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Pharmacon
Published by Universitas Muhammadiyah Surakarta
ISSN : 14114283     EISSN : 26855062     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Pharmacon: Jurnal Farmasi Indonesia is a collection of publication journals, covering all aspects of Pharmaceutical sciences, including Technology of Formulations, Excipients Optimization, Extract and Herbal Standardizations, Pharmacological activity determination on natural sources, Drug Synthesize and Development, Molecular Biology, Antibiotic Screening, Metabolite Profiling and Quantification, Clinical Pharmacy, Health and Environmental issues, published by Faculty of Pharmacy, Muhammadiyah University of Surakarta. We look forward to working with pharmaceutical community of researchers as we are intended to serve as a major resource for pharmaceutical information.
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Articles 345 Documents
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Front Matters Vol 17, No 2, 2020 Erindyah Wikantyasning
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 2 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

UJI TOKSISITAS AKUT DARI KOMBINASI EKSTRAK HERBA MENIRAN (Phyllanthus niruri auct. Non L.), DAUN TEMPUYUNG (Sonchus arvensis L.) DAN BIJI JINTEN HITAM (Nigella sativa L.) Muhtadi Muhtadi
Pharmacon: Jurnal Farmasi Indonesia Vol 12, No 2 (2011)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v12i2.35

Abstract

Telah dilakukan uji toksisitas akut pada tikus jantan dan betina dari kombinasi ekstrak herba meniran (Phyllanthus niruri auct. Non L.), daun tempuyung (Sonchus arvensis L.) dan biji jinten hitam (Coleus ambonicus Lour). Pengujian dilakukan dengan cara pemberian sediaan uji yang berupa kombinasi ekstrak dengan formula 1,5 : 3 : 1,5 dosis tunggal dengan peringkat dosis sebagai berikut: dosis I; 100 mg/kgbb, dosis II; 300 mg/kgbb, dosis III; 900 mg/kgbb, dosis IV; 2.700 mg/kgbb dan dosis V; 8.100 mg/kgbb. Kemudian dilakukan pengamatan gejala-gejala klinis yang timbul, perubahan berat badan per minggu dan histopatologi organ-organ vital yaitu: hati, ginjal, lambung, usus, limfa, jantung dan paru-paru. Pengamatan dilakukan selama 14 hari. Dari hasil penelitian dapat disimpulkan bahwa dosis tertinggi hingga 8100 mg/kgbb dari kombinasi ekstrak tersebut hampir tidak toksik terhadap tikus putih betina dan jantan galur SD. Kata kunci : uji toksisitas akut; kombinasi ekstrak; tikus jantan dan betina galur SD.
Aktivitas Sitotoksik Ekstrak Etanol, Fraksi Etanol, Etil-Asetat, dan Heksana Kulit Jeruk Purut (Citrus hystrix DC.) terhadap Sel Kanker Payudara T47D Isya Isma Nabilla; Peni Indrayudha
Pharmacon: Jurnal Farmasi Indonesia Vol 16, No 1 (2019)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v16i1.8173

Abstract

Kaffir lime peels (Citrus hystric DC.) have been reported that it has activity on HeLa cell. The purpose of this study was to determine the cytotoxic activity of ethanol extract, ethanolic, ethyl acetate, and hexane fraction of kaffir lime peels to T47D breast cancer cells and to identify the compounds of kaffir lime peels (Citus hystrix DC.). Extraction was done by maceration using 96% ethanol. The results of thick extracts were fractionated by the liquid-liquid partition method using solvent with different polarity, namely hexane, ethyl acetate, and ethanol. Cytotoxic activity tests were carried out using the MTT assay. Identification of compounds were carried out by Thin Layer Chromatography (TLC) method with silica gel GF 254 as a stationary phase. The mobile phase used was hexane:ethylacetate (6:4) for ethanol extract, ethyl acetate and hexane fractions, and hexane:ethylacetate (4:6) for ethanol fractions. IC50 ethanol extract, ethyl acetate and hexane fractions obtained were 268.49, 286.82, and 136.27 mg/mL respectively. Ethanol extract, ethyl acetate, and hexane fractions contain alkaloid, flavonoid, terpenoid and phenolic compounds, while the ethanol fraction contains only flavonoid compound. Cytotoxic results of ethanol extract, ethanol, ethyl acetate, and hexane fraction of kaffir lime peels did not active against T47D breast cancer cells.
Isolasi dan Uji Aktivitas Antioksidan Ekstrak Metanol Dari Buah Senduduk Bulu (Clidemia hirta (L.) D. Don) Haiyul Fadhli; Ihsan Ikhtiarudin; Putri Lestari
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 2 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i2.9846

