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Majalah Obat Tradisional

TradMedJ
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Published by Universitas Gadjah Mada

ISSN : 14105918 EISSN : 24069086 DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology Public Health

raditional Medicine Journal (Majalah Obat Tradisional), or Trad. Med. J. (ISSN 1410-5918 (print) and ISSN 2406-9086 (online)), is an international scientific journal published by Faculty of Pharmacy, Universitas Gadjah Mada, three times annually. Collaborating with Indonesian Pharmacist Association, Daerah Istimewa Yogyakarta, and we dedicate our journal to researches and development in traditional medicine. The journal receives papers on research laboratory, field research, and case studies of traditional medicine and its constituent, covering research topics including raw materials, cultivation, phytochemical, pharmacological effects and toxicology, formulation, and biotechnology.

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Articles 564 Documents

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FORMULASI TABLET HISAP EKSTRAK DAUN JAMBU BIJI (Psidium guajava L.) YANG MENGANDUNG FLAVONOID DENGAN KOMBINASI BAHAN PENGISI MANITOL-SUKROSA Yohanes Juliantoni; Mufrod Mufrod
Majalah Obat Tradisional Vol 18, No 2 (2013)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Flavonoid compounds found on the leaves of the guava are known to have an antibacterial activity. The aim of this study is to formulate an acceptable guava leaf extract preparations. Extract of guava leaves was formulated into several dosages of lozenges in combination with fillers manitol-sucrose. A Simple method of Lattice Design was used to know the influence of the combination physical properties of granule and lozenges and also predicting which formula is optimal. The extract was made by maceration of simplisia using ethanol 70%, thickened and then dried using the tool freeze dryer. The lozenges was created in 5 formula based on a combination of sucrose: manitol, F1 (0%: 100%); F2 (25% 75%); F3 (50%: 50%); F4 (75%: 25%); F5: 25% (75%) using a 5% aqueous gelatin as a binder. The dried granule then mixed with a lubricant and tested for the properties such as free flowing. The resulting lozenges were tested of its uniformity of weight, hardness tested tablets, fragility and responses to the taste. Simple lattice equation design and optimum formula predicted using Design software Expert version 8.0.5.2. Changes in the proportion of sucrose-manitol combinations affect the physical properties of granule and lozenges. Based on an analysis using the Design software Expert version 8.0.5.2, the optimal formula is given by a combination of manitol-sucrose 82,28%: 17.72%.

PENETAPAN KADAR ALKALOID DARI EKSTRAK ETANOLIK BUNGA KEMBANG SEPATU (Hibiscus rosa-sinensis L.) Mimiek Murrukmihadi; Subagus Wahyuono; Marchaban Marchaban; Sudibyo Martono
Majalah Obat Tradisional Vol 18, No 2 (2013)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Kembang sepatu flower (Hibiscus rosa-sinensis L.) was fractionally used as expectorant. Based on Bioassay Guided fractionation, an active fraction was separated, and the fraction was identified is Alkaloid was the major compound based on TLC analysis. Viscosity value measured by viscometer was used as a Bioassay model of expectorant activity in vitro and asetyl cysteine was used as positive control. Alkaloid content determination of the ethanolic extract was measured by TLC-Densitometric compared with standard curve of isolated alkaloid as the selected marker (Y=12.1360X+2901.4474). The alkaloid content in the ethanolic extract was determined as 2.35 ± 0.67 %.

AKTIVITAS ANTIBAKTERI MINYAK ATSIRI KULIT JERUK PONTIANAK TERHADAP Staphylococcus aureus dan Escherichia coli Rafika Sari; F. Nour Aulia Mustari; Sri Wahdaningsih
Majalah Obat Tradisional Vol 18, No 2 (2013)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

The infectious diseases can be caused by the pathogenic bacteria among Staphylococcus aureus and Escherichia coli. One of the plants that can be used as antibacterial is essential oils from Pontianak orange peels (Citrus nobilis Lour. var. microcarpa). This research aims to determine the antibacterial activity essential oils Pontianak orange peels againts the pathogenic bacteria by disc diffusion method. This research carried out by using the experimental Completely Randomized Design (CRD) Factorial and outcome data were analyzed using the program CoStat Two Way ANOVA method and continued by using LSD (Least Significant Different). The results showed that the essential oils from Pontianak orange peels contain flavonoids, saponins, and triterpenoids. The essential oils from Pontianak orange peels have antibacterial activity againts Escherichia coli and Staphylococcus aureus, where the average zone of inhibition obtained from the concentrations from 0,5; 1,5; and 2,5 mg/mL respectively are 15; 16; and 19 mm and 16,33; 18; and 21 mm. The concentration that gives the biggest inhibition zone is 2,5 mg/mL.

