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INDONESIA
Jurnal Farmasi Udayana
Published by Universitas Udayana
ISSN : 23017716     EISSN : 26224607     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Udayana merupakan jurnal elektronik yang dikelola oleh jurusan Farmasi FMIPA Udayana. Jurnal ini yang merupakan media publikasi penelitian dan review article pada semua aspek ilmu farmasi yang bersifat inovatif , kreatif, original dan didasarkan pada scientific. Artikel yang dimuat dalam jurnal ini meliputi penemuan obat, sistem penghantaran obat serta pengembangan obat. Jurnal ini memuat bidang khusus di farmasi seperti kimia medisinal, farmakologi, farmakokinetika, farmakodinamika, analisis farmasi, sistem penghantaran obat, teknologi farmasi, bioteknolofi farmasi, obat herbal dan komponen aktif tanaman serta evaluasi klinik obat
Arjuna Subject : -
Articles 7 Documents
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Search results for , issue "Vol. 13, No. 1, Tahun 2024" : 7 Documents clear
Hubungan Kepatuhan Terapi Antihiperglikemia Terhadap Terkontrolnya HbA1c pada Pasien Terdiagnosa Diabetes Melitus Tipe 2 di RSU Prima Medika, Denpasar Ariyanti, Ni Kadek Nining; Virginia, Dita Maria; Hendra, Phebe
Jurnal Farmasi Udayana Vol. 13, No. 1, Tahun 2024
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

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Abstract

Diabetes mellitus is a disease caused by chronic metabolic disorders accompanied by increased blood glucose levels. Adherence to treatment is very important to achieve therapeutic success in type 2 diabetes mellitus (T2DM) patients and prevent complications. HbA1c value is one of the parameters used to see the success of T2DM therapy. This study was conducted to determine the relationship between compliance with antihyperglycemic therapy for T2DM patients and the patient's HbA1c value. This study used a cross-sectional research design and data collection was carried out by non-random sampling with purposive sampling technique. The research subjects were 100 T2DM patients at RSU Prima Medika Denpasar, Bali with the age of 40-70 years. The level of patient compliance in taking medication was measured by the Medication Possession Ratio (MPR) method based on patient treatment records. The results showed 78% aged 40-59 years, 53% female, 86% T2DM with comorbidities 62% received combination therapy, 87% were compliant with taking medication. There was no significant relationship between the characteristics of T2DM patients and compliance (p-value > 0.05). There was a significant association between medication adherence and controlled HbA1c values in patients with T2DM (p-value < 0.05; OR (95%CI) : 4,902 (1,026 - 23,430)).
Review Artikel Beyond Use Date Sediaan Steril Rekonstitusi wahyuni, LP eka; Warditiani, Ni Kadek; Suryani, N.P Febri; Sugiantara, I.W Eka; Rahayu, N.P Savitri; Dewi, N.P Apsari; Jayanti, N.K.P Aprilia; Adi P.S, I.K; Chantika P, N.K; Bayu J.K, I.M; Diah K, Shinta
Jurnal Farmasi Udayana Vol. 13, No. 1, Tahun 2024
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

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Abstract

Beyond Use Date (BUD) is the last date on which a medicinal preparation is considered stable and safe for use after reconstitution or preparation. Determination Beyond Use Date (BUD) functions to keep injection preparations sterile, protected from contaminants, protected from physical and chemical degradation. The method used in preparing this article is based on pharmaceutical literature, especially related literature steril coumponding method and pharmaceutical libraries. The purpose of this review article is to find out the importance of information regarding the BUD of reconstituted sterile preparations and how to use the drug after reconstitution. Determination of BUD for sterile preparations based on literature review United states of Phamacophea, American Society of Health-System Pharmacists (ASHP), and national and international published journals. The results of the article preparation are that the BUD determination is based on factors such as the chemical, physical and microbiological stability of the diluted drug. Reconstitution injection is a process in which a drug in dry form, such as powder or crystals, is converted into an injectable solution by adding a certain solvent or liquid. Quality requirements for reconstituted preparations include criteria that must be met by medicinal preparations after the reconstitution process to ensure their quality, safety and effectiveness. There are obstacles in determining the BUD for sterile preparations because the BUD time available is shorter after reconstitution, so there are several solutions that can be applied to maintain the stability of the preparation.
Literatur Review: Gambaran Pengetahuan Masyarakat Mengenai Beyond Use Dates Obat Racikan Padat Non Steril Prascitasari, Ayu; Warditiani, Ni Kadek; Septiarini, Putu Ayudia; Permatasari, Ni Made Ayu Dinda; Ananda Putri, Ida Ayu Ngurah Trisna Noviani; Andika, Dewa Made Dwi; Candrayani, Komang Tri; Arkhania, Ni Putu Ayu Dhea; Sanjaya, Sadina Vania Tsany Dyah; Ariswari, Ni Kadek Putri; Nugrahaeni, Luh Gede Ratih Dewi Tri
Jurnal Farmasi Udayana Vol. 13, No. 1, Tahun 2024
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

