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MNJ (Malang Neurology Journal)
Published by Universitas Brawijaya
ISSN : 24076724     EISSN : 24425001     DOI : -
Core Subject : Science,
Neuroscience
Malang Neurology Journal is a peer-reviewed and open access journal that focuses on promoting neurological sciences generated from basic neurosciences and clinical neurology. This journal publishes original articles, reviews, and also interesting case reports. Brief communications containing short features of medicine, latest developments in diagnostic procedures of neurology disease, treatment, or other health issues related to neurology that is important also acceptable. Letters and commentaries of our published articles are welcome.
Arjuna Subject : -
Articles 278 Documents
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THE INFLUENCE OF SAMPLING TIME TO SERUM GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) LEVELS IN ACUTE STROKE Raisa, Neila; Sujuti, Hidayat; Purnomo, Hari; Rahayu, Masruroh; Dalhar, Mochamad
Malang Neurology Journal Vol 5, No 1 (2019): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2019.005.01.5

Abstract

Background: Serum Glial Fibrillary Acidic Protein (GFAP) is a great potential for biomarker that is widely studied as a diagnostic biomarker of acute stroke. Sampling within 6 hours after onset is the best time window, but in Indonesia, stroke patients often arrive late more than 6 hours.Objective: To identify the difference in time of blood sampling with serum GFAP levels within 24 hours onset of ischemic stroke (IS) patients and intracerebral hemorrhage (ICH) strokes.Methods: Cross-sectional analysis with purposive sampling, sampling in IS and ICH strokes that arrive at the ER within 24-hour on-site. The serum GFAP examination was performed with ELISA.Results: In this study, 41 acute stroke patients with 24-hour onset of each stroke were grouped into group 1 (<6 hours), group 2 (6-12 hours) and group 3 (12-24 hours). One Way ANOVA and Tukey's analysis showed no significant difference in GFAP levels among the three groups in both IS and ICH. Conclusion: There was no significant difference in GFAP levels in samples <6 hours, 6-12 hours, and 12-24 hours in ischemic strokes and ICH strokes.
AROMATASE AND NEUROREGENERATION Ulhaq, Zulvikar Syambani
Malang Neurology Journal Vol 5, No 1 (2019): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2019.005.01.9

Abstract

Aromatase (cyp19a1) is a converting enzyme for estrogen biosynthesis. A single gene of cyp19a1 identified in mammals and specific promoter differentially regulates E2 produce in the brain.Interestingly, teleost fish having two isoforms of cyp19a1, cyp19a1a and cy19a1b, encoding ovarian and brain aromatase, respectively. In addition, teleost fish are characterized by having highly aromatase activity and neuroregenerative response. In contrast with fish, neuroregeneration process is limited in mammals. Therefore, understanding molecular mechanism of estradiol signaling in neural injury in fish may give a new insight for the development of novel treatment in mammals, particularly in neurodegenerative diseases. Here, the author briefly reviews and discusses the potential role of neural estrogen for regeneration process.
EFFECT ANTHOCYANIN OF PURPLE POTATO GUNUNG KAWI ON MDA LEVELS, EXPRESSION OF CASPASE-3, AND SPATIAL MEMORY FUNCTION ON DIABETIC WISTAR RATS Prabawati, Risma Karlina; Ratnawati, Retty; Rahayu, Masruroh; Prakosa, Ardani Galih
Malang Neurology Journal Vol 5, No 1 (2019): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2019.005.01.6

Abstract

Background: Hyperglycemia condition will decline cognitive function. No basic therapy has been 2 found for this. Purple potato anthocyanins are useful as anti-inflammatory, antioxidant, neuroprotectant, and antidiabetic.Objective: Evaluate effect of purple potato’s anthocyanins on MDA levels, brain’s caspase-3 expressiom, and spatial memory function in diabetic model of Wistar rats.Methods: This is an experimental study using diabetic model rats. The sample was divided into negative and positive control, anthocyanin dose of 10 mg/kg, 20 mg/kg, and 80 mg/kg groups. MDA levels were measured using spectrophotometer, caspase-3 expression with immunohistochemistry, and spatial memory function using Morris water maze test.Results: Tukey test showed that anthocyanin 10, 20, and 80 mg/kg lowering MDA levels, caspase-3 expression, and Morris water maze’s travel time compared to control positive (p = 0.000). But anthocyanin 80 mg/kg make a significant increase on these three variabels compared to 10 and 20mg/kg groups (p = 0.010). Pearson test showed that there no correlation between anthocyanin’s dose, MDA levels, caspase-3 expression, and Morris water maze test.Conclusion: Anthocyanin doses 10 and 20 mg/kg lowering MDA levels and caspase-3 expression, also improves spatial memory function on diabetic model of Wistar rats.
A REVIEW OF BURDEN OF CAREGIVERS OF PATIENTS WITH ALZHEIMER'S DISEASE Ridzuan, Sayyidah Aqilah; Darussalam, Siti Eliza; Hisham, Nur Hazrina Mohamed; Namasivayam, Prashaantini; Nichole, Yam Min Yi; Zaid, Danial Syafiq Shahrir; Nor, Nurul Huda Mohd; Mohamed, Mohd Hazmi; Mooi, Ching Siew; Devaraj, Navin Kumar; Ismail, Iskasymar Bin Itam; Hashim, Hasnur Zaman; Mat, Liyana Najwa Inche; Kee, Hoo Fan; Basri, Hamidon; Sulaiman, Wan Aliaa Wan
Malang Neurology Journal Vol 5, No 1 (2019): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2019.005.01.7

