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INDONESIAN JOURNAL OF PHARMACY

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Published by Universitas Gadjah Mada

ISSN : 23389427 EISSN : 23389486 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.

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Articles 706 Documents

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Visible spectrophotometric determination of Cefadroxil using ethyl acetoacetate and formaldehyde reagents Susidarti, Ratna Asmah; Rianti, Andrih; Martono, Sudibyo
Indonesian Journal of Pharmacy Vol 19 No 1, 2008
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Visible spectrophotometric method can be used to determine cefadroxil in the pharmaceutical dosage form. The reaction of cefadroxil with the condensation product of 2 mol ethyl acetoacetate and 1 mol formaldehyde in acidic condition (pH 3,5) at 45Â°C for 20 minutes yielded yellow product giving absorption at 367 nm. The concentration of Cefadroxil was calculated by using standard curve Y = 1.6063 X + 0.1634, r = 0.9932, p = 0,001 and Vxo = 9,7%. Determination of cefadroxil capsule â€Xâ€ (562.4 mg/capsule) showed that the concentration of cefadroxil observed is 490.5 mg/capsule (CV = 0.89%) and recovery value is 102.88% (CV = 0.67%). Key words: visible spectrophotometry, Cefadroxil, ethyl acetoacetate, formaldehyde

THE CLEAVING ACTIVITY ASSAY ON SUPERCOILED DNA BY PROTEIN FRACTIONS FROM Morinda citrifolia LEAVES Nanik Sulistyani; Sismindari .; Sudjadi .
Indonesian Journal of Pharmacy Vol 13 No 4, 2002
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Study on supercoiled DNA cleaving activity assay of protein fraction from Morinda citrifolia leaf had been done. The aim of this research is to compare the supercoiled DNA cleaving abilities among the fractions. This is a preliminary screening to find RIP from Morinda citrifolia Fractionation of protein was done by adding Ammonium Sulphate up to 20%, 40%, 60%, 80% and 100% in the crude extract, saturated solution was then centifugated to get the pellet fractions and coded as F-20, F-40, F-60, F-80 and F-100. The mixture of pUC19 plasmid and protein fractions, in the same protein concentration were incubated at room temperature for one hour, the cleaving ability of protein fraction on supercoiled DNA.was investigated. The results indicated that protein fractions, of F-80 had the highest cleaving activity to supercoiled DNA.Key words : Ribosome-Inactivating Protein (RIP), supercoiled DNA , protein fraction, Morinda citrifolia.

Teratogenicity study of combination of ginger rhizome extract and noni fruit extract in Wistar rat Elin Yulinah Sukandar; Atun Qowiyah; Rik Rik Purnamasari
Indonesian Journal of Pharmacy Vol 20 No 1, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Ginger (Zingiber officinale Roscoe var. sunti Val.) extract in combination with noni (Morinda citrifolia Linn.) extract has been proven to be effective in tuberculosis patients. To examine its safety in pregnancy condition, the influence of combination of ethanol extract of ginger and ethanol extract of noni fruit had been studied in pregnant Wistar rat. The ginger and noni extract were administered orally at dose level combination of 50 and 50 mg/kg BW , 500 and 500 mg/kg BW , 1000 and 1000 mg/kg BW on day sixth to fifteenth of gestation. The mother was sacrified on day nineteenth of gestation to observe life fetus, resorption, and growfail fetus. One third of the fetuses eviscerated for skeletal staining with alizarin red and two third of the fetuses were hardened with Bouin’s fixation solution. No malformation were found in the eviscerated group. The combination at all doses did not cause any fetus resorption, growth failure and did not cause malformation in organ and skeleton. The combination dose of 500 and 500 as well as 1000 and 1000 mg/kg BW caused dark red to black color in the liver of rat fetuses of 7.3 and 8.3 % respectively.Key words: teratogenicity study, Zingiber officinale Roscoe var. sunti Val, Morinda citrifolia Linn.

