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Global Medical and Health Communication

gmhc
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Published by Universitas Islam Bandung

ISSN : 23019123 EISSN : 24605441 DOI : https://doi.org/10.29313/gmhc

Core Subject : Health, Science,

Dentistry Health Professions Immunology & microbiology Nursing Public Health

Global Medical and Health Communication is a journal that publishes research articles on medical and health published every 4 (four) months (April, August, and December). Articles are original research that needs to be disseminated and written in English. Subjects suitable for publication include but are not limited to the following fields of anesthesiology and intensive care, biochemistry, biomolecular, cardiovascular, child health, dentistry, dermatology and venerology, endocrinology, environmental health, epidemiology, geriatric, hematology, histology, histopathology, immunology, internal medicine, nursing sciences, midwifery, nutrition, nutrition and metabolism, obstetrics and gynecology, occupational health, oncology, ophthalmology, oral biology, orthopedics and traumatology, otorhinolaryngology, pharmacology, pharmacy, preventive medicine, public health, pulmonology, radiology, and reproductive health.

Arjuna Subject : Kedokteran - Epidemilogi

Articles 422 Documents

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Depression Leads to Physical Inactivity in Patients with Beta-Thalassemia Major Faza Nurul Wardhani; Susanti Dharmmika; Hilmi Sulaiman Rathomi
Global Medical & Health Communication (GMHC) Vol 9, No 2 (2021)
Publisher : Universitas Islam Bandung

Beta-thalassemia major (BTM) is difficult to treat chronic disease, causing physical and psychological burdens for the patient. Several studies have confirmed a decrease in physical activity and depression in thalassemia patients, but limited studies examine the relationship between these two conditions. This study aims to analyze the relationship between depression and physical activity in BTM patients in Bandung city. It was analytical observational research with a cross-sectional design. Data were collected during September–December 2018 by interviewing 65 patients selected by simple random sampling from 300 thalassemia patients registered at the Association of Parents with Thalassemia Indonesia/Perhimpunan Orangtua Penderita Thalassemia Indonesia (POPTI) Bandung city. The instruments used were the Global Physical Activity Questionnaire (GPAQ) to measure physical activity and the Beck Depression Inventory (BDI) to assess depressive symptoms. Data were analyzed by chi-square test using SPSS for Windows ver. 23.0. The results showed that most BTM patients in Bandung city were depressed (52%) and had low physical activity levels (65%). Furthermore, there was a statistically significant relationship between depression and physical activity in thalassemia patients in Bandung city (p=0.04, p<0.05). Therefore, it can be concluded that BTM patients in Bandung city with depression have lower physical activity. DEPRESI BERDAMPAK PADA AKTIVITAS FISIK YANG RENDAH PADA PASIEN TALASEMIA BETA MAYORTalasemia beta mayor merupakan penyakit kronis yang sulit disembuhkan sehingga menimbulkan beban fisik dan psikologis bagi pasien. Beberapa penelitian telah mengonfirmasi penurunan aktivitas fisik dan depresi pada pasien talasemia, namun studi yang mengkaji hubungan antara kedua kondisi ini masih terbatas jumlahnya. Penelitian ini bertujuan menganalisis hubungan antara kondisi depresi dan tingkat aktivitas fisik pada penderita talasemia beta mayor di Kota Bandung. Desain penelitian bersifat observasional analitik dengan rancangan potong lintang. Pengambilan data dilakukan selama September–Desember 2018 dengan mewawancarai 65 pasien yang dipilih secara simple random sampling dari 300 pasien talasemia yang terdaftar di Perhimpunan Orangtua Penderita Thalassemia Indonesia (POPTI) Kota Bandung. Instrumen yang digunakan adalah Global Physical Activity Questionnaire (GPAQ) untuk mengukur aktivitas fisik dan Beck Depression Inventory (BDI) untuk menilai gejala depresi. Data dianalisis dengan uji chi-square menggunakan SPSS for Windows ver. 23.0. Hasil penelitian menunjukkan mayoritas penderita talasemia beta mayor di Kota Bandung mengalami depresi (52%) dan memiliki tingkat aktivitas fisik rendah (65%). Selanjutnya, terdapat hubungan bermakna secara statistik antara depresi dan aktivitas fisik pada penderita talasemia di Kota Bandung (p=0,04; p<0,05). Oleh karena itu, dapat disimpulkan bahwa penderita talasemia beta mayor di Kota Bandung yang mengalami depresi memiliki aktivitas fisik yang lebih rendah.

