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Jurnal Kedokteran
Published by Universitas Mataram
ISSN : 23015977     EISSN : 25277154     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
The Unram Medical Journal managed by the Medical Faculty of Mataram University is a scientific journal to publish the results of the latest research in the field of medical and health related. This journal promote medical sciences generated from basic sciences, clinical, and community research to integrate researches in all aspects of human health. This journal publishes original articles, reviews, and also case reports.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 408 Documents
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Karakteristik Pasien Ketoasidosis Diabetik Sebelum dan Saat Pandemi COVID-19 di RSUD Abdul Wahab Sjahranie Samarinda Muhammad Wiryansyah; Yuliana Rahmah Retnaningrum
Unram Medical Journal Vol 10 No 3 (2021): Jurnal Kedokteran volume 10 nomor 3 2021
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v10i3.554

Abstract

Background: The Corona Virus Disease-19 (COVID-19) pandemic has put obstacles in management of diabetes mellitus (DM) thus making patients more susceptible to complications, including diabetic ketoacidosis (DKA). DKA cases during the pandemic have been reported to increase and could be precipitated by COVID-19. This study aims to determine the characteristics of DKA patients before and during pandemic at Regional Public Hospital Abdul Wahab Sjahranie Samarinda Methods: This study uses a descriptive observasional design with total sampling method. The variables studied were demography, clinical, laboratory examination, and type of infection. Result: 59 patients were met the criteria (17 during pandemic vs 42 before pandemic). Adult age group (58,82% & 71,43%), female (64,7% & 66,67%), and DM type 2 (58,82% & 71,43%) were dominant in both groups. During the pandemic, cases of severe DKA were relatively high (82,35% vs 76,19%). Mortality was relatively decreased (23,52% & 45,23%), but still higher than other studies. Blood glucose levels, HbA1c, HCO3-, pCO2, anion gap, and leukocytes were relatively higher before the pandemic. Even so, we found higher levels of pH, ketonuria, urea, and creatinine during the pandemic. Among both group, almost all patients had history of infection that precipitate DKA (94,11% & 92,85%) with sepsis as the most common type of infection. However, we not found that Severe Acute Respiratory Syndrome-Corona Virus-2 (SARS-CoV-2) infection triggers DKA in this study. Conclusion: The COVID-19 pandemic has an impact on clinical and outcome of DKA patients
Prevalensi dan Karakteristik Pasien Katarak Senilis di RSUD Provinsi NTB Pada Periode Januari - Juni 2019 Cindra Indah Salsabila
Unram Medical Journal Vol 10 No 3 (2021): Jurnal Kedokteran volume 10 nomor 3 2021
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v10i3.563

Abstract

Background: Cataract is the leading cause of blindness in the world. WHO reported that cataract happens more often in the aging population (>50 years old). This study aims to determine the prevalence and the characteristics of senile cataract in RSUD Provinsi NTB from January of 2019 until June of 2019. Methods: This is a descriptive study with a cross-sectional design using data of the medical record. Population of this study is all cataract patient aged ?50 years old in RSUD Provinsi NTB during the study period and without a known history of eye trauma. Results: The prevalence of senile cataract in RSUD Provinsi NTB on January – June 2019 is 192 patients (70,6%). Based on the demographic characteristic, the most prevalent cases is in male (54,7%), aged 56-65 (45,3%), and lived in Mataram (37,5%). Based on the clinical characteristic, most of senile cataract cases is in bilateral of the eyes (60,4%), with uncorrected visual acuity <3/60 (43,3% right eye and 41,8% left eye), best corrected visual acuity <3/60 (42% right eye and 39,2% left eye) <3/60 and immature stage (66,7% right eye and 66,5% left eye) and from 192 patients, 123 of them have a comorbid disease. If it is associated between cataract stages and visual acuity, most of the eyes of cataract patients have an immature stage with moderate visual impairment (visual acuity <6/18-6/60). Conclusion: Based on this study, senile cataract is the most common type of cataract and most of the patients came with blindness.
PENGARUH TERAPI MUSIK TERHADAP HEMODINAMIK ANAK DENGAN LEUKEMIA idyatul Hasanah
Unram Medical Journal Vol 10 No 3 (2021): Jurnal Kedokteran volume 10 nomor 3 2021
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v10i3.571

