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Berkala Kedokteran
Published by Universitas Lambung Mangkurat
ISSN : 14120550     EISSN : 25485660     DOI : http://dx.doi.org/10.20527
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Berkala Kedokteran is a journal contains scientific articles from original research and literature review in medical and health scope. It is published twice in a year, on February and September.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 478 Documents
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The Potential of Candida Biofilm Protein as Bioreceptor for Candidiasis Immunoassay Masfufatun, Masfufatun; Haryanto, Loo; Harsono, Harsono
Berkala Kedokteran Vol 14, No 1 (2018)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v14i1.4539

Abstract

Abstract: Candidiasis or infection that is caused by Candida has become a new list of the therapeutical problems recently. The difficulties in diagnosing are the main cause of the unsatisfactory results from common therapies and diagnosis methods. This has urged researchers to find alternative ways in candidiasis diagnosis such as serology-based detection using antigen or antibody development. The aim of this study was to evaluate the potential of protein derived from Candida albicans biofilm as bioreceptor on candidiasis immunoassay through Dot Blot method. The research method used descriptive method with the following stages: (1) preparation of Candida albicans biofilm (2) extraction of Candida albicans protein through enzymatic and mechanical methods, (3) determination of protein molecular weight with SDS-PAGE (4) production of polyclonal anti- candida and (5) analysis of protein extract as bioreeceptor on dot blot. Profile of biofilm proteins on SDS-PAGE analysis were shown on molecular weight 27,42; 29,89; 38,10; 44,90; 48,75; 52,92; 55,14; 59,86; 70,56; 87,36; 102,54;115,05; 130,14;143,14;181,53 kD. There were differences in the intensity of dots in the control group (44070) and treatment groups (63170.5). It is noticeable that biofilm protein extract of C. albicans can be used for induction of anti-Candida polyclonal antibody production as the potential candidate of bioreceptor in candidiasis immunoassay. Keywords: SDS-PAGE, polyclonal antibody, immunoassay, dot blot, biofilm
AKTIVITAS LARVASIDA EKSTRAK ETANOL DAUN BINJAI (Mangifera caesia) TERHADAP LARVA Aedes aegypti Nadila, Isfarani; Istiana, Istiana; Wydiamala, Erida
Berkala Kedokteran Vol 13, No 1 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v13i1.3441

Abstract

Abstract: Binjai leaf is known to have effective secondary metabolites as larvacide. The aim of this study was to recognize larvacidal effectivity of Binjai leaf ethanol extract toward Aedes aegypti larva. This was experimental study with posttest only control group design by using 7 treatment and 4 replication. Treatment was available from preliminary test which were 1000, 5000, 10.000, 15.000 and 20.000 (mg/L), negative xontrol (water) and positive control (themephos 100 mg/L). Probit test resulted in LC50 value=5493.390 mg/L and LC90 value=14988.861mg/L Kruskal-Wallis test resulted in p=0,000 which meaned there was an effect of binjai leaf ethanol extract toward Aedes aegypti larva. Meanwhile, Mann-Whitney test resulted in p=0,371 which meaned there was no significant difference between concentration of 20.000 mg/L and temephos 100 mg/L. In conclusion, binjai leaf (Mangifera caesia) ethanol extract have larvacidal activity as effective as temephos toward Aedes aegypti larva. Keywords: Larvacide, Binjai leaves, Aedes aegypti Abstrak: Daun binjai diketahui memiliki kandungan metabolit sekunder yang berpotensi sebagai larvasida. Tujuan penelitian ini adalah untuk mengetahui efektivitas larvasida ekstrak etanol daun binjai terhadap larva Aedes aegypti. Penelitian ini menggunakan jenis eksperimental dengan metode posttest only contol grup design menggunakan tujuh kelompok perlakuan dan 4 replikasi. Tujuh kelompok perlakuan tersebut adalah 5 serial konsentrasi yang diperoleh dari uji pendahuluan: 1000, 5000, 10.000, 15.000 dan 20.000 (mg/L), kontrol negatif (air) dan kontrol positif (temephos 100 mg/L). Hasil uji probit didapatkan  nilai LC50 dan LC90 sebesar 5493.390 dan 14988.861 (mg/L). Uji kruskal-Wallis didapatkan  nilai p=0,000, terdapat pengaruh ekstrak etanol daun binjai terhadap larva Aedes aegypti. Hasil uji Mann-whitney didapakan nilai  p=0,371, tidak terdapat perbedaan signifikan antara konsentrasi 20.000 mg/L dengan kontrol positif. Kesimpulan dari penelitian ini ekstrak etanol daun binjai memiliki aktivitas larvasida dan efektivitas setara dengan temephos 100 mg/L terhadap larva Aedes aegypti. Kata-kata kunci :  Larvasida, daun binjai, Aedes aegypti
THE EFFECT OF Trichuris muris EGG ON THE GOBLET CELLS IN INTESTINE OF MICE (MUS MUCULUS) Ulfadila, Lulu Hasna; Husairi, Ahmad; Istiana, Istiana
Berkala Kedokteran Vol 13, No 2 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v13i2.4078