Abstract

Many are still unaware of the fact that Alzheimer’s disease (AD) also affects the caregivers quite significantly. Caregivers refer to people who are accountable of taking care of AD patients which provide helps with his or her daily living activities and may become a full-time commitment for the caregiver. This gives rise to a concept called caregiver burden. As these caregivers spend most of their time taking care of AD patients, most of them suffer psychologically as well as physically.Unfortunately, the risk of mental and physical impairment among the caregivers of Alzheimer’s patient may cause poor quality of life to both the patients and their caregivers. In addition, due to their role and responsibilities as a caretaker, they often do not have the opportunity to seek help and advices. This review article was conducted by sieving through numerous literature and studies regarding the challenges and how to help the burden of the caregivers of Alzheimer’s patients . This paper aims to give and overview, suggestions as well as to increase the awareness of the caregiver’s burden.
KEARNS-SAYRE SYNDROME MIGHT BE MIXED UP WITH CPEO PLUS Finsterer, Josef; Mahjoub, Sinda Zarrouk-
Malang Neurology Journal Vol 5, No 1 (2019): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2019.005.01.8

Abstract

In a recent article, Al Ghamdi presented a 40yo parturient with Kearns-Sayre syndrome (KSS) who had received an implantable cardioverter defibrillator (ICD) because of an AVblock II (Mobitz 2 (2:1)) 11y earlier and underwent caesarean delivery for preeclampsia in local anesthesia with bupivacaine and fentanyl.(1) We have the following comments and concerns.
EXTRACRANIAL METASTASIS OF GLIOBLASTOMA: A RARE CASE Rahmawati, Dessika; Marhaendraputro, Eko Arisetijono; Kurniawan, Shahdevi Nandar; Wirathmawati, Andina
Malang Neurology Journal Vol 5, No 1 (2019): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2019.005.01.10

Abstract

Glioblastoma is the most common primary malignant tumor in the neural tissue and a highly aggressive primary tumor in human. It involves glial cells in 52% of functional brain tissue cases and 20% of all intracranial tumors. Extra cranial metastasis of Glioblastoma is very rare. Metastasis outside CNS was uncommon in GBM but it could occur with frequency 0.2% and can spread in head and neck sites. The mechanism of this spread is not understood yet. The extracranial spread routes were speculated on the direct lymphatic connections, the venous system and the adjacent structure like dura and bone. We present a case of female patient with a known glioblastoma who had an extracranial metastasis on her left neck with complete Radiotherapy n Chemotherapy and survive more than 2 years.
PROFILE OF SUBJECTIVE SLEEP DISTURBANCE IN PATIENT WITH ANTIEPILEPTIC DRUGS Zahra, Farah Az; Islamiyah, Wardah Rahmatul; Budiono, Budiono
Malang Neurology Journal Vol 5, No 2 (2019): July
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2019.005.02.2

Abstract

Background: Epilepsy and sleep are well recognized for having bidirectional influences upon one another. The effects of antiepileptic drugs (AEDs) on sleep are of particular concern.
Objective: The objective of this study is to know the profile of AEDs effect in patient’s sleep cycle. Methods: This analytical observational study observed total sleep time, sleep onset latency, sleep efficiency, daytime sleepiness, and insomnia in epileptic patient with AEDs of Neurology Clinic Airlangga University Hospital during May-September 2016. A cross sectional study was done by questionnaire and interview directly to the epileptic patients. Data collected was being analyzed analytically.Results: This research was conducted among 27 patients with epilepsy based on inclusion and exclusion criteria. Sleep disturbances that had been found in patients with phenytoin are prolong sleep onset latency (11.11%), decreased sleep efficiency (11.11%), and excessive daytime sleepiness (66.67%). Sleep disturbances that had been found in patients with valproate are decreased total sleep time (33.33%), prolong sleep onset latency (11.11%), decreased sleep efficiency (11.11%), excessive daytime sleepiness (66.67%), and insomnia (11.11%). Sleep disturbances that had been found in patients with carbamazepine are decreased total sleep time (44.44%), prolong sleep onset latency (33.33%), decreased sleep efficiency (22.22%), excessive daytime sleepiness (77.78%), and insomnia (11.11%).Conclusion: In conclusion, this study shows that epileptic patients who consumed AEDs regularly may have sleep disturbance that vary based on the type of AEDs, patients with carbamazepine may have bigger sleep disturbance than with phenytoin and valproate. It is necessary to give information and education to the epileptic patients who consumed AEDs regularly so that they will become aware of the sign of sleep disturbance.
NEUROPATHIC PAIN IN PATIENT WITH POST OPERATIVE SCHWANNOMA: A CASE REPORT PRIMARY INTRADURAL EXTRAMEDULLAR SPINAL CORD TUMOUR Santoso, Widodo Mardi; Nurlela, Siti; Marhaendraputro, Eko Arisetijono; Rahmawati, Dessika
Malang Neurology Journal Vol 5, No 2 (2019): July
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2019.005.02.7