Abstract

Background: Children with leukemia undergo various series of medical procedures during treatment. This can trigger physical and psychological responses in children. The physical reaction that may occur is hemodynamic changes. Music therapy is one of the complementary therapies that can be used to overcome these physical and psychological responses. This study aims to examine the effect of music therapy on hemodynamics in children with leukemia. Methods: This is a pre-experimental study with a one-group pre-test and post-test design. All children with leukemia who met the criteria underwent treatment in the ODC room of RSUP dr. Sardjito Yogyakarta, became the respondent. Hemodynamic measurements were taken before and after a music therapy session. Data were analyzed by paired t-test. Results: There were 30 children with leukemia who met the criteria. The mean systolic blood pressure before and after music therapy were 104±12.60 and 100±14.06 (p= 0.02). The mean diastolic blood pressure before and after music therapy were 67±10.65 and 65±10.83 (p=0.30). The mean pulse rate before and after music therapy were 92±16.19 and 87±16.75 (p=0.10), respectively. Conclusion: Music therapy can significantly reduce systolic blood pressure in pediatric patients with leukemia undergoing treatment but does not affect diastolic blood pressure and pulse rate.
Cisternografi Radionuklida Endah Indriani Wahyono
Unram Medical Journal Vol 10 No 3 (2021): Jurnal Kedokteran volume 10 nomor 3 2021
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v10i3.572

Abstract

Radionuclide cisternography is one of nuclear medicine imaging modality for dynamic analyses from cerebrospinal fluid. This examination selected if there is any contraindication for examination with convensional modality or if there is still any inconclusive findings with them. We present why, when, how, the procedure and clinical cases in this paper.
Antibodi Monoklonal Anti-CD3 Sebagai Terapi Diabetes Mellitus Tipe 1: Sebuah Kajian Sistematis dan Meta-analisis Visakha Vidyadevi Wiguna; Abiyyu Didar Haq; Luh Ade Dita Rahayu
Unram Medical Journal Vol 10 No 3 (2021): Jurnal Kedokteran volume 10 nomor 3 2021
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v10i3.580

Abstract

Introduction: Type 1 Diabetes Mellitus (T1DM) is a chronic autoimmune disease which marked by a persistent increase in blood glucose (hyperglycemia). T1DM is thought to be caused by an autoreactivity of T cell which mediates the apoptosis of insulin-producing cells in the pancreas. Those mechanism causes a life-long dependance on exogen insulin. Current immunotherapy strategy is inhibiting or deleting the lymphocyte subset and/or through the use of agents which will induce the tolerance by activating regulatory T cell such as the use of anti-CD3. Therapy using monoclonal antibody also has a continous effect as compared to immunosupressive agents that traditionally being used.Methods: A systematic review was conducted based on PRISMA through PubMed, ScienceDirect, Directory of Open Access Journal, Wiley, Cochrane Library, Google Scholar, and Scopus, searching for randomized controlled trials which analyze anti-CD3’s effects on clinical outcomes of T1DM patients. Studies selected were then assessed for bias risk with CONSORT criteria. Random-effects meta-analysis was performed to estimate the pooled mean difference (MD) along with their 95% confidence intervals (CIs).Results: The search yielded ten RCTs with a total of 1,458 subjects. Anti-CD3 intervention is proven to be effective in reducing insulin’s usage (MD -0,18 [95% CI: -0.22, -0.13],I2=59%, p<0,0001) and HbA1C (MD -0.71[95% CI: -1.18, -0.24], I2=78%, p=0.003) significantly. Furthermore, there is another clinical benefits, such as reducing the decrease of C-peptide response significantly. Conclusion: To conclude, anti CD-3 showed promising results to be widely implemented as treatment for T1DM patients.
UJI PENGGUNAAN PROTOTIPE BOARDGAME “TERMOSTED” DALAM MENINGKATKAN PENGETAHUAN MENGENAI DEMAM BERDARAH DENGUE PADA PELAJAR SEKOLAH DASAR DAERAH 3T DI KECAMATAN SUKAMULIA, LOMBOK TIMUR Putra Suartha
Unram Medical Journal Vol 10 No 3 (2021): Jurnal Kedokteran volume 10 nomor 3 2021
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v10i3.594

