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Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy)

Farmasi
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Published by Universitas Wahid Hasyim Semarang

ISSN : 16937899 EISSN : 27163814 DOI : 10.31942

Core Subject : Health,

Medicine & Pharmacology

Selamat datang di situs e-Publikasi Ilmiah Fakultas Farmasi Unwahas (Universitas Wahid Hasyim) Semarang. Situs ini berisi kumpulan publikasi ilmiah yang diterbitkan oleh Fakultas Farmasi Unwahas. Publikasi berasal dari jurnal-jurnal serta hasil prosiding seminar yang dilaksanakan oleh Fakultas Farmasi Unwahas.

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Articles 349 Documents

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HUBUNGAN GAYA KEPEMIMPINAN TERHADAP PRODUKTIVITAS DEPARTEMEN PRODUKSI PT X YANG DIMEDIASI OLEH MOTIVASI KERJA (STUDI KASUS DI BAGIAN TABLET DEPARTEMEN PRODUKSI SALAH SATU INDUSTRI FARMASI DI JAWA TENGAH) Indra Putra Taufani; Achmad Fudholi; Sumarni Sumarni
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 13 No 2 Desember 2016
Publisher : Universitas Wahid Hasyim Semarang

INTISARI Penelitian ini bertujuan untuk mengidentifikasi hubungan gaya kepemimpinan terhadap produktivitas karyawan di Bagian Tablet Departemen Produksi PT. X yang dimediasi oleh motivasi kerja. Penelitian ini menggunakan rancangan penelitian metode asosiatif dengan jenis penelitian survey yang akan mengungkapkan hubungan dua variabel, yaitu Gaya Kepemimpinan sebagai variabel bebas dan produktivitas Bagian Tablet Departemen Produksi PT X sebagai variabel terikat. Data primer berasal dari kuesioner yang disebarkan kepada karyawan Bagian Tablet Departemen Produksi PT X, dan hasil diskusi dengan karyawan bagian tersebut. Data sekunder berasal dari data produktivitas Bagian Tablet yang dilihat dari penilaian karyawan 6 bulan Januari hingga bulan Juni 2012. Selanjutnya data yang diperoleh dianalisis menggunakan metode korelasi dan regresi linear. Dari penelitian ini diperoleh hasil bahwa nilai r untuk variabel gaya kepemimpinan terhadap produktivitas adalah 0,027 dan nilai t adalah 0,179. Ada hubungan antara gaya kepemimpinan terhadap produktivitas, namun tidak saling mempengaruhi. Nilai r untuk variabel gaya kepemimpinan terhadap motivasi adalah 0,393 dan nilai t adalah 2,869. Ada hubungan antara gaya kepemimpinan terhadap motivasi dan gaya kepemimpinan berpengaruh positif terhadap motivasi. Nilai r untuk variabel motivasi terhadap produktivitas adalah 0,443 dan nilai t adalah 3,315. Ada hubungan antara motivasi terhadap produktivitas dan berpengaruh positif. Kata kunci : Gaya kepemimpinan, Motivasi kerja, Produktivitas karyawan, Departemen produksi. ABSTRACT This study aims to identify the relationship of leadership style on employee productivity in Tablet Section of Production Department PT. X mediated by work motivation. This study using the associative method study design with the survey research type that would reveal the relationship between two variables, are leadership style as independent variables and employee productivity in Tablet Section of Production Department PT X as the dependent variable. Primary data taken from questionnaires distributed to employees in Tablet Section of Production Department PT X, and the results of discussions with the employees of that section. Secondary data taken from productivity assesment from January to June 2012. The acquired data were analyzed using correlation and linear regression. From this study showed that the value of r for the leadership style to the productivity was 0.027 and the value of t is 0.179. There is a relationship between leadership style on productivity, but do not affect each other. The value of r for the leadership style to motivation is 0.393 and the value of t is 2,869. There is a relationship between leadership style to motivation, and leadership style give positive effect on motivation. The value of r for motivation to productivity is 0.443 and the value of t is 3.315. There is a relationship between motivation to productivity and motivation give positive effect on productivity. Keywords : Leadership style, Work motivation, Employee productivity, Production Departement.