Abstract

Abstract: Goblet cells are the immune response in the intestinal epithelium to produce mucus as a defense digestive tract mucosa caused by Trichuris muris infestation. The study purpose was to analyze the effect Trichuris muris towards goblet cells number in mice’s intestine. This research was a true experimental with the posttest control group design. The subjects were 30 male mice types BALB / c which 2 months old with an average weight 20-30 gram. Samples were taken by simple random sampling. Mice divided into a control group, low-dose group (40 worm eggs) and high-dose groups (200 worm eggs) observed for 30 days and then counted the goblet cells number in each preparation. The data analysis was tested by shapiro wilk test and one-way ANOVA and continued by post hoc test. The results demostrated the average value of the goblet cells number in the control group, low-dose and high dose increased by higher dose worm eggs and had the value (p =< 0.05). This described there were Trichuris muris’s eggs inflluence towards the goblet cells number in mice (Mus musculus). Keywords: Trichuris muris,  mice (Mus musculus), goblet cells in intestinum
HUBUNGAN SKOR GLASGOW COMA SCALE (GCS) DENGAN JUMLAH TROMBOSIT PADA PASIEN CEDERA KEPALA DI IGD RSUD ULIN BANJARMASIN Yutami, Annisa; Sikumbang, Kenanga Marwan; Asnawati, Asnawati
Berkala Kedokteran Vol 12, No 2 (2016)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v12i2.1879

Abstract

Abstract: Head injuries are a public health and a serious socio-economic problems in the world. Head injury classified quantitatively using the Glasgow Coma Scale (GCS) score. Consumptive coagulopathy that often arises in patients with head injury associated with a tenfold adjusted risk of death. Consumptive coagulopathy marked by a decrease in the number of platelets. The purpose of the study was to analyze the relationship between GCS score with total platelet count in head injury patients at Emergency Department Ulin General Hospital Banjarmasin. This study was an observational analytic cross sectional study. Seventy three samples were obtained according to the inclusions criteria with 28 mild head injury patients, 26 moderate head injury patients, and 19 severe head injury patients. Seven patients had thrombocytopenia, from moderate head injury and severe head injury groups. From statistical test using one way ANOVA with confidence level of 95% was obtained p=0.402. It can be concluded that there is no relationship between GCS score with total platelet count in head injury patients at Emergency Department Ulin General Hospital. Keywords: head injury, GCS, platelet count Abstrak: Cedera kepala merupakan masalah kesehatan masyarakat dan sosial ekonomi yang serius di dunia. Cedera kepala diklasifikasikan secara kuantitatif menggunakan skor Glasgow Coma Scale (GCS). Koagulopati konsumtif yang sering muncul pada pasien cedera kepala dapat meningkatkan risiko kematian menjadi sepuluh kali lipat. Koagulopati konsumtif ditandai dengan penurunan jumlah trombosit. Tujuan penelitian untuk mengetahui apakah terdapat hubungan antara skor GCS dengan jumlah trombosit pada pasien cedera kepala di IGD RSUD Ulin Banjarmasin. Penelitian ini bersifat observasional analitik cross sectional. Didapatkan 73 sampel yang sesuai dengan kriteria inklusi, dengan perincian 28 pasien cedera kepala ringan (CKR), 26 pasien cedera kepala sedang (CKS), dan 19 pasien cedera kepala berat (CKB). Tujuh pasien mengalami trombositopenia, dari kelompok pasien cedera kepala sedang dan cedera kepala berat. Dari uji statistik  menggunakanone-way ANOVA dengan tingkat kepercayaan 95% didapatkan nilai p=0,402. Dapat disimpulkan bahwa tidak terdapat hubungan antara skor GCS dengan jumlah trombosit pada pasien cedera kepala di IGD RSUD Ulin Banjarmasin. Kata-kata Kunci: cedera kepala, GCS, jumlah trombosit
CORRELATION TRIGLISERIDA LEVEL AND MONOCYTE IN CORONARY HEART DISEASE AT ULIN GENERAL HOSPITAL BANJARMASIN Juwita, Gusti Adistya Naila; Arifin, Miftahul; Yuliana, Ida
Berkala Kedokteran Vol 13, No 2 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v13i2.4069

