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Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy)
ISSN : 16937899     EISSN : 27163814     DOI : 10.31942
Core Subject : Health,
Selamat datang di situs e-Publikasi Ilmiah Fakultas Farmasi Unwahas (Universitas Wahid Hasyim) Semarang. Situs ini berisi kumpulan publikasi ilmiah yang diterbitkan oleh Fakultas Farmasi Unwahas. Publikasi berasal dari jurnal-jurnal serta hasil prosiding seminar yang dilaksanakan oleh Fakultas Farmasi Unwahas.
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Articles 349 Documents
UJI AKTIVITAS ANTIDIABETES KOMBINASI EKSTRAK ETANOL DAUN ALPUKAT DAN RIMPANG TEMULAWAK PADA TIKUS DM TIPE-2 YANG MENGALAMI RESISTENSI INSULIN Mamik Dwi Anggraini; Yance Anas; Sumantri Sumantri
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 14 No 2 Desember 2017
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (506.279 KB) | DOI: 10.31942/jiffk.v14i2.2059

Abstract

ABSTRACT Avocado’s leaves and Curcuma xanthorrizarhizoma contain compounds of flavonoids, alcaloids,triterpenoids and curcumin, where the compounds are effective as antidiabetic agents. This study aims to prove the effect of antidiabetic combination of extracts on insulin resistence type-2 diabetic rats then to compare it with a single extract. This research used pre-test and post-test control group design. The 30 test animals were divided into two treatment groups. Five control groups of rats were they given 1,25 mL aquabides/KgBW/day, and 25 rats were divided into five groups and given were given 1,8 IU insulin/KgBW/day for 14 days. Group I was control of 12,5 mL CMC-Na/KgBW/day 0,5%, group II was positive control of 150 mg metformin/KgBW/day, group III was avocado’s leaves extract, group IV was extract of Curcuma xanthorriza rhizoma, and group V was combination extract. The extracts of group III-V were given the same dose, that was given 200 mg/KgBW/day for 14 days. The meansurement of antidiabetic effect was done by comparing the GDP value of rats before and after treatment. The GDP concentrations of rats were analyzed using T-paired testand Wilxocon test, whereas the comparative data of percentage GDP decrease was tested using Kruskall Wallis test then followed by Mann-Whitney test. The results showed that the effect of antidiabetic combination of extract in insulin resistence type-2 diabetic rats as the percentage GDP decrease was 22.03%. The effect of decreasing GDP concentration at the ratio of 1:1 extract did not differ significantly with the single extract of 200 mg Curcuma xanthorrizarhizoma/KgBW/day. Keywords: Avocado’s leaves, Curcuma xanthorriza rhizoma, Antidiabetic effect test, Comparison combination of both extracts with single extract.
IDENTIFIKASI DAN ISOLASI SENYAWA LIKOPEN DARI SEMANGKA (CITRULLUS LANATUS) Eva Monica; Rollando Rollando
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & farmasi Klinik Vol 16 No 1 Juni 2019
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (244.068 KB) | DOI: 10.31942/jiffk.v16i01.2933

Abstract

ABSTRACTLycopene is one of the phytochemical compounds of the carotenoid group, the main producer of red pigments found in watermelons. Watermelon is a round-shaped vines containing vitamin C and vitamin A and has high antioxidant levels. This study aims to identify lycopene compounds in watermelons. Extraction of watermelon flesh by maceration method. Identification of lycopene compounds with UV-Visibel spectrophotometry instrument followed by identification with the TLC method and fractionation of extracts using preparative TLC with chloroform: ethanol (1: 1) solvents, and identification of fractionation results with Fourier Transform Infrared Spectroscopy (FT-IR). The results of the identification of watermelon fruit extract using the TLC method obtained three spots and the results of UV-Vis spectrophotometry showed three peaks namely between 440-520 nm. The identification of fractionation of watermelon extract using FT-IR obtained a constituent group of lycopene structures, but did not show the R-CH = CH-R group that is owned by lycopene, whereas the results of the test with UV-Vis spectrophotometry appearing at 206 and 245 which indicate the presence of other compounds. From the results of the study it can be concluded that the testing of known extracts of watermelon fruit contains lycopene compounds, but the testing of lycopene identification on the results of fractionation of watermelon fruit extracts was not found with certainty the existence of lycopene because the FT-IR results were only shown and contained on the results UV-Vis spectrophotometry was found to be the wavelength of other compounds.keywords: Watermelon, Lycopene, UV-Vis Spectrophotometry, IR Spectrophotometry
STANDARDISASI PARAMETER NON SPESIFIK DAN SPESIFIK EKSTRAK ETANOL DAUN JAMBLANG (Syzygium cumini (L.) Skeels) Maria Ulfah; Ricky Chandra Kurniawan; Metalia Erny
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 17, No 2 (2020): Jurnal Ilmu Farmasi & Farmasi Klinik Vol. 17 N0. 02 Desember 2020
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (219.033 KB) | DOI: 10.31942/jiffk.v17i2.4066

