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Elkawnie
Published by Universitas Islam Negeri Ar-Raniry Banda Aceh
ISSN : 24608912     EISSN : 24608920     DOI : -
Core Subject : Science, Engineering,
Biochemistry, Genetics & Molecular Biology Engineering
Elkawnie is a journal of Integration Science and Technology with Islam. It's covering research and technology in the field of study of Architecture, Biology, Chemistry, Environmental Engineering, ICT, Physical Engineering and other science and technology field. In particular, Elkawnie's journal discusses the development of research and technology in contributing to development as part of Muslim scientists in the academic sphere.
Arjuna Subject : Teknik (semua kategori) - Teknik (Lain-Lain)
Articles 15 Documents
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Search results for , issue "Vol. 6 No. 1 (2020)" : 15 Documents clear
An Assessment of Room Acoustics Performance of Baiturrahman Grand Mosque Laina Hilma Sari; Zulfian Zulfian
Elkawnie Vol. 6 No. 1 (2020)
Publisher : Faculty of Science and Technology Universitas Islam Negeri Ar-Raniry

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v6i1.5420

Abstract

Abstract : Acoustical design as part of the audio comfort influences the architectural design strategy of a mosque significantly. As belonging to the speech room criteria, a mosque should meet some acoustic room requirements to deliver the solemnness to the worshipper during the prayer. Concerning this, the study aims to assess the indoor acoustics performance of Baiturrahman Grand Mosque, Banda Aceh. Baiturrahman grand mosque is an important place of worship for Acehnese and becoming a landmark of Banda Aceh City. The mosque which contains a lot of history of Aceh was built in heavy construction, i.e. concrete wall, marble coated floor, and concrete dome ceiling. Due to its significance, the room acoustics of the mosque as the primary design considerations in a speech room type is evaluated. The acoustics parameters estimated are Noise Criteria (NC), Sound Pressure Level (SPL), Reverberation Time (RT), and Rapid Speech Transmission Index (RASTI). The background noise was recorded for delivering the noise criteria and being the primary data carried out in the acoustic simulation. The study utilised CATT-Acoustic v7.2 software for simulating predicting SPL, RT, and RASTI.Abstrak : Desain akustik merupakan bagian dari parameter audio yang mempengaruhi desain arsitektur masjid secara signifikan. Masjid termasuk dalam kategori speech room yang harus memenuhi beberapa persyaratan akustik ruang untuk dapat menghadirkan kekhusyukan kepada jamaah selama sholat. Penelitian ini bertujuan untuk menilai kinerja akustik dalam ruangan Masjid Raya Baiturrahman, Banda Aceh. Masjid Raya Baiturrahman adalah tempat ibadah yang penting bagi orang Aceh dan menjadi simbol Kota Banda Aceh. Masjid yang memuat banyak sejarah Aceh ini terbuat dari dinding beton, lantai berlapis marmer, dan langit-langit kubah beton. Pada studi ini, parameter akustik ruang yang dievaluasi adalah Kriteria Kebisingan (NC), Tingkat Tekanan Suara (SPL), Waktu Gema (RT), dan Indeks Transmisi kecepatan Bicara (RASTI). Kebisingan latar belakang direkam untuk memberikan kriteria kebisingan dan menjadi data primer yang dilakukan dalam simulasi akustik. Studi ini menggunakan perangkat lunak CATT-Acoustic v7.2 untuk mensimulasikan prediksi SPL, RT, dan RASTI.
Analysis of BKO Content (Antalgin and Dexamethasone) in Herbal Medicine Using Iodimetry Titration and HPLC Method Agus Dwi Ananto; Lalu Undrus Yusditia M. G; Lalu Sanik Wahyu F. A
Elkawnie Vol. 6 No. 1 (2020)
Publisher : Faculty of Science and Technology Universitas Islam Negeri Ar-Raniry