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Abstract

Kurangnya pemahaman masyarakat terkait Beyond Use Date (BUD) disebabkan oleh minimnya informasi yang diberikan oleh tenaga kesehatan mengenai hal tersebut. BUD merupakan batas waktu obat bisa dikonsumsi setelah kemasan primernya dibuka. Metode yang digunakan dalam penyusunan artikel ini didasarkan pada Literatur Review mengenai penerapan Beyond Use Date (BUD) pada obat campuran padat non-sterile. Artikel yang dipilih telah memenuhi kriteria inklusi yang telah ditetapkan yaitu artikel yang terpublikasi pada tahun 2014-2024. Hasil yang diperoleh yaitu peningkatan pengetahuan masyarakat setelah diberikan sosialisasi terkait BUD tentang pengertian BUD, perbedaan BUD dan ED pada tablet, kapsul, obat racikan, dan non racikan. Sediaan padat harus memiliki BUD paling lambat sama dengan sisa waktu sampai tanggal kadaluarsa zat aktif terawal dalam sediaan atau 180 hari, dipilih yang paling singkat.
Analisis Kadar Glukomanan dan Evaluasi Biopolimer Edible Film Umbi Porang Sebagai Pengemasan Pangan Fungsional Putra, I Gusti Ngurah Trisna Meyana; Kusuma, I Made Gede Ari; Kurniadinata, I Putu Bagus; Wulandari, Ni Made Widya; Dewi, Ni Komang Gita Listyari; Astuti, Ni Made Widi
Jurnal Farmasi Udayana Vol. 13, No. 1, Tahun 2024
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

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Abstract

Kemasan mampu melindungi produk dari kontaminasi. Namun, disisi lain kemasan juga dapat sebagai sumber utama timbulnya limbah. Edible film adalah suatu bahan yang dapat diaplikasikan dalam pelapis dan pembungkus hidangan yang bisa dikonsumsi secara langsung bersama bahan makanan tersebut serta dapat menjaga sterilitas makanan dan mencegah hilangnya komponen gizi makanan. Produksi edible film dari glukomanan umbi porang ini melalui serangkaian tahapan produksi. Diawali dengan pembuatan tepung porang, penentuan kadar glukomanan, penentuan kadar kalsium oksalat, identifikasi dengan FTIR, pembuatan edible film, serta uji evaluasi atau karakterisasi edible film seperti uji organoleptis, ketebalan, kadar air, laju transmisi uap air, daya menahan air, dan daya menahan minyak. Kadar glukomanan dan kalsium oksalat yang didapatkan dari riset ini adalah sebesar 87,7% dan 59,1829 mg/100 g. Identifikasi dengan FTIR ditemukan adanya gugus -OH, -CH2, -CO dan -CH yang sesuai dengan pustaka. Hasil uji ketebalan edible film adalah 0,123 mm; 0,143 mm; 0,156 mm. Hasil uji kadar air adalah 6,331%; 6,728%; 7,6%. Hasil uji laju transmisi uap air adalah 10,147 g/jam.m2 ; 13,345 g/jam.m2 ; dan 24,108 g/jam.m2 . Hasil uji daya menahan air adalah 7,209 g/g; 7,266 g/g; dan 7,389 g/g. Hasil uji daya menahan minyak adalah 2,698 g/g; 2,495 g/g; dan 2,483 g/g.
AKTIVITAS ANTIBAKTERI FUNGI ENDOFIT DAUN SIRSAK (Annona Muricata Linn.) TERHADAP Vibrio Cholerae DAN Bacillus Subtilis Ratnah, St.; Andriani, Novita; Daswi, Dwi Rachmawaty; Pakadang, Sesilia Rante; Salasa, Alfrida Monica
Jurnal Farmasi Udayana Vol. 13, No. 1, Tahun 2024
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

