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Majalah Obat Tradisional

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Published by Universitas Gadjah Mada

ISSN : 14105918 EISSN : 24069086 DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology Public Health

raditional Medicine Journal (Majalah Obat Tradisional), or Trad. Med. J. (ISSN 1410-5918 (print) and ISSN 2406-9086 (online)), is an international scientific journal published by Faculty of Pharmacy, Universitas Gadjah Mada, three times annually. Collaborating with Indonesian Pharmacist Association, Daerah Istimewa Yogyakarta, and we dedicate our journal to researches and development in traditional medicine. The journal receives papers on research laboratory, field research, and case studies of traditional medicine and its constituent, covering research topics including raw materials, cultivation, phytochemical, pharmacological effects and toxicology, formulation, and biotechnology.

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Articles 10 Documents

Search results for , issue "Vol 23, No 1 (2018)" : 10 Documents clear

Microemulsion Formulation of Combination of Virgin Coconut Oil and Rice Bran Oil for Hair Growth Wira Noviana Suhery; Mira Febrina; Ivone Permatasari
Majalah Obat Tradisional Vol 23, No 1 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Research on micro emulsion formulation of combination of virgin coconut oil (VCO) and rice bran oil (RBO) as a hair growth promoter has been done. The purpose of this study was to formulate and produce the best formula that is physically stable and optimally promoting the hair growth by varying the content of VCO and RBO in the form of micro emulsions. These dosage formulations were prepared in three formulas using 45% tween 80 as surfactants and 20% glycerin as co surfactant i.e.: F,I containing a combination of VCO and RBO 1:1; FII (1:2) and FIII (2:1). Physical evaluation of the preparation was carried out for 8 weeks of storage which included organoleptic examination, pH, homogeneity, density, globule particle size, phase freeze thaw, and rabbit hair growth activity test for 18 days. Based on the results of the evaluation, it was found that the FI, FII and FIII micro emulsion formulations were physically stable for 8 weeks of storage with a pH ranging from 6.7 to 7.0, density of 1.085-1.088 g/mL, average globul particle size of FI (34.6 nm ), FII (54 nm) and FIII (68.8 nm). The best formulas is FIII for hair growth length of 1.26 cm for 18 days.

Anti-Tuberculosis Activity of Extract Ethyl Acetate Kenikir Leaves (Cosmos caudatus H.B.K) and Sendok Leaves (Plantago Major L.) By In Vitro Test Tatang Irianti; Sylvia Utami Tanjung Pratiwi; Kuswandi Kuswandi; Nanan Tresnaasih; Dharmastuti Cahya; Fatmarahmi Fatmarahmi; Yulia Paramitha
Majalah Obat Tradisional Vol 23, No 1 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

The increasing therapy problem including multidrug-resistant tuberculosis (TB) has made it important to discover a new anti-TB drug candidate. The aim of this study was to acknowledge the activity of ethyl acetate extracts of kenikir (Cosmos caudatus H.B.K) and sendok (Plantago major L.) leaves against Mycobacterium tuberculosis (M. tuberculosis) H37Rv. This research used Middlebrook (MB) 7H9 media and observed the growth of M. tuberculosis using Lowenstein Jensen (LJ) media. The concentration of extracts were 0.25 mg/ml, 0.50 mg/ml, and 1.00 mg/ml. The result of this study showed that ethyl acetate extracts exhibited anti-TB activity in 1000 µg/ml of both extracts. The active compound group was detected by thin layer chromatography (TLC) and the separation of compounds was shown by retardation factor (Rf) and the color of the spots. Based on TLC chromatograms, it is known that there are types of compounds, such as ortho-dihydroxy compounds, phenolic compounds, and compound leads to terpenoids for both extracts.