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v6i1.5428

Abstract

Abstract : Misuse of adding chemical drugs – BKO – into herbal medicines is often done by irresponsible people. The aim is to increase efficacy instantly, to attract consumer interest. BKO, which are often added to herbal medicine, are antalgin and dexamethasone. Antalgin content analysis was carried out quantitatively using the iodimetry titration method by conducting a preliminary test. The dexamethasone content analysis was carried out with qualitative and quantitative methods. The qualitative method was carried out using TLC. The quantitative method was carried out using the HPLC technique. The results obtained for the analysis of antalgin content of 10 samples were obtained two samples of herbal medicine containing antalgin, respectively 0,0749% and 0,1083%. Analysis of the dexamethasone content from 10 samples obtained 5 herbal samples containing dexamethasone respectively 0.0979%, 0.222%, 0.4521%, 0.5131% and 0.2809%. So based on these results, it is necessary to take action from the relevant institution regarding the discovery of the content of BKO in the herbal medicine on the market in Lombok.Abstrak : Penyalahgunaan penambahan bahan kimia obat (BKO) kedalam jamu sering sekali dilakukan oleh oknum yang tidak bertanggung jawab. Hal ini dilakukan dengan tujuan meningkatkan khasiat secara instan, sehingga dapat menarik minat konsumen. BKO yang sering ditambahkan kedalam jamu adalah antalgin dan deksametason. Analisis kandungan antalgin dlakukan dengan cara kuantitatif menggunakan metode titrasi iodimetri dengan melakukan uji pendahuluan. Sedangkan analisis kandungan deksametason dilakukan dengan metode kualitatif dan kuantitatif. Metode kualitatif dilakukan dengan menggunakan KLT. Metode kuantitatif dilakukan dengan menggunakan teknik HPLC. Hasil yang diperoleh untuk analisis kandungan antalgin dari 10 sampel didapat 2 sampel jamu yang mengandung antalgin masing-masing sebesar 0,0749% dan 0,1083%. Analisis kandungan deksametason dari 10 sampel diperoleh 5 sampel jamu yang mengandung deksametason masing masing sebesar 0,0979%; 0,222%; 0,4521%; 0,5131% dan 0,2809%. Sehingga berdasarkan hasil tersebut maka perlu dilakukan adanya tindakan dari instansi terkait perihal masih ditemukannya kandungan BKO dalam sediaan jamu yang beredar di pasaran pulau Lombok.
Effect of Ethanol Extract of Jamblang Aceh (Syzygium cumini) in Diabetic Mice (Mus musculus) and Its Potential As Anti-Diabetic Agent Ayu  Nirmala Sari; Januardi Januardi; Diky Setya Diningrat
Elkawnie Vol. 6 No. 1 (2020)
Publisher : Faculty of Science and Technology Universitas Islam Negeri Ar-Raniry

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v6i1.5496

Abstract

Abstract : This study was designed to evaluate the anti-diabetic activity of the ethanol extract of Syzygium cumini leaves in alloxan-induced diabetes mice. The anti-diabetic activity of EDS was investigated in mice (Mus musculus SW.) Alloxan-induced diabetes. The effect of ethanol extract of Syzygium cumini leaves on normal blood glucose levels and oral glucose tolerance tests were studied in normoglycemic mice while the anti-diabetic effect was evaluated in alloxan-induced hyperglycemic mice. Ethanol extract of Syzygium cumini leaves (200 and 400 mg/kg) is given orally for 21 days. Glibenclamide (5 mg/kg, oral for 21 days) is used as a reference standard. Giving ethanol extract of Syzygium leaves causes a significant decrease in blood glucose levels in normoglycemic and hyperglycemic mice and also increases glucose tolerance test. Ethanol extract of Syzygium leaves reduces glycosylated hemoglobin levels, lactate dehydrogenase, and creatinine kinase in alloxan-treated mice. Ethanol extract of Syzygium leaves also improves TBARS oxidative stress parameters, catalase and superoxide dismutase activity and glutathione levels. The ethanol extract of Syzygium cumini leaves shows anti-diabetic activity through increased insulin secretion and this effect can be attributed to the content of flavonoids and phenolic compounds present in the ethanol extract of Syzygium cumini leaves.Abstrak : Penelitian ini dirancang untuk mengevaluasi aktivitas anti-diabetes dari ekstrak etanol daun Syzygium cumini (L) Skeels (EDS) pada mencit diabetes yang diinduksi aloksan. Aktivitas anti-diabetes EDS diselidiki pada mencit (Mus musculus SW.) diabetes yang diinduksi aloksan. Pengaruh ekstrak etanol daun Syzygium cumini (EDS) pada kadar glukosa darah normal dan uji toleransi glukosa oral dipelajari pada mencit normoglikemik sedangkan efek antidiabetik dievaluasi pada mencit hiperglikemik yang diinduksi aloksan. EDS (200 dan 400 mg/kg) diberikan secara oral selama 21 hari. Glibenclamide (5mg/kg, oral selama 21 hari) digunakan sebagai standar referensi. Pemberian EDS menyebabkan penurunan signifikan dalam kadar glukosa darah pada mencit normoglikemik dan hiperglikemik dan juga meningkatkan uji toleransi glukosa. EDS mengurangi kadar hemoglobin glikosilasi, laktat dehidrogenase, dan kreatinin kinase pada mencit yang diberi aloksan. EDS juga memperbaiki parameter stres oksidatif TBARS, aktivitas katalase dan superoksida dismutase dan kadar glutathione. Ekstrak etanol daun Syzygium cumini (EDS) menunjukkan aktivitas antidiabetik melalui peningkatan sekresi insulin dan efek ini dapat dikaitkan dengan kandungan flavonoid dan senyawa fenolik yang ada dalam ekstrak daun.
The Effect of Applied Voltage in The Electrocoagulation Process of Reducing Pond and River Water Turbidity Masthura Masthura
Elkawnie Vol. 6 No. 1 (2020)
Publisher : Faculty of Science and Technology Universitas Islam Negeri Ar-Raniry

