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MNJ (Malang Neurology Journal)
Published by Universitas Brawijaya
ISSN : 24076724     EISSN : 24425001     DOI : -
Core Subject : Science,
Neuroscience
Malang Neurology Journal is a peer-reviewed and open access journal that focuses on promoting neurological sciences generated from basic neurosciences and clinical neurology. This journal publishes original articles, reviews, and also interesting case reports. Brief communications containing short features of medicine, latest developments in diagnostic procedures of neurology disease, treatment, or other health issues related to neurology that is important also acceptable. Letters and commentaries of our published articles are welcome.
Arjuna Subject : -
Articles 278 Documents
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INTERPRETATION OF NERVE CONDUCTION STUDY IN POLYNEUROPATHY WITH MULTIBACILLARY LEPROSY TYPE 2 REACTION Sari, Diane Tantia; Widasmara, Dhelya; Kurniawan, Shahdevi Nandar
Malang Neurology Journal Vol 4, No 2 (2018): July
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (616.7 KB) | DOI: 10.21776/ub.mnj.2018.004.02.7

Abstract

Leprosy reaction contributes to disability due to peripheral nerve damage. Nerve conduction study (NCS) provides a profound physiological description of peripheral nerves. This study aims to report a case of polyneuropathy in leprosy with type 2 reactions (T2R) which is evaluated using NCS. A 33-year-old woman complain of painful bumps in her arms and legs, fever, swollen feet since 2 days ago, and history of leprosy. Dermatologic examination on the right superior palpebra, right and left arms and legs revealed multiple tenderness erythematous nodules; right claw hand; and both legs oedema. Slit skin smear revealed positive result. Histopathologic examination supported T2R description. The NCS examination concluded severe axonal demyelinating motoric sensoric polyneurophaty, with left worse. She was treated with MDT-MB, bed rest, orally methylprednisolone, vitamin B, paracetamol, ferrous sulfas, and topical olive oil. Clinical improvement was achieved after 2 weeks. The NCS is used to assess the nerve impuls conduction along the peripheral nerves. In this case, it was found that NCS could showed early neuropathy in nerves that were clinically undetectable. It can be concluded that the NCS examination is an important diagnostic modalities for early detection of neuropathy and confirmed the diagnosis of clinical neuropathy in leprosy.
THE DIFFERENCE LEVEL OF NUTRITIONAL STATUS WITH CLINICAL OUTCOME IN PATIENT WITH ACUTE PHASE ISCHEMIC STROKE Junaidi, Edwina Narulita Sari Agustin; Winarsih, Sri; Nasution, Tina Handayani
Malang Neurology Journal Vol 3, No 1 (2017): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (551.974 KB) | DOI: 10.21776/ub.mnj.2017.003.01.4

Abstract

Background. Nutritional status is predictor that can affects on clinical outcome in patient with acute phase ischemic stroke.Objective. To investigate the difference of nutritional status level with clinical outcome in patient with acute phase ischemic stroke.Methods. Cohort retrospective design used medical record of all registered acute ischemic stroke patient in hospital Dr. Saiful Anwar Malang. 60 sample that inquired inclusion criteria and classified into three groups (the group of patient with acute phase ischemic stroke with normal nutrition status, undernutrition status, and overnutrition status). Nutritional status measured with body mass index parameter and clinical outcome measured with of NIHSS score admission and NIHSS score discharge.Results. There were 60 had good clinical outcome with undernutrition status (n=20) amount 65%, normal nutrition status (n=20) amount 70% and overnutrition status (n=20) amount 60%. The difference of nutritional status level with clininical outcome in patient with acute phase ischemic stroke showed that no significantly difference (chi square, p-value=0,803).Conclusion. There is no difference of nutritional status level with clinical outcome in patient with acute phase ischemic stroke.
MYCOBACTERIUM TUBERCULOSIS STRAIN H37RV INFECTION TOWARDS MATRIX METALLOPROTEINASE (MMP)-2 IN BRAIN Hartono, Kevin; Adi, Prasetyo; Hidayati, Dwi Yuni Nur
Malang Neurology Journal Vol 3, No 2 (2017): July
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (491.56 KB) | DOI: 10.21776/ub.mnj.2017.003.02.2

