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Dental Journal (Majalah Kedokteran Gigi)

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Published by Universitas Airlangga

ISSN : 19783728 EISSN : 24429740 DOI : -

Core Subject : Health,

Dentistry

The Dental Journal (Majalah Kedokteran Gigi) (e-ISSN:2442-9740; p-ISSN:1978-3728) is published by the Faculty of Dental Medicine, Universitas Airlangga. Its diciplinary focus is dental science and dental hygiene. The Dental Journal (Majalah Kedokteran Gigi) is published in English on a quarterly basis with each 50-60 page edition containing between nine and eleven scientific articles on research, study literature and case studies. Contributors to the Dental Journal (Majalah Kedokteran Gigi) included: dental researchers, dental practitioners, lecturers, and students drawn from Indonesia and a wide range of other countries.

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Articles 964 Documents

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Various curing methods on transverse strength of acrylic resin Sherman Salim
Dental Journal (Majalah Kedokteran Gigi) Vol. 43 No. 1 (2010): March 2010
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Acrylic resin were first used in dentistry for denture bases. The basic knowledge of acrylic resin curing method should be known by the dentist, because the improved performance of acrylic resin depends on the curing method. Purpose: This study was aimed to find the most effective curing method to produce the highest transverse strength of acrylic resin. Method: 18 rectagular acrylic resin samples with 65 x 10 x 2.5 mm size, divided into 3 groups based on difference curing method (Japan Industrial Standard, 24 hour in 70° C boiling water, and microwave). There were tested for their transverse strength. Result: The result of this study showed that conventional JIS method has the highest mean and deviation scores (60.85 MPa ± 2.10) compared to those of 24 hour in 70° C boiling water method (55.77 MPa ± 2.09) and of microwave method (56.60 MPa ± 1.45). Conclusion: The highest transverse strength is derived from the conventional JIS curing method.Latar belakang: Resin akrilik pertama kali dipakai dalam bidang kedokteran gigi untuk basis protesa gigi. Pengetahuan dasar berbagai metode polimerisasi resin akrilik harus diketahui oleh dokter gigi karenapenyempurnaanpenampilan resin akrilik tergantung dari berbagi metode polimerisasi. Tujuan: Penelitian ini bertujuan untuk mendapatkan metode polimerisasi yang menghasilkan resin akrilik dengan kekuatan transversal yang paling tinggi. Metode: 18 sampel dari resin akrilik berbentuk balok dengan ukuran 65 x 10 x 2,5 mm dibagi dalam 3 kelompok berdasarkan metode polimerisasi yang berbeda (JIS, 24 jam dalam air 70° C, dan microwave). Hasil: Hasil dari penelitian ini menunjukkan bahwa rerata dan angka deviasi metode polimerisasi JIS konvensional adalah yang terbesar kekuatan transversa (60,85 MPa ± 2,10) dibandingkan dengan metode air 70° C 24 jam (55,77MPa ± 2,09) dan metode microwave (56,60 MPa ± 1,45). Kesimpulan: Kekuatan transversa yang paling besar diperoleh dari metode polimerisasi JIS konvensional.