IDENTIFIKASI SENYAWA KIMIA DAN PENELUSURAN AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOLIK DAUN TUMBUHAN TEROMPET UNGU Eva Monica
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 14 No 2 Desember 2017
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Petunia (Ruellia brittoniana Leonard) is a wild plant species belonging to the Acanthaceae family. This study aimed to identify the content of ethanolic extract of petunia leaf. A total of 185 grams of petunia leave powder were macerated with ethanol resulting 17.5 grams of ethanolic extract. Chemical identification was performed by using reagents. The test using reagents showed that the extract contains tertiary alkaloid, polyphenol, saponin, and essential oil. The antioxidant activity of the extract was recorded by using DPPH assay with the value of ES54 was 53,39 µg/mL. Keywords: Ruellia brittoniana, Acanthaceae, extract, antioxidant.

AKTIVITAS INHIBISI ASETILKOLINESTERASE EMPAT JENIS SAYURAN SECARA IN VITRO Maulita Cut Nuria; Elin Yulinah Sukandar; Asep Gana Suganda; Muhamad Insanu
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & farmasi Klinik Vol 16 No 1 Juni 2019
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTAcetylcholine is a conducting compound of nerve excitatory (neurotransmitter), while acetylcholinesterase is an enzyme that can hydrolyze the acetylcholine into choline and acetic acid. This reaction is needed so that the nerves can return to take a rest after the activation process, but it can cause damage to the cells in the brain. The most common case is dementia characterized by memory loss. The prevalence of this disease is lower in China and some other Asian countries compared to the United States. It supposed because food consumption commonly by Asians contain vegetables. Extracts derived from vegetables potentially inhibit the activity of acetylcholinesterase (AChE) enzyme which related to chemical contents of the plant. This research aims to investigate the inhibitory activity of acetylcholinesterase enzyme from 4 types of vegetables namely soybean sprouts (bean sprout of Glycine max (L.) Merr.), green bean sprouts (bean sprout of Vigna radiata), carrot (Daucus carota L.), and winged beans (Psophocarpus tetragonolobus (L.) DC.) by in vitro with the Ellman method. Total phenolic and flavonoids contents from fourth types of extracts were also determined. The winged beans extract had the smallest total phenolic and flavonoid contents, but the inhibitory activity against AChE was the biggest. The results showed that IC50 extract of winged beans was 893.86 μg/ml, IC50 carrot extract higher than 1500 μg/ml while the other extracts had no activity. The winged beans extract potential to be further developed as an inhibitor AChE.Keywords : inhibitor of acetylcholinesterase, IC50, vegetables

EFEK GASTROPROTEKTIF EKSTRAK ETANOL BUAH LABU KUNING (Cucurbita moschata (Duch.) Poir) PADA TIKUS JANTAN GALUR WISTAR YANG DIINDUKSI ASPIRIN Maulida Shofiatun; Ririn Lispita Wulandari
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 17, No 2 (2020): Jurnal Ilmu Farmasi & Farmasi Klinik Vol. 17 N0. 02 Desember 2020
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Non-steroidal anti-inflammatory drugs (NSAIDs) can cause side effects of gastric ulcers. Based on previous research, it is known that pumpkin contains flavonoids which can protect the gastric mucosa. The aim of this study was to determine the gastroprotective effect of ethanol extract of Cucurbita moschata (Duch.) Poir fruit in male rats Wistar-induced by aspirin. The study used a randomized matched posttest only control group design. Cucurbita moschata (Duch.) Poir fruit extraction was carried out by ultrasonic method. A total of 24 rats were divided into 6 groups: normal control (CMC Na 0,5%; ulcer control (CMC Na 0,5%); positive control (ranitidine HCl 10 mg/kg BW); treatment group (Cucurbita moschata (Duch.) Poir fruit ethanol extract at dose of 100, 200, and 400 mg/kg BW). Treatments lasted for 14 days. One hour after administering the test solution on the 14th day, all rats were given 200 mg/kg BW of aspirin (except normal controls) orally, then fasted for 12 hours. On the 15th day, all rats were sacrificed, dissected and their stomachs were taken. Gastric histology preparations were made with hematoxylin-eosin staining, microscopically read, discussed the number and severity of ulcers. Both data were processed and analyzed by Kruskal Wallis and Mann Whitney (95% confidence level). The results showed that the administration of EEBLK doses of 100, 200, and 400 mg/kg BW resulted in a score of the number and severity of ulcers that were lower significantly than of ulcer controls (p