Identification of Health Knowledge of Lung Function in Predicting Respiratory Disorders in Smokers Amelia Lorensia; Rivan Virlando Suryadinata; Lalita Tirsa
Global Medical & Health Communication (GMHC) Vol 9, No 2 (2021)
Publisher : Universitas Islam Bandung

Chronic obstructive pulmonary disease (COPD) is a high risk for active smokers. Early assessment of the condition of lung function is needed to prevent a decrease in lung function. Knowledge of self-management that determines lung health. The purpose of this study was to determine the knowledge of lung function health in predicting respiratory disorders. The study design was a case-control from August 2018 to January 2019. Data was collected through a questionnaire, namely a lung health knowledge questionnaire consisting of categories: risk factors, symptoms, and therapy for respiratory disorders. The research sample was adult men who work in the transportation sector in Surabaya city using purposive sampling. Data analysis using chi-square. The data obtained were 300 people, consisting of 126 people without lung function disorders and 174 people with pulmonary function disorders. The risk factor knowledge category showed a significant difference (p=0.000) between the group, with the most disorders at the low knowledge level (42.0%). The symptom knowledge category showed a significant difference (p=0.000) between groups, and most of the groups with disorders were at a low knowledge level (55.8%). The category of knowledge of respiratory symptoms showed a significant difference (p=0.000) between groups, with the knowledge level in both of them mostly at a sufficient level. Therefore, low lung function health knowledge reflects low lung function conditions. IDENTIFIKASI PENGETAHUAN KESEHATAN FUNGSI PARU DALAM MEMPREDIKSI GANGGUAN PERNAPASAN PADA PEROKOKPenyakit paru obstruktif kronik (PPOK) berisiko tinggi dialami oleh perokok aktif. Pengkajian dini terhadap kondisi fungsi paru diperlukan untuk mencegah penurunan fungsi paru. Pengetahuan tentang manajemen diri yang menentukan kesehatan paru. Tujuan penelitian ini adalah mengetahui pengetahuan kesehatan fungsi paru dalam memprediksi gangguan pernapasan. Desain penelitian adalah case-control dari Agustus 2018 hingga Januari 2019. Pengumpulan data dilakukan melalui kuesioner, yaitu kuesioner pengetahuan kesehatan paru yang terdiri atas kategori: faktor risiko, gejala, dan terapi gangguan pernapasan. Sampel penelitian adalah laki-laki dewasa yang bekerja di sektor transportasi di Kota Surabaya dengan menggunakan purposive sampling. Analisis data menggunakan chi-square. Data yang diperoleh sebanyak 300 orang, terdiri atas 126 orang tanpa gangguan fungsi paru dan 174 orang dengan gangguan fungsi paru. Kategori pengetahuan faktor risiko menunjukkan perbedaan yang bermakna (p=0,000) antarkelompok dengan gangguan terbanyak pada pengetahuan tingkat rendah (42,0%). Kategori pengetahuan gejala menunjukkan perbedaan yang bermakna (p=0,000) antarkelompok dan sebagian besar kelompok dengan gangguan berada pada pengetahuan tingkat rendah (55,8%). Kategori pengetahuan gejala pernapasan menunjukkan perbedaan yang bermakna (p=0,000) antarkelompok dengan tingkat pengetahuan keduanya sebagian besar pada tingkat cukup. Oleh karena itu, pengetahuan kesehatan fungsi paru yang rendah mencerminkan kondisi fungsi paru yang rendah.

Effect of Labor Camera on the Duration of the Second Stage Labor in Primipara Yetti Purnama; Kurnia Dewiani; Linda Yusanti
Global Medical & Health Communication (GMHC) Vol 9, No 2 (2021)
Publisher : Universitas Islam Bandung

Fear and anxiety due to severe labor pains could also lead to prolonged labor. The efforts made to accelerate the second stage labor process are by providing emotional support with the support of a labor camera. The mother is allowed to observe the development state of her baby's head through video on a tablet or laptop screen. Furthermore, the mother's emotional level becomes more provoked and motivated to strain the labor process faster. This study aims to determine the effect of the labor cameras on the second state duration in primiparous. The design of this study was a posttest-only control group design experiment with a total sample of 30 primiparous of the second stage at independent midwife practice in Bengkulu city in November–December 2020. Each group consisted of 15 for treatment (with labor cameras) and 15 for control (without labor cameras)—the assessment of the labor duration by counting the labor time in seconds during the second state. The statistical results using the t test and chi-square test analysis showed that the intervention group's labor duration (1,393.3 seconds) was shorter than the control group's (2,340.6 seconds). The mean difference in the delivery time was 947.3 seconds or 15.7 minutes faster in the intervention group than in the control group. In conclusion, using a labor camera on the labor duration of the second stage in primiparous mothers is an effect of using a labor camera. PENGARUH KAMERA PERSALINAN TERHADAP DURASI PERSALINAN KALA II PADA PRIMIPARARasa takut dan cemas akibat nyeri persalinan yang berat juga dapat menyebabkan partus lama. Salah satu upaya yang dilakukan untuk mempercepat proses kala II persalinan adalah memberikan dukungan emosional dengan bantuan kamera persalinan. Ibu diberi kesempatan untuk melihat perkembangan pengeluaran kepala bayinya melalui video pada layar tablet atau laptop sehingga tingkat emosional ibu menjadi lebih terbangun dan termotivasi untuk mempercepat proses persalinan. Penelitian ini bertujuan mengetahui pengaruh kamera persalinan terhadap durasi persalinan kala II pada primipara. Desain penelitian adalah eksperimen posttest-only control group design dengan jumlah sampel 30 primipara kala II di bidan praktik mandiri Kota Bengkulu pada November–Desember 2020. Tiap-tiap kelompok berjumlah 15 untuk kelompok perlakuan (menggunakan kamera persalinan) dan 15 untuk kontrol (tidak menggunakan kamera persalinan). Penilaian durasi persalinan dengan menghitung detik selama kala II berlangsung. Pengujian statistik menggunakan analisis uji t dan uji chi-square menunjukkan bahwa durasi persalinan kelompok perlakuan (1.393,3 detik) lebih singkat daripada kelompok kontrol (2.340,6 detik). Selisih perbedaan waktu persalinan rerata selama 947,3 detik atau 15,7 menit lebih cepat pada kelompok intervensi dibanding dengan kelompok kontrol. Simpulan, terdapat pengaruh penggunaan kamera persalinan terhadap durasi persalinan kala II pada ibu primipara.