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v6i1.5538

Abstract

Abstract : The study about the effect of the applied voltage to decrease the water turbidity from local pond and river have been conducted. This study aims to investigate the ability of the electrocoagulation process in removing pollutants containing groundwater from the pond and river. The water sample obtained from Dusun I Paya Perupuk Tanjung Pura in Langkat Regency. Indonesia which has been reported having high water turbidity. A copper plate was used as a sacrificial electrode with a specific variation of applied voltage of 6, 9, and 12 Volts. The result showed that applying 9 and 12 volts of voltages were able to reduce 60% and 66% of water turbidity from water pond, respectively. In river water, both optimum applied voltages could reduce approximately 98% of water turbidity. The result indicated that the electrocoagulation process potentially devoted as an alternative way to treat the massive local groundwater.Abstrak : Penelitian mengenai pengaruh tegangan listrik terhadap penurunan kekeruhan air sumur dan air sungai pada proses elektrokoagulasi telah dilakukan. Penelitian ini bertujuan untuk mengetahui kemampuan proses elektrokoagulasi dalam menghilangkan polutan yang berada di air yang diperoleh dari air sumur dan air sungai. Sampel air diperoleh dari Dusun I Desa Paya Perupuk Tanjung Pura Kabupaten Langkat. Lapisan plat tembaga (Cu) digunakan sebagai elektroda dengan variasi spesifik voltase sebesar 6, 9, dan 12 volts. Hasil menunjukkan bahwa pemberian voltase 9 dan 12 dapat menurunkan kekeruhan air sumur sebesar 60 dan 66%. Pada sample air sungai, pemberian kedua voltase optimum dapat menurunkan 98% dari kekeruhan air. Hasil penelitian mengindikasikan proses elektrokoagulasi berpotensi sebagai sebuah cara alternative untuk mengolah air.
The Characterization of Oyster Shell (Crassostrea gigas) as Adsorbent in The Removal of Cr(VI) Ions. A Study of NaOH and H2SO4 Activation Effect Lia Handayani; Cut Rahmawati; Nurhayati Nurhayati; Yayuk Astuti; Adi Darmawan
Elkawnie Vol. 6 No. 1 (2020)
Publisher : Faculty of Science and Technology Universitas Islam Negeri Ar-Raniry