PENELUSURAN POTENSI AKTIVITAS SITOTOKSIK FRAKSI KULIT BATANG TUMBUHAN FALOAK (Sterculia quadrifida R.Br) Rollando Rollando; Siswadi Siswadi
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI & FARMASI KLINIK VOL. 13 NO. 1 JUNI 2016
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT People on Timor island use Faloak (Sterculia quadrifida R.Br.) bark as herbal remedy to cure diseases such as liver diseases, gastroenteritis and as stamina booster. This study aims to analyze the ability of anticancer fraction of faloak bark ethanol extract. The mashed bark of faloak plants extracted by maceration method using ethanol. The ethanol extract fractionated using preparative thin layer chromatography with mixture mobile phase which, chloroform, n-butanol, ethyl acetate with ratio (3: 4: 1,5). Chromatogram detected with visible light, UV254, UV366, and cerium sulfate reagent, then marked. Fraction obtained five fractions. Cytotoxic test against T47D cell and Vero cell conducted using MTT, IC50 and selectivity sndex (SI) used as an anticancer efficacy parameter. Fraction 4 showed moderate anticancer activity with IC50 of 21.89 μg/mL in T47D cell line. Keywords: Faloak bark, anticancer activiy, T47D cell line

IDENTIFIKASI DAN ANALISIS KANDUNGAN MAKRONUTRIEN GLUKOMANAN UMBI PORANG (Amorphophallus onchophyllus) Bekti Nugraheni; Anastasia Setyopuspito P; Yustisia Dian Advistasari
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 15 No 2 Desember 2018
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTThe purpose of this study is identification and analysis of the macronutrient glucomannan from porang tuber (Amorphophallus onchopyllus). The stages done in this research are extraction, identification, and macronutrient analysis of glucomannan of the porang tuber. Prior to extraction, the oxalic acid was removed from porang tuber using mixture of 2% lime juice and 5% lime, then the glucomannans was extracted using ultrasonic method. The glucomannan then was identified using Fourier transform infra red spectrometer (FTIR) instrument and macronutrient analyzer such as Soxhlet method for fats and fibers, Kjedahl method for protein, and Antrone method for carbohydrates. The results of identification using FTIR showed the presence of β-pyranose at wave numbers of 900-810 cm -1 . The carbonyl on on acetyl group was found at 1726 cm-1 . The area between 870-800 cm-1 showed the β-glycosidic and β-manosidic compounds. The C-O ether group was shown in the area of 1260-1200 cm -1 , while for C-O alcohol was shown in the area of 1050 cm-1 showed the C-O bond in alcohol. At 2925 cm-1 it showed C-H, while at 3000-3700 cm-1 O-H group. The levels of porang glucomannan macronutrients included fat at 0.50%, protein at 1.05%, fiber at 22.34%, and carbohydrates at 31.33%.Key word: Porang tuber, glucomannan, FTIR, macronutrient analysis.

PERAN KONSELING APOTEKER TERHADAP PENGETAHUAN PENGGUNAAN OBAT DENGAN SEDIAAN KHUSUS DI KETANGGUNGAN – BREBES Muhammad Dwi Suprobo; Nia Fadillah
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 17, No 01 (2020): Jurnal Ilmu Farmasi & farmasi Klinik Vol 17 No. 01, Juni 2020
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Counseling is a precious job as known as pharmacists have a provide pharmaceutical services. Counseling given to the publics for drug therapy, treatment, and the drugs with special dosage form is very important to increase publics knowledge. The purpose of this study was to increase the awareness of pharmacists to counseling provide to the public, and increase the public knowledge when using the drugs with special dosage form in Ketanggungan – Brebes regency. Fifty respondents who participated in this study with observasional cohort design. The data collection in pre-test and post-test prospective. Analysis test used is non parametric t test using Wilcoxon alternative test. The last education status of respondents was dominated by Senior High School and the monthly visit to the pharmacy was less than five times as 27 respondents. The results obtained from this study are p = 0.001 and the mean difference is 11.22 with pre-test score mean was 27,54 and post-test was 38,76. There are significant results on the knowledge of the use of drugs with special dosage form after the pharmacist provides counseling. Keywords: pharmacist, counsleing, drugs, pharmaceutical care, knowledge

