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Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy)

Farmasi
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Published by Universitas Wahid Hasyim Semarang

ISSN : 16937899 EISSN : 27163814 DOI : 10.31942

Core Subject : Health,

Medicine & Pharmacology

Selamat datang di situs e-Publikasi Ilmiah Fakultas Farmasi Unwahas (Universitas Wahid Hasyim) Semarang. Situs ini berisi kumpulan publikasi ilmiah yang diterbitkan oleh Fakultas Farmasi Unwahas. Publikasi berasal dari jurnal-jurnal serta hasil prosiding seminar yang dilaksanakan oleh Fakultas Farmasi Unwahas.

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HUBUNGAN GAYA KEPEMIMPINAN TERHADAP PRODUKTIVITAS KERJA KARYAWAN BAGIAN LIQUID PT ITRASAL YANG DIMEDIASI OLEH MOTIVASI KERJA Endang Rachmawati
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 15 No 1 Juni 2018
Publisher : Universitas Wahid Hasyim Semarang

INTISARI Penelitian ini bertujuan untuk mengidentifikasi hubungan Gaya Kepemimpinan terhadap Produktivitas Karyawan PT. ITRASAL yang dimediasi oleh Motivasi Kerja. Penelitian ini menggunakan rancangan penelitian metode asosiatif dengan jenis penelitian survey yang akan mengungkapkan hubungan dua variabel, yaitu Gaya Kepemimpinan sebagai variabel bebas dan Produktivitas sebagai variabel terikat. Data primer berasal dari kuesioner yang disebarkan kepada karyawan bagian Liquid Departemen Produksi PT ITRASAL, dan hasil diskusi dengan karyawan bagian tersebut. Selanjutnya data yang diperoleh dianalisis menggunakan metode korelasi dan regresi linear. Dari penelitian ini diperoleh hasil bahwa nilai r untuk variabel Gaya Kepemimpinan terhadap Produktivitas adalah 0,557 dan nilai t adalah 8.951. Nilai r untuk variabel Gaya Kepemimpinan terhadap Motivasi adalah 0,278 dan nilai t adalah 5,022. Terdapat hubungan positif antara Gaya Kepemimpinan terhadap Produktivitas dan Gaya Kepemimpinan berpengaruh positif terhadap Motivasi. Nilai r untuk variabel Motivasi terhadap Produktivitas adalah 0,377 dan nilai t adalah 6,251. Terdapat hubungan positif antara Motivasi terhadap Produktivitas. Kata kunci : Gaya kepemimpinan, Motivasi kerja, Produktivitas karyawan ABSTRACT This study aims to identify the relationship of leadership style to employee productivity PT. ITRASAL is mediated by work motivation. This research uses the research design of associative method with the type of survey research that will reveal the relationship of two variables, namely Leadership Style as independent variable and productivity as dependent variable. Primary data comes from a questionnaire distributed to employees of the Liquid Department of Production Department of PT ITRASAL, and the results of discussions with employees of that section. Further data obtained were analyzed using correlation and linear regression method. From this research, the result that r value for leadership style variable to productivity is 0,557 and t value is 8,951. The r value for the leadership style variable for motivation is 0.278 and the t value is 5.022. There is a positive relationship between leadership style on productivity and leadership style have a positive effect on motivation. The r value for the Motivation variable on productivity is 0.377 and the t value is 6.251. There is a positive relationship between motivation to productivity. Keywords: Leadership style, Motivation work, Employee productivity

UJI DAYA ANTIINFLAMASI EKSTRAK ETANOLIK KULIT TERONG BELANDA (Solanum betaceum, Cav.) PADA MENCIT JANTAN YANG DIINDUKSI KARAGENIN Margareta Retno Priamsari; Rina Ayu Krismonikawati
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 16, No 02 (2019): Jurnal Ilmu Farmasi & farmasi Klinik Vol 16 No 02 Desember 2019
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Inflammation is a normal response to injury due to release of chemical mediators such as prostaglandins. Solanum betaceum Cav. skin contains flavonoid compounds. This study aims to determine the antiinflammatory power and the effect of variations in the dose of ethanolic extract of the skin of Solanum betaceum Cav on Swiss male strain mice caragenin-induced. The ethanolic extract of Solanum betaceum Cav skin was obtained using remaseration method with 96% ethanol solvent. Antiinflammatory power test using edema formation method with induction of caragenin 1% intraplantar 30 minutes before administration of the test material. Tests were carried out on 25 mice records which were divided into 5 groups namely negative control (0.5% CMC Na suspension), positive control (diclofenac sodium suspension in 0.5% CMC Na dose 7 mg/kgBW) and given suspension respectively. Dutch eggplant skin ethanolic extract in CMC Na 0.5% dose 70 mg/kgBW; 140 mg/kgBW; 280 mg/kgBW orally. The parameters observed were edema thickness measured using calipers at 30 minute intervals for 360 minutes. The results of edema thickness difference are used to calculate the Area Under Curve (AUC) and the percentage of antiinflammatory power (% AIP). Dat a were analyzed statistically with the One Way Anova test and continued by the Post Hoc Test with a 95% confidence level. The results showed that the ethanolic extract of Solanum betaceum Cav skin contains flavonoid compounds and has antiinflammatory power. The greater the dose of ethanolic extract of Solanum betaceum Cav skin, the greater the anti-inflammatory power. Keywords: Solanum betaceum Cav., antinflammation, caragenin