New concept in allergy: Non-allergic rats becomes allergic after induced by Porphyromonas gingivalis lipopolysaccharide Haryono Utomo
Dental Journal (Majalah Kedokteran Gigi) Vol. 46 No. 2 (2013): June 2013
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: As a theory, seemingly it is impossible that allergic diseases, including asthma, are the result of exposure to a transmissible agent. The fact that nearly all children with asthma are allergic, but only a small proportion of allergic children have asthma, at least raises the possibility that other factors are involved. Interestingly, non-allergic children become allergic after their parents came from working in allergic people for several months. Recent research revealed that periodontal pathogens are also transmissible from mother and caregivers to infants.Therefore, it is logical that non-allergic children could become allergic after exposed to periodontopathic bacteria. However, the mechanism is still unclear. Purpose: The objective of this study is to verify a new concept that non-allergic rat may become allergic after exposed to Porphyromonas gingivalis lipopolysaccharide. Methods: Randomized control series design experimental study was conducted to 24 male Wistar rats, two experimental groups and one control group. One group was subjected to intrasulcular injection of PgLPS1435/1450. Tissue examination were done for allergy biomarkers with peroxidase immunohistochemistry for leukotriene C4 (LTC4) and eosinophilic cationic protein (ECP) in bronchus tissue. Serum level examination of interleukin 4 (IL-4), and immunoglobulin E (IgE) was done with ELISA. Data were analyzes using ANOVA. Results: after four days, LTC4 and ECP expression increased significantly (p=0.001); even insignificant, IL-4 and IgE serum level also increased. Conclusion: PgLPS is able to stimulate immunocompetent cells which changed the host immune response of non-allergic rats. Therefore, it is possible that they become allergic.Latar belakang: Menurut teori, penularan penyakit alergi termasuk asma merupakan hal yang mustahil. Fakta menunjukkn bahwa hampir semua anak penderita asma mempunyai alergi, tetapi tidak semua anak alergi menderita asma, sehingga mungkin ada faktor lain ya ng terlibat. Hal yang menarik adalah timbulnya gejala alergi pada anak non-alergi setelah orang tua mereka bekerja beberapa bulan pada orang yang alergi. Penelitian mutakhir juga menemukan bahwa bakteri periodontopatogen juga dapat ditularkan ke bayi dari ibu dan pengasuhnya. Sebagai akibatnya, sangat nasuk akal bila anak non-alergi menjadi alergi setelah terpajan bakteri periodontopatogen. Tujuan: Untuk verifikasi konsep baru, yaitu bahwa tikus non-alergi dapat menjadi alergi setelah terpajan lipopolisakarida. Metode: Pada 24 tikus Wistar jantan; dua kelompok perlakuan dan satu kontrol. Satu kelompok diberikan injeksi intrasulcular dengan PgLPS1435/1450. Pemeriksaan jaringan dilakukan pada biomarker alergi menggunakan imunohistokimia peroxidase untuk leukotriene C4 (LTC4) dan eosinophilic cationic protein (ECP) dari jaringan bronkus. Pemeriksaan kadar serum pada interleukin 4 (IL-4), dan immunoglobulin E (IgE) menggunakan metode ELISA. Data dianalisis dengan ANOVA. Hasil: Setelah empat hari, LTC4 ekspresi ECP meningkat secara bermakna (p=0.001); walau tidak bermakna, kadar IL-4 and IgE serum juga meningkat. Simpulan: PgLPS dapat merangsang sel imunokompeten sehingga dapat merubah respons imun tikus non-alergi menjadi alergi.