PENGARUH KOMBINASI BASIS PEG 400 DAN BASIS PEG 4000 DALAM FORMULASI SALEP EKSTRAK DAUN SUKUN (Artocarpus altilis) TERHADAP AKTIVITAS ANTIBAKTERINYA Sella_Arbi Nur_Ullya Dewi; Dewi Andini_Kunti Mulangsri; Mufrod Mufrod
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 15 No 2 Desember 2018
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTBreadfruit leaves contain flavonoid compounds that can inhibit the growth of Staphylococcus aureus bacteria. Breadfruit leaf extract is practical and effective formulated in ointment preparations. The base combination of PEG 400 and PEG 4000 decreases the melting point of PEG 4000, so that it is compatible and can increase the penetration of drugs in the skin. The objective of this study to determine the breadfruit leaf extract ointment with a combination of PEG 400 and PEG 4000 bases as well as antibacterial activity against Staphylococcus aureus bacteria. Breadfruit leaf extract (BLE) was obtained by maceration with 70% ethanol. Salve preparations were made into III formulas with variations in base concentrations of PEG 400 and PEG 4000, namely (F1) 75%: 25%, (F2) 50%: 50%, (F3) 25%: 75%, using the fusion method. Antibacterial activity test used agar well diffusion method. Kruskal Wallis test and Mann Whitney test used for analyzed data from antibacterial activity test. The ointment of Breadfruit leaves extract showed the color of brown ointment, semi-solid form, distinctive aroma of breadfruit leave. All of three ointment formulas have antibacterial activity indicated by the formation of inhibitory zones around the well. All of three ointment formulas have significant differences which means the combination of PEG 400 and PEG 4000 can affect antibacterial activity of BLE ointment. The higher of the concentration PEG 4000 compared PEG 400 caused inhibiton zone become smaller that means the potency of antibacterial decreased. The formula has the greatest antibacterial activity in the FI is 8,02mm.Keywords: breadfruit leaves, ointment, PEG 400 and PEG 4000, antibacterial

ANALISIS KARAKTERISTIK MUTU SABUN TRANSPARAN BEKATUL BERAS MERAH (Oryza nivara) BERBAHAN DASAR MINYAK GORENG BEKAS Maria Mita Susanti; Syela Puspitaningtyas
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 16, No 02 (2019): Jurnal Ilmu Farmasi & farmasi Klinik Vol 16 No 02 Desember 2019
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT The free radicals exposure from daily activities can cause the damage the skin, therefore to avoid this damage effect can use antioxidants compounds . Brown rice bran is rice milling waste which has high antioxidant with IC50 is 43,2349 ppm. Efforts to increase the economic value of rice bran high in antioxidant compounds is by processing rice bran into transparent soap products. This research was conducted to analyze the quality characteristics of transparent red rice bran soap (Oryza nivara) based on used cooking oil. The quality characteristics of transparent rice soap which includes organoleptic soap, pH, foam power, free alkali, and water content. The data were analyzed descriptively by comparing the results of research with SNI 06-3532 -1994 Based on the results of the study obtained the results of the characteristics of soap that meets the quality characteristics of SNI 06-3532-1994 soap requirements with a pH of 10,2 , foam power of 2,54 cm, free alkali of 0,034%, and 3,85% moisture content. Keywords : transparent soap, brown rice bran, used cooking oil, solid soap quality characteristics

EKSTRAK ETANOL DAUN SUJI (Pleomele angustifolia) TERENKAPSULASI NANOPARTIKEL KITOSAN DALAM SEDIAAN KRIM TABIR SURYA DENGAN VARIASI TWEEN 80-SETIL ALKOHOL Muhammad Ridho Putra Santosa; Malinda Prihantini
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 18, No 2 (2021): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Antioxidants in the ethanolic extract of suji leaves (Pleomele angustifolia) have the potential as a sunscreen. The use of chitosan in the nanoparticle system is able to protect the degradation of flavonoids due to the influence of temperature and light. Tween 80 and cetyl alcohol play a strategic role in the formation of cream preparations. The purpose of this study was to determine the characteristics of sunscreen cream with variations of Tween 80-cetyl alcohol containing the active ingredient of ethanol extract of suji leaves encapsulated in a nanoparticle system. Chitosan nanoparticles of suji leaf ethanol extract (KEEDS) were prepared using ultrasonic agitation. KEEDS nanoparticles were made into cream preparations with variations of Tween 80-cetyl alcohol (T80:SA) FI (3:3)%, FII (3:10)%, FIII (10:10)%. The formed cream was observed for organoleptic, homogeneity, type of cream, and measured the value of pH, spreadability, adhesion, viscosity, and sunscreen activity using a UV-Vis Spectrophotometer at a wavelength of 290–320 nm. Organoleptic data, homogeneity, pH and cream type were analyzed descriptively, while the spreadability, adhesion, viscosity and sunscreen activity were analyzed using ANOVA with 95% confidence limit. KEEDS nanoparticle cream visually looks homogeneous, with a brownish white color, soft texture, and the aroma of suji leaves. The pH value of the preparation is 4.74-4.88, the type of cream is O/W. The variation of the T80:SA combination resulted in significant differences in the values of dispersion, adhesion, viscosity and sunscreen activity between the three formulas (sig < 0.05).

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