PENINGKATAN DISOLUSI CELECOXIB MELALUI PEMBENTUKAN DISPERSI PADAT DENGAN HPMC-PEG 6000 Eva Kartalina; Danang Novianto Wibowo
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 18, No 2 (2021): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Celecoxib (CLX) is a drug that has low solubility and high permeability and belongs to BCS class II. The low solubility of CLX results in the bioavailability of CLX being only 40%, so it is necessary to increase the dissolution using a solid dispersion (DP) technique. This study aims to determine the dissolution profile of CLX in DP with a carrier combination of HPMC and PEG 6000. DP CLX were prepared by solvent evaporation method using drug-HPMC-PEG 6000 ratios were (1:1:1), (1:1:2) and (1:2:1). Pure CLX, physical mixture (CF) at the same ratio and DP were tested for dissolution in tribasic sodium phosphate 0.04 M (pH 12) and 1% sodium lauryl sulfate (SLS). The data from the dissolution test in the form of Q45 and DE60 values were analyzed statistically using non-parametric test. Overall Q45 DP CLX value > 75% and significantly different from pure CLX and CF. DE60 CLX value in DP ratio (1:1:1) 59.13±0.44%; ratio (1:1:2) 60.77±0.09%; ratio (1:2:1) 60.47±0.42%. Solid dispersion with a combination of HPMC polymer and PEG 6000 was able to increase the dissolution of celecoxib compared to the physical mixture and pure celecoxib.

PENENTUAN PENGURANGAN KADAR FORMALIN PADA IKAN ASIN SEPAT DENGAN PERENDAMAN PERASAN BELIMBING WULUH DAN VARIASI SUHU AKUADES Afdhil Arel; B.A. Martinus; Halimatun Sya’diyah
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 14 No 2 Desember 2017
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT This research was conducted with the aim to determine the effect of soaking with starfruit (Averrhoa bilimbi L) and the effect of soaking with variations in water temperature to reducing levels of formaldehyde the salted fish. Research using Spektroquant NOVA 400 on wavelength 565 nm and using reagent HCHO-1 and HCHO-2 to know levels of formaldehyde in the salted fish. The results showedpercentage levels of formaldehydewithout soaking is 0%, while soaking with cold water (28ºC - 29ºC) is 31,62%, soaking with warm water (50ºC - 60ºC) is 53,69%, soaking with hot water (98ºC - 99ºC) is 62,78%, while soaking with starfruit konsentration 100% is 94,47%. This shows the soaking with water can reduce levels of formaldehyde highest with hot water, but soaking with starfruit konsentration 100% can reduce levels of formaldehyde higher of the soaking with hot water. Statistical calculation results with one-way ANOVA (p<0,05) gives results significantly differentbetween each treatment. Keywords : Formaldehyde, Starfruit (Averrhoa bilimbi L), Salted Fish, Spektroquan NOVA 400

UJI AKTIVITAS PENINGKAT DAYA INGAT FRAKSI ETIL ASETAT EKSTRAK ETANOL BUAH KEMUKUS (Piper cubeba L. f) PADA MENCIT JANTAN GALUR BALB/C DENGAN METODE RADIAL ARM MAZE (RAM) Junvidya Heroweti; Yance Anas; Idress Muhammed Hama
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & farmasi Klinik Vol 16 No 1 Juni 2019
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTNeurodegenerative is often associated with aging. The aging process will affect the decrease in nerve cells, especially brain nerve cells. Ethyl acetate fraction of kemukus fruit ethanol extract (FEAEE) of kemukus fruit has been investigated as a memory enhancer with the Morris water maze (MWM) method. One of the shortcomings of the Morris water maze method is that it causes stress in test animals, thus affecting their memory. This study aims to determine the memory enhancing activity of FEAEE of kemukus fruit with the radial arm maze method This research is an experimental study with pre and posttest matched control group design using 25 male mice, Balb/c strains divided into 5 groups. Mice group 1 as a negative control group were given a 1% CMC Na solution of 17.5 mg/mL. Group mice 2 - 5 were given FEAEE of kemukus fruit with doses of 63, 126, 252, and 504 mg/kgBB, respectively. Test material is given orally for 21 days. Observations were made on the frequency of mice passing the platform correctly and incorrectly and calculating memory scores using the radial arm maze (RAM) method. Differences in memory scores were analyzed by the Mann Whitney test. The results showed that FEAEE steamed fruit has memory enhancing activity. Memory activity was indicated at doses of 63 and 252 mg / kg.Keywords: steamed fruit (Piper cubeba, L. f), ethyl acetate fraction, memory score, radial arm maze