OPTIMASI FORMULA TABLET HISAP EKSTRAK KULIT AKAR SENGGUGU (Clerodendrum serratum (L.) Moon.) SEBAGAI SEDIAAN OBAT PENGENCER LENDIR (MUKOLITIK) DENGAN KOMBINASI BAHAN PENGISI LAKTOSA – SORBITOL Wahyono Wahyono; Luthfia Hanifah Kurniati; TN Saifullah Sulaiman
Majalah Obat Tradisional Vol 20, No 2 (2015)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Senggugu root bark has mucolytic activity and has been used empirically, so it needs to be formulated as lozengeswhich can be used practically and comfortable for the patients. Senggugu root bark powder was extracted by maceration using aethanol 70%. Lozenges was optimized using lactose-sorbitol filler mix through three formulas, formula A ( 100% lactose), formula B (100% sorbitol), formula C (50% lactose-50% sorbitol). Lozenges was made by wet granulation method. The optimum formula was obtained from theresults of physical granul test and lozenges using SLD, and analyzed by its granul flow, hardness, dissolution time, and taste responsiveness, and also qualitative and quantitative analysis. The results show that lactose-sorbitol filler mix can increase hardness and taste responsiveness, decrease granul flow and dissolution time. The oprimum formula from this research is 100% sorbitol:0% lactose.

PERBANDINGAN METODE PEMBUATAN EKSTRAK TERPURIFIKASI BEE PROPOLIS DARI LEBAH MADU (Apis mellifera) BERDASARKAN KADAR FLAVONOID TOTAL DIHITUNG SEBAGAI RUTIN Suwijiyo Pramono; Agustina Dian Puspitasari
Majalah Obat Tradisional Vol 20, No 2 (2015)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Propolis is a complex mixture of beeswax, sugar, and gum trees collection of honeybees (Apis mellifera). One of the compounds that have a pharmacological effect is flavonoid. Flavonoid can be obtained in large concentration and high purity with purified extraction method. The extraction was done with 96% ethanol, followed by purification with 30% ethanol, chloroform, ethyl acetate (in Method I), or followed with hot water and ethyl acetate (in Method II). The content of flavonoids detected by Thin Layer Chromatography, the stationary phase, silica gel 60F 254, the mobile phase n-butanol- acetic acid- water (3: 1: 1 % v/v ). The total flavonoid concentration was measured by UV-Vis spectrophotometer based on Zou method, calculated as routine. Results were analyzed by paired sample t-test. The mean level of total flavonoids from propolis extract before purification was 1.23 ± 0.3698 %w / w. Purification of ethanolic extract of 96% propolis with Method I and II, resulting in a total flavonoid concentration of 9.97 ± 1.5656 (8.1 times) and 11.78 ± 1.2965% w / w (9.6 times). Paired samples t-test with SPSS 16 showed the effectiveness of purification with significance value 0.048.

OPTIMASI FORMULA TABLET HISAP EKSTRAK KULIT AKAR SENGGUGU (Clerodendrum serratum L. MOON) SEBAGAI SEDIAAN OBAT PENGENCER LENDIR (MUKOLITIK) DENGAN KOMBINASI BAHAN PENGISI MANNITOL-LAKTOSA-SUKROSA T.N. Saifullah Sulaiman; Desi Elvira Cindy Puspita; Wahyono Wahyono
Majalah Obat Tradisional Vol 20, No 2 (2015)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Senggugu root bark (Clerodendrum serratum L. Moon) is known as a mucolitics. Senggugu root bark is made in the dosage form of lozenges in combination with sucrose, mannitol and lactose in order to obtain good flavor and comfortable when consumed. The purpose of this study was to determine the effect of the combination of fillers on the physical properties of granules and tablets as well as the composition of the combination of excipients to produce lozenges of extract of senggugu root bark with optimum physical properties. Seven formulas were made with a combination of mannitol, lactose and sucrose as follows: FI (100%: 0%: 0%), FII (0%: 100%: 0%), FIII (0%: 0%: 100%), FIV (50 %: 50%: 0%), FV (50%: 0%: 50%), FVI (0%: 50%: 50%), and FVII (33.3%: 33.3%: 33.3% ). The results showed that the combination of mannitol, lactose and sucrose affected the physical properties of the granules and lozenges of extract of senggugu root bark i.e. flow rate, hardness, dissolved time, compactibility and perceptive sense. The dominant amount of sucrose and lactose can improve the physical properties of granules and tablets. The optimal composition of the combination of mannitol, lactose and sucrose obtained from Design Expert 7.1.5. program was 5.491%: 37.387%: 57.122%, respectively.

UJI AKTIVITAS REPELAN MINYAK ATSIRI DAUN KEMANGI (Ocimum basilicum (L.) f. Citratum Back) TERHADAP NYAMUK Aedes aegypti DALAM SEDIAAN LOTION DAN UJI SIFAT FISIK LOTION Mimiek Murrukmihadi; Dias Anita Fajarini
Majalah Obat Tradisional Vol 20, No 2 (2015)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Essential oils of basil leaves that have spesific aroma can be used as a mosquito repellent. Lotions are more practical, easy to apply, easy to pour, and more efficient so repellent made in dosage form of lotion. The purpose of this study was to determine the repellent activity of volatile oil of basil leaf (Ocimum basilicum (L.) f. Citratum Back) against Aedes aegypti in lotion. Basil leaves are air-dried, then distilled by water and steam distillation for ± 6 hours. Essential oils with some concentrations(15% v / v, 25% v / v, and 35% v / v in 95% ethanol)are formulated in lotion. Physical properties (homogeneity, viscosity, dispersive power, and adhesion power) and repellent activity of lotions are tested. The data obtained are analyzed using the Kolmogorov-Smirnov test analysis, 2-way ANOVA test, and Turkey HSD test. The repellent activity is analyzed using One-Way ANOVA and Turkey test in level of 95%. The results showed that lotions with increasedessential oil concentration (15% v / v, 25% v / v, 35% v / v in 95% ethanol) are homogeneous and easily poured. Lotion with that increased concentration of essential oils of basil leaves (15% v / v, 25% v / v, 35% v / v in 95% ethanol) showed repellent activity with time protection of 3522, 4611, and 5435 seconds.