Abstract

A study on isolation and antioxidant activity of secondary metabolit of methanol extract of fruit of Senduduk Bulu (Clidemia hirta (L.) D. Don) has been carried out. Senduduk bulu is used for folk medicine to many diseases. Flavonoid and phenolic has been reported to its activity as antioxidant. The aim of this research was to find antioxidant compound and antioxidant activity of this fruit. Isolation works were conducted using Vacuum Liquid Chromatography and Column Chromatography method. Antioxidant activity was determined using DPPH free radical scavenging methods. The isolation works afforded 10 mg of pure compound CHP1 which was obtained as white crystal, with its melting point of 165–167ºC, soluble in chloroform and slightly soluble in methanol. This compound gave positive reaction with Liebermann-Burchard (LB) reagent and concluded as terpenoid. Based on it UV spectrum, this compound showed a λ max of 316 nm. Its FT-IR spectrum showed appearence of some functional groups of OH, C-H aliphatic, C=O ester,C=C alkene, CH bending and C-O. The 1H-NMR spectrum showed the alkene protons and methyl protons which is a characteristic of terpenoid compounds. The pure compound (CHP1) provided a weak antioxidant activity with the IC50  of 327,01µg/mL.
Skrining Aktivitas Antibakteri Ekstrak Etanol 70% Sepuluh Daun Tanaman Terhadap Klebsiella Pneumoniae Nurul Qolbi; Ratna Yuliani
Pharmacon: Jurnal Farmasi Indonesia Vol 15, No 1 (2018)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v15i1.6169

Abstract

Klebsiella pneumoniae causes several diseases such as chronic obstructive lung disease and community pneumonia. The antibiotics used for treating the infectious diseases cause several side effects. Therefore, alternative medicines which have minimal side effects are needed. This research aimed to investigate antibacterial activity of ten ethanolic extract of leaves against K. pneumoniae, identify compounds and active compounds in extract which has the highest antibacterial activity. Compounds in leaves were extracted using 70% ethanol with maceration method. The disk diffusion method was used for screening antibacterial activity against K. pneumoniae. The identification of group of compounds in extract with the largest inhibitory zone diameter was done using Thin Layer Chromatography (TLC) and bioautographic test was performed to determine the active compounds. The results of antibacterial activity screening tests showed that all extracts have antibacterial activity except bamboo leaf extract. Breadfruit extract (Artocarpus altilis) has the highest antibacterial activity with diameter of inhibition zone of 18,33 ± 5,57 mm. Breadfruit extract contains tannin, polyphenol, alkaloid, terpenoid, saponin, and the active antibacterial compounds were terpenoid and saponin.
Optimalisasi Penggunaan Obat yang Bijak dalam Keluarga dengan Program Gema Cermat Handri Mursiti; Galau Menanti Embri; Ana Prasanti; Agnez Maysha; Vivin Rosvita; Yusuf Muamar Bashori; Yeni Farida
Pharmacon: Jurnal Farmasi Indonesia Edisi Khusus: RAKERDA, SEMINAR, PID IAI
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v0i0.10106

