteksi HIV secara dini dan diikuti dengan evaluasi. Untuk menentukan bayi tidak mengidap HIV, diperlukan minimal dua kali pemeriksaan polymerase chain reaction (PCR) RNA HIV dengan hasil negatif, yaitu pada usia 4-6 minggu dan pada usia 4-6 bulan. Pada saat bayi berusia 18 bulan dilakukan pemeriksaan antibodi terhadap HIV dengan cara Enzyme-linked Immunosorbent Assay (ELISA) untuk konfirmasi. Laboratorium memegang peranan penting dalam melakukan deteksi dini HIV serta membantu dalam proses follow up sehingga dapat mendukung program PMTCT.                                                                        Kata kunci: PMTCT, HIV, PCR, ELISA   [Laboratory Role In The Prevention of Mother to Child Transmission (PMTCT) of HIV]The Human Immunodeficiency Virus (HIV) is a RNA retrovirus which causes the clinical disease termed the acquired immunodeficiency syndrome (AIDS). Mother-to-child transmission (MTCT) may occurred because of the intrapartum maternal blood exposure, infected genital tract secretions and during breastfeeding. The aim of this paper is to explain the role of laboratory to support PMTCT program. Laboratory plays an important role in PMTCT, that given the starting point of PMTCT is early detection of HIV and followed by evaluation. To determine the baby does not have HIV, it takes at least two times the HIV RNA PCR with negative results, (at 4-6 weeks of age and at the age of 4-6 months). And then infants examined for HIV antibodies by Enzyme-linked Immunosorbent Assay (ELISA) for confirmation at 18-month-old. Laboratory has an important role to support diagnose of HIV and their follow up, so it can be support PMTCT program.Keywords: PMTCT, HIV, PCR, ELISA
Korelasi Antara Kadar Leptin dengan IMT, Lingkar Pinggang dan RLPP pada Orang Dewasa Obesitas Usia 19-25 Tahun di Universitas Warmadewa Komang Trisna Sumadewi
WMJ (Warmadewa Medical Journal) Vol 1 No 2 (2016): November 2016
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.1.2.30.71-82