Abstract

Latar Belakang: Demam Berdarah Dengue (DBD) merupakan permasalahan kesehatan utama didunia. Di provinsi NTB telah tercatat 1.608 kasus DBD pada tahun 2017. Salah satu kabupaten yang memiliki angka kejadian DBD yang cukup tinggi di NTB yakni di Kabupaten Lombok Timur. Berbagai upaya telah dilakukan pemerintah Indonesia dalam menangani kasus DBD, salah satunya dengan mengintervensi anak SD. Dewasa ini, beberapa peneliti memiliki metode baru dalam memberikan penyuluhan kesehatan untuk anak-anak guna menanggulangi permasalahan DBD, yakni menggunakan boardgame. Tujuan dari penelitian ini yaitu untuk mengetahui efektifitas penggunaan boardgame “Termosted” dalam meningkatkan pengetahuan terkait penyakit demam berdarah dengue pada anak sekolah dasar daerah 3T di Kecamatan Sukamulia, Lombok Timur. Metode: Penelitian ini memakai rancangan analitik komparatif tidak berpasangan dengan pendekatan eksperimental. Subjek pada penelitian ini adalah 64 siswa yang terdiri dari kelas 4 dan kelas 5 SDN 2 Dasan Lekong dan SDN 3 Dasan Lekong menjadi 2 kelompok yaitu kelompok boardgame “Termosted” dan kelompok penyuluhan. Pengambilan data dalam penelitian ini yakni menggunakan kuesioner yang diberikan sebelum dan sesudah dilakukannya intervensi. Penelitian ini dilaksanakan dalam satu hari. Hasil: Pada nilai rata-rata ­pretest didapatkan hasil pa =0,005 yang artinya bahwa terdapat perbedaan bermakna nilai pengetahuan sebelum dilakukan intervensi sedangkan setelah dilakukan intervensi hasil pb =0,783 yang artinya tidak terdapat perbedaan signifikan antara nilai setelah dilakukannya intervensi pada kelompok boardgame dan kelompok penyuluhan. Berdasarkan selisih ­pre-post test pada kelompok boardgame dan kelompok penyuluhan didapatkan hasil pc =0,049 yang artinya bahwa terdapat perbedaan signifikan antara selisih pre-post test kelompok boardgame dan kelompok penyuluhan.
INTERLEUKIN-6 DAN POTENSI TERAPI INHIBISI INTERLEUKIN-6 DALAM TATA LAKSANA COVID-19 Fariz Nurwidya; Itsna Arifatuz Zulfiyah; Moulid Hidayat
Unram Medical Journal Vol 10 No 3 (2021): Jurnal Kedokteran volume 10 nomor 3 2021
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v10i3.595

Abstract

Infeksi SARS-CoV-2 dapat menyebabkan disregulasi respons imunitas tubuh yang menimbulkan sekresi sitokin proinflamasi yang berlebihan, menyebabkan kondisi yang disebut sebagai badai sitokin. Badai sitokin ini memiliki peran penting dalam progresi penyakit COVID-19 karena dapat menyebabkan disfungsi multi organ, gangguan koagulasi, dan kematian. Sitokin proinflamasi yang paling banyak mengalami peningkatan selama badai sitokin pada pasien COVID-19 adalah IL-6. Dari pengetahuan ini, peneliti mulai mencari tahu kemungkinan digunakannya terapi inhibisi IL-6 sebagai bagian dari tata laksana COVID-19. Tiga macam terapi inhibisi IL-6 yang sedang diteliti adalah inhibitor reseptor IL-6, antagonis IL-6, dan inhibitor JAK. Ketiga agen terapi inhibisi IL-6 ini terbukti dapat memperbaiki klinis dan mengurangi mortalitas pasien COVID-19 dengan gejala berat. Akan tetapi, pemberian terapi inhibisi IL-6 masih belum memberikan hasil yang konsisten pada pasien COVID-19 yang disertai dengan gejala kritis sehingga pemberian pada kelompok ini harus lebih hati-hati. Oleh karena itu, penelitian lebih lanjut mengenai efektivitas dan keamanan terapi ini harus tetap dilakukan.
Manajemen Terkini Amnesia Pasca Cedera Otak Lalu Wahyu Alfian Muharzami
Unram Medical Journal Vol 10 No 3 (2021): Jurnal Kedokteran volume 10 nomor 3 2021
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v10i3.596