Bioaccumulation of poly-aromatic hydrocarbons in plankton, algae and fish in south sea waters in Jogjakarta Endang Lukitaningsih; Ari Sudarmanto
Indonesian Journal of Pharmacy Vol 21 No 1, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

As a pollutant, the presence of Poly Aromatic Hydrocarbons (PAH) in the environment must be always monitored, because of their ability to spread widely through the food chain and also their carsinogenic properties. The solubility of PAH in water is very low, therefore it is difficult to analyze their presence in water environment by using water as a sample. By utilizing the phenomenon of the accumulation of PAH in biolipids, the analysis method has been developedusing bioindicators. In this research, the concentration of four kinds of PAH (pyrene, benzo(a)anthracene, benzo(k)fluoranthene and perylene) in several samples (water, plankton, algae and fish) that collected from the south sea Jogjakarta has been determined. The bioaccumulation factor (BAF) of PAH in each sample has been calculated and the results were from 4498 to 432754; 2552 to 49265; 14156 to 730991, respectively for plankton, algae and fish. Based on the BAF values, plankton can be used as a bioindicator for short term PAH monitoring, while the Upeneus moluccensisfish primarily gills organ can be used as a bioindicator for medium term (months) PAH monitoring.Key words : poly aromatic hydrocarbons, bioaccumulation factor, bioindicator, Upeneus moluccensis

THE PROTECTIVE EFFECT OF SARANG SEMUT (Myrmecodia tuberose) TUBERS INFUSION ON GENTAMICIN-PIROXICAM INDUCED NEPHROTOXICITY IN RATS Tanti Azizah Sujono
Indonesian Journal of Pharmacy Vol 25 No 2, 2014
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Kidney is very important organ for blood filtration. Impaired renal function often results in chronic kidney disease. Sarang semut (Myrmecodia tuberosa) is traditionally used to cure various diseases. This research was conducted to determine the effect of sarang semut infusion in nephrotoxicity rats models by gentamicin-piroxicam. Thirty male Wistar rats were divided into 6 groups. Group I as normal control (CMC Na was treated orally for 7 days), group II was treated sarang semut infusion dose of 1g/kgBW orally for 7 days, group III as nephrotoxic control was injected by gentamicin 100mg/kgBW intraperitoneally and piroxicam 3.6mg/kgBW orally daily for 7 days and group IV until VI were rats simultaneously treated with sarang semut infusion at the dose of 1, 2, and 4g/kgBW, respectively and induced by gentamicin-piroxicam daily for 7 days. Parameters of kidney function such as serum creatinine and blood urea nitrogen (BUN) levels were measured on day 0 and 7 using spectrophotometer. The rats were then sacrificed, kidneys tissue were removed for examination of renal index and kidney histology. These results showed that sarang semut tubers infusion at the dose of 1, 2, and 4g/kgBW reduced BUN and creatinine levels on induced-nephrotoxic rats. Creatinine level was reduced significantly to 1.76±0.13; 0.86±0.15; 0.60±0.07mg/dL, respectively. The creatinine level of nephrotoxic control was 5.16±0.27mg/dL. BU level decreased significantly to 55.66±6.22; 18.49±2.61; 16.81±1.24mg/dL, respectively. Meanwhile the BUN level of nephrotoxic control was 276.65±50.52mg/dL. Rat histological profile of the three doses tratment showed improvement in renal cell after administration of sarang semut infusion for 7 days.

CHEMICAL CONTENT OF TURMERIC ;CURCUMIN AND ITS DERIVATIVES Supardjan A. M.
Indonesian Journal of Pharmacy Vol 12 No 3, 2001
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

A brief review on turmeric from the stand-point of chemical content are presented. Recent studies on turmeric showed that at least 7 compounds of curcumin derivatives have been found, including cyclocurcumin the newer curcumin derivative.Keywords : curcumin, curcumin derivatives.

Phytochemical compounds and the effect of ‘bangunbangun’ leaves (Coleus amboinicus, L.) water extract on phagocytosis activity of neutrophil cell rat (Rattus norvegicus) Christin Marganingsih Santosa; Triana Hertiani
Indonesian Journal of Pharmacy Vol 16 No 3, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Traditional medicine has been recognized and widely used in Indonesia for healthy care or alternative medication in certain diseases. However, without scientific evidence, traditional medicine of empirical evidence cannot be used for modern health medication. This research was designed to find out the mains compound despite of Bangun-bangun aqueous extract from Kaliurang district using phytochemistry analysis such as Thin Layer Chromatography method and determine the effect on neutrophil cell activities by observing their phagocytosis. The result showed that the main compounds of Bangun-bangun leaves from Kaliurang district are polyphenol, saponin, flavonol glycoside and essential oil. Administration of the extract with the doses of Bangun-bangun leaves treatment 19,0 g/kg bw/oral/day (group A) and 31,5 g/kg bw/oral/day (group B) increased neutrophil cell phagocytosis up to 50% and 60 %, respectively, compared to those of controls which is 10% during 30 days treatment. Neutrophil cell phagocytosis in group B and C capability increase up to 80% (p

