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INDONESIA
Berkala Kedokteran
Published by Universitas Lambung Mangkurat
ISSN : 14120550     EISSN : 25485660     DOI : http://dx.doi.org/10.20527
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Berkala Kedokteran is a journal contains scientific articles from original research and literature review in medical and health scope. It is published twice in a year, on February and September.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 478 Documents
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Influence of Extract Swiftlet Nest (Collocalia Fuciphago) as Antihyperglycemia to Circulating Endothelial Cells in Rat (Rattus novergicus) Induced by Streptozotocin Alexandra, Francisca Diana; M, Satriyandi; Frethernety, Agnes; Triawanti, Triawanti
Berkala Kedokteran Vol 14, No 1 (2018)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v14i1.4528

Abstract

Abstract: Hyperglycemia could increase the oxidative stress by catalyzes the formation of free radical as anion superoxide(O2-). Oxidative stress will effect in endothelial damaged. This study aimed to evaluated the influence of  extract swiftlet nest  (Collocalia fuciphago) to glucose level and  CEC in rat (Rattus novergicus). Rats were classified into 4 groups, there were control group (K) and 3 treatments group (dose 1; 10 and 100 mg / kgBW) The seventh day  after induced by Streptozotozin (i.p),  the rats  had increased  glucose ± 102 – 108 mg/dL, then treated  with the  extract of   Swiftlet  nest for 28  days  by  oral.  The CEC was measured by Hladovec method. The results showed  the blood glucose level were significant differences ( p = 0.035). The number of CEC decrease significantly (p=0,002). In  conclusion  that extract of Swiftlet  nest  can effect  to decrease  glucose level and CEC number in plasma rat (Rattus novergicus) Keywords: Hyperglycemia, Circulating Endothelial Cells, Collocalia fuciphago
POLA KEPEKAAN ISOLAT BAKTERI AEROB PADA KONJUNGTIVITIS TERHADAP ANTIBIOTIK TERPILIH DI POLIKLINIK MATA RSUD ULIN BANJARMASIN Atmawati, Tri Utami; Faisal, M. Ali; Rahmiati, Rahmiati
Berkala Kedokteran Vol 13, No 1 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v13i1.3435

Abstract

Abstract: Bacterial conjunctivitis is a conjunctiva inflammation that caused by bacterial. This disease including to the most ten diseases of ophthalmology polyclinic at RSUD Ulin Banjarmasin; however there is no data given on the sensitivity pattern to the antibiotic. The aim this research was to assess aerob bacterial sensitivity patterns causes conjunctivitis to a topical antibiotic. This research used the descriptive method with a cross-sectional study. The  result with 21 samples isolate bacteria demonstrated that aerob bacterial sensitivity patterns to tobramicin (100%), to gentamicin (80,95%), to polymixin (80,95%), to ofloxacin (61,90%), to levofloxacin (61,90%), to chloramphenicol (42,86%); resistance to chloramphenicol (23,80%), to ofloxacin (9,52%), and to levofloxacin (9,52%). Based on the result, it can be concluded that tobramicin has the highest sensitivity pattern, followed by gentamicin, polymixin, ofloxacin, and levofloxacin. However, chloramphenicol has the smallest sensitivity pattern. Keywords: bacterial conjunctivitis, sensitivity patterns, antibiotic, ophthalmology polyclinic    Abstrak: Konjungtivitis bakteri merupakan suatu peradangan pada konjungtiva yang disebabkan oleh bakteri. Penyakit ini masih termasuk di dalam sepuluh besar penyakit yang ada di poliklinik mata RSUD Ulin Banjarmasin dan belum ada data pada kepekaan isolate terhadap terhadap antibiotik. Penelitian ini bertujuan untuk mengetahui pola kepekaan isolat bakteri aerob penyebab konjungtivitis terhadap antibiotik topikal. Penelitian ini menggunakan metode deskriptif dengan pendekatan crossectional. Hasil penelitian dengan jumlah 21 sampel isolat bakteri didapatkan gambaran pola kepekaan bakteri aerob sensitive terhadap tobramisin (100%), gentamisin (80,95%), polimiksin (80,95%), ofloksasin (61,90%), levofloksasin (61,90%), dan kloramfenikol (42,86%); resisten terhadap kloramfenikol (23,80%), ofloksasin (9,52%), dan levofloksasin (9,52%). Berdasarkan hasil penelitian ini dapat disimpulkan bahwa tobramisin merupakan antibiotik dengan kepekaan tertinggi, diikuti gentamisin, polimiksin, ofloksasin, dan levofloksasin. Sedangkan kloramfenikol memiliki kepekaan terendah. Kata-kata kunci: konjungtivitis bakteri, pola kepekaan, antibiotik, poliklinik mata
IMMATURE TO TOTAL NEUTROPHIL RATIO (I/T RATIO) ON NORMAL AND SEPSIS RISK NEONATUS FACTOR AT ULIN GENERAL HOSPITAL BANJARMASIN Noor, Muhammad Rifky Ersadian; Hendriyono, F.X.; Yunanto, Ari
Berkala Kedokteran Vol 13, No 2 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v13i2.4072