Abstract

ABSTRACT The content of active compounds and the quality of extracts cannot be guaranteed to always be in a constant amount, so it is necessary to standardize. This study aims to prove the ethanol extract of jamblang leaves (Syzygium cumini (l.) Skeels) fulfill the standardization of non-specific and specific parameters as a natural medicine. The ethanol extract of jamblang leaves was extracted by extracting using ultrasonic methods The extract was tested for non-specific parameters including: determination of water content, total ash content, acid insoluble ash content, drying losses and heavy metal contamination. Whereas the specific parameter tests include: identity, organoleptic extract, compounds dissolved in water and ethanol, and chemical content. Test results were analyzed descriptively and compared to standard parameters. The results of non-specific parameters showed a moisture content of 8.04 ± 2.83%, a total ash content of 3.81 ± 1.95%, an acid insoluble ash content of 0.54 ± 0.73%, a drying loss of 9.08 ± 3.01, metal contamination Pb
EVALUASI KARAKTERISTIK FISIKA-KIMIA SEDIAAN KRIM DAN LOTION EKSTRAK KULIT BUAH NANAS (Ananas comosus L.Merr) Elya Zulfa; Mufrod Mufrod
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 15 No 2 Desember 2018
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (251.791 KB) | DOI: 10.31942/jiffk.v15i2.2565

Abstract

ABSTRACTIn previous research, ethanolic extract of pineapple peel (EEPP) has activity as a sunscreen because of the content of flavonoids. EEPP can be formulated in the form of creams and lotions to facilitate use on the skin. This study aims to evaluate the physical chemistry characteristics of EEPP creams and lotions. Creams and lotions were made in 3 formulas based on variations in FI extract concentrations (15.0%), FII (17.5%), FIII (20.0%), base controls and positive controls (preparations on the market). The cream obtained was evaluated for physical chemical characteristics including organoleptic, homogeneity, adhesion and dispersion, viscosity, pH and SPF values which were analyzed descriptively. cream with varying concentrations of green, the distinctive smell of pineapple, homogeneous and in accordance with the pH of the skin. Increasing the concentration of EEPP in the preparation has an effect on increasing viscosity, adhesion but decreasing the dispersion. Whereas the lotion shows greenish color, aromatic odor and semisolid texture and is easily applied. The increase in EEPP in lotion affects the increase in pH, adhesion, but decreasing the dispersion.Keywords: Creams, lotions, sunscreen, pineapple fruit skin
FORMULASI DAN EFEK SALEP EKSTRAK ETANOL DAUN JAMBU BIJI (Psidium guajava,L.) DENGAN BASIS HIDROKARBON TERHADAP LUKA SAYAT PADA TIKUS JANTAN GALUR WISTAR Ririn Lispita Wulandari; Elya Zulfa; Dwara Andriani Astuti
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 16, No 02 (2019): Jurnal Ilmu Farmasi & farmasi Klinik Vol 16 No 02 Desember 2019
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (700.271 KB) | DOI: 10.31942/jiffk.v16i02.3239

Abstract

ABSTRACT The ethanol extract of guava leaves (EEGL) is proven to heal various types of wounds.This study aims to determine the physicochemical characteristics of the EEGL ointment with a hydrocarbon base formula and examine the effect of the ointment against cut wounds on wistar male rat. The EEGL was obtained by maceration using 70% ethanol solvent. The ointment made 3 formulas with a ratio of hydrocarbon base composition (cera alba:vaselin album) namely F1 (2.5:92.5)%; F2 (5:90)%; F3 (7.5:87.5)%. The physicochemical characteristics of all ointments examined included organoleptic, homogeneity, pH, viscosity, spreadability, and adhesion. Organoleptic, homogeneity and pH data were analyzed descriptively, while viscosity, spreadability and adhesion data were analyzedstatistically. Testing the effect of all ointment formulas on the wound was done by applying 0.5 gram 2x a day for 9 days compared to wound control without treatment and positive control used commercial product.The parameter of effect measured was the length of the cut wound on the 9th day, then analyzed with the Kruskall Wallis test followed by the Mann Whitney test.The physicochemical characteristics of EEGL ointment (F1, F2, F3) are known that all ointment formulas are brown in color, typical of guava, homogeneous, pH according to skin pH, viscosity and adhesion are significantly different, while the spredability is not significant.The EEGL ointment had an effect on the cut wound of the male wistar rats, ie the length of the wound on the 9th day was reduced and compared to wound controlwas differentsignificantly. Keywords :Guava leaves, ointment, cut of wound.
PENINGKATAN DISOLUSI NIFEDIPIN DENGAN PELARUT PVP K-30 MENGGUNAKAN METODE DISPERSI PADAT Asri Prahmanita Sadiarti; Endang Diyah Ikasari; A.Ariani Hesti W.S
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 19, No 1 (2022): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (917.651 KB) | DOI: 10.31942/jiffk.v19i1.6680