Thirdhand Smoke Exposure Affects Mice Pancreas Microstructure Eva Rianti Indrasari; Annisa Rahmah Furqaani; Listya Hanum Siswanti; Ihsan Muhammad Nauval; Putra Zam Zam Rachmatullah
Global Medical & Health Communication (GMHC) Vol 9, No 2 (2021)
Publisher : Universitas Islam Bandung

Cigarette residue toxins can accumulate in the body, including the pancreas, which potentially reduces pancreas function. In addition, the active compounds in cigarettes are reporting to interfere with an elevation of reactive oxygen species, leading to disruption of pancreatic microstructures. Furthermore, pancreatic cell dysfunction is responsible for developing diabetes mellitus disease. The objective of this study was to analyze the effect of thirdhand smoke exposure on mice pancreatic microstructure image. It was an in vivo laboratory experimental study with a completely randomized design at the Medical Biology Laboratory of the Universitas Islam Bandung from November 2020–June 2021. The subjects were 20 adult male mice aged 8–10 weeks, weighing 25–30 grams, in good health condition, and randomly divided into two groups (control group and treatment group exposed to thirdhand cigarette smoke for four weeks). After the completion of the exposure period, pancreatic cells isolation was performing. The parameters observed in this study were the number and diameter islet of Langerhans. Data analysis used the independent t test parametric (α=5%). The results showed that the number and diameter islet of Langerhans in the treated group were significantly lower than the control group (p<0.05). The average number in the control group was 9.40±3.20, while in the treatment group was 4.90±2.74 (28% smaller). The average diameter of control was 225.96±50.15 mm, while treatment was 162±49.68 mm (50% lower). In conclusion, thirdhand smoke exposure alters the pancreas microstructure. The toxic compounds on thirdhand cigarette smoke are involving in generating an elevation of free radical levels, depletion of antioxidants, and alteration of signal transduction resulted in acceleration of apoptosis rate of the islet of Langerhans, especially pancreatic β-cells. PENGARUH PAPARAN ASAP ROKOK TERSIER PADA GAMBARAN MIKROSTRUKTUR PANKREAS MENCITToksik residu rokok dapat terakumulasi pada tubuh, termasuk pankeas sehingga dapat menurunkan fungsi pankreas. Selain itu, senyawa aktif dalam rokok dilaporkan meningkatkan radikal bebas yang menyebabkan kerusakan mikrostruktur pankreas. Selanjutnya, disfungsi sel pankreas meningkatkan risiko diabetes melitus. Penelitian ini bertujuan menganalisis pengaruh asap rokok tersier terhadap gambaran mikrostruktur pankreas mencit. Penelitian ini merupakan penelitian eksperimental laboratorium in vivo dengan rancangan acak lengkap di Laboratorium Biologi Medik Universitas Islam Bandung periode November 2020–Juni 2021. Subjek penelitian adalah 20 mencit jantan dewasa berumur 8–10 minggu, bobot 25–30 gram, kondisi sehat, dan dibagi secara acak menjadi dua kelompok (kelompok kontrol dan kelompok perlakuan yang mendapat paparan asap rokok tersier selama empat minggu). Setelah periode pemberian paparan selesai, dilakukan isolasi sel pankreas. Parameter yang diamati dalam penelitian ini adalah jumlah dan diameter pulau Langerhans (islet of Langerhans). Analisis data menggunakan parametrik independent t test (α=5%). Hasil penelitian menunjukkan bahwa jumlah dan diameter pulau Langerhans pada kelompok perlakuan lebih rendah dibanding dengan kelompok kontrol (p<0,05). Jumlah rerata pada kelompok kontrol adalah 9,40±3,20, sedangkan pada kelompok perlakuan 4,90±2,74 (lebih rendah 28%). Diameter rerata pada kelompok kontrol adalah 225,96±50,19 mm dan kelompok perlakuan 162,89±49.68 mm (lebih rendah 50%). Simpulan, paparan asap rokok tersier dapat memengaruhi gambaran mikrostruktur pankreas. Senyawa toksik pada asap rokok tersier diduga terlibat dalam peningkatan kadar radikal bebas, penurunan kadar antioksidan, dan perubahan transduksi sinyal yang mengakibatkan peningkatan laju apoptosis pulau Langerhans, terutama sel β pankreas.