Abstract

Abstract: Neonatal sepsis is the main cause of morbidity and mortality in neonates. Early diagnostic and appropriate treatment can reduce the mortality and morbidity rate. Immature neutrophil ratio tand total neutrophil (I/T ratio) can be used as one of early diagnostic tool of neonatal sepsis. The purpose of this research was to find difference of I/T ratio between normal neonates and neonates with sepsis risk factor at Ulin General Hospital Banjarmasin on April – June 2016. It was an analytic observational study and collected by accidental sampling. From 39 neonates, there was 23 normal neonates and 16 neonates with sepsis risk factor who diagnosed by competence pediatrics based on mayor and minor risk factor. Mean I/T ratio from normal neonates is 0,06 and neonates with sepsis risk factor is 0,16. From statistical test with independent T-test, there is significant difference p=0,000 (p<0,05). In conclusion, there is a difference of I/T Ratio between normal neonates and neonates with sepsis risk factor. Keywords: neonatal sepsis, I/T ratio, risk factor, neonates
EFEK ANTIOKSIDAN IKAN SALUANG (Rasbora spp.) TERHADAP KADAR MALONDIALDEHID (MDA) OTAK TIKUS PUTIH (Rattus norvegicus) MALNUTRISI Rakhmawati, Yuli; Triawanti, Triawanti; Yunanto, Ari
Berkala Kedokteran Vol 12, No 2 (2016)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v12i2.1873

Abstract

Abstract: Malnutrition because of protein deficiency on diet caused antioxidant deficiency state and oxidative stress on brain that marked by increased MDA level. The aim of this study was to analyze the antioxidant effects of saluang (Rasbora spp.) on brain MDA level in malnourished rats. This was an experimental study with a Posttest Only with Control Group Design, consisted of malnutrition control group (M), group that feed with saluang (S), group that given standard feeding (P), and group that given standard feeding added with DHA supplement (D). Brain MDA level measured with TBARS method in spectrophotometer. Mean brain MDA level for each group in a row is M = 210,750 μΜ, S = 194,125 μΜ, P = 202,625 μΜ, and D = 200,875 μΜ. Kruskal-Wallis and Mann Whitney test showed that there were significant differences between the group that feed with saluang and the other groups (p<0.05). Based on this research, concluded that the administration of saluang (Rasbora spp.) significantly affects the decrease of brain MDA level in malnourished rats. Keywords: antioxidant, saluang fish, MDA, malnutrition Abstrak: Malnutrisi karena defisiensi protein akan menimbulkan keadaan kekurangan antioksidan dan menimbulkan stres oksidatif pada otak yang ditandai dengan peningkatan kadar MDA. Tujuan penelitian ini untuk menganalisis efek antioksidan ikan saluang terhadap kadar MDA otak tikus putih malnutrisi. Penelitian ini merupakan penelitian eksperimental dengan Posttest Only with Control Group Design, terdiri dari kelompok kontrol malnutrisi (M), kelompok pemberian pakan saluang (S), kelompok pemberian pakan standar (P), dan kelompok pemberian pakan standar yang ditambah suplemen DHA (D). Kadar MDA otak diukur dengan menggunakan metode TBARS secara spektrofotometer. Rerata kadar MDA otak masing-masing kelompok perlakuan berturut-turut adalah M = 210,750 μΜ, S = 194,125 μΜ, P = 202,625 μΜ, dan D = 200,875 μΜ. Uji Kruskal-Wallis dan uji Mann Whitney menunjukkan bahwa terdapat perbedaan bermakna antara kelompok yang diberi pakan saluang dengan kelompok lainnya (p<0,05). Berdasarkan penelitian yang dilakukan dapat diambil kesimpulan bahwa pemberian ikan saluang (Rasbora spp.) berpengaruh secara bermakna terhadap penurunan kadar MDA otak tikus putih malnutrisi. Kata-kata kunci: antioksidan, ikan saluang, MDA, malnutrisi
Effect of Anti-Tuberculosis Multi Drug Resistance Regimen on Hematological Lung Tuberculosis Patients Profile with Multi Drug Resistance Putra, Pradana Maulana
Berkala Kedokteran Vol 14, No 1 (2018)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v14i1.4550

