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Majalah Obat Tradisional

TradMedJ
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Published by Universitas Gadjah Mada

ISSN : 14105918 EISSN : 24069086 DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology Public Health

raditional Medicine Journal (Majalah Obat Tradisional), or Trad. Med. J. (ISSN 1410-5918 (print) and ISSN 2406-9086 (online)), is an international scientific journal published by Faculty of Pharmacy, Universitas Gadjah Mada, three times annually. Collaborating with Indonesian Pharmacist Association, Daerah Istimewa Yogyakarta, and we dedicate our journal to researches and development in traditional medicine. The journal receives papers on research laboratory, field research, and case studies of traditional medicine and its constituent, covering research topics including raw materials, cultivation, phytochemical, pharmacological effects and toxicology, formulation, and biotechnology.

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Articles 564 Documents

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IDENTITAS MAKROSKOPI, MIKROSKOPI, KIMIAWI, RIMPANG C. Mangga, C. Zedoaria, DAN K. Rotunda Sri Mulyani; Novia Dwi Nugraheni; Hendri Marinda Sari; A. Zulvita Anani Siswondo
Majalah Obat Tradisional Vol 18, No 2 (2013)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Zingiberaceae plants in Indonesia has been widely used as traditional medicine, such as Curcuma mangga, C. zedoaria, and Kaempferia rotunda. These three plants known as the temu putih. This study aims to determine the chemical content, macroscopic and microscopic characteristics, in order to obtain characteristics of each of these plants as an aid for identification. Macroscopic examination is conducted by observing the characteristics of the rhizome in both fresh and dried state, while the microscopic examination is done by observing the microscopic characteristics of the powder and fresh rhizome. Examination of the essensial oil is conducted to determine phytochemical compound by using GC-MS method. Result shown these three specimens, macroscopically have different taste and smell. Microscopically, these three specimens have different cork thickness, secrete cell colors, and different amylum size. As identity compound, for C. mangga, C. zedoaria, and K. rotunda oils are mirsena, germakrona and benzilbenzoat respectively.

PENGARUH TRAGAKAN SEBAGAI PENGIKAT TERHADAP SIFAT FISIK TABLET HISAP EKSTRAK JAHE (Zingiber officinalle Roxb.) Wintari Taurina; Yandi Syukri; Asih Triastuti
Majalah Obat Tradisional Vol 18, No 2 (2013)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Ginger (Zingiber Officinale Roxb.) is a traditional plants usually used to relieve pain, rheumatism, and neutralize poison. The aim of this study was to get the optimum concentration of tragacanth as a binding agent in ginger lozenges formulation. The components from ginger were extracted using percolation with ethanol 70% and then evaporated using rotary evaporator. Lozenges were made in three formulas ; formula 1 (5%), 2 (7,5%), 3 (10%) of tragacanth using wet granulation method. Granules and tablets were tested for its physical properties, and analyzed using Pearson correlation. The result showed that, all of three formulas were good, comply with a regulation of physical properties and soluble time in the mouth. Variation of tragacanth concentration affected physical properties of tablets. It showed that the greater concentration of tragacanth, the larger the hardness and the longer the soluble time of tablets. The formula (tragacanth 10% b/v) gave an optimum physical properties and soluble time of tablets, with weight variety deviation 0,98%, hardness 10,18 kg, friability 0.11% and soluble time 11.50 minutes. The three formulas were received by respondens with prerequirement of improving sweetness, repairing form and the color of tablets.

INTERAKSI SENYAWA AKTIF DARI Aegle marmelos CORREA SEBAGAI ANTI INFLAMASI DENGAN RESEPTOR COX-1 DAN COX-2 Dani Dwi Agistia; Hari Purnomo; Maulana Tegar; Agung Endro Nugroho
Majalah Obat Tradisional Vol 18, No 2 (2013)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

The compounds in Aegle marmelos have an activity as anti inflammation. The objective of this study is to evaluate six active compounds in Aegle marmelos Correa, (E,R)- Marmin, skimmianine, (S)-aegeline, aurapten, zeorin, and dustanin as anti inflammation to the COX-1 and COX-2 as target receptors. Method: Molecular docking was done with PLANTS. Ligand preparation used MarvinSketch, and protein preparation was done by using YASARA. The result was marmin, skimmianine, aegeline, aurapten, zeorin, and dustanin have interaction with Arg120, tyr 355, and Ile 523 in COX-1 and Ser353, Arg 513, and Ser 530 in COX-2. Based on the result of molecular docking, active compounds in Aegle marmelos Correa have potency as anti inflammation agent.

