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MNJ (Malang Neurology Journal)
Published by Universitas Brawijaya
ISSN : 24076724     EISSN : 24425001     DOI : -
Core Subject : Science,
Neuroscience
Malang Neurology Journal is a peer-reviewed and open access journal that focuses on promoting neurological sciences generated from basic neurosciences and clinical neurology. This journal publishes original articles, reviews, and also interesting case reports. Brief communications containing short features of medicine, latest developments in diagnostic procedures of neurology disease, treatment, or other health issues related to neurology that is important also acceptable. Letters and commentaries of our published articles are welcome.
Arjuna Subject : -
Articles 297 Documents
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CHARACTERISTICS OF ACUTE ISCHEMIC STROKE PATIENTS DUE TO SMALL VESSEL OCCLUSION Richard Suherlim; Nyoman Angga Krishna Pramana; Kumara Tini; Ida Bagus Kusuma Putra; Ida Ayu Sri Indrayani
MNJ (Malang Neurology Journal) Vol. 9 No. 1 (2023): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2023.009.01.5

Abstract

Background: Ischemic stroke account for about 87% of all stroke cases. This study will focus on ischemic stroke due to small vessel occlusion as one of the subtypes based on TOAST (trial of ORG 10172 in acute stroke treatment). Objective: To determine the characteristics of ischemic stroke patients caused by small vessel occlusion and are expected to be used as a basis for further research. Methods: A descriptive observational retrospective study regarding the characteristics of acute ischemic stroke patients due to small vessel occlusion at Sanglah Hospital. Secondary data were obtained from patient medical records. Results: The total number of cases of small vessel occlusion was 338. The majority of the sample were men (64.5%) between 40-60 years old (53.6%). Most of the samples were patients who had experienced an ischemic stroke for the first time (75.1%) with NIHSS (National Institute of Health Stroke Scale) scores showing mild (48.2%) and moderate (51.5%) symptoms. Around half of them had a history of hypertension (60.1%), dyslipidemia (59.5%), and diabetes mellitus (44.1%). The most common location of infarction was in the anterior circulation (77.5%) with almost the same ratio of right and left hemisphere locations. Conclusion: Ischemic stroke due to occlusion of small vessels at Sanglah Hospital Denpasar for 3 years was 35.2% of the total ischemic stroke cases. Half of the total sample had classic vascular risk factors. Further research is needed to determine another effective treatment strategy other than just secondary prevention such as life style moderation to prevent recurrency.
KERNOHAN’S NOTCH PHENOMENON IN AN ACUTE COMPONENTED CHRONIC SUBDURAL HEMATOMA PATIENT: A CASE REPORT Ziya Asan
MNJ (Malang Neurology Journal) Vol. 9 No. 1 (2023): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2023.009.01.11

Abstract

Kernohan's notch phenomenon is a rare examination finding in cases diagnosed as an intracranial space-occupying lesion. The localization of the space-occupying lesion in this clinical status, which is considered as a sign of herniation, is on the opposite side of the predicted side. The most typical finding is motor deficit and mydriasis on the same side as the space-occupying lesion. A 61-year-old female patient was evaluated in the emergency department due to sudden loss of consciousness. Her neurological examination revealed anisocoria and right hemiparesis findings, including mydriasis in the right pupil. Cranial computed tomography examination revealed a large, acute component combined with chronic subdural hematoma in the right frontoparietal region and midline shift. Clinical and radiological findings were evaluated as Kernohan’s Notch Sign phenomenon. The patient, who was operated on urgently, was discharged on the 7th postoperative day without any neurological deficits.
NEUROLOGICAL ADVERSE EVENTS FOLLOWING IMMUNIZATION (AEFI) ON HEALTH WORKFORCE OF A SECONDARY REFERRAL HOSPITAL IN SOUTH SULAWESI WHO RECEIVED THE Lutpyah L; Arthur Hendrik Philips Mawuntu; Hamdana H; Mieke Actrees Hanna Nelly Kembuan
MNJ (Malang Neurology Journal) Vol. 9 No. 1 (2023): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2023.009.01.6