Abstract

Self-medication practices has been widely reported in various developed and developing countries which is increasing globally so that it may potentially causes various problems. WHO emphasized that education and supervision of self-medication practices are needed. The Indonesian Ministry of Health has launched the “GeMaCerMat” program to encourage public awareness and understanding of proper drug uses. This study aims to analyzed the effect of GeMaCerMat's socialization on community knowledge and behavior about the correct use of drugs through a family approach. Survey research was conducted using questionnaire instruments and interview respondents. Respondents are Surakarta’s people in the fostered area of the Agent of GeMaCerMat (AoC) which is determined by purposive sampling. The results of the knowledge assessment before and after the intervention were compared and the differences were analyzed by paired t tests. Among 206 respondents involved,  the results show that the average respondent has very less knowledge (52.48). Posttest value indicates an increase in knowledge of the average respondent to 80.24 (good). GeMaCerMat's socialization influenced peoples’s knowledge that prooven by significant differences between pretest and postest (P=0,000; P0,05).  Behavioral assessment shows that after socialization, the average respondent has good behavior (89.02%) in applying how to get drugs, use, store and dispose of drugs properly.
The Evaluation of Antibiotics Using to Pediatric Acute Upper Respiratory Tract Infection Patients at Health Centers in Kunduran Blora 2013 Tesar Zulmi Antoro; Nurul Mutmainah
Pharmacon: Jurnal Farmasi Indonesia Vol 14, No 1 (2017)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v14i1.551

Abstract

Acute respiratory tract infection is an acute infection which attacks one or more part of respiratory tractfrom nose to alveoli. This disease is an important society’s health problem especially in the developingcountries which attacks children easily especially who have low body’s immunity. This aim of the researchwas to know representation of the treatment and the accuracy of antibiotics distribution as the treatment ofpediatric patients of acute upper respiratory tract infection (AURTI) at Health Center in Kunduran, Blora2013 which is observed by appropriate parameter indication, appropriate drugs, appropriate dose andappropriate patients using the standard from WHO (2003). This research was categorized as qualitativeand non experimental research. In obtaining the data, the researcher trace the pediatric patient’s medicalrecord in the registration book in the health center Kunduran, Blora regency year 2013. The obtained datawas analyzed descriptively to evaluate the rationality of antibiotics distribution for AURTI. The researchresult showed that over 110 of the available samples in children aged up to 12 years old which werediagnosed as AURTI sufferer, 92 cases (83.63%) used amoxicillin antibiotics, 18 cases (16.37%) usedkotrimoksazol, 72 cases (65.50%) were proper indication, 59 case (53.63%) were proper drugs, 110 cases(100%) were proper patients, 87 case (79.09%) were proper dose, and 47 case (42.70) were rational in thetreatment
Evaluasi Penggunaan Antibiotik pada Balita Penderita Pneumonia Rawat Inap di RSUD “Y” di Kota “X” Tahun 2016 Panji 'Utsman; Hidayah Karuniawati
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.5991

Abstract

Pneumonia was pulmonary lung disease called parenchyma caused by microorganism, Pneumonia can be cured byantibiotic to prevent the resistantof bacteria and to improve the effective of the treatment, the right antibiotic must be determining. This research purpose is to determine the accuracy of using antibiotic in toddler patients suffering pneumonia who hospitalized in RSUD “Y” “X” City, in 2016. This is nonexperimental research. Data collected retrospectively and was analized descriptively. Samplestaken by purposive sampling method which searched the medical report of toddler patient suffer pneumonia hospitalized in RSUD “Y”X City, in 2016 which met the inclusion criteria. Reseach accuracy was analized used “Pedoman Pelayanan Medis Ikatan Dokter Anak Indonesia year 2009” and “British National Formularium for Children 2011-2012”, Such as indication accuracy, precision medicine accuracy, patient accuracy and drug dose accuracy. The result of the research was found that in 49 toddler patient suffering pneumonia, the kind of antibiotic used was cefotaxime (89,80%), Ampicillin (4,08%), combination of cefotaxime + gentamicin (4,08%) and ampicillin + gentamicin (2,04%). Evaluation of accuracy of the use antibiotic 100% right in indication, precision medicine by 93,87%,100% patient accuracy, and 10,20% drug dose accuracy.
UJI AKTIVITAS ANTIRADIKAL EKSTRAK ETANOL DAUN Elephantopus schaber L., Ocimum basilicum L.forma citratum Back., Graptophylum pictum Griff, dan Gynura procumbens Merr. DENGAN METODE DPPH (1,1- Difenil-2- Pikril Hidrazil) SERTA PENETAPAN KADAR FENOLIK TOT Muhammad Da'i; Astrina Dewi Ratnaningrum; Arifah Sri Wahyuni; Rosita Melannisa; Ika Trisharyanti Dian Kusuma
Pharmacon: Jurnal Farmasi Indonesia Vol 13, No 2 (2012)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v13i2.8