FORMULASI EMULGEL EKSTRAK ETANOL DAUN JAMBU BIJI (Psidium guajava Linn.) SEBAGAI ANTI ACNE CLEANSER Anindi Lupita Nasyanka; Janatun Na’imah; Norainny Yunitasari
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 17, No 2 (2020): Jurnal Ilmu Farmasi & Farmasi Klinik Vol. 17 N0. 02 Desember 2020
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Acne is a major problem for teenagers, especially at puberty. Guava leaves (Psidium guajava Linn .) are plants that contain several secondary metabolites, including the tannins, triterpenoids, glycosides, and flavonoids, which have anti-acne activity. So far, acne reduction is still being done using synthetic cosmetics. However, synthetic cosmetics often irritate, so that herbal cosmetics are an alternative. Formulation of herbal cosmetics for acne need to do. This study aims to determine the best formula for anti-acne cleanser emulgel from the ethanol extract of guava leaves based on the physical evaluation. Guava leaf extract as obtained by the maceration method uses ethanol as a solvent, then an emulgel was prepared with an extract concentration of F1 (5%) and F2 (10%). Emulgel characteristics were determined by physical evaluation including organoleptic, pH, emulsion type, viscosity, spreadability, homogeneity, foam stability, power clean, and hedonism. The best formula was determined by the number of tests that meet the requirements and are liked by consumers. The results had shown F1 is the best formula based on physical evaluation. Keywords: Acne, emulgel, guava leaves, physical evaluation

AKTIVITAS ANTIDIARE EKSTRAK ETANOL DAUN NANGKA (Artocarpus heterophyllus Lam.) DAN DAUN ANGSANA (Pterocarpus indicus Wild.) PADA MENCIT JANTAN GALUR BALB/C Yance Anas; Devi Nisa Hidayati; Aristya Kurniasih; Lalu Ksatria D.S.
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI & FARMASI KLINIK VOL. 13 NO. 1 JUNI 2016
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Traditionally, jackfruit leaves (Artocarpus heterophyllus Lam.) and angsana leaves (Pterocarpus indicus Wild.) have been used as an herb for diarrhea treatment. The purpose of this experimental study was to investigate the antidiarrheal effect of jackfruit leaves ethanol extract (JLEE) and angsana leaves ethanol extract (ALEE) on Balb/C male mice with castor oil-induced diarrhea method. The study design is a randomized matched two group post test-only. JLEE and ALEE produced by maceration. An antidiarrheal activity of both of extracts compared with loperamide-HCl 10 mg/Kg BW. JLEE (100, 200 and 400) mg/Kg BW and ALEE (80, 160 and 320) mg/Kg BW significantly (p <0.05) decrease the amount of liquid and soft feces, and delay the onset of diarrhea compared with controls (NaCl 0.9% 10 mL/Kg BW). The ability JLEE 400 mg/Kg BW and EEDA 320 mg/Kg BW on inhibiting the formation liquid and soft feces are higher than loperamide HCl 10 mg/Kg BW with antidiarrheal effect amounted to 72.31%, 65.47%, and 54.46% respectively. The potency of JLEE and ALEE as antidiarrheal (ED50) are (20.85 and 3.52) mg/Kg BW respectively. However, in this study, a single dose of loperamide-HCl, JLEE and ALEE treatments are not able to heal the diarrhea symptom (p> 0.05). Keywords: Antidiarrheal, castor oil-induced diarrhea,ethanol extract, Artocarpus heterophyllus Lam., Pterocarpus indicus Wild.