Abstract

Abstract: Coronary heart disease (CHD) is an unbalance condition between oxygen supply and demand in heart muscle which caused by coronary artery obstruction known as atherosclerosis. Both triglyceride and monocyte have important role in the process of atherosclerosis plaque forming which cause CHD. This research aimed to analyse correlation between triglyceride level and monocyte count in patients with coronary heart disease at Ulin General Hospital Banjarmasin on August 2014-August 2015. This research is an analytical observational research with cross-sectional approach. Total sample for this research are 94 CHD patients selected by inclusion criteria. The result discovered the average rate for triglyceride level is 114 mg/dL and for monocyte count is 0,62 thousand/µL. Based on result of data analysis with Pearson correlation test demonstrates the value of r=0,347 and p=0,01. It can be concluded that there is weak, significant and positive correlation between triglyceride level and monocyte count in CHD patients Keywords: triglyceride, monocyte, coronary heart disease
IDENTIFIKASI BAKTERI PENYEBAB TONSILITIS KRONIK PADA PASIEN ANAK DI BAGIAN THT RSUD ULIN BANJARMASIN Nizar, Muhammad; Qamariah, Nur; Muthmainnah, Noor
Berkala Kedokteran Vol 12, No 2 (2016)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v12i2.1867

Abstract

Abstract: Chronic tonsillitis is a condition where tonsil is enlarged, accompanied by repeated infections. Bacterial chronic tonsillitis can be caused by different bacteria, depends on its region. Research for patterns of bacteria causing chronic tonsilitis is needed to determine the target of antibiotics used by hospitals. The general objective of this research was to determine the type of bacteria that cause chronic tonsillitis obtained through a throat swab from pediatric patients in the ENT Ulin Hospital Banjarmasin from August to October 2015. This is a descriptive research using cross sectional approach. The sample in this study is the pediatric patients aged 1-17 years who were diagnosed chronic tonsillitis by ENT specialist at the ENT Ulin Hospital Banjarmasin. Swab was taken from the palatine tonsil and cultured in media isolation and examined using macroscopic, microscopic and biochemical tests. The results showed that 7 isolates of Staphylococcus aureus (53.84%), 1 sample of Escherichia coli (7.69%), and 5 samples of Streptococcus sp. (38.46%) are three major bacteria which infected chronic tonsillitis patients in Ulin GeneraL Hospital Banjarmasin. Keywords: chronic tonsillitis, bacterial identification, pediatric patients Abstrak: Tonsilitis kronis merupakan kondisi di mana terjadi pembesaran tonsil disertai dengan serangan infeksi yang berulang-ulang. Bakteri penyebab infeksi  tonsilitis kronis dapat berbeda-beda antar daerah. Perlu adanya penelitian tentang pola kuman agar pemberian antibiotik tepat sasaran.Tujuan umum dalam penelitian ini adalah untuk mengetahui jenis bakteri penyebab tonsilitis kronik yang didapat melalui swab tenggorok pasien anak di bagian THT RSUD Ulin Banjarmasin pada Agustus-Oktober 2015. Metode yang digunakan dalam penelitian ini adalah metode deskriptif dengan pendekatan cross sectional. Sampel dalam penelitian ini adalah pasien anak umur 1-17 tahun yang didiagnosis tonsilitis kronis oleh dokter spesialis THT di bagian THT RSUD Ulin Banjarmasin. Identifikasi diambil dari swab pada tonsila palatinadan dibiakkan pada media isolasi yaitu dengan pemeriksaan secara makroskopis, mikroskopis, dan uji biokimia. Hasil penelitian menunjukkan terdapat tiga jenis isolat bakteri yaitu Staphylococcus aureus 7 isolat (53,84%), Escherichia coli 1 isolat (7,69%), dan Streptococcus sp. 5 isolat (38,46%). Kata-kata kunci: Tonsilitis kronis, identifikasi bakteri, pasien anak
POLA KEPEKAAN ISOLAT BAKTERI AEROB PADA RHINOSINUSITIS KRONIS Saputra, Alvin; Qamariah, Nur; Muthmainah, Noor
Berkala Kedokteran Vol 13, No 1 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v13i1.3446