Abstract

Background: The COVID-19 vaccination can relate to the occurrence of neurological adverse events following immunization (AEFI) that could impact work and daily activities. This problem is particularly important in the health workforce. However, little is known about neurological AEFI among the health workforce working in peripheral facilities. Objective: To study the neurological AEFIs and their impact among the health workforce who received the COVID-19 vaccination in a secondary referral hospital in South Sulawesi, the Andi Makassau Hospital (Rumah Sakit Umum Daerah Andi Makassau/RSAM). Methods: The COVID-19 pandemic, we created a questionnaire about neurological AEFIs and their effects which were distributed online using the Google Form application to the health workforce at the RSAM who had received at least one dose of COVID-19 vaccination. Results: We obtained 97 subjects. There were 78.5% neurological AEFIs with the most reported type being muscle pain (16%). Most neurological AEFIs were experienced by women (84.9%), age group 21-35 years (53.8%), and non-doctors/nurses (60.8%). The significant influencing factors in multivariate analysis were age group 36-45 years (p = 0.04), nursing proffesion (p = 0.005), and non- viral-based baccine type (p = < 0.0001). Conclusion: Neurological AEFI is commonly found among the health workforce who received the COVID-19 vaccination. However, it only has a little impact on their work and attitudes towards vaccination. This may be because all subjects experienced mild neurological AEFI.
A CASE OF COMBINED CENTRAL AND PERIPHERAL DEMYELINATION IN A PATIENT WITH PEDIATRIC MULTIPLE SCLEROSIS AFTER SARS-COV-2 VACCINATION Angeloglou Stella; Gkantzios Aimilios; Kourtesis Ioannis; Samaras Nikolasos; Barmpari Athanasia; Filippi Aikaterini; Taulant Jupe; Kosta Natalia; Maltezou Maria
MNJ (Malang Neurology Journal) Vol. 9 No. 1 (2023): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2023.009.01.12

Abstract

We present a case of combined central and peripheral demyelination in a patient with pediatric multiple sclerosis after the first dose of ChAdOx1-S (Chimpanzee Adenovirus Oxford 1) vaccination. The patient presented with ascending flaccid quadriparesis with respiratory failure that required mechanical ventilation. The lumbar puncture revealed albuminocytological dissociation, was negative for presence of JCV (John Cunningham Virus) in the CSF (Cerebrospinal Fluid) and ruled out other infections. A few days later he developed anisocoria and multiple new enlarging acute demyelinating lesions in the brain MRI (Magnetic Resonance Imaging). He was treated with intravenous immunoglobulin, corticosteroids and plasma exchange with gradual improvement. All other diseases were excluded via MR Spectroscopy, MR Angiography and serum and CSF laboratory investigations. Seven months later, the patient is under intense physiotherapy and is improving every day.
DEALING WITH UNCONTROLLED SEIZURE IN CATAMENIAL EPILEPSY: A CASE REPORT Machlusil Husna; I Wayan Arsana Wiyasa; Ria Damayanti; Syah Sembung Wasiso; Fahimma Fahimma; Kartika Agustina
MNJ (Malang Neurology Journal) Vol. 9 No. 1 (2023): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2023.009.01.16

Abstract

Catamenial epilepsy refers to a seizure pattern that coincides with the menstrual period. Patients with catamenial epilepsy often leads to intractable epilepsy and may have an adverse impact on quality of life. Several medications are the therapeutic options, however, there is uncertainty regarding the best treatment, and these medications often fail to control the seizure. This makes catamenial epilepsy categorized as pharmaco-resistant epilepsy. This paper reported a case of perimenstrual catamenial epilepsy with an uncontrolled seizure problem. Seizures still occur with optimal management, and thereby clinicians must continue to re-evaluate clinical conditions and treatment selection to achieve optimal management. Personalized-based treatment should be considered in catamenial epilepsy management. This report discusses the challenges of catamenial epilepsy, understanding the catamenial process, and dealing with the problem with a practical personalized approach.
FACTORS AFFECTING THE FUNCTIONAL STATUS OF PATIENT WITH MENINGIOMA IN DR. SAIFUL ANWAR GENERAL HOSPITAL MALANG Dessika Rahmawati; Badrul Munir; Nanik Setijowati; Catur Ari Setianto; Ria Damayanti; Bimo Mubyarto
MNJ (Malang Neurology Journal) Vol. 9 No. 1 (2023): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2023.009.01.17