AKTIVITAS EKSTRAK ETANOL DAUN KEDONDONG (Spondias pinnata (L.F) Kurz.) TERHADAP ANTIBODI IgM DAN IgG PADA MENCIT BALB/C YANG DIINDUKSI VAKSIN HEPATITIS B Maria Ulfah; Penni Dwi Royani; Rita Febrianti_Lidya Putra
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 15 No 2 Desember 2018
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTAntibodies play a role in maintaining the body’s immune system from various microorganism. When the body experiences an imbalance, the body needs a compound that can increase antibodies. Flavonoids, polyphenols and alkaloids can increase antibodies. Flavonoids, polyphenols and alkaloids can increase antibodies. Ethanol extract of kedondong leaves contains compounds of flavonoid, alkaloids, and polyphenols. The purpose of this study was to determine the immunomodulatory activity of ethanol extract in IgM and IgG antibodies in balb /c mice induced by hepatitis B vaccine. Ethanol extract of kedondong leaves was macerated with 96% ethanol. The doses of the concentration of ethanol extract of kedondong leaves used were 5, 10 and 20% p.o for 46 days and vaccination was carried out on the 7th, 28th and 43rd days. Positive control was used with levamisole at a dose of 0.45mg / 20gBB by p.o. Analysis of Optical Density (OD) IgM and IgG on days 14, 35 and 46 using Friedman and Mann Whitney statistical tests. The results showed that the ethanol extract of kedondong leaves had activity of increasing IgM and IgG antibodies at concentrations of 5, 10 and 20% on days 14, 35 and 46 and contained flavonoids, alkaloids and polyphenols.Keywords: Hepatitis B Vaccine, IgM, IgG, Optical Density (OD)

EFEKTIVITAS PEMBERIAN PARASETAMOL ORAL VERSUS PARASETAMOL REKTAL UNTUK ANTIPIRETIK PADA ANAK: SYSTEMATIC REVIEW Sitta Hasanatin Sholihah
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 17, No 01 (2020): Jurnal Ilmu Farmasi & farmasi Klinik Vol 17 No. 01, Juni 2020
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Paracetamol is available in oral and rectal formulations for decades. Controversies regarding conformity of formulations and dosages were found in the use of paracetamol as antipyretic. The purpose of this research is to know the effectiveness of paracetamol oral administration compared to the rectal administration for the loss of fever (antipyretic) in children that is systematic review. Research was done through searches from the database PubMed, NEJM, EBSCO, ProQuest, Science Direct. Systematic review was done on the child subject that aged 3 months to 13 years old and 1 month with fever and randomized trial with blind. Trials are examined based on predesigned inclusion criteria and exclusion criteria. Conducted systematic review and systematic review of randomized controlled trials was done to determine the effectiveness of the administration of paracetamol orally compared to the rectally. Data is homogeneous with RR 0.98 (CI 95%: 0.85-1.13). The effectiveness of the rectally compared to the oral administration of paracetamol is not significantly different in spite of the effectiveness of orally paracetamol amount of 0.98 times compared to the rectally. Keywords: antipyretic, child, orally paracetamol, rectally paracetamol

PENGARUH PEMBENTUK FILM PVA PADA SEDIAAN MASKER GEL PEEL-OFF EKSTRAK ETANOL BAWANG DAYAK (Eleutherina palmifolia (L.) Merr) TERHADAP AKTIVITAS ANTIBAKTERI Staphylococcus aureus PENYEBAB JERAWAT Husnani Husnani; Fitri Sri Rizki
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 15 No 2 Desember 2018
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTDayak Onion (Eleutherine palmifolia) is one of the plants that can inhibit Staphylococcus aureus bacteria that causes acne. This study aims to determine the effect of polyvinyl alcohol on peel-off gel mask preparations from onion dayak ethanol extract on the antibacterial activity of Staphylococcus aureus that causes acne. Extraction using maceration method with 96% ethanol. The concentration of dayak onion extract was made at 5%, 7.5%, and 10% and the peel-off gel mask formula from dayak onion extract with variations in extract concentration were 5%, 7.5%, and 10% based on Polyvinyl Alcohol (PVA). Antibacterial activity is carried out using the disk disc method. In testing the inhibition of dayak onion extract at a concentration of 5% resulted in a clear zone of 15.5 mm, a concentration of 7.5% and 10% producing the same clear zone diameter of 17.1 mm. The peel-off gel mask in formulation I obtained a clear zone diameter of 8.7 mm, formulation II the diameter of the clear zone was 12.2 mm, and formula III the diameter of the clear zone was 15.3 mm. The results of this study indicate that on dayak onion extract has a greater inhibitory power compared to the dayak onion extract peel-off gel mask preparation. It can be concluded that the PVA in the preparation affects the amount of inhibitory power on the bacteria forming acne, namely Staphylococcus aureus.Keywords: Dayak onion extract, Staphylococcus aureus, disk discs, antibacterial inhibitory test, acne-causing bacteria, peel-off gel mask.

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