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v6i1.5543

Abstract

Abstract : Oyster shell as one of the highest bio-waste in Alue Naga Aceh Besar District, Indonesia, was used as an adsorbent to remove a heavy metal Cr (VI) ion. The study was started by calcinating oyster shells at a high temperature of 800 ºC for 3 hours. The effect of various acid (H2SO4) and base (NaOH) activator was studied using characterization and adsorption experiments. The characterization obtained the sample activated by 10% NaOH (Na10-ACT) and 10% H2SO4 (H10-ACT) had the highest surface area which had 14.23 m2/g, 10.77 m2/g, respectively. Furthermore, the adsorption experiments confirmed the highest surface area by showing the highest Cr (IV) ion removal of 57.66%, 70.7%, respectively. The further investigation using X-ray fluorescence (XRF) determined that the Na10-ACT adsorbent has a better composition compared to the H10-ACT due to its high purities.Abstrak : Cangkang tiram sebagai salah satu bio-limbah padat di Desa Alue Naga Kabupaten Aceh Besar, digunakan sebagai adsorben untuk menghilangkan ion logam berat Cr (IV). Penelitian ini diawali dengan mengkalsinasi cangkang tiram pada temperatur tinggi 800ºC selama tiga jam. Pengaruh penambahan aktivator asam (H2SO4) dan basa (NaOH) juga dipelajari melalui karakterisasi dan pengujian adsorpsi. Hasil karakterisasi menunjukkan sampel yang diaktivasi dengan 10% NaOH (Na10-ACT) dan 10% H2SO4 (H10-ACT) memiliki luas permukaan tertinggi yaitu 14,23 m2/g, 10,77 m2/g, masing-masing. Lebih lanjut, pengujian adsorpsi juga mendukung luas permukaan yang tinggi dengan menghilangkan ion Cr (IV) sebesar 57,66%, 70,7%, masing-masing. Investigasi melalui analisa XRF menyimpulkan bahwa Na10-ACT memiliki komposisi yang lebih baik dibanding H10-ACT karena memiliki kemurnian yang tinggi.
Integrated Email Management System Based Google Application Programming Interface Using OAuth 2.0 Authorization Protocol Zuhar Musliyana; Andita Ghaitsa Satira; Mahendar Dwipayana; Ayu Helinda
Elkawnie Vol. 6 No. 1 (2020)
Publisher : Faculty of Science and Technology Universitas Islam Negeri Ar-Raniry

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v6i1.5545

Abstract

Abstract : Google Apps is a service provided by Google that allows users to use Google products with their own domain names. Among the products offered by Google Apps are email (Gmail), Docs (Google Drive), and Classroom services. In addition, Google Apps also provides Application Programming Interface (API) services that can be used by developers to take advantage of various features provided by Google. Universitas Ubudiyah Indonesia (UUI) is one of the universities that use Google Apps service for managing student emails. At present, UUI student email management through Google Apps is still not integrated with academic information system data. As a result, UUI must allocate special resources for managing student emails manually. Based on these problems, this study proposes an integration system for UUI student email management using the Google Apps API. This system is designed using PHP programming. The Google Apps API authentication method uses OAuth 2.0. The results of this study indicate that student email management on Google Apps can be done through campus academic information systems. With this system, students can activate email independently without having to be registered manually to the Google Apps page by the campus email managers.Abstrak : Google Apps adalah sebuah layanan yang disediakan oleh Google yang memungkinkan pengguna dapat menggunakan produk google dengan nama domain sendiri. Di antaranya produk yang disediakan Google Apps yaitu layanan email (Gmail), dokumen (Google Drive), dan Classroom. Selain itu, Google Apps juga menyediakan layanan Application Programming Interface (API) yang dapat dimanfaatkan oleh pengembang untuk memanfaatkan berbagai layanan yang disediakan oleh Google. Universitas Ubudiyah Indonesia (UUI) merupakan salah satu universitas yang menggunakan layanan Google Apps untuk pengelolaan email mahasiswa. Saat ini pengelolaan email mahasiswa UUI melalui Google Apps masih belum terintegrasi dengan data sistem informasi akademik. Akibatnya UUI harus mengalokasikan sumber daya khusus untuk mengelola email mahasiswa secara manual. Berdasarkan permasalahan tersebut penelitian ini mengusulkan sistem integrasi pengelolaan email mahasiswa UUI menggunakan API Google Apps. Sistem ini dirancang menggunakan pemograman PHP. Metode autentikasi API Google Apps menggunakan OAuth 2.0. Hasil penelitian ini menunjukkan pengelolaan email mahasiswa pada Google Apps dapat dilakukan melalui sistem informasi akademik kampus. Dengan adanya sistem ini mahasiswa dapat melakukan aktivasi email secara mandiri tanpa harus didaftarkan secara manual ke halaman Google Apps oleh pengelola email kampus.
Estimation of Orangutan Population in Sibongkaras Pakpak Bharat Village Forest Area Juhardi Sembiring; Taufiq Siddiq Azvi
Elkawnie Vol. 6 No. 1 (2020)
Publisher : Faculty of Science and Technology Universitas Islam Negeri Ar-Raniry