Association of Chest X-Rays Features with the Length of Stay in Suspected COVID-19 Status Zulmansyah Zulmansyah; Gaga Irawan Nugraha; Dwi Agustian; Dida Akhmad Gurnida
Global Medical & Health Communication (GMHC) Vol 9, No 2 (2021)
Publisher : Universitas Islam Bandung

Coronavirus disease 2019 (COVID-19) is a new type of respiratory infection that first emerged in December 2019 in Wuhan, Hubei, China. COVID-19 is caused by a new variant of virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Examining the chest x-rays is one technique to diagnose COVID-19. This study aims to determine the association of chest x-rays features in suspected COVID-19 patients with the length of stay at Al-Ihsan Regional General Hospital West Java Province and Banten Regional General Hospital in June–November 2020. The subject was 29 COVID-19 people were confirmed, whereas 31 people were not. The statistical analysis used Pearson correlation and multi-linear regression. This study found that tuberculosis had a strong association with length of stay (p value=0.048, association=0.4), and also there is a robust association between bilateral pneumonia and duration of stay (p value=0.028, association=0.873). A linear regression model discovery of TB chest x-rays on the subject raises the treatment by 0.5867 days. In addition, the discovery of bilateral pneumonia increases the length of stay of treatment by 0.32218 days more than the discovery of unilateral pneumonia. In general, tuberculosis, bacterial pneumonia, viral pneumonia, and bilateral pneumonia together affected the outcome of length of stay of patients with suspected COVID-19. ASOSIASI GAMBARAN RONTGEN TORAKS DENGAN LAMA RAWAT PADA PASIEN SUSPEK COVID-19Coronavirus disease 2019 (COVID-19) adalah jenis infeksi saluran pernapasan baru yang pertama kali mewabah pada Desember 2019 di Wuhan, Hubei, Cina. COVID-19 disebabkan oleh varian virus baru yang disebut severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Pemeriksaan rontgen toraks merupakan salah satu teknik mendiagnosis COVID-19. Penelitian ini bertujuan mengetahui asosiasi gambaran rontgent toraks pada pasien suspek COVID-19 dengan lama rawat inap di RSUD Al-Ihsan Provinsi Jawa Barat dan RSUD Banten pada Juni–November 2020. Subjek penelitian adalah 29 orang terkonfirmasi COVID-19 dan 31 orang tidak. Analisis statistik menggunakan korelasi Pearson dan regresi multilinier. Penelitian ini menemukan bahwa tuberkulosis memiliki hubungan yang kuat dengan lama perawatan (p=0,048; asosiasi=0,4) dan juga terdapat hubungan yang kuat antara pneumonia bilateral dan lama perawatan (p=0,028; asosiasi=0,873). Penemuan model regresi linier rontgent toraks TB pada subjek meningkatkan risiko perawatan 0,5867 hari lebih lama. Selain itu, penemuan pneumonia bilateral meningkatkan risiko perawatan 0,32218 hari lebih lama dibanding dengan penemuan pneumonia unilateral. Secara umum, tuberkulosis, pneumonia bakteri, pneumonia viral, dan pneumonia bilateral secara bersama-sama berpengaruh terhadap luaran lama rawat inap pasien suspek COVID-19.

Activity of Javanese Ginger, Turmeric, Garlic, and Pomegranate Flower on LDL-C and Total-C on Dyslipidemia Model Rats Larissa Larissa; Penny Setyawati Martioso; Diana Krisanti Jasaputra
Global Medical & Health Communication (GMHC) Vol 9, No 2 (2021)
Publisher : Universitas Islam Bandung