Abstract

Background. Tuberculous infection in brain can cause microglia to secrete inflammatory factors like Tumor Necrosis Factor alpha (TNF-α) and Interleukin 1 beta (IL-1β) which will be shown as body immune respons. Those inflammatory factors eventually can trigger microglia to secrete Matrix Metalloproteinase-2 (MMP-2) which will regenerate necrotic or apoptosis cells because of inflammation process. MMP-2 has been proven to have important role in brain tuberculous infection.Objective. To ascertain MMP-2 expression in mus musculus brain tissue with no infection, infection for 8 weeks, and infection for 16 weeks.Methods. This research used semiquantitative method to compare MMP-2 expression in 3 samples group. Observation of MMP-2 expression in mus musculus brain tissue were made by using immunohistochemistry colouration method which then would be observed in microscope with 400x magnification. Brain cell which express MMP-2 will become brown in cell nucleus, cytoplasm, and wall.Results. The result which had be obtained was overtime reduction of MMP-2 expression.Conclusion. MMP-2 expression didn’t decrease after 8 weeks time of infection.
PATHOPHYSIOLOGY AND MANAGEMENT OF CEREBRAL EDEMA Husna, Ully; Dalhar, Mochamad
Malang Neurology Journal Vol 3, No 2 (2017): July
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (604.425 KB) | DOI: 10.21776/ub.mnj.2017.003.02.7

Abstract

Cerebral edema comprehensively defined as a pathological increase of water in the whole brain that leads to an increased of brain volume. Cerebral edema can be classified into focal or global topography. According to the etiology, it can be categorized as cytotoxic, vasogenic, interstitial, or a combination. The symptoms of cerebral edema are not specific and are associated with secondary effects of mass, vascular compression and herniation. Clinical and radiological changes are usually reversible in the early stages during the underlying cause is corrected. Cerebral edema need to be discussed more specifically in the pathophysiology and management. By understanding the pathophysiology and management quickly and accurately will be able to improve the prognosis of patients with cerebral edema.
DIAGNOSTIC TEST OF TORONTO AND MODIFIED TORONTO SCORING, MONOFILAMENT TEST, AND VIBRATE SENSATION TEST USING 128 HZ TUNING FORK FOR DIABETIC POLYNEUROPATHY Purbasari, Bethasiwi; Anggraini, Vivi Laras; Pratiwi, Made Dinda; Husna, Machlusil; Kurniawan, Shahdevi Nandar
Malang Neurology Journal Vol 4, No 1 (2018): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (841.806 KB) | DOI: 10.21776/ub.mnj.2018.004.01.5

Abstract

Background. The prevalence of diabetes mellitus has been epidemically increasing throughout all the world population, and diabetic polyneuropathy (PNP-DM) is one of the most common neurologic manifestation of this disease. Clinical research has proved that effective bedside screening of PNP-DM can significantly reduce the incidence of foot ulcer and limb amputation. Objective. To measure the diagnostic test of polyneuropathy scoring, monofilament 10-g SemmesWeinstein test, and 128 Hz tuning fork test as an early detection measure for PNP-DM.Methods. This research was conducted using a cross sectional approach from Januari 2016 to Juli 2017.Results. Among the total study population of 43 (23 men and 20 woman), Modified Toronto Score has the highest sensitivity (100%), PPV (93%) and accuracy (93%). Toronto score has the highest NPV (9%).Conclusion. Modified Toronto Score has good diagnostic value as screening tool in PNP-DM.
THE ROLE OF TNF-α AND IL-6 CYTOKINE IN CHILDREN WITH STATUS EPILEPTICUS Wibowo, Agung Prasetyo; Sujuti, Hidayat; Rahayu, Masruroh; Muid, Masdar; Kawuryan, Siti Lintang
Malang Neurology Journal Vol 4, No 2 (2018): July
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (682.222 KB) | DOI: 10.21776/ub.mnj.2018.004.02.2

Abstract

Background. One of pediatric emergencies that has high mortality is status epilepticus (SE). Correlation between tumor necrosis factor (TNF)-α, interleukin (IL)-6, and SE had been reported but human study of it is limited. Objective. To compare TNF-α and IL-6 level in children with SE to those of children without SE and to find correlation between both cytokines.Methods. Cross-sectional study was conducted in dr.Saiful Anwar Hospital Malang with 48 children were enrolled in this study. All subjects were divided into three groups, including children who had SE; children who had seizure but not SE; and children who have no seizure. The levels of TNF-α and IL-6 serum were measured by ELISA.Results. TNF-α and IL-6 serum level were not significantly different between groups (p=0.920, p=0.829). We found interesting fact that the level of IL-6 in children with SE who have no disability was significantly higher than that of children who died or had disability (p=0.015). There was strong correlation between TNF-α and IL-6 in SE group (R 2 = 0.841 and p = 0.0001).Conclusion. IL-6 serum level was higher in SE children who have no disability and correlate with TNF-α serum level.
ELECTRONEUROMYOGRAPHY EXAMINATION OF DIABETIC POLYNEUROPATHY PATIENTS Nurlaela, Siti; Kurniawan, Shahdevi Nandar; Husna, Machlusil
Malang Neurology Journal Vol 5, No 1 (2019): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2019.005.01.1