Abstract

Majority of spinal cord tumour is a benign tumour with symptoms are due to spinal cord compression. One of the symptoms that are often difficult to treat is a sensory deficit. The authors report a case of primary intradural extramedullar spinal cord tumour in 57-year-old man. This tumour was presenting symptoms of chronic low back pain, gradual progressive inferior paraplegia, and sensory deficit on both legs. MRI thoracal showed intradural lesion at Th 4-5-6, with isointensity on T1-weighted images and hyperintensity-isohomogen on T2-weighted images. The tumour was completely resected, and histopathology examination revealed schwannoma types. Patient showed a clinical improvement in motoric function noticeable after surgery, but showed sensory deficits sequelae requiring therapy for neuropathic pain.
FACTORS AFFECTING THE KNOWLEDGE ABOUT STROKE RISKS AND EARLY SYMPTOMS IN EMERGENCY DEPARTMENT EAST JAVA - INDONESIA Rachmawati, Dewi; Ningsih, Dewi Kartikawati; Andarini, Sri
Malang Neurology Journal Vol 6, No 1 (2020): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2020.006.01.3

Abstract

BackgroundThe knowledge about stroke risks and early symptoms is pivotal to minimize the arrival delay in the hospital and maximize the effective treatments.ObjectiveInvestigating the factors affecting the knowledge about stroke risks and early symptoms in the emergency department (ED).MethodsThe study employed a cross-sectional design by means of a prospective approach. Samples were taken by consecutive sampling technique recruiting in a total of 58 respondents. The respondents were the family or relatives of acute ischemic stroke patients who happened to know and directly involved in taking the patients to the ED. Data analyzed by utilizing univariate analysis, independent t-test, and one-way ANOVA to determine the differences in the knowledge of every respondent based on several characteristics. Multivariate analysis was used to investigate the factors affecting the knowledge about stroke risks and early symptoms.ResultsThe average age of the 58 respondents was 34 – 57 years old. 46.5% of whom were graduating from primary school; 51.7% have never been equipped with the necessary information about stroke; 55.2% are female, and 50% of whom were unemployed. There were differences in the knowledge about stroke risks based on the prior information about stroke and education background. As for stroke early symptoms, there were differences towards occupations, prior information about stroke, and education background. The most affecting factor towards the knowledge of stroke risks is education background (p=0.000); while the knowledge about stroke early symptoms were mostly affected by prior information about stroke (p=0.012) and education background (p=0.000).Discussions Most respondents were less equipped with the necessary knowledge about stroke risks and symptoms. The respondents’ knowledge about stroke risks and early symptoms was considered less, while education background was the affecting factor towards the knowledge about stroke risks and symptoms.
IDENTIFICATION AND ANALYSIS OF GENETIC EPILEPSY AND EPILEPTIC ENCEPHALOPATHIES IN THE OUTPATIENT PRACTICE OF EPILEPSY SPECIALISTS Rakhmanina, Olga; Volkov, Iosif; Shestakova, Olga; Tomenko, Tatyana; Volkova, Oksana; Belyaev, Оleg; Levitina, Elena
Malang Neurology Journal Vol 6, No 1 (2020): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2020.006.01.7

Abstract

Background: Given the significant share of gene mutations in the etiology of epilepsy, it is important for the practitioners to evaluate progress in this area.Objective: To describe the spectrum of being detected gene mutations in patients with epilepsy or epileptic encephalopathy in clinical practice of neurologists specializing in epilepsy with an analysis of diagnosed epileptic syndromes, the characteristics of seizures, the timing of a genetic diagnosis, options and treatment efficacy.Methods: The study included 100 patients (40 boys, 60 girls) with epilepsy/epileptic encephalopathy and a gene mutation identified. The average age was 6.9±5.1 years. Through remote access, epilepsy specialists filled out a specially designed unified table containing information from outpatient case history.Results: In the outpatient practice of epilepsy specialists, there are patients with a wide range of gene mutations, the leading of which is a mutation in the SCN1A gene (15%). Nowadays, the main method (85%) of detection remains the next generation sequencing in the “Hereditary Epilepsy” panel. Years pass from the onset of the disease to the genetic diagnosis (Me - 3 years). In most cases, patients with severe (52% have epileptic encephalopathy, 88% have developmental disorders) and pharmacoresistant (mean amount of anti-epileptic drugs - 3,8±2,2, multitherapy -70%) syndromes have undergone genetic testing. In the treatment of these patients epileptologists are increasingly (52%) use alternative methods: steroids, ketogenic diet and others. The absence of seizures was observed only in 46% of patients.Conclusion: Thus, in the outpatient practice of epileptologists of Russia, patients with a wide range of gene mutations are found. As a rule, these are patients with severe, therapy-resistant epileptic syndromes.

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