Abstract

Abstract: ATD administration of tuberculosis in combination and duration often causes multi drug resistance (MDR) ATD due to discontinuation of treatment. Reported hematologic abnormal changes due to ATD. This study investigated hematological changes before and during MDR therapy of MDR TB patients in Tuberculosis MDR RSUD Ulin Banjarmasin from September to December 2017. The study population was patients treated in TB MDR Poly and selected samples with a time-limiting method. Inclusion and exclusion criteria were MDR-TB patients detected by Gene Xpert® examination, treated <30 days, between 18 and 65 years of age, HIV negative, as well as identification and laboratory data recorded in the complete medical record. 17 samples collected by hematological parameters were collected. There were significant changes in hemoglobin, hematocrit, platelets, RDW-CV, MCV, eosinophils, lymphocytes, granulocytes, and monocytes after treatment. It was concluded that MDR regimen ATD did not cause anemia and thrombocytopenia. There was also no significant change in WBC even though the count of the species changed significantly Keywords:                  Tubeculosis, Multi Drug Resistency (MDR), Anti Tuberculosis Drugs (ATD), profil hematologis
STUDY OF INTERACTION BETWEEN LEAD AND GASTRIC MUCOSAL PROTEIN OF RATS WITH FORENSIC TOXICOLOGY APPROACH Aflanie, Iwan; Thalib, Iskandar; Suhartono, Eko
Berkala Kedokteran Vol 13, No 2 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v13i2.4065

Abstract

Abstract: Recently, forensic toxicology has been an interesting concern, especially in exposing the phenomena associated with the law. Using the forensic toxicology approach, several cases of lead (Pb) poisoning have been widely revealed. In this present study will be investigate the interaction between Pb and amino acid gastric mucosal constituent proteins, especially cysteine and tyrosine groups. This research is a pure experimental research with posttest control group design, which is divided into 4 groups with 6 rats (Rattus novergicus) in each group. Treatment in each group as follows; P0 was control group were given 2 ml of distilled water; P1 = administration of Pb 0.1 g/L; P2 = Pb administration of 1 mg/L; and P3 = Pb administration of 10 g/L for 4 weeks repectively. According to the results, it can be concluded that Pb-Protein interaction tends to binding of Pb-Cysteine rather than Pb-Tyrosine Keywords: Gastric Mucosa, Lead, Protein
The Increase in Nutritional Status by Fermented Milk Supplement on Elementary School Children from Fishermans Village in Bantul, Yogyakarta Province of Indonesia Kesetyaningsih, Tri Wulandari; Orbayinah, Salmah; Suryani, Lilis
Berkala Kedokteran Vol 14, No 1 (2018)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v14i1.4538

Abstract

Abstract: Probiotics drinks, containing Lactobacillus, were rapidly developed because of its benefit to the health. The bacteria reduced the pathogenic microorganism growth such as virus, fungi, and protozoa. The nutritional status is influenced by food intake, immunity and infection. The children of fisherman’s village are included in the insecure nutrition group because of the low social economic status and healthy living behavior. The aim of this research was to know the influence of daily consumption of probiotics in fermented milk to the nutrition status in elementary school children. This research is quasi-experimental with pretest-posttest control group design. Subjects of 95 elementary school children were divided into 2 groups: 62 children as treatment group and 33 children as control group. Determination of nutritional status is based on anthropometry according to CDC 2000 (BMI-age) growth-chart; and the biochemistry parameter consist of the level of serum total protein, albumin, blood urea nitrogen (BUN), urine creatinine and hemoglobin. Determination of serum total protein and BUN were carried out by Microkjeldahl method, hemoglobine by cyanmet hemoglobin method, albumin by dye-binding method, and creatinine level by Jaffe reaction method. The infection status was determined by anamnesis and laboratory examination of feces which was conducted to find the parasite in the stool. Of sixty five ml fermented milk, that contains of 6.5 x 109 Lactobacillus shirota strain, was consumed every day in 37 days. The data was analyzed by Wilcoxon test for nonparametric data and paired T-test for parametric data.  The result shows that after the treatment, it increased the nutritional status athropometrically from underweight to normal (12.9%) and overweight to normal (3.23%). In biochemically, it increased the total protein level from 6,111 to 6,705 mg/dL (p=0,001) and decreased the BUN from 42,709 to 41,127 mg/dL (p=0,004) significantly eventhough it was in normal range. The conclusion is that consuming fermented milk for 37 days in children is proven to enhance the nutritional status both by anthropometric and biochemistry parameter. Keywords: probiotic, nutritional status, Lactobacillus, fermented milk supplement
HUBUNGAN PENGETAHUAN DENGAN PEMANFAATAN KLINIK SANITASI PADA IBU BAYI DAN BALITA PENDERITA DIARE AKUT Husnawati, Herwinda; Arifin, Syamsul; Yuliana, Ida
Berkala Kedokteran Vol 13, No 1 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v13i1.3440