Synthesis of diacetyl gamavuton-0 using acetyl chloride as an acylating agent Margono, Supardjan Amir; Zendrato, Ridho Nugroho
Indonesian Journal of Pharmacy Vol 17 No 1, 2006
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Gamavuton-0 (GVT-0) is a curcumin-like compound, which is more stable than curcumin and still has an antioxidant property. The synthesis of diacetyl gamavuton-0 (diAcGVT-0) yielding an acetylation product that is more lipophile than GVT-0. The synthesis of diAcGVT-0 has been done by reacting GVT-0 and acetyl chloride as an acylating agent and tertiary amines as primary bases. DiAcGVT-0 was formed as the major product of synthesis but the product was not pure. Structure elucidation using UV-Vis, IR, 1H NMR and MS spectra showed that the main product was diAcGVT-0.Key words : diacetyl gamavuton-0, acetyl chloride, acylating agent, lipophile

IDENTIFICATION OF X GENE MUTATIONS, GENOTYPE AND SUBGENOTYPE OF HEPATITIS B VIRUS (HBV) Fatimawali .; Billy Kepel; Sitti Romlah; Catur Riany; Debbie Retnoningrum
Indonesian Journal of Pharmacy Vol 25 No 4, 2014
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Infection of hepatitis B virus (HBV) is a global health problem, including in Indonesia. There are currently an estimated 2 billion people worldwide are infected with HBV, about 75% of them are in Asia and 350 million of them will develop into chronic hepatitis B. Factors that influence the development of chronic hepatitis B into liver carcinoma include x gene mutation, HBV genotype and subgenotype. This research aims to identify x gene mutation, genotype and subgenotype of HBV infecting hepatitis B patients in Manado associated with the onset of liver carcinoma. HBV DNAs were isolated from blood samples of 30 hepatitis B patients. X gen was amplified using nested PCR with pre-designed primer pairs. Amplified DNA fragments were electrophoresed in 1.5% agarose and visualized under UV. DNA fragments were then separated and purified using Qiagen column, then sequenced to determine their nucleotide sequences of x gene. Amino acid of x protein were deduced from nucleotide sequence of x gene and used as basic to determine HBV genotype and subgenotype. X protein was aligned with those similar protein with the same subgenotype retrieved from GenBank to determine if there was a mutation at amino acid. The mutated x protein were compared with other mutation found in x protein in other literatures associated with the onset of liver carcinoma. Genotype and subgenotype of HBV isolated from blood samples of 10 patients was detected and showed that five patients were infected with B genotype HBV (2 patients were infected with B2 subgenotype, 2 patients with B3 subgenotype and 1 patient with B9 subgenotype). The rest of 5 patients were infected with C genotype HBV (1 patient with C1 subgenotype, 2 patients with C2 subgenotype, and 2 patients with C5 subgenotype). The mutation in x protein is related significantly to the clinical severity of the liver and hepatocellular carcinoma (HCC), ie V5L in subgenotype C2, and I127T and H94Y in subgenotype C5.

Evaluation of the implementation of the good manufacturing practice for traditional medicine industries in Central Java Marchaban .; Achmad Fudholi; Bambang Suryadi
Indonesian Journal of Pharmacy Vol 15 No 2, 2004
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The study of the GMP implementation for the traditional medicine industries in Central Java has been performed. The GMP for traditional medicine industry is the guidance how to produce and to manage the quality of the product so that it meets to the quality of design and the quality of conformance. The aim of the study is to evaluate how far the GMP is implemented in the traditional medicine industries in Central Java.The method used of the study was a descriptive evaluative qualitative data collected from several traditional industries namely: M, N, O, P, Q, R and S by assessing the implementation level of the GMP in those industries. The evaluation instrument used was the primary data directly collected by interviewing the directors, the managers and the heads of department, and then followed by visitation to the industries to check the primary data and the actual condition. The result showed that the evaluation of the GMP implementation for the traditional medicine industries in Central Java reached the score of 86.10% that meant of good category, although the quality control, the selfevaluation, and the documentation aspect had to be ameliorated.Key word : GMP, traditional medicine industries

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