Abstract

Daun  Elephantopus schaber L. (tapak liman), Ocimum basilicum L.forma citratum Back., (selasih) Graptophylum pictum Griff (daun ungu), dan Gynura procumbens Merr. (sambung nyawa) memiliki kandungan kimia yang dapat berperan sebagai antiradikal, diantaranya adalah senyawa fenolik. Penelitian ini dilakukan untuk melihat korelasi kandungan fenolik total keempat daun terhadap aktivitas antiradikalnya. Sampel uji yaitu ekstrak etanol daun selasih, ungu, sambung nyawa, dan tapak liman ditentukan aktivitas antiradikal dengan menggunakan metode DPPH (1,1 difenil-2-pikrilhidrazil) kemudian dihitung nilai inhibitory concentration (IC50). Kandungan fenolik total ditentukan secara spektrofotometri menggunakan pereaksi Folin-Ciocalteu dan dihitung sebagai GAE (gallic acid equivalent) yaitu jumlah kesetaraan miligram asam galat dalam satu gram sampel. Penelitian menunjukkan ekstrak etanol daun selasih, ungu, sambung nyawa dan tapak liman memiliki aktivitas antiradikal dengan nilai IC50 berturut-turut 36,028; 54,998; 103,650; 252,857µg/mL dan kadar fenolik total berturut-turut 167,451; 147,064; 39,371 dan 20,539 mg/g sampel. Hasil penelitian secara keseluruhan menunjukkan ekstrak etanol daun selasih, ungu, sambung nyawa dan tapak liman berkorelasi positif terhadap aktivitas antiradikalnya.  Kata kunci: Antiradikal, DPPH, IC50, fenolik total, Elephantopus schaber L., Ocimum basilicum L.forma citratum Back., Graptophylum pictum Griff, Gynura procumbens Merr.
Perilaku Masyarakat dalam Pelaksanaan Protokol Kesehatan sebagai Upaya Pencegahan Covid-19 di Punggawan, Banjarsari Surakarta Rasmaya Niruri; Yeni Farida; Fea Prihapsara; Adi Yugatama; Siti Ma'rufah
Pharmacon: Jurnal Farmasi Indonesia Vol 18, No 1 (2021)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v18i01.12522

Abstract

The Covid-19 infection has spread to almost all regions of Indonesia. The government has issued a health protocol policy for the public in carrying out their activities to minimize the transmission of covid-19. This study aimed to obtain an overview of public compliance behavior in implementing health protocols as an effort to prevent Covid-19. The questionnaire survey was conducted at one of the pharmacies in the Banjarsari area of Surakarta for the period 14-30 September 2020. The research subjects were determined by purposive sampling method. The questionnaire contains 16 statement items covering the domain of social distancing, use of masks, maintaining hygiene and hand washing, and cough etiquette. Respondent behavior was classified into 2 categories, namely compliance and noncompliance. Respondent characteristic data (gender, age, and occupation) were tested for their relationship with compliance behavior. This study involved 54 respondents who were dominated by women (68.52%), age range 36- 45 years (37.18%), and work as private employees (37.04%). A study on 54 respondents showed that 51.85% of respondents had complied with the implementation of health protocols. Community non-compliance was still high in the domain of maintaining hygiene and cough etiquette. Gender, age, and occupation were not significantly related to respondent behavior.

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