High levels of LDL cholesterol are risk factors for coronary heart disease. Different types of medicinal plants have hypolipidemic effects. The study aimed to compare the potential of Javanese ginger ethanol extract, turmeric, garlic, and pomegranate flowers with rosuvastatin on levels of LDL cholesterol (LDL-C) and total cholesterol (total-C) male Wistar rats dyslipidemia models. This experimental laboratory research was conducted in Maranatha Animal Research Laboratory Bandung and was carried out in January–December 2020. The experimental animals were divided into six groups (n=5): the control group, the Javanese ginger group, the turmeric group, the garlic group, the pomegranate flower group, and the comparison control group. The induction given to experimental animals was administering vitamin D3, a high-fat diet, and propylthiouracil for 14 days. The results showed that the administration of 175 mg/kg BW of garlic ethanol extract (−44.85%), pomegranate flowers (−58.74%), and rosuvastatin (−40.00%) reduced LDL-C compared to control (p<0.05). The administration of 175 mg/kg BW of Javanese ginger ethanol extract (−15.16%), turmeric (−14.02%), garlic (−22.80%), pomegranate flower (−65.24%), and rosuvastatin (−18.70%) reduced total-C compared to controls (p<0.05). The conclusion is that garlic and pomegranate flowers lowered LDL-C, while Javanese ginger, turmeric, garlic, and pomegranate flowers reduced total-C. AKTIVITAS TEMULAWAK, KUNYIT, BAWANG PUTIH, DAN BUNGA DELIMA TERHADAP K-LDL DAN K-TOTAL PADA TIKUS MODEL DISLIPIDEMIAKadar kolesterol LDL yang tinggi adalah faktor risiko penyakit jantung koroner. Berbagai jenis tanaman obat memiliki efek hipolipidemik. Penelitian ini bertujuan membandingkan potensi ekstrak etanol temulawak, kunyit, bawang putih, dan bunga delima dengan rosuvastatin pada kadar kolesterol LDL (K-LDL) dan kolesterol total (K-total) tikus Wistar jantan model dislipidemia. Penelitian laboratorium eksperimental ini dilakukan di Laboratorium Penelitian Hewan Maranatha Bandung dan dilakukan pada Januari–Desember 2020. Hewan coba dibagi menjadi enam kelompok (n=5), yaitu kelompok kontrol, kelompok temulawak, kelompok kunyit, kelompok bawang putih, kelompok bunga delima, dan kelompok pembanding. Induksi yang diberikan kepada hewan coba adalah pemberian vitamin D3, pakan lemak tinggi, dan propyltiouracil selama 14 hari. Hasil penelitian menunjukkan bahwa pemberian 175 mg/kgBB ekstrak etanol bawang putih (−44,85%), bunga delima (−58,74%), dan rosuvastatin (−40,00%) mengurangi K-LDL dibanding dengan kontrol (p<0,05). Pemberian 175 mg/kgBB ekstrak etanol temulawak (−15,16%), kunyit (−14,02%), bawang putih (−22,80%), bunga delima (−65,24%), dan rosuvastatin (−18.70%) mengurangi K-total dibanding dengan kontrol (p<0,05). Kesimpulannya, bunga bawang putih dan delima menurunkan K-LDL, sedangkan temulawak, kunyit, bawang putih, dan bunga delima menurunkan K-total.

Halal Critical Point Analysis of Bajakah Wood (Spatholobus littoralis Hassk.) Nano Particle as Anticancer Agent Lelly Yuniarti; Yuktiana Kharisma; Titik Respati; Maya Tejasari
Global Medical & Health Communication (GMHC) Vol 9, No 2 (2021)
Publisher : Universitas Islam Bandung

Bajakah wood contains phenolic compounds, flavonoids, tannins, and saponins with anticancer activity. The discovery and development of new drugs require several stages. In the process, there are many possibilities of adding other substances to form new active substances or as solvents that allow drug preparations to be doubtful of halalness. Hence, it is necessary to analyze the critical point of halal ingredients. The purpose of this study was to determine the characteristics of the nanoparticles of bajakah wood (Spatholobus littoralis Hassk.) and to test the anticancer activity in several cancer cell cultures, as well as to analyze the critical point of halalness of the material. This research method is a composition test using chromatography and anticancer activity test using MTT. Analysis of the critical point of halal materials using hazard analysis critical control point (HACCP). The research was carried out at the Indonesian Engineering Nanotechnology Laboratory South Tangerang and the UGM Integrated Laboratory Sleman in July–December 2020. The results showed that bajakah wood nanoparticles contained pure water as a solvent, viscosity 0.08878 cP, scattering intensity 1.1059 cps, diameter 176.1+/−43.7 (nm). Cytotoxic test results showed IC50 against cell culture MCF7 1,063.28 (±114.98) g/mL, HepG2 53.34 (±0.35) g/mL, T47D 150.63 (±8.44) g/mL, WiDR 114.38 (±7.82) μg/mL, HTB 97.50 (±3.49) μg/mL, HeLa 182.95 (±36.22) μg/mL, and Vero 710.10 (±106.46) μg/mL. This study concludes that bajakah wood nanoparticles are not critical in terms of halal ingredients. At the same time, their anticancer activity is weak against breast cancer and uterine cervical cancer, medium categories against liver cancer and lung cancer, and is not toxic to normal cells. ANALISIS TITIK KRITIS KEHALALAN NANOPARTIKEL KAYU BAJAKAH (SPATHOLOBUS LITTORALIS HASSK.) SEBAGAI AGEN ANTIKANKERKayu bajakah mengandung senyawa fenolik, flavonoid, tanin, dan saponin yang memiliki aktivitas antikanker. Penemuan dan pengembangan obat baru memerlukan beberapa tahapan. Dalam prosesnya terdapat banyak kemungkinan penambahan zat lain untuk membentuk zat aktif baru atau sebagai pelarut yang memungkinkan sediaan obat diragukan kehalalannya. Oleh sebab itu, perlu dilakukan analisis titik kritis kehalalan bahan. Tujuan penelitian ini mengetahui karakteristik sediaan nanopartikel kayu bajakah (Spatholobus littoralis Hassk.) dan menguji aktivitas antikanker pada beberapa kultur sel kanker, serta menganalisis titik kritis kehalalan bahan. Metode penelitian ini adalah uji komposisi menggunakan kromatografi dan uji aktivitas antikanker menggunakan MTT. Analisis titik kritis kehalalan bahan menggunakan hazard analysis critical control point (HACCP). Penelitian dilakukan di Laboratorium Nanovasi Rekayasa Indonesia Tangerang Selatan dan Laboratorium Terpadu UGM Sleman pada Juli–Desember 2020. Hasil penelitian menunjukkan sediaan nanopartikel kayu bajakah mengandung pelarut air murni, viskositas 0,08878 cP, scattering intensity 1,1059 cps, berdiameter 176,1+/−43,7 (nm). Hasil uji sitotoksik menunjukkan IC50 terhadap kultur sel MCF7 1.063,28 (±114,98) μg/mL, HepG2 53,34 (±0,35) μg/mL, T47D 150,63 (±8,44) μg/mL, WiDR 114,38 (±7,82) μg/mL, HTB 97,50 (±3,49) μg/mL, HeLa 182,95 (±36,22) μg/mL, dan Vero 710,10 (±106,46) μg/mL. Kesimpulan penelitian ini bahwa nanopartikel kayu bajakah bersifat tidak kritis dalam kehalalan bahan. Selain itu, aktivitas antikankernya lemah terhadap kanker payudara dan kanker serviks uteri, sedang terhadap kanker hati dan kanker paru, serta tidak toksik pada sel normal.