Abstract

Background: Diabetic polyneuropathy (DPN) is one of the chronic complications that occur in approximately 80% of diabetes mellitus (DM) patients. This condition is a results of metabolic, vascular, and immunological disorders.Objective: To determine the profile of electroneuromyography (ENMG) examination of DPN patients at neurology clinic of Saiful Anwar General Hospital.Methods: This cross-sectional observational descriptive study was carried out at Saiful Anwar General Hospital Malang from June 1, 2015 to December 31, 2015, with purposive sampling method. A total of 43 DM patients with symptoms of polyneuropathy fulfilling inclusion criteria and no exclusion criteria were examined for ENMG. ENMG examirnation were including distal latency, amplitude and nerve conduction velocity of 4 motoric nerves (median, ulnar, tibial, peroneal) & 3 sensory nerves (median, ulnar, sural), and F waves of ulnar, median and peroneal nerves of the left and right extremities.Results: Of the 43 patients evaluated in this study, the mean sensory sural nerve conduction velocity was 13.01 m/s. The majority type of nerve damage in diabetic polyneuropathy patients in this studywere mixed type (52.33% in the median nerve, 60.47% in the ulnar nerve, 72.10% in the tibial nerve, and 54.65% in the peroneal nerve in motor nerve studies and 80.23% in the median nerve and 88.37% in the peroneal nerve in the sensory nerve studies).Conclusion: The nerve damage that occurs in DPN patients at Saiful Anwar general Hospital is severe, with the majority being the axonal demyelinating type, especially in the sensory nerve fibers in the inferior extremities.
COMPARISON EFFECT BETWEEN PEGAGAN (Centella asiatica) EXTRACT AND PRAMIPEXOLE TOWARD LOCOMOTOR ACTIVITIES, α - SYNUCLEIN, AND NRF2 EXPRESSION IN ZEBRAFISH PARKINSON MODEL Trisnawati, Ayu; Anasrulloh, Anasrulloh; Rianawati, Sri Budhi; Khotimah, Husnul; Ali, Mulyohadi; Susetya, Budi
Malang Neurology Journal Vol 5, No 1 (2019): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2019.005.01.2

Abstract

Background: Parkinson disease is characterized with deposition of Lewy Bodies containing α–synuclein happened due to the effect of chronic neuroinflammation that causes the death of dopaminergic neurons through oxidative stress processes, so it involves the response of Nuclear factor erythroid 2-like 2 (Nrf2). Centella asiatica  (C.asiatica) contains antioxidant effect, inhibits the aggregation of α–synuclein and improves the locomotor on Parkinson-model animals so it needs to compare to the standard medication.Objective: To compare the C. asiatica extract and Pramipexole to the zebrafish Parkinson model by determining the locomotor activity, α–synuclein expression, and Nrf2.Methods: This study used six groups of zebrafish: negative control, rotenone rotenone [5 μg/L], pramipexole1, 2, 3 (rotenone + pramipexole [3,5] ng/mL, [7] ng/mL, [14] ng/mL), and C. asiatica(rotenone + C. asiatica [10] μg/mL). The observations of locomotor activity of day 0, 14, and 28 were continued to the α–synuclein immunohistochemical examination, and Nrf2 on the midbrain area.Results: There are significant differences in locomotor activity on day 28 among the C. asiatica group with rotenone (p<0,05), while there are no significant differences among the C. asiatica group with pramipexole [7] ng/mL and [14] ng/mL (p>0,05). α–synuclein expression of the C. asiatica group is the lowest and significantly different from all groups (p<0,05), while Nr2 had no significant differences (p>0,05).Conclusion: C. asiatica extract [10] μg/mL is equal to pramipexole [7] ng/mL and [14] ng/mL in improving locomotor activity, but C. asiatica extract holds excellence as it decreases α–synuclein expression better than pramipexole, while Nrf2 expression shows no differences.
COMPARISON OF CARPASTRETCH® WITH SPLINT IN NON-SURGICAL TREATMENT OF CARPAL TUNNEL SYNDROME: A RANDOMIZED OPEN LABEL STUDY Malshikare, Vijay; Desai, Sanjay Mukund; Arekar, Anil Shridhar; Bhosale, Neelambari Abhay; Bonde, Shital Ravindra; Awdhani, Mansi Abhishek
Malang Neurology Journal Vol 5, No 1 (2019): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (33.469 KB) | DOI: 10.21776/ub.mnj.2019.005.01.3