Abstract

Nifedipine is an anti-hypertensive included in the Biopharmaceutics Classification System (BCS) class II to its nature of being poorly soluble in water, resulting in low bioavailability. One technique that can be used to improve the solubility of the dispersion technique. This research aimed to determine the effect of the concentration of PVP K-30 on physical characteristics, the dissolution rate of solid dispersions, and the interactions that occur between nifedipine with PVP K-30. The method of manufacturing solid dispersion is a melting-solvent method. FI - F III is a solid dispersion and F IV-VI F is a physical mixture. Formula used is the ratio of nifedipine: PVP K-30 FI (10%: 90%), F II (20%: 80%), F III (30%: 70%), F IV (10%: 90%), FV (20%: 80%), F VI (30%: 70%), and used as a control of pure nifedipine. Testing was conducted on the organoleptic test, flow rate, moisture content, melting point, dissolution testing, and FT-IR analysis. Dissolution test parameters used C (20). The data was obtained and analyzed by non-parametric test KruskalWallis and Mann-Whitney with a level of 95%. The results showed that solid dispersions aregranulated, yellow, and have a free-flowing nature. Test results C (20) FI, F II, F III, F IV, FV, F VI, and controls respectively were 89,48%; 51,75%; 22,58%; 12,88%; 24,07%; 26,34%; 24,95%. The results showed that the FI has the highest dissolved. Results of FT-IR spectra showed no interaction between nifedipine with PVP K-30. 
PENETAPAN KADAR KOFEIN DALAM MINUMAN BERNERGI YANG BEREDAR DI PASARAN DENGAN METODE KROMATOGRAFI CAIR KINERJA TINGGI Afdhil Arel; B.A. Martinus; Romi Nofiandri
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 14 No 1 juni 2017
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (67.1 KB) | DOI: 10.31942/jiffk.v14i1.1767

Abstract

INTISARI                            Telah dilakukan penelitian tentang penetapan kadar kofein dalam minuman berenergi yang beredar dipasaran secara Kromatografi Cair Kinerja Tinggi. Minuman energi ini difraksinasi dengan kloroform. Hasil fraksi kloroform diuapkan dengan  rotary  evaporator. Kadar kofein diukur dengan kromatografi cair kinerja tinggi menggunakan kolom LC- 20AD dengan panjang 25 cm dan detektor SPD-20MAD dengan panjang gelombang 272nm. Fase gerak yang digunakan Metanol : Air (50:50)dengan laju alir 1 mL/menit. Dari hasil penelitian didapatkan kadar kofein dalam 1 botol sampel Kr =27,73 mg,  M =34,14 mg, , Pm=28,41 mg dan sampel Lv =69,78 mg. Hasil tersebut sampel Lv yang melebihi batas yang telah ditentukan oleh SNI No. 01-6684-2002 yaitu kurang dari 50 mg persaji. Kata Kunci : KCKT (Kromatografi cair kinerja tinggi, Koffein  ABSTRACT This research is telling about estimating amount of coffeine cosumption in energy drink which available in the market with HPLC method. Energy drink filtrat fractionated with chloroform  and chloroforom fractionation evaporated by rotary evaporator. Coffein amount measured by HPLC using column LC- 20 AD ( Length 20 cm ) and detector SPD – 20 MAD (λ 272 nm) with mobile phase methanol : water (50:50).  Amount  estimating  of  coffein  from  this  research  in  1  bottle  Sample Kr =27,7264 mg, M =34,140 mg, Pm=28,41 mg and sample Lv= 69,78 mg. The results sample Lv that exceed the limit set by SNI Num. 01-6684-2002 is less than 50 mg. Keywords: HPLC(high performance liquid chromatography), Coffeine
AKTIVITAS ANTIDIARE FRAKSI AIR EKSTRAK ETANOL DAUN SALAM (Syzygium polyanthum (Wight.) Walp.) PADA MENCIT Kiki Damayanti; Risha Fillah Fithria; Rokhila Kamala Sari; Dewi Ratna Ningsih
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 15 No 1 Juni 2018
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (416.236 KB) | DOI: 10.31942/jiffk.v15i01.2172