SENYAWA ANTIBAKTERI BIS (2-ETILHEKSIL) ESTER DAN TRITERPENOID DALAM EKSTRAK n-HEKSANA DAUN TEMPUYUNG (Sonchus arvensis L.) I Made Sukadana; Sri Rahayu Santi
Majalah Obat Tradisional Vol 16, No 1 (2011)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Isolation of antibacterial compounds from n-hexane extract of tempuyung leaf (Sonchus Arvensis L.) has been carried out. n-hexane extract (9,15 g) showed antibacterial inhibition zone of 9 mm on Staphylococcus aureus and 8 mm on Escherichia coli at concentration of 1000 ppm. Fractionation of n-hexane extract using column chromatography resulted on 5 fractions (F1, F2, F3, F4, and F5). Antibacterial test of the fractions toward Staphylococcus aureus and Escherichia coli showed that fraction F2 and F4 positive toward Staphylococcus aureus and Escherichia coli. Fraction F3 showed just positive toward Escherichia coli while fraction F5 just positive toward Staphylococcus aureus. Further separation using preparative thin layer chromatography (TLC) technical resulted in 3 fractions (F4.1, F4.2 and F4.3 fractions), in which F4.1 fraction indicates the most active inhibition growth test again bacterial with diametric inhibition zone of 9 mm towards Staphylococcus aureus and 11 mm for Escherichia coli within concentration of 100 ppm. Gas Chromatography–Mass Spectroscopy (GC-MS) was employed in order to identity the F4.1 fraction. From WILEY7 database, it was identified that isolate are mixture of 2 compound components namely bis (2-ethylhexyl) ester and possibility of new compound included triterpenoid group with molecule formula C32H66O6.

PENGARUH PRAPERLAKUAN JUS KUBIS BUNGA (Brassica oleracea L. var botrytis L.) TERHADAP AKTIVITAS DIKLOFENAK DALAM TERAPI INFLAMASI Endang Sri Sunarsih; Dwi Hadi Setya Palupi; Indriati Hapsari
Majalah Obat Tradisional Vol 16, No 1 (2011)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

A drug therapy together with food consumption could influence the drug effectiveness. This research aimed to know the influence of cauliflower (Brassica oleracea L. var botrytis L.) juice pretreatment on diclofenac activity in inflammation therapy to wistar white male rats. Thirty rats divided into 6 groups randomized design. Group I (negative control) was only given aquadest, while group II (positive control) was given treatment with sodium diclofenac orally and the dose was 5,04 mg/kg BW. Group III was given pretreatment cauliflower juice with the dose of 20 ml/kg BW. It was given one hour before treatment with sodium diclofenac. Group IV was given pretreatment cauliflower juice with the dose of 20 ml/kg BW and it was given one day before treatment with sodium diclofenac. Group V was given pretreatment cauliflower juice with single dose 20 ml/kg BW for 3 days before treatment with sodium diclofenac, and group VI was given pretreatment cauliflower juice with single dose 20 ml/kg BW for 5 days before treatment with sodium diclofenac. Thirty minutes after treatment with sodium diclofenac, the rat’s paw was injected with 1% carrageenan 0,10 ml subplantary. Edema volume was measured from 0th hour to 5th hour after carrageenan injection used the pletismometer. The result of statistic analysis of AUC and DAI data have shown that cauliflower juice pretreatment given one hour before treatment with sodium diclofenac did not show significant different with positive control. The research showed that cauliflower juice pretreatment for 3 and 5 days was capable to reduce antiinflamation activity of diclofenac, therefore inflammation therapy with diclofenac was not maximum.