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v6i1.5549

Abstract

Abstract : Orangutan is classified as an endangered species. Forest clearance for a variety of purposes and functions over the region led to the limited habitat for orangutans. Orangutans habitat is fragmented into several regions led to the survival of a population of a species depends on habitat conditions. Performing a nest survey is important to give a deeper understanding of the ecology and help determine the best protective management measures. We provide basic data of orangutan density and orangutan nesting characteristics in protected forest area Sibongkaras village. This study was conducted in April 2019 until June 2019 in protected forest area Sibongkaras village, Pakpak Bharat. Tracking begins with observed the presence of a nest based on a purposive sampling method. And data retrieval was done by line transect method. Data analyzed at Universitas Nahdlatul Ulama Sumatera Utara. Our result showed that the orangutan population density was 0.0072 individuals/km2 or 0.72 individuals/ha. The dominant position of the nest is in a position which is a position I nest close to the main stem of the tree with the nest number 13 (43.3%). Generally, the nest is found at an altitude of  >15 meters with a sum of 27 nests (90%).Abstrak : Orangutan diklasifikasikan sebagai spesies yang terancam punah. Penebangan hutan untuk berbagai tujuan dan fungsi di kawasan tersebut menyebabkan terbatasnya habitat orangutan. Habitat orangutan yang terfragmentasi menjadi beberapa wilayah menyebabkan kelangsungan hidup suatu populasi suatu spesies tergantung pada kondisi habitat. Melakukan survei sarang penting untuk memberikan pemahaman yang lebih dalam tentang ekologi dan membantu menentukan langkah-langkah manajemen perlindungan terbaik. Kami menyediakan data dasar kepadatan orangutan dan karakteristik sarang orangutan di kawasan hutan lindung Desa Sibongkaras. Penelitian ini dilakukan pada bulan April 2019 hingga Juni 2019 di kawasan hutan lindung Desa Sibongkaras, Pakpak Bharat. Pengamatan dimulai dengan mengamati keberadaan sarang berdasarkan metode purposive sampling. Dan pengambilan data dilakukan dengan metode transek garis. Data yang diperoleh di analisis di Universitas Nahdlatul Ulama Sumatera Utara. Hasil Penelitian kami menunjukkan kepadatan populasi orangutan di 0,0072 individuals/km2 atau 0,72 individu / ha. Posisi sarang yang dominan adalah pada posisi sarang yang berada di posisi paling dekat dengan batang utama, dengan jumlah sarang 13 (43,3%). Umumnya sarang ditemukan di ketinggian > 15 meter dengan jumlah 27 sarang (90%).
Inhibition of α-Glucosidase Activity and The Toxicity of Tristaniopsis merguensis Griff. Leaf Extract Robby Gus Mahardika; Occa Roanisca; Fajar Indah Puspita Sari
Elkawnie Vol. 6 No. 1 (2020)
Publisher : Faculty of Science and Technology Universitas Islam Negeri Ar-Raniry

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v6i1.5732

Abstract

Abstract : This study aims to determine the antidiabetic activity and toxicity of the acetone extract of Tristaniopsis merguensis Griff leaf. The antidiabetic test was the α-glucosidase inhibition method, while the toxicity test used the Brine Shrimp Lethality Test (BSLT) method. The acetone extract possessed antidiabetic activity with an IC50 value of 8.83 ± 0.31 (μg/mL). This value is not much different from the positive control of quercetin which has an IC50 value of 6.04 ± 0.14 (μg/mL). The characteristics of the FT-IR spectrum of acetone extract showed that Tristaniopsis merguensis leaf has the groups Ar-OH (phenolic), -OH (hydroxyl), C=O (ketone) and C=C (aromatic). Based on the toxicity test, the Tristaniopsis merguensis leaf acetone extract has an LC50 value of 959.25 ppm which means that the acetone extract is toxic. Therefore, the acetone extract of Tristaniopsis merguensis might be the potential agent of antidiabetic.Abstrak : Penelitian ini bertujuan untuk mengetahui aktivitas antidiabetes dan toksisitas dari ekstrak aseton daun Tristaniopsis merguensis Griff. Uji aktivitas antidiabetes ditentukan berdasarkan metode inhibisi enzim α-glucosidase, sedangkan toksisitas ditentukan berdasarkan metode Brine Shrimp Lethality Test (BSLT). Ekstrak aseton memiliki aktivitas antidiabetes dengan nilai IC50 8,83 ± 0,31 (μg/mL). Nilai ini tidak jauh berbeda dengan kontrol positif quersetin yang memiliki nilai IC50 6,04 ± 0,14 (μg/mL). Karakteristik spektrum FT-IR ekstrak aseton menunjukkan bahwa daun Tristaniopsis merguensis memiliki gugus fungsi Ar-OH (fenolik), -OH (hidroksil), C=O (keton) dan C=C (aromatik). Berdasarkan uji toksisitas, ekstrak aseton daun Tristaniopsis merguensis memiliki nilai LC50 sebesar 959,25 ppm yang berarti bahwa ekstrak aseton bersifat toksik. Oleh karena itu, ekstrak aseton dari Tristaniopsis merguensis berpotensi untuk dijadikan agen antidiabetes.
Usability Evaluation of Islamic Learning Mobile Applications Syeda Hamna Bibi; Rumsha Muhammad Munaf; Narmeen Zakaria Bawany; Arifa Shamim; Zara Saleem
Elkawnie Vol. 6 No. 1 (2020)
Publisher : Faculty of Science and Technology Universitas Islam Negeri Ar-Raniry