Correlation Between Total Flavonoid Contents and Macrophage Phagocytosis Activity of Fractions From Faloak (Sterculia quadrifida R.Br.) Barks Ethanolic Extract In Vitro Rima Munawaroh; Siswadi Siswadi; Erna Prawita Setyowati; Retno Murwanti; Triana Hertiani
Majalah Obat Tradisional Vol 23, No 1 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

On Timor island, Nusa Tenggara Timur, faloak barks (Sterculia quadrifida R.Br.) has been used empirically to restore stamina. Faloak bark ethanolic extract proved to have immunomodulatory activity in vitro, which can increase macrophage phagocytosis activity. This research aimed: (i) to determine the immunomodulatory active fraction of faloak bark ethanolic extract, (ii) to determine the total flavonoid contents of faloak extract and fractions, and (iii) to evaluate the correlation of the total flavonoid contents of those extract and fractions with their macrophage phagocytosis activity. The simplisia powder is macerated with 96% ethanol. The extract was dissolved in methanol:water (9:1v/v) was then subsequently partitioned with n-hexane, ethyl acetate, and water to obtain n-hexane fraction, ethyl acetate fraction, water fraction, and insoluble fraction. Faloak extract and fractions at concentration 62,5; 125; 250; 500μg/mL were tested for their effect on the peritoneal macrophage phagocytosis of Balb/c mice in vitro by the latex beads method. Phagocytosis capacity and phagocytosis index were analyzed using one-way anova and post hoc Tukey HSD test with 95% confidence level. The results showed that ethyl acetate fraction had the highest macrophage phagocytosis capacity and the highest total flavonoid content compared to other fractions. The highest macrophage phagocytosis capacity of ethyl acetate fraction at concentration of 250 μg/mL was 51,94±4,67%, this value was significantly different from cell control (7,50±1,29%), negative controls of 0,0625% dimethylsulphoxide (6,25±0,36%), as well as positive control of 200 μg/mL echinaceae extract syrup® (9,97±0,33%). The total flavonoid content of ethyl acetate fraction determined by aluminum chloride method was 4,290±0.029 mg of quercetin equivalent/g fraction. There was a positive and strong correlation between the total flavonoid content of these extract and fractions with their macrophage phagocytosis capacity (Pearson correlation coefficient of 0,781) and showing linear relationship y=4,721x+19,663; R2=0,61.

Optimization Formula Tablet Extract of Bengkuang (Pachyrrhizus erosus) Variation Avicel® Ph 101 and Crospovidone Rizki Kharisma; Ika Puspita Sari; Angi Nadya Bestari
Majalah Obat Tradisional Vol 23, No 1 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Bengkuang (Pachyrrhizus erosus) contains daidzein which is pro-estrogenic compound, suppressing bone restoration by directing mechanism in bone estrogen receptor. Bengkuang can be developed into a useful source of phytoestrogens as a supplement in menopausal women. This study aims to determine the stability and influence of Avicel® PH 101 and crospovidone on granular flow properties and physical properties of Bengkuang tuber extract. Bengkuang tuber extracts were made into tablet preparations by wet granulation method. Variation of crospovidone composition was between 2-5%, while Avicel® PH 101 was between 38.86 to 41.86%. The tablet formulation is optimized using the Simplex Lattice Design method. The results show that the addition of Avicel® PH 101 can improve the index of determination, water absorption, moisture content, hardness, time of disintegration, and friability of the tablet, as well as crospovidone addition. Avicel® PH 101 and crospovidone interactions increase water content, decrease hardness, and tablet friability. The optimum tablet formula consists of composition of 293 mg of Avicel® PH 101 and 14 mg of crospovidone per tablet. Testing of optimum formula results with SLD method did not differ significantly to the response of the compression index, hardness and friability of the tablet. The tablet was stable at room temperature (30ºC ± 2 ºC) for four weeks.

Macroscopy and Microscopy Study of Scopraia dulcis L. Djoko Santosa; Subagus Wahyuono; Sugeng Riyanto; SM Widyastuti
Majalah Obat Tradisional Vol 23, No 1 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

A morphological diversity analysis of Scoparia dulcis by macroscopy and microscopy has been conducted. The aim of this research is to determine the morphological and anatomical character of S. dulcis which grow in Opak watershed, Special Region of Yogyakarta. Samples were taken from Sleman (Cangkringan, Ngemplak Kalasan, and Prambanan) and Bantul (Imogiri and Pundong) region. Selection of sampling location is based on altitude difference. The samples are the third leaf order from the tip of the stem. They were measured in length and width. Microscopy analysis was performed by observing the number of glandular trichomes, palisade cells in the epidermis and stomata in the upper and lower epidermis. The data obtained were analyzed using principal component analysis (PCA). The results show that based on morphological and anatomical assessment, there were found 3 clusters of S. dulcis, i.e. Cangkringan-Ngemplak-Prambanan, Kalasan, and Imogiri-Pundong cluster.