Antagonic Effect of Soursop Leaf Aqueous Extract and Doxorubicin Combination in MCF7 and T47D Breast Cancer Cell Miranti Kania Dewi; Siti Annisa Devi Trusda; Lelly Yuniarti
Global Medical & Health Communication (GMHC) Vol 9, No 3 (2021)
Publisher : Universitas Islam Bandung

The success of breast cancer therapy is still not optimal and the side effects caused by breast cancer therapy. The use of standard drug combinations with herbs is often used as co-chemotherapy and is believed to increase the drug's effectiveness. However, research on the antagonistic effect of the drug combination is still minimal. This study examines the anticancer effect of soursop leaf aquoxes extract and the combined impact of doxorubicin on MCF7 and T47D breast cancer cells. This research is pure in vitro experimental study of MCF7 and T47D breast cancer culture cells at the Parasitology Laboratory of the Faculty of Medicine, Universitas Gadjah Mada in August 2018. Toxicity tests were carried out using the method of tetrazolium 3-(4,5-dimethylthiazol-2-yl) 2,5-diphenyltetrazolium bromide (MTT) to calculate cell viability. The IC50 value was obtained by analyzing probit regression calculation using SPSS software. The synergism of this compound with doxorubicin was determined based on the value of the Combination Index (CI) using a combination test with series 1/2 IC50, 3/8 IC50, 1/4 IC50, and 1/8 IC50 and the data was analyzed using Compusyn 1.0 software. In this study, the effect of soursop leaf preparations will be tested on T47D and MCF7 breast cancer cell cultures and assess the impacts of co-chemotherapy of soursop leaf aqueous extract with doxorubicin. This study showed that IC50 soursop leaf aqueous extract in T47D breast cancer culture was 84 μg/mL and in MCF7 166.5 μg/mL. In contrast, the combined test showed that soursop leaf aqueous extract was antagonistic with doxorubicin in both T47D and MCF7 cancer cell cultures. EFEK ANTAGONIS KOMBINASI EXTRAK AIR DAUN SIRSAK DAN DOKSORUBISIN PADA KULTUR SEL KANKER MCF7 AND T47DKeberhasilan terapi kanker payudara saat ini masih belum optimal dan terdapat efek samping yang ditimbulkan dari terapi kanker payudara tersebut. Penggunaan kombinasi obat standar dengan herbal sering digunakan sebagai ko-kemoterapi dan diyakini dapat meningkatkan efektivitas obat, tetapi penelitian mengenai efek antagonis kombinasi obat masih sangat terbatas. Penelitian ini mengkaji efek antikanker ekstrak air daun sirsak dan kombinasinya dengan doksorubisin pada sel kanker payudara MCF7 dan T47D. Penelitian ini merupakan eksperimental murni secara in vitro pada sel kanker payudara MCF7 dan T47D di Laboratorium Parasitologi Fakultas Kedokteran Universitas Gadjah Mada periode Agustus 2018. Uji toksisitas dilakukan menggunakan metode tetrazolium 3-(4,5-dimethylthiazol-2-yl) 2,5-diphenyltetrazolium bromide (MTT) untuk menghitung viabilitas sel. Nilai IC50 didapatkan melalui analisis menggunakan perhitungan regresi probit menggunakan perangkat lunak SPSS. Efek sinergis senyawa ini dengan doksorubisin ditentukan berdasar atas nilai Indeks Kombinasi (IK) menggunakan uji kombinasi dengan seri 1/2 IC50, 3/8 IC50, 1/4 IC50, dan 1/8 IC50 serta data dianalisis menggunakan perangkat lunak Compusyn 1.0. Efek sediaan daun sirsak pada penelitian ini akan diujikan terhadap kultur sel kanker payudara T47D dan MCF7 serta menilai efek ko-kemoterapi ekstrak air daun sirsak dengan doksorubisin. Hasil penelitian ini menunjukkan bahwa IC50 ekstrak air daun sirsak pada kultur sel kanker T47D adalah 84 μg/mL dan pada kultur sel kanker MCF7 166.5 μg/mL, sedangkan uji kombinasi memperlihatkan bahwa ekstrak air daun sirsak berefek antagonis dengan doksorubisin pada kultur sel kanker T47D dan MCF7.