UJI SITOTOKSISITAS, ANTIPROLIFERATIF, DAN PENGARUHNYA TERHADAP EKSPRESI P53 DAN BCl2 DARI FRAKSI ETANOL INFUSA DAUN TEH (Camellia sinensis (L.) O.K.) TERHADAP SEL HeLa Laela Hayu Nurani
Majalah Obat Tradisional Vol 16, No 1 (2011)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Tea (Camellia sinensis (L.) O.K.) is one of medical plant traditionally used by society as anticancer. The aim of this research is to evaluate the citotoxic and antiproliferative effect of ethanolic fraction of tea (Camellia sinensis (L.) O.K.) and its effect on P53 and bcl-2. Tea were collected and extracted by infundation and fractioned with ethanol as solvent. Citotoxicity test was done by incubating HeLa cell at a density of 2.104 with treatment using extract in concentration of 250; 125 ; 62,5; 31,25; 15,63; and 7,81 µg/mL during 24 hours. Antiproliferative test were done by calculating doubling time which was equaling a life cell on treatment sample concentration 31,25 µg/mL; 15,63 µg/mL; 7,81 µg/mL; and 3,91 µg/mL with cell control at 24, 48 and 72 hours. Imunohistochemistry assay was used in LC50 with p53 and bcl-2 antibody. P53 and bcl-2 expression is compared to control. The result indicated that ethanol fraction of tea (Camellia sinensis (L.) O.K.) leaf infuse has citotoxicity effect on HeLa cell with LC50 of 24,45 µg/mL. The result of doubling time test indicated that doubling time value for a solvent control is 74,11 hours and a cell control is 78,22 hours. While, with treatment 31,25 µg/mL; 15,63 µg/mL; 7,81 µg/mL; and 3,91 µg/mL resulted on negative slope then did not produce doubling time. The extract can induce p53 expression and inhibit bcl-2 expression compared to control.

PENAPISAN AKTIVITAS ANTIOKSIDAN DAN BEBERAPA TUMBUHAN OBAT INDONESIA MENGGUNAKAN RADIKAL 2,2-DIPHENYL-1 PICRYLHYDRAZYL (DPPH) Dewi Wulansari; Chairul Chairul
Majalah Obat Tradisional Vol 16, No 1 (2011)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Antioxidant is a compound useful to prevent oxidative damage generated by free radical in human body, thus protecting body from many diseases. The aim of this research is to investigate antioxidant activity of some Indonesian medicinal plants. A total of 37 methanolic extracts of Indonesian plants have been screened for their antioxidant activity by in vitro method using the free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH). Vitamin C was used as positive control. Of the samples investigated, 29 exhibited radical scavenging properties more than 50% at 1000 ppm. Five extracts exhibited high activities i.e. bark extracts of Sapium baccatum and Leucosyke capitellata, leaves extracts of Ardisia crispa, Glochidion cauliflorum, and Glochidion superbum.

UJI EFEK ANALGETIKA EKSTRAK RIMPANG TEMU KUNCI (Boesenbergia pandurata (Roxb.) Schlechter PADA MENCIT JANTAN GALUR SWISS Lina Winarti; Wantiyah Wantiyah
Majalah Obat Tradisional Vol 16, No 1 (2011)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