PEMBUATAN CHEWABLE LOZENGES EKSTRAK DAUN LEGUNDI (Vitex trifolia L. ) DENGAN VARIASI PROPORSI BASIS GLISERIN-GELATIN TN. Saifullah Sulaiman; Dina Aryani; Yosi Bayu Murti
Majalah Obat Tradisional Vol 20, No 2 (2015)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Legundi Leaf (Vitex trifolia L. ) often used in traditional medicine as anti asthma in Indonesia. The use of this plant in treatment is less practical and less accepted, so it needs to make in more appropriate preparation like chewable lozenges. Materials that can provide chewy texture are glycerin and gelatin. The goal from this research is to know the variations effect in the proportion of base glycerin – gelatin to physical properties of chewable lozenges and viteksikarpin bioavailability from preparation. Chewable lozenges was made with molding mixture method. There are three formulas with variations in the glycerin- gelatin proportions, those were Formula I (10 % : 90 %), Formula II (20 % : 80 %) dan Formula III (30 % : 70 %). Formed chewable lozenges was tested physical properties includes weight uniformity test, dissolving time, water content, TLC –densitometry and taste test using questionnaire response by respondent. Obtained data analyzed statistically with one way variance analysis the level of confidence (α) = 0,05. Result showed that presence variant in the proportion of glycerin and gelatin affected physical properties of legundi leaf extract chewable lozenges. The more proportion of gelatin will lengthen dissolving time (significance < 0,05), and the more proportion of glycerine the higher water level of chewable lozenges (significance < 0,05). Formulation of chewable lozenges affect to bioavailability of viteksikarpin from preparation. The more proportion of gelatin the fewer bioavailability of viteksikarpin. Based on taste test legundi leaf extract chewable lozenges subjectively, formula II is the most favorite by respondent.

PENGARUH WAKTU PEMANENAN DAN TINGKAT MATURASI DAUN TERHADAP KADAR VITEKSIKARPIN DALAM DAUN LEGUNDI (Vitex trifolia L.) Yosi Bayu Murti; Indrawan Kurnia Dwinatari
Majalah Obat Tradisional Vol 20, No 2 (2015)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Legundi (Vitex trifolia L.) is one of Indonesia’s traditional crops that have not been studied and developed into fitofarmaka. Legundi leaves can be used for therapy in asthmatics with optimum level. Therefore it is necessary for optimization of harvesting Legundi leaves which includes time and degree of maturation of the leaves. Harvesting time optimization by means of harvesting the leaves at the different times i.e. morning, noon, and evening, while the leaf maturation level optimization by way of harvesting leaves numbered one through five of the youngest end, then the time of harvesting and leaves that provide optimum levels of viteksikarpin were assigned. Measurements of viteksikarpin assigned using TLCdensitometry then analyzed using Wincats software and Microsoft Office Excel 2007. The highest viteksikarpin levels in Legundi leaves harvested in the afternoon, then during the day, and the lowest in the morning. The highest viteksikarpin levels of Legundi leaves were on second leaf, first leaf, third leaf, fourth leaf, and the lowest on fifth leaf. Optimum levels of viteksikarpin in Legundi leaves was harvested in the afternoon by picking the first until the third leaf.

ISOLASI DAN PENETAPAN KADAR ALKALOID EKSTRAK ETANOLIK BUNGA KEMBANG SEPATU (Hibiscus rosa-sinensis L.) SECARA SPEKTRODENSITOMETRI Mimiek Murrukmihadi; Kurniati Pamungkas
Majalah Obat Tradisional Vol 20, No 2 (2015)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

This research aims to isolate and determine relative concentration of alkaloid in Hibiscus rosa-sinensis L flowers. using spectrodensitometry. Ethanolic extract of H. rosa-sinensis flowers was made by maceration methode using etanol 70% as solvent. Fractionation of alkaloid compound was using VLC (Vaccum Liquid Chromatography) and using organic solfent mixture of methanol-ethyl acetate in variation concentration. Isolate was used as standard curve, then the concentration of H. rosa-sinensis flowers extract was determined using spectrodensitometry with silica gel as stationer phase and ethyl acetate: methanol ( 1:5 v / v) as mobile phase. The relative concentration of alkaloid was calculated by using standard curve Y = 29023.75 X + 5809.35, r = 0.996. Determination of isolate showed the relative concentration of alkaloid was 0.210 ± 0.035 % and this can be used as marker compound.

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