Abstract

Abstract: Chronic rhinosinusitis is an inflammation of the sinus mucosa caused by viruses or bacteria. Needed research on antibiotic susceptibility of the bacteria that cause chronic rhinosinusitis targeted antibiotics. The purpose of this study was to determine the sensitivity of some selected antibiotics against bacteria of different causes of chronic rhinosinusitis at the Department of Otolaryngology Ulin General Hospital Banjarmasin. This is a descriptive study with cross-sectional approach using diffusion method of Kirby-Bauer zone of inhibition was then compared with standard antibiotics against bacterial antibiotic inhibition zone according to CLSI 2016. The sample in this study were all patients with chronic rhinosinusitis who come for treatment to the Department of Otolaryngology Ulin General Hospital and Moch. Ansari Saleh General Hospital Banjarmasin in the period from June to August 2016. Obtained from 12 samples, 6 samples of Staphylococcus aureus, Staphylococcus epidermis 10 samples, 1 sample Eschirechia coli and 1 sample Bacillus sp. Staphylococcus aureus showed the highest sensitivity to antibiotics cefixime, cefuroxime, ciprofloxacin and clindamycin 66,6%, and the lowest amoxicillin clavulanate 50%. Staphylococcus epidermis showed the highest sensitivity to the antibiotic cefuroxime and clindamycin 100%, cefixime 50% and the lowest amoxicillin-clavulanate and cefuroxime 25%. Escherichia coli showed the highest sensitivity to the antibiotic amoxicillin-clavulanate and cefixime 100%, and the lowest cefuroxime, ciprofloxacin, and clindamycin 0%. Bacillus sp showed the highest sensitivity to the antibiotic cefuroxime, ciprofloxacin, and clindamycin 100% in the lowest 0% for amoxicillin and cefixime. Keywords : chronic rhinosinusitis, sensitivity test, antibiotics Abstrak: Rhinosinusitis kronis adalah peradangan pada mukosa sinus yang disebabkan oleh virus atau bakteri. Perlu adanya penelitian tentang kepekaan antibiotik terhadap kuman penyebab rhinosinusitis kronis agar pemberian antibiotik tepat sasaran. Dengan demikian, tujuan penelitian ini untuk mengetahui kepekaan beberapa antibiotik terpilih terhadap kuman penyabab rhinosinusitis kronis di Bagian THT RSUD Ulin dan RSUD Moch. Ansari Saleh Banjarmasin. Penelitian ini bersifat observasional dengan pendekatan cross sectional menggunakan metode difusi Kirby-Bauer kemudian dibandingkan zona hambat antibiotik terhadap bakteri dengan standar zona hambat antibiotik menurut CLSI 2016. Sampel dalam penelitian ini adalah semua pasien rhinosinusitis kronis yang datang berobat ke Bagian THT RSUD Ulin dan RSUD Moch. Ansari Saleh Banjarmasin pada periode Juni - Agustus 2016. Dari 12 sampel didapatkan, 6 sampel Staphylococcus aureus, 4 sampel Staphylococcus epidermidis, 1 sampel Eschirechia coli dan 1 sampel Bacillus sp. Staphylococcus aureus menujukkan kepekaan tertinggi terhadap antibiotik sefiksim, sefuroksim, siprofloksasim, dan klindamisin sebesar 66,6% serta yang terendah yakni amoksisilin klavulanat sebesar 50%. Staphylococcus epidermidis menujukkan kepekaan tertinggi terhadap antibiotik sefuroksim dan klindamisin sebesar 100%, sefiksim 50% serta yang terendah amoksisilin klavulanat dan sefuroksim sebesar 25%. Eschirechia coli menunjukkan kepekaan tertinggi terhadap antibiotik amoksisilin klavulanat dan sefiksim 100% serta terendah sefuroksim, siprofloksasim dan klindamisin 0%. Bacillus sp menunjukkan kepekaan tertinggi terhadap antibiotik sefuroksim, siprofloksasim, dan klindamisin sebesar 100% serta terendah amoksisilin klavulanat dan sefiksim 0%. Kata-kata kunci : rhinosinusitis kronis, uji kepekaan, antibiotic
Potency of Swallow Nest Extract (Collocalia fuciphago) as Pancreaprotector Through Oxidative Mechanism in Rats (Rattus norvegicus) Induced by Streptozotocin Frethernety, Agnes; M, Satriyandi; Alexandra, Francisca Diana
Berkala Kedokteran Vol 14, No 1 (2018)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v14i1.4534