This research is conducted to evaluate analgetics effect of Boesenbergia pandurata (Roxb.) Schlechter extract using Witkin et al method. This method is conducted to see the elimination effect of pain after the administration of acetate acid by intraperitoneal injection to swiss furrow male mice. Pain effect by the administration of acetate acid causing stomach wall contraction, till the head and feet pulled rear and abdomen touch the cage room base. This symptom is named by writhing reflex and this symptom can be eliminated with an analgesic. Analysis was done by comparing the amount of writhe that happened after the giving of Boesenbergia pandurata (Roxb.) Schlechter extract with acetosal as positive comparator and aquadest as negative control. Writhing effect calculated during 30 minute after the administration of acetate acid by intraperitoneal injection. Boesenbergia pandurata (Roxb.) Schlechter extract between dose 15; 30 and 60 mg / kgBW have significant difference ( P<0.05). In the dose-effect relation it can be seen that more higher the dose give more higher effect. The amount of writhing in Boesenbergia pandurata (Roxb.) Schlechter extract dose 30 mg / kgBW not significantly differ with Acetosal, while Boesenbergia pandurata (Roxb.) Schlechter extract dose 15 mg / kgBW and 60 mg / kgBW have significant difference with Acetosal. Boesenbergia pandurata (Roxb.) Schlechter extract dose 15 mg / kgBB showing the amount of writhing larger than Acetosal and Boesenbergia pandurata (Roxb.) Schlechter extract dose 60 mg / kgBB has amount of writhing fewer than Acetosal. From the calculation of protection percentage administration significant difference between group. Boesenbergia pandurata (Roxb.) Schlechter extract dose 30 mg / kgBW and 60 mg / kgBW do not show significant difference with Acetosal. While from effectiveness percentage analysis also showing significant difference between group except Boesenbergia pandurata (Roxb.) Schlechter extract dose 30 mg / kgBW with Acetosal 130 mg / kgBW. So from overall of analysis resulting that analgetics activity of Boesenbergia pandurata (Roxb.) Schlechter extract start from dose 30 mg / kgBW have effective effect to reduce the pain induced with acetatic acid which equivalent with Acetosal as positive control. More great the dose give higher activity. From this research the dose of Boesenbergia pandurata (Roxb.) Schlechter extract 60 mg / kgBW have analgetics activity stronger than Acetosal

PENGARUH KADAR FENOLIK PADA DAUN TEH Camelia xinensis L. TERHADAP PREFERENSI EMPOASCA SP. (Homoptera : Cicadellidae) Saiful Saiful; Sudarsono Sudarsono
Majalah Obat Tradisional Vol 18, No 2 (2013)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Phenolic compounds are secondary metabolites found in all parts of the plants aree.g.:fruits, barks, roots, and leaves of plants serve as chemical defenses as repellent against insects and herbivorous detterent. On tea leaves, the results of research gallocatechin (a derivate of catechin) was functioning known as mechanism of resistance to Empoasca sp. (Homoptera: Cicadelliadae). The aim of this research was to know the total phenolic content of the young tea leaf (Camelia sinensis L.) and it was to found out the effect of the phenolic compounds of preference Empoasca sp. The results obtained that the clone of “Pasir Sarongge” (PS) had total phenol content (polyphenol average ± SD) 25,69 ± 0,1 higher than Kiara clone 18,47 ± 0,13. The higher the polyphenol in the young tea leaf bud could be act as Empoasca sp. Detterent.

FORMULASI MOUTHWASH MINYAK ATSIRI DAUN KEMANGI (Ocimum basilicum L.) SERTA UJI ANTIBAKTERI DAN ANTIBIOFILM TERHADAP BAKTERI Streptococcus mutans SECARA IN VITRO Ardiana Dewi Yosephine; Martha Purnami Wulanjati; Teuku Nanda Saifullah; Puji Astuti
Majalah Obat Tradisional Vol 18, No 2 (2013)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Basil leaves (Ocimum basilicum L.) contain essential oil that have been reported to have antibacterial activity. Based on this antibacterial activity, basil oil can be developed as mouthwash to prevent a dental plaque. This study aims to investigate the influence of tween 80 (as emulsifying agent) and glycerin (as stabilizer) on physical characteristics of the mouthwash, the ratio between tween 80 and glycerin for best stability, and in vitro antibacterial and antibiofilm activity of the mouthwash against Streptococcus mutans. Basil oil was extracted by water and steam distillation, then was formulated into mouthwash with a variation amount of tween 80 and glyserin. Antibacterial and antibiofilm activities weretested with micro dilution method. Result of study showed that tween 80 gives significant increase on viscosity and glycerin on specific mass when they were added at more than 2.5 mL in 50 mL mouthwash. From five formulas, formula with ratio of tween 80 and glycerin = 3.75 mL : 1.25 mL was found to be the best. Basil mouthwash showedin vitro antibacterial and antibiofilm activities against Streptococcus mutans. This product had MIC of 0.1 % v/v with 87,50 ± 3,33 % of bacterial inhibition. The MIC of biofilm formation and biofilm degradation was 0.1 % v/v and 0.2 % v/v, with % inhibition and degradation of 77,52 ± 0,82 % and 57,64 ± 6,09 %, respectively.

Page 34 of 57 | Total Record : 564

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