Abstract

Background: Meningioma is one of the most commonly reported primary central nervous system (CNS) tumors, originating from arachnoid meningeal cells and including intracranial extra-axial neoplasms. Although meningioma is considerably benign, the patient conditions are reported to be diverse resulting in severe and life-threatening neurological deficits. Hence the assessment regarding functional status is deemed pivotal to provide a prognostic perspective as patient presentation exhibits disability due to lesions and other factors. Objective: This research aims to analyze factors affecting the functional status of patients with meningioma in Dr. Saiful Anwar General Hospital Malang. Methods: An analytic retrospective study was conducted with cross-sectional study involving 62 samples from patients visits with meningioma brain tumor in RSUD dr. Saiful Anwar General Hospital Malang from January 2017 to December 2020. The data was selected through non-probability sampling, generating sampling type from brain tumor register data Neurology. Results: Data obtained from 62 meningioma patients in RSUD dr. Saiful Anwar General Hospital Malang met the inclusion criteria from January 2017 to December 2020, based on demographic characteristics such as age of <50 in 38 patients (61.3%) and age of >50 in 24 patients (38.7%). Clinically, it was found that 58 patients (93.5%) experienced headache, 28 patients (45.2%) experienced decreasing consciousness, 15 patients (24.2%) had hemiplegia, and 17 patients (27.4%) had hemiparesis, 17 people had hemiparesis. 17 patients (27.4%) experienced visual disturbances, and 24 patients (38.7%) are with seizures. Based on the radiology screening sites, 46 patients (74.2%) were screened in Convexity sphere, 9 patients (14.5%) were screened at Cranial base, 3 patients (4.8%) were screened at Parasagittal, and 4 patients (6.5%) were screene at Falx, from which the 41 patients (66.1%) exhibited herniation. Based on comorbidities, 12 patients (19.4%) had sepsis, and 1 patient (1.6%) had pneumonia. From the analysis test results, it was found that decreasing consciousness (GCS) was significantly correlated with functional status, referred to Karnofsky Performance Scale of <70 (p: 0.013, p <0.05). Seizures were reported to be correlated significantly with functional status, referred to Karnofsky Performance Scale of > 70 (p: 0.015, p<0.05). Tumor location was significantly correlated with functional status, reffered to Karnofsky Performance Scale of > 70 (p: 0.027, p<0.05). Conclusion: The factors affecting the functional status based on the Karnofsky Performance Scale (KPS) of a patient with meningioma at Dr. Saiful Anwar General Hospital Malang included: decreasing consciousness (GCS), and seizures, and tumor location.
THE RELATIONSHIP OF EPILEPTIFORM WAVES IN ELECTROENCEPHALOGRAM WITH EPILEPSY TYPE OF SCHOOL-AGE EPILEPSY PATIENTS Jerome Constantine Lekatompessy; Bertha Jean Que; Laura Bianca Sylvia Huwae
MNJ (Malang Neurology Journal) Vol. 9 No. 2 (2023): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2023.009.02.5

Abstract

Background: Epilepsy in children causes memory problems in the learning process, so an early diagnosis of epilepsy is needed. The modality for determining the diagnosis of epilepsy is an electroencephalogram (EEG) examination. EEG recording results in epilepsy patients are epileptiform waves that can vary according to the type of epilepsy suffered. Objective: This study aims to determine the relationship of epileptiform waves on an electroencephalogram (EEG) with the type of epilepsy in school-age epilepsy patients. Methods: This study is an analytical study that uses secondary data in the form of medical records with cross sectional design. The research subjects were 106 patients taken with total sampling technique. Data collection is done by recording medical record data on the data collection form made by researchers. Correlation analysis between variables in this study used the Fisher test. Results: The results of this study indicate there is a relationship between epileptiform waves on the electroencephalogram (EEG) with the type of epilepsy in school-age epilepsy patients, with p = 0.018 in 0.050 significance value. Conclusion: It can be concluded that there is a correlation between epileptiform waves on an electroencephalogram (EEG) with the type of epilepsy in school-age epilepsy patients.
POOR COGNITIVE RESERVE STATUS AS PREDICTORS OF MEMORY IMPAIRMENT AMONG ELDERLY Herpan Syafii Harahap; Yanna Indrayana
MNJ (Malang Neurology Journal) Vol. 9 No. 2 (2023): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2023.009.02.6

Abstract

Background: Cognitive impairment in the elderly population is commonly associated with age-associated neurodegenerative processes in the brain. The integrity of the cognitive reserve status may be an important factor that can compensate this age-associated neurodegenerative processes. Objective: To investigate the predictor role of poor cognitive reserve status on memory impairment among elderly subpopulation in Mataram, West Nusa Tenggara. Methods: This cross-sectional study involved elderly subjects recruited at Panti Jompo Tresna Werdha Puspa Karma. Data collected included age, gender, hypertension, diabetes, cognitive reserve status (years of education, leisure activity, occupation, and exercise), and memory status. Memory status obtained based on scores of 3 neuropsychological tests (wordlist memory task, recall, and recognition tests). Subjects with normal memory status had normal scores on at least 2 of the 3 neuropsychological tests. Multivariate regression analysis was performed to examine the role of cognitive reserve as a predictor of memory impairment in subjects. Results: In Model 1 of multivariate regression analysis, the main predictors for memory impairment in elderly subjects are shorter years of education (odds ratio: 13.1; 95% confidence interval: 1.8 – 95.0) and absence of leisure activity (odds ratio: 5.9; 1.2 – 28.8). In model 2, the main predictors for memory impairment are consistently shorter years of education (OR: 11.0; 95% CI: 1.4 – 84.0) and absence of leisure activity (OR: 5.3; 95% CI: 1.0 – 27.7). Conclusion: Shorter years of education and the absence of leisure activity were predictors for memory impairment in the subpopulation of the elderly in Mataram, West Nusa Tenggara.
ASSOCIATION OF PHYSICIAN BURNOUT WITH HEADACHE AND LOW BACK PAIN DURING PANDEMIC COVID-19 Kharisma Ridho Husodo; Dea Hadfina Kartika Sari; Lintang Daru Jati; Airin Angelina
MNJ (Malang Neurology Journal) Vol. 9 No. 2 (2023): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2023.009.02.7