Abstract

Abstract: Based on data from Banjarmasin Department of Health in 2015, the highest diarrhea incident which is 1.056 cases, occurs at Puskesmas Kuin Raya Banjarmasin. There is an imbalance between diarrhea incident and visitation to sanitation clinic. Many factors are influencing someone’s behavior while knowledge is one of those. This research aimed to discover the correlation between education and sanitation clinic utilization on a mother of acute diarrhea toddlers at Puskesmas Kuin Raya Banjarmasin. This was an analytic observational study with cross sectional design. The samples were 50 mothers chosen by systematic random sampling method. The analysis was conducted by chi-square test. The result portrayed 12% of high education, 22% of fair education and 66% of low education. Meanwhile, there were 64% non-utilization and 36% utilization of sanitation clinic. The correlation p-value was 0,000 (p<0,05). In conclusion,  there is a correlation between education and sanitation clinic utilization on a mother of acute diarrhea toddlers at Puskesmas Kuin Raya Banjarmasin. Keywords: acute diarrhea, sanitation clinic utilization, education Abstrak: Data Dinas Kesehatan Kotamadya Banjarmasin tahun 2015 didapatkan angka kejadian diare tertinggi sebanyak 1,056 kasus di Puskesmas Kuin Raya Banjarmasin. Terdapat kesenjangan antara angka kejadian diare dengan jumlah kunjungan ke klinik sanitasi. Banyak faktor yang mempengaruhi pemanfaatan klinik sanitasi, salah satunya adalah pengetahuan. Tujuan penelitian ini untuk mengetahui hubungan pengetahuan dengan pemanfaatan klinik sanitasi pada ibu bayi dan balita penderita diare akut di Puskesmas Kuin Raya Banjarmasin. Metode penelitian ini adalah observasional analitik dengan pendekatan cross sectional. Sampel berjumlah 50 responden dengan teknik systematic random sampling. Analisis data menggunakan uji chi-square. Hasil penelitian adalah 12% mempunyai pengetahuan tinggi, 22% berpengetahuan cukup dan 66% berpengetahuan rendah. Sementara itu, untuk pemanfaatan klinik sanitasi didapatkan hasil tidak memanfaatkan klinik sanitasi 64% dan memanfaatkan 36%. Nilai korelasi p = 0,000 (p< 0,05). Kesimpulan penelitian ini terdapat hubungan pengetahuan dengan pemanfaatan klinik sanitasi pada ibu bayi dan balita penderita diare akut di Puskesmas Kuin Raya Banjarmasin. Kata-kata kunci: diare akut, pemanfaatan klinik sanitasi, pengetahuan
POTENTIAL ETHANOL OF Carica papaya L. EXTRACT AS IMMUNOMODULATORY THROUGH HISTOLOGY OBSERVATION AT MICE BALB/C SPLEEN Tasminatun, Sri; Pravitasari, Ria; Makiyah, SN. Nurul
Berkala Kedokteran Vol 13, No 2 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v13i2.4077

