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INDONESIAN JOURNAL OF PHARMACY

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Published by Universitas Gadjah Mada

ISSN : 23389427 EISSN : 23389486 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.

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Articles 706 Documents

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THE INFLUENCE OF AQUEOUS EXTRACT OF CORIANDRI (Coriandrum sativum L) FRUCTUS TO BLOOD GLUCOSE LEVEL IN GLUCOSE- PRE LOADED RATS Agung Endro Nugroho
Indonesian Journal of Pharmacy Vol 13 No 1, 2002
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Coriander contains some active compounds capable of decreasing the level of blood glucose. Moreover, aqueous extract of coriander (Coriandrum sativum L.) fruits has insulin-releasing and insulin-like activities. This research has been performed to obtain information on the effect of aqueous extract of coriander fruits on the blood glucose level in glucose-preloaded rats. The study was conducted by employing a complete random design in male Wistar rats (age 2-2,5 months, 150-250g).After the design treatments, the blood samples were collected (100-200 ul) at certain time interval. The result of each group were compared and analysed using the Mann-Whitney non-parametric method (95%). The result showed that low doses (0.014 and 0.07 % w/v) of aqueous extract of coriander fruits were unable to decrease significantly (p>0.05) the blood glucose level in glucose-preloaded glucose. On the other hand, high doses, 0.35 and 1.75 % w/v, were capable to decrease significantly (p<0.05), which are 22.11 ± 3.09 and 18.41 ± 4.88 %, respectively. Nevertheless, in the present study, the highest hypoglycaemic effect of aqueous extract of coriander fruits still lower than that of tolbutamide (p<0.05).Keywords: coriander, hypoglycaemic, glucose, tolbutamide

Antiangiogenic effect of sambung nyawa leaves (Gynura procumbens (Lour.) Merr.) etanolic extract on chick embryo chorioallantoic membrane (CAM) Riris Istighfari Jenie; Edy Meiyanto; Retno Murwanti
Indonesian Journal of Pharmacy Vol 17 No 1, 2006
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Antiangiogenesis (inhibition of new blood vessels formation) has become a strategy to inhibit cancer development lack of nutrition and oxygen supply. The aim of the present research is to investigate antiangiogenesis effect of ethanolic extract of Gynura procumbens (Lour.) Merr. Leaves in situ using chick embryo chorioallantoic membrane (CAM). Eight to 9 days old fertilized chicken eggs were treated with b-FGF (angiogenesis inductor) and extracts. Eggs were then incubated for 3 days in order to observe its angiogenesis response (new blood vessels converged toward the implant).The results showed that the ethanolic extract of G.procumbens could inhibit angiogenesis in a dose-dependent manner. Doses 10, 20, 40, 80 ug gave angiogenesis response of (in percent) 82.32 ± 6.33; 68.38 ± 6.24; 56.48 ± 11.61; 41.43 ± 7.46 (p<0.05), respectively. These results indicate a potential antiangiogenic effect of the extract.Key words: antiangiogenic, CAM, G.procumbens.

Evaluation of antibiotic usage in patient with fever in a private hospital in Yogyakarta (period January – June 2002) Aris Widayati; L. Endang Budiarti; Imono Argo Donatus
Indonesian Journal of Pharmacy Vol 15 No 3, 2004
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Fever as a symptom may indicate to any other diseases. According to the standard therapy by IDI (1998) fever should be treated without antibiotic, but the fact showed that 70 % antibiotics were used for treatment. This study aimed at describing about fever and evaluating antibiotic usage in patients with fever as a final diagnose by appropriateness, effectiveness, and safety as a criteria of evaluation.The present study was done with retrospective data collection and descriptive-evaluative design. Data was collected from medical records within a period from 2002 January to June. A number of 157 patients were used for the assesment.The highest percentage of patient’s fever was a group of 17 – 60 years old (63. 28%). The final diagnose was fever (29.58%) and others (70.42%) such as viral infection (17.16%), DHF (8.28%), DF (7.01%) and acute respiratory traction infection (5.92%). There were 29 kinds of antibiotics (79.62%) that given to the patients as an empirical therapy and the highest was pefloxacin (13.14%). The percentage of antibiotic usage in patients with fever as a final diagnose (50 patients) was 86.00% (21 kinds of antibiotics) and the highest was pefloxacin (17.19%). Both of fever less than 5 days ormore than 5 days were treated with antibiotic, which was inappropriate usage because fever less than 5 days related to viral infection. There was only 4.65% had a culture and sensitivity test, which was appropriate antibiotics usage. There were 46.51% no growth of culture and 48.84% without culture, which was inappropriate antibiotics usage. Treatment with and without antibiotics could normalize vital signs each was 90.70% and 85.71% with no significant difference (with non parametric exact probability Fisher analysis, CI 0.05) and RR value (95%, 0.69-1.30). Patient’s recoveries were 88.37% and 85.71% with and without antibiotic therapy with no significant difference (CI 95% and 0.96 RR value with CI 95%; 0.66 – 1.41). There were two cases (4.00%) of contraindication and 12.00% of potential drug interactions. According to the standard therapy and supporting data of this study, so that fever should not always be treated with antibiotic.Key words: antibiotic, fever, evaluation.