The Increased Knowledge of Children Dental and Oral Health at the Baitus Syukur Orphanage in Bandung Siska Nia Irasanti; Yuniarti Yuniarti; Yuli Susanti; Yani Dewi Suryani; Revika Ilma Nurul Uswah; Risya Farisatul Aini; Novita Arya Cahyani; Hilal Muhammad Dimas Nugraha; Muhammad Mufti
Global Medical & Health Communication (GMHC) Vol 9, No 3 (2021)
Publisher : Universitas Islam Bandung

The COVID-19 pandemic has led to restrictions on visits to the dentist except for emergency cases. It causes the examination and treatment of dental and oral diseases to be hampered, which is feared to impact a person's overall health condition negatively. Therefore, each individual is expected to maintain optimal dental and oral health to prevent it. Until now, based on the results of interviews with the head of the Baitus Syukur orphanage, it was stated that the level of awareness of foster children on the importance of maintaining dental and oral health was low, and they did not yet have a special examination program related to dental and oral health. This study aims to analyze whether there is an increase in children's knowledge in the Baitus Syukur orphanage after counseling on oral health. This type of research is a quasi-experiment with pre and post-test methods in March–April 2021. This study uses a total population of 24 children in the Baitus Syukur orphanage. The data were analyzed with the results of the Wilcoxon Test analysis at a 95% confidence level. It showed that statistically, there was a significant difference between the values before and after giving counseling materials to participants with p value=0.003 (p value≤0.05). The conclusion is that there is an increase in children's knowledge about dental and oral health at the Baitus Syukur orphanage after counseling. PENINGKATAN PENGETAHUAN KESEHATAN GIGI DAN MULUT ANAK DI PANTI ASUHAN BAITUS SYUKUR BANDUNGKondisi pandemik COVID-19 menyebabkan pembatasan kunjungan ke dokter gigi kecuali untuk kasus penyakit kesehatan gigi dan mulut darurat. Hal ini menyebabkan pemeriksaan dan perawatan penyakit gigi dan mulut terhambat yang dikhawatirkan akan menimbulkan dampak negatif terhadap kondisi kesehatan seseorang secara menyeluruh. Untuk mencegah hal ini, setiap individu diharapkan dapat menjaga kesehatan gigi dan mulutnya secara optimal. Sampai saat ini, berdasar atas hasil wawancara dengan Ketua Panti Asuhan Baitus Syukur menyatakan bahwa tingkat kesadaran anak asuh dalam menjaga kesehatan gigi dan mulut rendah dan belum memiliki program pemeriksaan khusus terkait kesehatan gigi dan mulut. Penelitian ini bertujuan menganalisis apakah terdapat peningkatan pengetahuan anak di Panti Asuhan Baitus Syukur setelah dilakukan penyuluhan mengenai kesehatan gigi dan mulut. Jenis penelitian ini adalah eksperimen quasi dengan metode pre and post-test pada Maret–April 2021. Penelitian ini menggunakan total populasi anak di Panti Asuhan Baitus Syukur yang berjumlah 24 orang. Data dianalisis menggunakan Uji Wilcoxon pada derajat kepercayaan 95% menunjukkan bahwa secara statistik, terdapat perbedaan yang signifikan antara nilai sebelum dan setelah pemberian materi penyuluhan pada partisipan dengan p=0,003 (p≤0,05). Simpulan, terdapat peningkatan pengetahuan anak mengenai kesehatan gigi dan mulut di Panti Asuhan Baitus Syukur setelah dilakukan penyuluhan.

Clinical Characteristics, Comorbidities, Length of Stay, and Mortality of COVID-19 Patients in RSUD Cideres, Majalengka, West Java Herry Garna; Dika Rifky Fernanda; Gibran Bramasta Dirgavansya; Heru Haerudin; Zulmansyah Zulmansyah; Samsudin Surialaga; Lelly Yuniarti
Global Medical & Health Communication (GMHC) Vol 9, No 3 (2021)
Publisher : Universitas Islam Bandung