Abstract

INTISARI  Beberapa penelitian membuktikan ekstrak dan infus daun salam sebagai antidiare. Fraksinasi dapat menyederhanakan senyawa dalam ekstrak. Penelitian ini bertujuan untuk mengetahui aktivitas fraksi air ekstrak etanol daun salam (FAEEDS) sebagai protektor diare yang diinduksi castor oil, antimotilitas usus, dan mengetahui keberadaan flavonoid dan tanin didalamnya. Penelitian ini merupakan penelitian eksperimental menggunakan randomized matched posttest only control group design. FAEEDS dosis 1, 2, dan 3 g/kgBB diberikan pada mencit secara per oral. Kelompok kontrol positif yang digunakan adalah loperamid HCl 0,5 mg/kgBB dan PGA 3% 25 ml/kgBB diberikan pada kelompok kontrol negatif. Satu jam kemudian, mencit diberi  castor oil secara per oral. Banyaknya feses cair dan tidak terbentuk yang terbentuk selama 4 jam diamati. Pengujian aktivitas antimotilitas dilakukan dengan memberikan suspensi norit 10% 10 ml/kgBB 45 menit setelah pemberian castor oil. Satu jam kemudian dilakukan pengukuran panjang usus yang dilalui marker norit dan panjang usus seluruhnya. Data banyaknya feses yang cair dan tidak berbentuk serta data rasio panjang usus yang dilalui norit diuji perbedaannya dengan uji Mann-Whitney dengan taraf kepercayaan 95%. Keberadaan flavonoid dan tanin diketahui melalui kromatografi lapis tipis.  Hasil penelitian menunjukkan FAEEDS beraktivitas sebagai protektor diare dan antimotilitas usus pada semua dosis. Flavonoid dan tanin terkandung dalam FAEEDS.  Kata kunci: fraksi air, daun salam, protektor diare, antimotilitas, castor oil, loperamid HCl  ABSTRACT  Some research proves extracts and infusion of salam leaf as antidiarrheal. Fractination can simplify the compounds in the extract. The aim of this research is to know the diarrhea protector activity of water fraction of ethanol extract of salam leaf (WFEESL), the antimotility activity, and to verify the persence of flavonoids and tannins in the fraction. The research was an experimental study using randomized matched posttest only control group design. WFEESL doses 1, 2, and 3 g/kgBW were given to mice orally. The positive control group was given loperamide HCl 0.5 mg/kgBW. One hour later, each mouse was given 1 ml of castor oil orally. Observations were made on the weight of liquid and unformed stools that formed during 4 hours of observation. Ten percent of carbo adsorbent suspensian 10 ml/kgBW was given orally as marker to the mice in the group of antimotilily activity 45 minutes after castor oil. The parameter which measure was the length of intestinal which passed by carbo adsorbent compared with the whole intestinal length. The data analyzed by Kruskal Wallis test, continued with Mann Withney test, with 95% of confidence level. The presence of flavonoids and tannins are known by thin layer chromatography. The results showed that WFEESL exhibits protective diarrhea and antimotility activity at all doses. Flavonoids and tannins are contained in WFEESL.  Keywords: water fraction, salam leaves, diarrhea protector, antimotility, castor oil, loperamide HCl
Jurnal Ilmu Farmasi & Farmasi Klinik Journal of Pharmaceutical Science & Clinical Pharmacy cover cover
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 16, No 02 (2019): Jurnal Ilmu Farmasi & farmasi Klinik Vol 16 No 02 Desember 2019
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (172.767 KB) | DOI: 10.31942/jiffk.v16i02.3230