Abstract

Background: The present study was conducted with an aim to compare the efficacy and safety of CarpaStretch® relative to wrist splinting in patients with CTS.Objective: To examine the effect of using CarpaStretch®, a novel dynamic splint for the treatment of Carpal Tunnel Syndrome.Methods: The efficacy and safety of CarpaStretch® was compared with conventional splints in a prospective 6-month trial with a follow-up at 12 months. 30 subjects with confirmed Carpal Tunnel Syndrome were enrolled in each group. Nerve conduction tests, wrist MRI, provocation tests and patient satisfaction questionnaires were assessed in the study.Results: At the end of 6 months, there were significant increases in sensory nerve conduction velocity in both intervention and control groups, and the difference between groups were not significant. A higher proportion of subjects using CarpaStretch® showed improvement in severity grade relative to control at 6 months. Small but clinically meaningful increases were seen in carpal tunnel dimensions in the CarpaStretch® group. There was a greater reduction in the incidence of paraesthesia and increase in the time of paraesthesia in the CarpaStretch® group. No adverse effects were reported in either group, but 4 subjects in the control group opted for surgery.Conclusion: CarpaStretch® can be used for effective non-surgical management of Carpal Tunnel Syndrome.
DIAGNOSTIC TEST OF POLYNEUROPATHY SCORE, 10-G SEMMES WENSTEIN MONOFILAMENT (SWM) AND VIBRATION PERCEPTION TRESHOLD (VPT)-QUANTITATIVE SENSORY TESTING (QST) IN DISTAL SENSORY POLYNEUROPATHY (DSP)-HUMAN IMMUNODEFICIENCY VIRUS (HIV) Purbasari, Bethasiwi; Kurniawan, Shahdevi Nandar; Husna, Machlusil; Candradikusuma, Didi; Al-Rasyid, Harun
Malang Neurology Journal Vol 5, No 1 (2019): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2019.005.01.4

Abstract

Background: HIV/AIDS is a worldwide pandemic. Peripheral neuropathy is the most common neurologic complication with distal sensory polyneuropathy (HIV-DSP) as the most frequent form of manifestation. HIV-DSP is one of the major causes of global pain morbidity and often undiagnosed earlier, resulting in treatment given when HIV-DSP grade is already severe. Early detection is imperative to prevent the progression of HIV-DSP and improve patient’s quality of life. Polyneuropathy score, 10-g Semmes-Weinstein Monofilament (SWM) and vibration perception threshold (VPT)-quantitative sensory testing (QST) are considered to be potential candidates for HIVDSP screening tool.Objective: To measure the reability of Polyneuropathy Score, SWM and VPT- QST in diagnosing HIV-DSP.Methods: This research is a descriptive study with cross-sectional design. Research was conducted on 77 patients of HIV/AIDS outpatient clinic in RS Saiful Anwar (RSSA) during November 2016 - April 2017 (n = 77). Patients were screened for HIV-DSP by using polyneuropathy score, such as: Michigan Neuropathy Screening Instrument (MNSI), Toronto Clinical Scoring Sysytem (TCSS), Brief Peripheral Neuropathy Score (BPNS), SWM, and VPT-QST. Sensitivity, specificity, positive predictive value and negative predictive value of BPNS, TCSS, MNSI, SWM and VPT-QST are analyzed using cross tabulation. Area under receiver operating characteristic (ROC) curve analysis was used to measure diagnostic accuracy of each tools. SPSS 19.0 was used for statistical analysis.Results: TCSS had a sensitivity, specificity, positive predictive value, negative predictive value positive likelihood ratio, negative likelihood ratio, and accuracy as much as: 70%, 97%, 97%, 74%, 23,33, 0,28 and 83%. The result of TCSS analysis using ROC showed that TCSS had excellent diagnostic value with AUC (Area Under Curve) of 0.89 (95%CI 82%-96,5%). The AUC of BPNS score, monofilamen and VPT-QST respectively: 0,469, 0,194, and 0,189.Conclusion: The result of the HIV-DSP diagnostic test using TCSS score has the best value compared to other tools.

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