Until now, the world is still facing the COVID-19 pandemic caused by SARS-CoV-2. The number of deaths of COVID-19 patients in Indonesia is quite large when compared to other countries. Clinical manifestations, comorbidities, length of stay, and the mortality of COVID-19 vary widely in each study. This study analyzes clinical characteristics, comorbidities, length of stay, and mortality of COVID-19 patients in RSUD Cideres, Majalengka, West Java. This study is an observational study with total sampling and purposive sampling. Subjects were patients with nasal swabs confirmed SARS-CoV-2 and hospitalized at RSUD Cideres from January to July 2021. Clinical manifestations, comorbidities, length of stay, and mortality of COVID-19 patients aged ≥17 years old, were extracted from medical records. Results showed that the majority of 213 COVID-19 patients were age 41–60 years 114 (53.5%), female 114 (53.5%), with an upper respiratory tract in 207 (97.1%), and shortness of breath in 203 (95.3%) patients. 153 (71.8%) patients had a fever, while headache, diarrhea, and anosmia respectively 49 (23.0%), 19 (8.9%), and 10 (4.6%), respectively. Vital signs were the Glasgow Coma Scale (GCS) normal in 190 (89.2%) patients. Most of patients had respiration rate >20/min in 201 (94.3%), oxygen saturation <90% in 98 (46.0%), and chest x-rays: bronchopneumonia 134 (62.9%) and pneumonia 23 (10.7%). Comorbidities were hypertension, diabetes mellitus, and chronic heart failure in 74 (34.7%), 56 (26.2%), and 46 (11.7%) patients, respectively. The length of stay who died for 1–7 days (22 patients) and 8–14 days (9 patients); means almost all patients (29 of 32) died during the length of stay for 1–14 days. In conclusion, the majority of COVID-19 patients at RSUD Cideres are female, aged 41–60 years, had upper respiratory tract/shortness of breath, GCS normal, saturation oxygen <90%, chest x-rays: bronchopneumonia and pneumonia, comorbidities: hypertension, and length of stay for patients who died 1–7 days. KARAKTERISTIK KLINIS, KOMORBITAS, LAMA RAWAT, DAN MORTALITAS PASIEN COVID-19 DI RSUD CIDERES, MAJALENGKA, JAWA BARATHingga saat ini, dunia masih menghadapi pandemi COVID-19 yang disebabkan oleh SARS-CoV-2. Jumlah kematian pasien COVID-19 di Indonesia cukup besar jika dibanding dengan negara lain. Manifestasi klinis, komorbid, lama rawat, dan mortalitas pasien COVID-19 sangat bervariasi pada setiap penelitian. Tujuan penelitian ini menganalisis karakteristik klinis, komorbiditas, lama rawat, dan mortalitas pasien COVID-19 di RSUD Cideres, Majalengka, Jawa Barat. Penelitian ini adalah penelitian observasional dengan total sampling dan purposive sampling. Subjek adalah pasien dengan nasal swab terkonfirmasi SARS-CoV-2 dan dirawat di RSUD Cideres periode Januari hingga Juli 2021. Data manifestasi klinis, komorbid, lama rawat, dan mortalitas pasien COVID-19 usia ≥17 diambil dari rekam medik. Hasil menunjukkan bahwa mayoritas 213 pasien COVID-19 berusia 41–60 tahun 114 (53,5%) dan wanita 114 (53,5%) dengan keluhan saluran napas atas 207 (97,1%) dan napas pendek 203 (95,3%) pasien. 153 (71,8%) pasien mengalami demam, sedangkan sakit kepala, diare, dan anosmia masing-masing 49 (23,0%), 19 (8,9%), dan 10 (4,6%) pasien. Tanda vital Glasgow Coma Scale (GCS) normal pada 190 (89,2%) pasien. Kebanyakan pasien mempunyai frekuensi napas >20/menit pada 201 (94,3%) pasien, saturasi oksigen <90% pada 98 (46,0%) pasien, serta rontgen toraks: bronkopneumonia pada 134 (62,9%) pasien dan pneumonia pada 23 (10,7%) pasien. Komorbid adalah hipertensi, diabetes melitus, dan chronic heart failure pada 74 (34,7%), 56 (26,2%), dan 46 (11,7%) pasien berturut-turut. Lama rawat pasien yang meninggal 1–7 hari (22 pasien) dan 8–14 hari (9 pasien), berarti hampir semua pasien (29 dari 32) meninggal selama rawat 1–14 hari. Simpulan, mayoritas pasien COVID-19 di RSUD Cideres adalah wanita, berusia 41–60 tahun, keluhan saluran napas atas/napas pendek, GCS normal, rontgen toraks: bronkopneumonia dan pneumonia, komorbid: hipertensi, serta lama rawat pasien yang meninggal paling banyak 1–7 hari.

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Agus Chalid

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Agus Chalid

Contact Email gulid.p@gmail.com

Phone +6285220013654

Journal Mail Official gmhc.unisba@gmail.com

Editorial Address Jalan Hariangbanga No. 2, Tamansari, Bandung 40116

Location Kota bandung, Jawa barat INDONESIA

Abstract

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Contact Name
Agus Chalid

Contact Email
gulid.p@gmail.com

Phone
+6285220013654

Journal Mail Official
gmhc.unisba@gmail.com

Editorial Address
Jalan Hariangbanga No. 2, Tamansari, Bandung 40116

Location
Kota bandung,

Jawa barat

INDONESIA