Isolation of Tracheopasmolytic Compounds From Piper cubeba Fruits Wahyono .; L. Hakim; S. Wahyuono; A. Mursyidi; R. Verpoorte; H. Timmerman
Indonesian Journal of Pharmacy Vol 14 No 3, 2003
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The fruits of Piper cubeba (kemukus;Javanese)have been used in traditional medicine to treat illnesses such as asthma. Extracts were prepared by gradual maceration of the dried fruits with n-hexane, and by extraction of the residue with ethanol, and were tested for their tracheospasmolytic effects on isolated guinea-pig trachea contracted with metacholine at a dose of 0.25 mg/ml. Both extracts demonstrated spasm inhibition but the effect of the ethanol extract was lower than that of the n-hexane extract. However, TLC analysis did not distinguish between the extracts. The ethanol extract was then partitioned with n-hexane, and the first and second n-hexane extracts were combined and dried before further fractionation using vacuum liquid chromatography. The fractions were tested for tracheospasmolytic effects. Two active fractions were obtained and separated by column chromatography and preparative TLC. Four pure compounds were obtained. One of these is a lignan compound and identified as dihydrocubebin, had tracheospasmolytic activities.Key words: Piper cubeba; lignan, dihydrocubebin; tracheospasmolytic effect.

FATTY ACID CONTENT IN DURIAN (Durio zibethinus, Murr) SEED Eni SR; Sumarno .
Indonesian Journal of Pharmacy Vol 12 No 2, 2001
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Fatty acids are part of fatty oils found in plants, animals and other organisms. Fatty oils are useful for human being, and they are also used as drug solvents, soaps, cosmetics and paint. Plant seeds usually contain fatty oil, protein and carbohydrate, useful for plants growth Durian seeds were just as common rubbish, therefore an investigation of fatty acids found in durian seeds were might be beneficial. Durian seeds were collected, dried, powdered, and was extracted with petroleum ether using Soxhlet apparatus. Physical and chemical parameters of Fatty oil i.e colour, acid value, saponification value, iodine value, and peroxide value were determined. Methyl ester of fatty acid composition produced by fatty oil transesterification was analyzed using a gas chromatography. The chemical parametrs of fatty oil are found to be: acid value (19,4 ± 0,17 ), saponification value (190,65 ± 0,84) , iodinevalue (81,7 ± 0,53) , and peroxide value (3,93 ± 0,12). Physical properties of fatty oil were : concentration of fatty oil was 6,12 ± 0,16 (%), w/w of dried seeds; transparenty yellow and durian odoured, the water content of durian seeds was 12,17 %. The composition of fatty acid containing in fatty oil was unsaturated fatty acid: oleic acid (14,95%) and linoleic acid (12,46%), and saturated fatty acid which is consist of stearic acid (45,84%) and palmitic acid, ( 26,75 %), relatively to pure stearic acid (E.Merck, pro analysis).Key Word: Durio zibethinus Murr, durian seed, fatty acids, identification

PHARMACY, PHARMACIST, AND SOCIAL PHARMACY Sudjaswadi, Riswaka
Indonesian Journal of Pharmacy Vol 12 No 3, 2001
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

In order to express more clearly about the role of pharmacist in the health care, a general review of the sources of the pharmacy (pharmacist) has been carried out. Considering the facts and several survey results, Pharmacy/Pharmacist is a typical profession capabler to develop wider in a health care system and that provides more beneficial for community along with the advancement of Social Pharmacy.Key words: Profession, Professional, changing context of Pharmacy, Professionalization.

Ethanolic extract of Areca catechu seeds inhibit proliferation and induce apoptosis on MCF-7 cells Meiyanto, Edy; Susidarti, Ratna Asmah; Handayani, Sri; Rahmi, Fitria
INDONESIAN JOURNAL OF PHARMACY Vol 19 No 1, 2008
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Areca catechu seed contains antioxydant substances, supposed to have anticancer property. This research therefore addressed to examine the inhibitory effect of Areca catechu seed ethanolic extract (EP) on proliferating breast cancer cells, MCF-7. Areca catechu seed ethanolic extract (EP) standardization was done according to the standard of BPOM. Areca catechu seed powder extraction was done using ethanol 96%. Cytotoxic assay â to get the value of IC50 and to prevent the cell proliferation (using doubling time assay) â was carried out by using MTT assay. Apoptosis observation was done by acrydine orange- etidium bromide staining method (double staining). The result showed that treatment with Areca catechu seed ethanolic extract (25-100 Âµg/m) for 48 h caused 13-84% growth inhibition (IC 5077 Âµg/mL) of the cells, while arecoline (ARE) treatment (10-500 Âµg/mL) showed 8-73% inhibition (IC50 180 Âµg/mL). The extract also inhibited cell proliferation and induced apoptosis. These results conclude that Areca catechu seed ethanolic extract (EP) possesses antiproliferative effect through growth inhibition and apoptosis induction.Key words:MCF-7, Areca catechu, antiproliferativeÂ