Abstract

Jurnal Ilmu Farmasi & Farmasi Klinik Journal of Pharmaceutical Science & Clinical Pharmacy Pemimpin Umum/ Penanggung jawab Dekan Fakultas Farmasi Universitas Wahid Hasyim Pemimpin Redaksi Ketua Program Studi Farmasi Fakultas Farmasi Universitas Wahid Hasyim Dewan Penyunting Jurnal Dr. Yulias Ninik W., M.Si., Apt. Redaktur Ahli Dr. Ahmad Ainur Rofiq, M.Si., Apt. (Universitas Sebelas Maret), Burhan Ma’arif Zaenal Arifn, M.Farm. Apt. (UIN Maulana Malik Ibrahim), Dr. Isnaeni, M.S., Apt. (Universitas Airlangga), Kuni Zu’aimah Barikah, M.Farm., Apt. (Universitas Jember), Dr. Nurkhasanah, M.Si., Apt. (Universitas Ahmad Dahlan), Khoerul Anwar, M.Sc., Apt. (Universitas Lambung Mangkurat), Dr. Gunawan Pamudji Widodo, M.Si., Apt. (Universitas Setia Budi), Dr. Laela Hayu Nurani, M.Si., Apt. (Universitas Ahmad Dahlan), Dr. Iis Wahyuningsih, M.Si., Apt. (Universitas Ahmad Dahlan), Dr. Wahyu Widyaningsih, M.Si., Apt. (Universitas Ahmad Dahlan), Muhammad Ikhwan Rizki, M.Farm., Apt. (Universitas Lambung Mangkurat), Dr. Yulias Ninik W., M.Si., Apt. (Universitas Wahid Hasyim), Maulita Cut Nuria, M.Sc., Apt. (Universitas Wahid Hasyim), Yance Anas, M.Sc., Apt. (Universitas Wahid Hasyim), Risha Fillah Fithria, M.Sc., Apt. (Universitas Wahid Hasyim), Aqnes Budiarti, S.F..Sc., Apt. (Universitas Wahid Hasyim), Ririn Lispita Wulandari, M.Si.Med., Apt. (Universitas Wahid Hasyim), Maria Ulfah, M.Sc., Apt. (Universitas Wahid Hasyim), Elya Zulfa, M.Sc., Apt. (Universitas Wahid Hasyim), Anita Dwi Puspitasari, S.Si., M.Pd. (Universitas Wahid Hasyim), Dewi Andini Kunti Mulangsri, M.Farm., Apt. (Universitas Wahid Hasyim), Devi Nisa Hidayati, M.Sc., Apt (Universitas Wahid Hasyim), M. Fatchur Rochman, M.Farm. (Universitas Wahid Hasyim), Malinda Prihantini, M.Si., Apt. (Universitas Wahid Hasyim) Redaktur Pelaksana Elya Zulfa, S.Farm., M.Sc., Apt Staf Redaksi : Dewi Andini Kunti Mulangsri, M.Farm., Apt. Ririn Lispita W., S. Farm., M.Si.Med, Apt. Devi Nisa Hidayati, M.Sc., Apt Danang Novianto, S.Farm., Apt Erika Indah Safitri, M.Farm. Imam Asrofi, S.Farm. Distributor Sulistiyawati, S.E. Alamat Redaksi/Tata Usaha Fakultas Farmasi Universitas Wahid Hasyim Jl. Menoreh Tengah X/22 Sampangan Semarang Telp. 024-8505680, 8505681 Fax. 024-8505680 E-mail : jiffk@unwahas.ac.id Terbit 2 kali setahun sejak September 2004
STABILITAS NANOSTRUCTURED LIPID CARRIER COENZYME Q10 DENGAN VARIASI WAKTU PENGADUKAN Usrifatul Khasanah; M Fatchur Rochman
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 18, No 2 (2021): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (327.888 KB) | DOI: 10.31942/jiffk.v18i2.5958

Abstract

Coenzyme Q10 (Co-Q10) or Ubiquinone is an antioxidant that is unstable to light and is highly lipophilic causing instability during storage, so a Nanostructured Lipid Carrier (NLC) delivery system is needed that can improve stability. The manufacture of NLC uses the emulsification method by melting two types of lipids, namely solid lipid cetyl palmitate and liquid lipid alpha tocopherol with the help of stirring using a magnetic stirrer. The purpose of this study was to determine the characteristics and stability of NLC Co-Q10 at various stirring times. The results of testing the characteristics NLC Co-Q10, that stirring for 6 and 9 minutes, obtained pH values of 6,64 and 6,62 with particle sizes of 215.03 nm and 188.25 nm, the entrapment efficiency values were 75.57% and 77.96%, respectively. Increasing the speed and duration of stirring in the manufacture of the NLC Co-Q10 system will obtain high trapping efficiency values and be more stable in storage at room temperature for 28 days. 

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