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v6i1.5920

Abstract

Abstract : The trend of using mobile devices for the purpose of learning is gaining momentum. Apart from traditional education, various applications are being developed for religious learning. Pakistan is inhabited by around 98% of Muslims.  Hence, the informal learning of Islam is essential for Muslim child development. This research presents a usability study of different Islamic learning mobile applications available on the android platform for children. The purpose of this research is to evaluate the usability of different Islamic learning mobile applications for children of diverse age groups in order to understand what design principles must be followed that increase the usability of the application. The main focus of this research is to observe and evaluate how easily children of different age groups respond to different applications, how effectively the children understand the core features of the applications and how easily they are able to use the application by themselves. 
Anticancer Activity of N-Hexane Extract from Sphagneticola trilobata (L.) J.F Pruski Against MCF-7 Breast Cancer Cell Vivi Mardina; Tisna Harmawan; Halimatussakdiah Halimatussakdiah; Syafruddin Ilyas; Masitta Tanjung
Elkawnie Vol. 6 No. 1 (2020)
Publisher : Faculty of Science and Technology Universitas Islam Negeri Ar-Raniry

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v6i1.6183

Abstract

Abstract : Sphagneticola trilobata (L.) J.F. Pruski is one of the perennial herbs that is widely used by the national and international community to treat various diseases including cancer. The objective of this study was to assessment the anticancer activity of n-hexane extract of S. trilobata leaves for inhibiting the growth of MCF-7 breast cancer cells in vitro by MTT (microculture tetrazolium salt) method. The n-hexane extract of sernai leaves was obtained from the maceration process of samples that were collected from the Langsa city, Aceh. The cytotoxicity test was carried out by incubating MCF-7 cells which had been exposed to several series of sample levels, viz. 1000; 500; 100; 50; 25; 10; 5 and 1 µg/mL. LC50 values are calculated using probit analysis. The results revealed that the n-hexane extract of S. trilobata leaves was cytotoxic against breast cancer cells (MCF-7) with an LC50 value of  0.037 μg /mL.Abstrak : Sphagneticola trilobata (L.) J.F. Pruski merupakan salah satu tanaman herbal yang digunakan secara luas oleh masyarakat nasional dan internasional untuk mengobati berbagai penyakit termasuk kanker. Penelitian ini bertujuan untuk mengetahui aktivitas antikanker ekstrak n-heksana daun S. trilobata dalam menghambat pertumbuhan sel kanker payudara MCF-7 secara in vitro dengan metode MTT (microculture tetrazolium salt). Ekstrak n-heksana daun sernai diperoleh dari proses maserasi sampel yang dikoleksi dari kota Langsa, Aceh. Uji sitotoksisitas dilakukan dengan menginkubasi sel MCF-7 yang telah dipaparkan beberapa seri  kadar sampel yaitu 1000, 500, 100, 50, 25, 10, 5 dan 1 µg/mL. Nilai LC50 dihitung dengan menggunakan analisa probit. Hasil penelitian menunjukkan bahwa ekstrak n-heksana daun S. trilobata bersifat sitotoksik terhadap sel kanker payudara (MCF-7) dengan harga LC50 sebesar 0,037 µg/mL. 

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