Abstract

Background: Physician burnout is a common problem seen in health workers, especially doctors and it is characterized by emotional exhaustion, depersonalization, and reduced personal accomplishment in daily work. The pandemic of Corona Virus Disease 2019 (COVID-19) causes an increase in the workload among doctors which will affect the incidence of Burnout. Burnout not only includes psychological problems, but also has a risk for physical disorders including pain disorders. Objective: To investigate the association of burnout level with headache and low back pain among physicians at Yogyakarta Islamic Hospital PDHI. Methods: This research design was a descriptive analytic study with a cross-sectional design. The subjects in this study were 46 doctors who worked at the Yogyakarta Islamic Hospital PDHI. Burnout levels were assessed using the Maslach Burnout Inventory (MBI) test. The incidence of headache and its impact on daily activities were assessed using the Headache Impact Test (HIT-6) questionnaire while Low Back Pain was assessed using Oswestry Disability Index (ODI). Results: Among burnout parameters, depersonalization was the most influential parameter which caused burnout. COVID-19 pandemic gave more impact to burnout level. The headache and low back pain incidence were 39,1% (18 subjects) and 43,4% (20 subjects) respectively. There were significant correlations between headache and every burnout parameter. Low back pain also had significant correlations to each burnout parameters. Conclusion: There was association of Burnout level with headache and low back pain incidence among physicians.
NEUROPROTECTANT OF 7,8-DIHYDROXYFLAVONE IN ISCHEMIC STROKE THROUGH MODULATION GLUTATHIONE S-TRANSFERASE AND TYROSINE RECEPTOR KINASE C: A BIOINFORMATICS STUDY Aldita Husna Violita; Safira Dita Arviana; Rislan Faiz Muhammad; Basyar Adnani; Titin Andri Wihastuti; Husnul Khotimah; Shahdevi Nandar Kurniawan; Yuyun Yueniwati
MNJ (Malang Neurology Journal) Vol. 9 No. 2 (2023): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2023.009.02.8

Abstract

Background: Times New Roman 9, single space, contains the brief description of the research. Stroke is the greatest cause of disability and mortality worldwide. Several biological mechanisms underlying this disease such as failure of glutamate reuptake and ATP synthesis, resulting in high levels of reactive oxygen species (ROS), neuroinflammatory responses, and apoptosis, resulted in cell death and brain tissue damage. Neurotherapeutics agents are given to affect the pathophysiological pathways and prevent expanding infarct area. Objective: This study aims to analyze the modulation of Gluthatione S-Transferase (GST) and Tyrosine kinase receptor C (TrkC) by 7,8-DHF as neuroprotective agent in ischemic in silico. Methods: This study used in silico simulation to predict 7,8-dihydroxyflavone (DHF) as neuroprotective agent by using PubChem, RCSB, Biovia Discovery Studio, PyRx, and PyMol. This study analyzes the pharmacodynamics, pharmacokinetics, and molecular interactions between 7,8-DHF as a ligand with GST (13GS) and TrkC (6KZC) as protein target, compared to their native ligand. Results: 7,8-DHF may increase intracellular endogenous antioxidants mainly GST and stimulate TrkC to activate further neuron survival signaling. 7,8 DHF has a much lower bond energy (-8.1 Kcal/mol) when it binds to GST compared to the native ligand (-5.9 Kcal/mol). Besides, binding affinity between 7,8-DHF-TrkC was -9 Kcal/mol, while native ligand-TrkC was -10.6 Kcal/mol. This study showed that there were the same amino acid residues between 7,8-DHF-GST and 7,8-DHF-TrkC, compared to their native ligand. Conclusion: As an adaptive response to hypoxia caused by ischemic stroke, these findings are likely to induce protective mechanism through indirectly TrkC activation which regulates neurogenesis and increasing intracellular endogenous antioxidants.

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