Abstract

Cedera otak merupakan kerusakan jaringan otak mendadak yang disebabkan oleh proses traumatik dan tidak terdapat proses degeneratif maupun kongenital. Gangguan memori sering terjadi pasca cedera otak akibat adanya kerusakan struktur otak. Pada kondisi akut, pasien cedera otak sering mengalami amnesia pasca trauma. Amnesia pasca trauma merupakan kesulitan dalam mempelajari atau mengingat informasi baru maupun mengingat kejadian masa lalu yang terjadi setelah adanya cedera. Studi dilakukan dengan metode telaah literatur ilmiah dari berbagai situs seperti NCBI, Google Scholar, Google Search, Sciencedirect, dan researchgate dengan menggunakan kata kunci yang relevan seperti “post-traumatic amnesia”, “management of post-traumatic amnesia”, “therapy of post-traumatic amnesia”, “treatment of post-traumatic amnesia”. Setelah membaca judul dan abstrak, terdapat sebanyak 7 artikel penelitian yang sesuai dengan tujuan studi review ini. Berdasarkan 7 penelitian yang dianalisis, terdapat 4 terapi yang dapat diberikan kepada pasien cedera otak yang sedang dalam fase amnesia pasca trauma. Sebanyak 2 penelitian membahas tentang terapi latihan berdasarkan aktivitas sehari-hari, 2 penelitian membahas tentang terapi okupasi, terapi kognitif perilaku 1 penelitian, dan 2 penelitian membahas tentang pemberian terapi musik. Pada tahap akut perawatan terfokus pada kondisi vital pasien dan pencegahan terjadinya cedera sekunder. Perawatan pasien cedera otak yang mengalami amnesia pasca trauma diantaranya yaitu terapi okupasi dengan metode Activities of Daily Living (ADL), terapi okupasi dengan metode Perceive, Recall, Plan, and Perform (PRPP), terapi kognitif perilaku, dan terapi musik. Metode perawatan dapat dipilih berdasarkan kondisi pasien saat terapi, memungkinkan untuk diterapkan kepada pasien, dan terdapat sumber daya yang sesuai.
HBA1C SEBAGAI KANDIDAT BIOMARKER UNTUK PREDIKSI PROGESIVITAS GANGGUAN KOGNITIF TERKAIT DIABETES MELITUS TIPE 2 Putri Nurhayati; Achmad Mujahidin Irham; I Dewa Bagus Ketut Widya Pramana; Herpan Syafii Harahap
Unram Medical Journal Vol 11 No 1 (2022): vol 11 no 1
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v11i1.517

Abstract

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and hyperglycemia which underlie its complications, including cognitive impairment. T2dm-associated cognitive impairment is generally characterized by the decrease in at least one cognitive domain. However, its progression can be slowed by appropriate blood glucose control. Hb1Ac is a candidate of appropriate biomarker in predicting the progression of T2DM-associated cognitive impairment. This is based on several important characteristics it has, including a good blood glucose index, low daily biological variability, relatively unaffected by stress conditions, and unaffected by variations due to loading the amount of glucose.
Mikrobioma Kulit dan Peran Probiotik Pada Dermatitis Atopik Sonya Ananda Ellya John; Muhammad fahmi Tamami; Dedianto Hidajat
Unram Medical Journal Vol 11 No 1 (2022): vol 11 no 1
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v11i1.519

Abstract

Abstract Atopic dermatitis (AD) is a multifactorial inflammatory skin disease that has a high prevalence globally. Many underlying factors can be the occurrence of AD, one of which is an imbalance in the composition and diversity of the microbiome in the skin and gut or it can be called a condition of dysbiosis. Management and prevention of dysbiosis can be a treatment strategy in AD. Various studies have been conducted to see the effectiveness of using biotic products, such as probiotics, in the management strategy of AD. Based on available scientific evidence, this review discusses skin microbiome and the role of probiotics in AD. Keywords: atopic dermatitis, dysbiosis, microbiome, probiotic 1Medical Doctor Profession Education Program Faculty of Medicine University of Mataram 2Dermatovenereology Department, Faculty of Medicine University of Mataram / West Nusa Tenggara General Provincial Hospital Email : sonyaaej@gmail.com

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