Abstract

Abstract: The diameter of the alba pulp of the spleen will be enlarged, when the body responds to allergens by increasing the activity of the immune system. Papaya fruits (Carica papaya L.) containing flavonoid that can be as an immunomodulator. This study aims to determine the effect of C. papaya extract to the diameter size alba pulp of the spleen of Ovalbumin (OVA) induced Balb/C mice. The research design was experimental in vivo animal test with post-test only control group design. Thirty male Balb/C mice, ±20grams weight, 8 weeks old, divided into six groups consists of a normal control, negative control, Methylprednisolone, and C. papaya extract treatment group (175mg/kg, 350mg/kg and 700mg/kg dose per day). The extract and Methylprednisolone are given for 28 days, while OVA is given on 15thand 22ndday (intraperitoneal,) and 23rd until 28thday (peroral). On the 29thday the mice are sacrificed and the duodenum was made into histological preparation with HE staining. The immunomodulator effect is assessed by the average of the diameter size alba pulp of the spleen under a light microscope. The data were analyzed using SPSS15 with one way ANOVA continued with Tukey test. The average of the diameter size alba pulp of the spleen for control group is 10,165 ± 0,195; negative control group is 30,357 ± 0,826; methylprednisolone group is 10,220 ± 0,346; 175mg/kgbb dose extract is 14,956 ± 1,057; 350mg/kgbb dose extract is 14,030 ± 0,667; and 700mg/kgbb dose extract is 12,504 ± 0,729. The conclusion of this study is Carica papaya L. extract treatment group (175mg/kg, 350mg/kg and 700mg/kg dose per day) has an effect to the average of the diameter size alba pulp of the spleen in OVA-induced Balb/C mice significantly. 700mg/kg dose per day has the same effect with the methylprednisolone group. Keywords: immunomodulator, Carica papaya L., alba pulp of the spleen, ovalbumin
HUBUNGAN KONDISI VENTILASI RUMAH DENGAN KEJADIAN TB PARU DI WILAYAH PUSKESMAS KELAYAN TIMUR Sinaga, Ferdy Ricardo; Heriyani, Farida; Khatimah, Husnul
Berkala Kedokteran Vol 12, No 2 (2016)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v12i2.1878

Abstract

Abstract : Pulmonary TB is an infectious disease which is transmitted through air contaminated by Mycobacterium tuberculosis. TB remains a main health problem in all over the world and also one of leading causes of death from infectious disease. Enviromental characteristic is the key factor to the risk of transmition. Ventilation condition is one factor that contributes to the house’s environmental characteristic. This research aims to know the correlation between ventilation condition and the incidence of pulmonary TB in working area of Kelayan Timur Community Health Center. This is an analitic observasional research with study design of case control. Subjects were selected using the simple random sampling technique. Subjects were divided into 2 groups, 30 subjects for the case group and 30 subjects for the control group. Data was analyzed using Chi Square test with 95 % confidence interval. The result shows that 29 of 30 houses (96,67 %)  from the case group have an inproper ventilation meanwhile only 9 of 30 houses (30 %) from the control group which have an inproper ventilation. The analysis shows a significant correlation between ventilation condition and the incidence of pulmonary TB with ρ = 0,000.  Keywords: ventilation condition, pulmonary TB, Kelayan Timur Community Health Center. Abstrak : TB paru merupakan penyakit infeksi yang ditularkan melalui udara yang terkontaminasi Mycobacterium tuberculosis. TB masih menjadi masalah utama kesehatan di seluruh dunia dan merupakan salah satu penyebab kematian akibat penyakit infeksi. Keberlangsungan hidup kuman TB ditentukan oleh karakteristik lingkungannya. Kondisi ventilasi rumah merupakan salah satu faktor yang mempengaruhi karakteristik lingkungan dalam rumah. Penelitian ini bertujuan untuk mengetahui hubungan kondisi ventilasi rumah dengan kejadian TB paru di wilayah Puskesmas Kelayan Timur. Penelitian ini adalah penelitian observasional analitik dengan desain studi kasus kontrol. Subjek penelitian dipilih dengan menggunakan teknik simple random sampling. Subjek penelitian terdiri dari 2 kelompok yaitu 30 sampel kelompok kasus dan 30 sampel kelompok kontrol. Data dianalisa menggunakan uji Chi Square dengan tingkat kepercayaan 95 %. Hasil penelitian menunjukkan 29 dari 30 kelompok kasus (96,67 %)  memiliki kondisi ventilasi rumah yang tidak memenuhi syarat, sedangkan hanya 9 dari 30 kelompok kontrol (30 %) yang memiliki kondisi ventilasi rumah yang tidak memenuhi syarat. Hasil analisa mendapatkan nilai ρ=0,000 sehingga dapat disimpulkan bahwa terdapat hubungan yang bermakna antara kondisi ventilasi rumah dengan kejadian TB paru. Kata-kata kunci: kondisi ventilasi, TB paru, Puskesmas Kelayan Timur.

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