Identification of ɤ-Aminobutyric Acid (GABA) in Loloh as A Potential Drink as Antihipertension I Gusti Ayu Wita Kusumawati; Ni Made Indri Sugiantari; I Gede Ariyasa; Ida Bagus Agung Yogeswara
Majalah Obat Tradisional Vol 23, No 1 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Loloh sembung (Blumea balsamifera) is a functional drink that is widely consumed by Balinesse people and exhibit health-promoting effect. The purpose of this study was to identify GABA of loloh sembung which has physiological effect as antihypertensive. Proximate analysis was performed to determine nutritional value content of loloh sembung. Atomic Absorption Spectrophotometric (AAS) method was employed to determine potassium and sodium content, and identificatio of ɤ-aminobutyric acid (GABA) using Thin Layer Chromatography (TLC) method. In this study, water content of loloh sembung was 99.2324%, ash 0.0117. Fresh sembung leaves have water content 83.8112%, ash content 2.0617%, protein 0.9659%, fat 2.850%, and carbohydrate 10.3109%. Loloh sembung contained sodium, 51.65 mg/L and potassium 1353.10 mg/L. Subsequently, fresh sembung leaves contained sodium 579.72 mg/L and pottasium 1353.19 mg/L respectively. In this study, GABA was detected in loloh sembung and has promising prospect as antihypertensive-functional drink.

The usage of Jati Leaves Extract (Tectona grandis L.f) As color of lipstick Rety Setyawaty; Meldina R. Pratama
Majalah Obat Tradisional Vol 23, No 1 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Lipstick is one of the most used cosmetics by women. According to Tranggano and Latifah (2007), lipstick is a cosmetic applied to the lips, to protect the lips in cold and dry air so that the lips are not easy to dry and crack. Lipstick is used by women for a long time so that lipstick should be safe and do not cause irritation. Chemicals substances in the manufacture of lipstick can accidentally be consumed and long-term use so that its accumulation in the body would be harmful to health. Synthetic lipstick color is one part of the dangerous lipstick making material. Synthetic substances can be replaced with natural dyes. The use of natural dye limits on cosmetics is 5-15% (Mercado, 1991). One example of natural dyes that can be used is the dye from the Jati leaves (Tectona grandis L.f). This study aim is to prove that Jati leaves (Tectona grandis L.f) can be used as a natural dye in the material of lipstick. The method used in this research is the method of extraction maceration with jati leaf samples of 300 grams and ethanol of 96%. Component of lipstick formula which are cera alba, lanolin, vaseline, cetyl alcohol, paraffin solid, oleum ricini, oleum rosae, propylene glycol, butyl hydroxytoluene, methyl paraben, and the addition Jati leaf extract under the concentration of 0%, 18% , and 22%. The material of lipstick is easy to apply, stable, brown color, homogeneous, melting point of 600C, range pH between 3 at 4 and lipstick have a breaking point of 500 grams. Jati leaf extract (Tectona grandis L.f) can be used as a dye or color of lipstick.

Antifibrotic Effect of Ethanolic Extract of Nerium indicum Mill. Standardized 5α-Oleandrin on Keloid Fibroblasts Cells Mae Sri Hartati Wahyuningsih; Fara Silvia Yuliani; Dwiki Yuliya Rahmawati; Annisa Nurul Pratiwi
Majalah Obat Tradisional Vol 23, No 1 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Keloid is a skin lesion caused by an abnormal proliferation of fibroblasts and the deposition of collagen in the wound healing process. Therapy for keloids is relatively limited and mostly has side effects. Recent studies show that 5α-oleandrin from N. indicum Mill. (N. indicum) has anti-keloid effect by inhibiting (proliferation, migration activity and TGF-β1 expression) keloid fibroblast. Further studies with N. indicum extract standardized 5α-oleandrin should be conducted to develop it as an anti-keloid agent by performing at proliferative effects, collagen accumulation, and keloid fibroblast migration. The antifibrotic activity of N. indicum extract on the proliferation of keloid fibroblasts was measured by MTT assay, whereas collagen deposits were observed by Sirius Red method. Observation of keloid fibroblast migration by scratch assay is according to Liang et al. (2009). Ethanol extract of N. indicum standardized 5α-oleandrin can inhibit the proliferation of keloid fibroblas with IC50 0.458 μg/mL, also inhibited collagen deposits with IC50 0.055 μg/mL at incubation for 72 hours. In incubation 48 hours after treatment with ethanol extract of 1.0 μg/mL occurred inhibition of migration significantly compared with control.