Abstract

Abstract: Diabetes mellitus is a clinical syndrome with characteristics of hyperglycemia. Hyperglycemia can lead to the formation of excessive free radical compounds that trigger oxidative stress, especially on pancreatic β cells. Swallow nest contains amino acids which are insulin-forming compounds and glutathione that can act as a major reducing agent and antioxidant defense. The purpose of this study is to analyze the effect of swallow’s nest water extract as a pancreaprotector through oxidative mechanism in rats (Rattus norvegicus) induced by streptozotocin. The rats induced by streptozotocin at a dose of 40 mg/kg BW and then randomly divided into 4 groups. Control groups were given aquades and 3 treatment groups, respectively were administered swallow’s nest water extract at doses of 1, 10, 100 mg/kg BW for 21 days. Fasting blood glucose levels were measured on 7, 14 and 21 day. MDA measured after  the animal is determined  at day 28th.Level of  fasting blood glucose and MDA were analyzed by statistic using Kruskal Wallis test followed by multiple comparisons Mann Whitney test. There was a significant decrease in fasting blood glucose level with p = 0.04 in all treatment groups compared the control group. The administration of swallow nest extract significantly decreased MDA pancreas with p value = 0.000 and dose 100 mg/kgBW extract of swallow’s nest significantly decrease pancreatic MDA level. The administration of swallow’s nest water extract shows decrease of fasting blood sugar and has a protective effect on the rats’ pancreas  through oxidative mechanism. Keywords: Swallows nest extract, MDA
VALIDITAS PEMERIKSAAN GARPU TALA 128 HZ SEBAGAI DETEKSI DIABETIC PERIPHERAL NEUROPATHY PADA PASIEN DIABETES MELITUS TIPE 2 DI RSUD DR. H. MOCH ANSARI SALEH BANJARMASIN Bagus, I Gede; Yuwono, Agus; Wydiamala, Erida
Berkala Kedokteran Vol 13, No 1 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v13i1.3437