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Sirsak plant is traditional plant that believed empirically as cough medicine, dysentery, rheumatism, lowering uric acid levels and diarrhea community. Vibrio cholerae and Bacillus subtilis types bacteria can cause diarrhea. This study aims to determine the number endophytic fungi found from Sirsak leaves, to determine antibacterial activity endophytic fungi isolates from Sirsak leaves against Vibrio cholerae, and Bacillus subtilis. Furthermore, inoculated repeatedly on SDA for 5-7 days until isolates were obtained. Each isolate was fermented with GDP for 2-3 weeks and then extracted with ethyl acetate. Ethyl acetate extract was used antibacterial with agar diffusion method MHA media. Test results showed that 5 isolates were obtained, namely White DS isolate, Toska DS isolate, Green DS isolate, Cream DS isolate, and Blackish Brown DS isolate. Where DS White isolate suspected of Cylindrocladium sp, DS Toska isolate suspected of Aspergillus fumigatus, DS Green, isolate suspected of Aspergillus flavus, DS Cream isolate suspected of Aspergillus terreus, DS Blackish Brown isolate suspected of Aspergillus niger. Sirsak leaf endophytic fungal isolates (White DS, Toska DS, Green DS, Cream DS and Blackish Brown DS) showed antibacterial activity against Vibrio cholerae and Bacillus subtilis.
Penumbuh Rambut Hair Tonic Aloe vera secara in vivo pada Kelinci Warditiani, Ni Kadek; Armita Sari, Pande Made Nova; Maha Dewi, Ni Kadek Santi; Natalia Kote, Jessica Christy
Jurnal Farmasi Udayana Vol. 13, No. 1, Tahun 2024
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

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Hair loss is an event of hair loss from the scalp that occurs regularly. However, hair loss becomes a problem if the amount of loose hair exceeds the normal limit. A hair tonic serves as a base for taking care of the hair and scalp. Aloe vera is often used as a hair care ingredient. In addition, this natural ingredient has the function of accelerating hair growth and reducing hair loss. Another natural ingredient used in making hair tonic is patchouli oil, which of course has a distinctive smell. The intention of this examine became to assess the effectiveness of a mixture of aloe vera and patchouli oil as a hair tonic for hair growth. In this study using a rabbit ridge which will be divided into 5 treatment groups with each different treatment. The treatment group that was given consisted of normal control, negative control (basic hair tonic), comparison control (hair tonic on the market), treatment control 1 (hair tonic given every 2 days) and treatment control 2 (hair tonic given 3 times). once a day). The test results were carried out by measuring the length of the rabbit's hair every 7 days for 21 days. One Way ANOVA and the LSD test were then used to statistically test the collected data. The study's findings demonstrated that a hair tonic consisting of aloe vera and patchouli oil, administered once every three days, significantly (p<0.05) accelerated the development of hair in rabbits.
LITERATUR REVIEW_ EVALUASI PERBANDINGAN METODE FILTRASI DALAM PROSES STERILISASI Wulandari, Ni Made Widya; Putra, Putu Nico Januarta; Oktapiani, Ni Ketut; Ardiana, Made Galu Putra; Ngedo Reo, Maria Esmeralda Elvira
Jurnal Farmasi Udayana Vol. 13, No. 1, Tahun 2024
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

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Artikel ini membahas tentang perbandingan kinerja kapsul dan kaset pada teknologi filtrasi aliran tangensial (tangential flow filtration, TFF) untuk pemurnian polisakarida teraktivasi yang digunakan dalam pembuatan vaksin konjugat. Penelitian ini bertujuan untuk mengevaluasi kesesuaian kapsul sekali pakai sebagai alternatif agar kaset dapat digunakan kembali. Hasil penelitian menunjukkan bahwa nilai hasil pada skala besar sebanding (90% untuk kapsul sekali pakai vs 91% untuk kaset multi guna) untuk format perangkat kapsul dan kaset. Hasil untuk perangkat skala kecil dengan luas permukaan 88 cm2 juga menunjukkan hasil yang serupa (84%), mengindikasikan bahwa sifat kimia membran dan konfigurasi saluran TFF tidak mempengaruhi hasil pemurnian. Hasil yang lebih rendah untuk modul skala kecil kemungkinan disebabkan oleh proporsi volume proses yang lebih besar dalam sistem penundaan. Secara keseluruhan, hasil TFF untuk semua modul memperlihatkan bahwa kapsul sekali pakai dapat digunakan sebagai alternatif yang sesuai untuk kaset multi guna. Kata kunci: sterilisasi; filtrasi; membran; pemurnian; kaset, TFF.

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