The effect of the extract of pasak bumi roots (Eurycoma longifoliaJack.) on liver function Panjaitan, Ruqiah Ganda Putri; Manalu, Wasmen; Handharyani, Ekowati; ., Chairul
Indonesian Journal of Pharmacy Vol 22 No 1, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The aim of this research is to study the effects of the methanol extract and its derived fraction (n-hexane, chloroform, ethyl acetate, and methanolwater) on liver function of male rats. The treatment groups were administered 500 mg/kg body weight of metanol extract and its derived fractions (n-hexane, chloroform, ethyl acetate, n-butanol, methanol-water) of E. longifolia for 7 consecutive days. Positive control group received 25 mg silymarin/kg body weight and negative control group received 2 mL aquadest/kg body weight daily for 7 consecutive days. Liver function was monitored by measuring alanine transaminase (ALT), aspartate transaminase (AST), total protein, alkaline phosphatase (ALP), total bilirubin, direct bilirubin, and indirect bilirubin consentrations in the serum. Compared with control, oral administration of methanol extract and derived fractions of methanol extract of E. longifolia root had no significant effects on liver function (p>0.05). Methanol-water fraction gave similar results to silymarin.Key words: Eurycoma longfolia Jack.,liver function, biochemical blood Histopathologi

THE INFLUENCE OF DISTILATION TIME, POWDER SIZE, ON THE CINAMYLALDEHYDE CONTENT AND VOLATILE OIL Cinnamomum burmanii Nees ex. Bl. BARK Lisawati, Yovita; Sulianti, Sri Budi; ., Chairul
INDONESIAN JOURNAL OF PHARMACY Vol 13 No 3, 2002
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The content of volatile oil in samples depends on the harvest time, distilation method, sample powder size, and location of sample cultured. The aim of this study was to investigate the influences of interval time of distillation and mesh size of bark powder, upon the concentration of major component (cinamylaldehyde). The distillate was collected with various interval times 1, 2, 3 and 4 hours and it was counted after the first drop of distillate. The mesh size of bark powder (4, 8 and 20 mesh) was set after the interval time of distillation had been studied. The major component was analysed using Gas Chromatography (GC). The results showed that the interval time of distillation at the second hour gave the highest volatile oil and cinamylaldehyde contents in the relative prosentage 0.19 % and 29.36 % respectively, compared with the first hour distilate, (0.16 %, 24.88 %), third hours distilate (0.14 %, 23.29 %) and fourth distilate (0.08 %, 17.65 %). The powder size of bark (8 mesh) gave the highest volatile oil and cinamylaldehyde contents (0.22 %, 32.81 %), compared to powder size of 4 mesh( 0.17 %, 20.45 %) and 20 mesh (0.19 %, 21.32 %). The results is still lower than standard of cinnamon oil, (cinamylaldehyde content 60 %). The lowering cinamylaldehyde content could be caused by low quality of material, collected from marketing method, early harvesting time, and storing for long.time.Key words: C. burmanii, bark, distilation time, cinamylaldehide

Study of antiemetic pattern on cancer patients with cancer by cytostatic therapy hospitals in Yogyakarta Perwitasari, Dyah Aryani
Indonesian Journal of Pharmacy Vol 17 No 2, 2006
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The aim of the research was to know the description of antiemetic usage on the patients with cancer based on the medical records that were available in the hospital. Hereby, the use of antiemetic would be compared to literature for seeing the pattern.The study was a descriptive, analytic and retrospective study. The data taken from the medical records were written by doctor and nurses for cancer in patients hospital during Januari to June 2003. Data were grouped based on cytotoxic treatment with strong, medium and weak emetogenic effects, the condition of cancer patients, and antiemetic usage before and after having cytotoxic treatment.The results showed antiemetic usage before and after strong emetogenic cytotoxic treatment were not suitable because there was no combination with dexametason. Antiemetic usage which was used before and after mild emetogenic cytotoxic treatment were not suitable with ondansetron, metochlorpramide, combination of ondansetron â€“ metochlorpramide. The use of antiemetic on cancer patients who got strong and medium emetogenic cytostatic was not been suitable with literatures because the patients were not given dexamethasone as combination therapy. For cancer patients given before and after medical treatment with weak emetogenic effect werenâ€™t suitable in both of hospitals. Antiemetic usage before cytotoxic treatment that was not suitable was ondansetron and metoclopramide, where as antiemetic usage after cytotoxic that was suitable was metoclopramide.Key words: Antiemetic, Emetogenic Effect, Cytotoxic, hospital

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