Wound Healing Activity of Ethanolic Extract Gel of Tawas Ut Tuber (Ampelocissus rubiginosa L.) in Incisional Model Wistar Rats Khoerul Anwar; Dewita Fitri Widodo; Nurlely Nurlely; Liling Triyasmono; Sudarsono Sudarsono; Agung Endro Nugroho
Majalah Obat Tradisional Vol 23, No 1 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Tawas ut tuber (Ampelocissus rubiginosa Lauterb.) is empirically used in wound healing by Dayak community. The present study was undertaken to assess wound healing activity of gel from ethanol extract of A. rubiginosa tuber using parameters of the closure of wound length, tensile strength, and histopathological observations. This study used twenty-five male Wistar rats divided into five groups: positive control (Bioplacenton®), negative control (placebo gel), and three of testing groups with gel extract (concentrations of 1.5%, 2.0%, and 2.5%). Wound healing activity was evaluated to 4 cm length and ± 2 mm depth incision wound model on the back skin of rats. The measurement of wound length was observed on the day of 4th, 8th, 12th, 16th, and 20th used quantitative analyze. On the day of 20th, animal was anaesthetized and the skin has been taken for tensile strength evaluation and histopathological observations. This study showed that group treated with gel extract at the concentration of 2.5% experienced higher wound healing activity with average percentage of wound closure of 99.00% ± 0.16, tensile strength 3.8541 gram/mm2, and proved with the re-epithelization, neocapillarization, and increase collagen density appeared in histopathological observations. Based on this study, gel from ethanol extract of A. rubiginosa tuber possesses wound healing activity.

Optimizing Formula of Fast Disintegrating Tablet of Belimbing Wuluh Leaf Extract with Crospovidone and Croscarmellose Sodium as Superdisintegrant Citra Ariani Edityaningrum; Tantri Sofia Fauziah; Zainab Zainab; Hardi Astuti Witasari
Majalah Obat Tradisional Vol 23, No 1 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Averrhoa bilimbi L. leaves can be used as an antidiabetic in the presence of flavonoid. Antidiabetic drugs were widely consumed by elderly patients who often had difficulty in consuming conventional tablets. Research in developing formulations of an antidiabetic drug that is capable of rapid disintegration and quickly dissolves when placed on the tounge is necessary, therefore it is formulated in fast disintegrating tablet dosage forms. The research aimed to formulate FDT of ethanol extract of Averrhoa bilimbi L. leaves with variation of superdisintegrant crospovidone and croscarmellose sodium. Fast disintegrating tablet of Averrhoa bilimbi L. leaves extract was manufactured by direct compression. Furthermore, the tablet was evaluated with physical properties and the results were analyzed using Design expert 10.1.3 program to bring in simplex lattice design (SLD) equation to get the optimum formula. Data which had been obtained was then analyzed byone sample test with confidence interval 95%. Based on the research results, the combinations of crospovidone and croscarmellose sodium was able to reduce the response of physical properties such as weight variation, hardness, friability, disintegration time, and wetting time. The optimum formula consist of 6.8 mg crospovidone and 12.2 mg croscarmellose sodium which resulted in 4.41 kg of hardness response, 0.59% of friability, 11.21 seconds of wetting time, and 3,85 seconds of disintegration time. Analysis of one sample t-test showed that there was no significant difference between the parameter values predicted results with the results of the research, so it can be concluded that SLD equation can be used to develop a formula that gives optimum parameters of FDT.

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Pudyastuti Kusumaningrum

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Kab. sleman,

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