Abstract

Abstract: Diabetic peripheral neuropathy (DPN) is one of major complication on uncontrolled diabetes mellitus (DM) patient. Test of 128 Hz tuning fork is a simple test to detect DPN which is recommended by several international guidelines and available at a limited health facility. This research aimed to discover the validity of 128 Hz tuning fork test as diabetic peripheral neuropathy detection on type 2 diabetes mellitus patient at Dr. H. Moch. Ansari Saleh Banjarmasin hospital. This was diagnostic test research with a cross-sectional design.  Data was analyzed by using diagnostic test of 2x2 table and receiving operating characteristic (ROC) curve. Subjects were 69 DM outpatient at internal medicine clinic in Dr. H. Moch. Ansari Saleh Banjarmasin hospital. The analysis results were sensitivity, specificity, positive predictive value, negative predictive value, accuracy, and area under the curve. Respectively they were 40%; 100%; 100%; 73,33%; 78,26%; and 70% (0.7) (CI 95%: 55.9%-84.1%).  The test of 128 Hz tuning fork has fine validity and can be used as DPN detection on type 2 DM patient. Keywords: Validity, tuning fork 128 Hz test, diabetic peripheral neuropathy, diabetes mellitus      Abstrak: Diabetic peripheral neuropathy (DPN) merupakan salah satu komplikasi tersering pada pasien diabetes melitus (DM)  yang tidak terkontrol. Pemeriksaan garpu tala 128 Hz adalah salah satu pemeriksaan sederhana untuk mendeteksi DPN yang direkomendasikan oleh beberapa guideline internasional dan dapat dilakukan di fasilitas kesehatan dengan fasilitas terbatas. Penelitian ini bertujuan untuk mengetahui validitas pemeriksaan garpu tala 128 Hz sebagai prosedur deteksi neuropati perifer pada pasien diabetes melitus tipe 2 di RSUD Dr. H. Moch. Ansari Saleh Banjarmasin. Penelitian ini merupakan uji diagnostik dengan pendekatan cross-sectional. Data dianalis dengan uji diagnostik tabel 2x2 dan  kurva receiving operating characteristic (ROC). Subjek penelitian merupakan 69 pasien DM rawat jalan poliklinik penyakit dalam RSUD Dr. H. Moch. Ansari Saleh Banjarmasin. Hasil analisis yang didapatkan adalah sensitivitas, spesifisitas, nilai prediktif positif, nilai prediktif negatif, akurasi, dan area under curve dari pemeriksaan garpu tala 128 Hz berturut-turut adalah 40%; 100%; 100%; 74,57%; 78,26%; dan 70% (0.7) (IK 95%: 55.9%-84.1%). Pemeriksaan garpu tala 128 Hz mempunyai validitas yang cukup baik dan dapat digunakan sebagai deteksi DPN pada pasien DM tipe 2. Kata-kata kunci: Validitas, pemeriksaan garpu tala 128 Hz,  diabetic peripheral neuropathy, diabetes melitus
CD4 LYMPHOCYTE IN HIV / AIDS BEFORE AND AFTER ANTIRETROVIRAL THERAPY Prabowo, Rangsang Bagus; Pertiwi, Dewi Indah Noviana; Hendriyono, FX.
Berkala Kedokteran Vol 13, No 2 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v13i2.4074

Abstract

Abstract: Human Immunodefficiency Virus (HIV) is a virus that decreases the human immunity system, therefore the infected people become susceptible to any kind of infections. Examination of CD4 lymphocyte count periodically is one of the antiretroviral therapy success indicators. The purpose of this research was to determine the difference of CD4 lymphocyte count before and after antiretroviral therapy at Ulin General Hospital Banjarmasin on 2013-2015. The method of this research was observational analytic with cross-sectional approach. The study population was 55 patients which were selected by inclusion and exclusion criteria. Results portrayed an increase of the CD4 lymphocyte count in 51 patients after being given four kinds of antiretroviral for 6 months with the mean increase in CD4 lymphocyte count was 92,72 cell/µL. Data analysis result with Wilcoxon test portrayed a difference of the CD4 lymphocyte count before and after antiretroviral therapy with p value=0,000. In conclusion, there was a significant difference of the CD4 lymphocyte count before and after antiretroviral therapy. Keywords: Human Immunodeficiency Virus, CD4, lymphocyt, antiretroviral therapy

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