Abstract

Obesitas berdampak secara fisik maupun psikologis yang berkaitan dengan sindrom metabolik dan penyakit kardiovaskuler. Pengukuran antropometri seperti Indeks Massa Tubuh (IMT), lingkar pinggang, lingkar panggul dan rasio lingkar pinggang panggul (RLPP) digunakan untuk identifikasi obesitas. Leptin berasal dari jaringan adiposa yang dapat mengindikasikan banyaknya timbunan lemak yang terdapat dalam tubuh. Leptin dapat bekerja secara sentral sebagai hormon metabolik melalui mekanisme umpan balik negatif untuk menekan nafsu makan dan meningkatkan pembakaran kalori melalui peningkatan aktivitas tubuh. Penelitian ini bertujuan untuk membuktikan adanya korelasi antara kadar leptin dengan IMT, lingkar pinggang, RLPP pada orang dewasa obesitas usia 19-25 tahun di Universitas Warmadewa. Penelitian ini merupakan penelitian analitik korelasi dengan teknik pengambilan data cross sectional. Pengambilan 52 sampel darah baik laki-laki maupun perempuan yang mengalami obesitas dilakukan di Universitas Warmadewa dan diperiksa di Laboratorium Biologi Molekuler Fakultas Kedokteran dan Ilmu Kesehatan Universitas Warmadewa. Setiap sampel diperiksa tinggi badan, berat badan, lingkar pinggang, lingkar panggul dan kadar serum leptinnya dengan metode sandwich ELISA. Selanjutnya dilakukan analisis deskriptif dan korelasi. Hasil yang didapatkan, leptin berkorelasi signifikan dengan IMT (p=0,000; r=0,871 untuk perempuan; p=0,001; r=0,549 untuk laki-laki), lingkar pinggang (p=0,001; r=0,695 untuk perempuan; p=0,003; r=0,490 untuk laki-laki); RLPP (p=0,041; r=0,485 untuk perempuan; p=0,019; r=0,401 untuk laki-laki). Interval kepercayaan sebesar 95%. Kadar serum leptin memiliki korelasi positif dan signifikan dengan IMT, lingkar pinggang dan RLPP.Kata kunci: Leptin, IMT, lingkar pinggang, RLPP, obesitas. [Positive Correlation between Leptin Concentration, Body Mass Index, Waist Circumference and Waist-Hip Circumference Ratio in Obese Adults Aged 19-25 Years Old at Warmadewa University].Obesity causes negative impacts both psychologically as well as physically related to metabolic syndrome and cardiovascular diseases. Anthropometric measurements such as Body Mass Index (BMI), waist circumference, hip circumference, waist-hip circumference ratio (WHR) are used to identify obesity. Leptin originates from adipose tissue which can be used to identify obesity. Leptin works centrally as metabolic hormone through feedback negative mechanism to inhibit appetite and to increase calorie combustion along with increased body activity. This study aimed to confirm the correlation between leptin concentration and BMI, waist circumference, and WHR in adult obese individuals aged 19-25 years old at Warmadewa University. This study was an analytic correlation study carried out with a cross sectional data collection technique. Fifty two blood samples were collected from adult obese individuals at Warmadewa University, which were examined in Biomolecular Laboratory, Faculty of Medicine Warmadewa University. Fifty two adult obese individuals aged 19-25 years old, male and female, were measured for their height, weight, waist circumference, hip circumference and leptin concentration, by using sandwich ELISA method. Data were analyzed descriptively as well as statistically to assess the correlation. From this study, it was found that serum leptin concentration had a correlation with BMI (r=0.871 in females; p=0.001; r=0.549 in males), waist circumference (p=0.001; r=0.695 in females; p=0.003; r=0.490 in males); WHR (p=0.041; r=0.485 in females; p=0.019; r=0.401 in males). Confidence Interval (CI) 95%. Serum leptin concentration has significant positive correlation with BMI, waist circumference and WHR.Keywords: Leptin, BMI, waist circumference, WHR, Obesity.
The Correlation of Body Composition and Fitness Level of Students in Medical Faculty Unwar Wayan Rusni; Komang Trisna Sumadewi; Tanjung Subrata
WMJ (Warmadewa Medical Journal) Vol 4 No 2 (2019): November 2019
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.4.2.1044.61-65

Abstract

Medical students beside they are as a member of the medical rescuer, the team is also to have good physical fitness due to consider that Indonesia involves a disaster drawn area. The study was conducted on a member of Tim Bantuan Medis (Medical Rescuer Team) of FKIK Warmadewa University. This simple random sampling was carried out to choose the sample. The data was analyzed using the Spearman correlation test to find out the correlation between body composition and physical fitness. The result from body composition showed that the highest percentage is in the average category (40.7%) and the smallest percentage is in the fair category (3.35%). Whereas the level of physical fitness that assessed through muscle endurance and cardio-respiratory endurance show a level in the poor as follow 38,5% and 85,7%. The conclusion is a significant correlation (relatively strong)between body composition and physical fitness (muscle endurance and cardio-respiratory endurance ) (r=0.30 dan r=0.18)
Subgenual cingulate cortex activity in predicting risk factor and treatment response in depression Alva S. A. Supit; Ireine Roosdy
WMJ (Warmadewa Medical Journal) Vol 3 No 2 (2018): November 2018
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.3.2.743.53-60

Abstract

Major depressive disorder (MDD) contributes significantly to morbidity, disability, and decreased quality of life, despite the expansion of treatment options. This, in part, is caused by a lack of valid, applicable, and reliable biomarkers to predict the risk, treatment response, and prognosis of depression. In recent years, the anterior cingulate cortex, in particular pars subgenual (sgACC), has received much attention due to its potential utilization as a neural endophenotype for depression. This essay will discuss the functional activity of sgACC, mostly by functional magnetic resonance imaging, in relation to predicting risk for developing depression, predicting patient response-to-treatment, and eventually, to create a platform for personalized psychiatric approach to each patient. The caveats and conditions need to be met will also be discussed, in order to firmly establish sgACC activity as a valid biomarker for depression.

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