The effectiveness of sharp end and rounded end bristle toothbrush Paulus Januar; Anastasia Susetyo; Ratih Widyastuti
Dental Journal (Majalah Kedokteran Gigi) Vol. 43 No. 3 (2010): September 2010
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Numerous designs of manual toothbrush are available in the market with the claims of superiority in plaque removal. It often makes the public confuse which is the best design. The sharp end bristle toothbrush is a modification that commercially available in the market. Purpose: The objective of the study was to compare the effectiveness in plaque removal of the sharp end bristle toothbrush and the rounded end bristle toothbrush. Methods: This clinical trial was a double blind crossover design. The subjects were 65 dental students, divided into two groups for comparing the 2 types of toothbrush. On the 1st day, the allocated toothbrushes were distributedto each group according to their designation, and the subjects were instructed to use the toothbrushes according their normal daily practices. On the 1st, 7th, and 14th day, the subjects were scored using the patient hygiene performance index (PHP index) and the gingival index. Based on cross over design, the same procedure was repeated during the 2 week second test periods using different type of toothbrush respectively. Results: The mean scores of the 2 groups showed no significant difference on the beginning the study. Though minor differences were observed in the effectiveness of toothbrush, but the comparison of the two types of toothbrush showed no statistically significant differences on 7th and 14th day. Conclusion: There were no significant differences between sharp end and rounded end bristle toot brusher. There is no manual toothbrush superiorly designed than the others single superior design of manual toothbrush.Latar belakang: Berbagai jenis desain sikat gigi saat ini terdapat di pasaran, dengan masing-masing menyatakan keunggulannya dalam membersihkan plak. Penelitian ini dilakukan terhadap dua jenis sikat gigi manual yaitu sikat gigi dengan ujung bulu sikat runcing dan ujung bulus sikat bulat. Tujuan: Penelitian ini dilakukan untuk membandingkan efektivitas membersihkan plak antara 2 jenis sikat gigi. Metode: Penelitian ini merupakan percobaan klinis dengan desain penyilangan (crossover) secara tertutup ganda (double blind). Subyek penelitian 65 mahasiswa dibagi 2 kelompok. Pada hari pertama, sikat gigi dibagikan pada masing-masing kelompok yang telah ditentukan jenis sikat giginya, dan diinstruksikan untuk menggunakannya sesuai kebiasaan mereka. Pada hari ke 1, 7, dan 14 dilakukan pengukuran indeks PHP dan indeks gingiva. Berdasarkan desain penyilangan, proses yang sama diulangi pada masing-masing kelompok dengan menggunakan jenis sikat gigi yang berbeda. Hasil: Pada awal penelitian tidak terdapat perbedaan skor pada ke 2 kelompok. Meski terdapat sedikit perbedaan, namun tidak terdapat perbedaan yang bermakna dalam efektivitas kedua jenis sikat gigi setelah penggunaan selama 7 dan 14 hari. Kesimpulan: Tidak ada perbedaan yang bermakna antara sikat gigi jenis ujung bulu sikat bulat dan ujung bulu sikat runcing. Tidak terdapat satupun jenis sikat gigi yang paling baik.

The role of Actinobacillus actinomycetemcomitans fimbrial adhesin on MMP-8 activity in aggressive periodontitis pathogenesis Rini Devijanti Ridwan
Dental Journal (Majalah Kedokteran Gigi) Vol. 45 No. 4 (2012): December 2012
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Actinobacillus actinomycetemcomitans (A. actinomycetemcomitans) is Gram negative and a major bacterial agent associated with aggressive periodontitis in young adult, this bacteria was an important factor in pathogenesis of aggressive periodontitis. A. actinomycetemcomitans possesses fimbriae with an adhesin protein that was the first bacterial molecules to make physical contact with host. Purpose: The objective of this research was to analyzed the influence of A. actinomycetemcomitans fimbrial adhesin protein induction on MMP-8 activity. Methods: The research was an experimental laboratory study, the step in this study were isolation and identification A. actinomycetemcomitans, characterize A. actinomycetemcomitans adhesin and study the role of A. actinomycetemcomitans adhesin in Wistar rats. Results: The result of this research on the role of adhesin in Wistar rats after analysis with Analysis of Variance (ANOVA) showed significant differences in the control group with group induction with A. actinomycetemcomitans, A. actinomycetemcomitans plus adhesin and adhesin. MMP-8 activity increased with induction A. actinomycetemcomitans and 24 kDa A. actinomycetemcomitans adhesin. This fimbrial adhesin protein showed that A. actinomycetemcomitans has the ability to adhesion, colonization and invasion for host in aggressive periodontitis pathogenesis. Conclusion: A. actinomycetemcomitans fimbrial adhesin protein induction increasing MMP-8 activity for aggressive periodontitis pathogenesis.Latar belakang: A. actinomycetemcomitans merupakan salah satu bakteri Gram negatif yang terkait dengan periodontitis agresif yang menyerang penderita usia muda dan merupakan faktor penting dalam patogenesis periodontitis agresif. A. actimycetemcomitans mempunyai fimbriae dengan protein adhesin yang merupakan molekul pertama dari bakteri untuk melakukan kontak fisik dengan host. Tujuan: Tujuan penelitian ini adalah menganalisis pengaruh induksi adhesin A. actinomycetemcomitans terhadap aktivitas MMP-8. Metode: Penelitian ini merupakan studi eksperimental laboratori, langkah dari penelitian ini adalah isolasi dan identifikasi A. dan identifikasi A. actinomycetemcomitans, isolasi dan karakterisasi adhesin A. actinomycetemcomitans dan uji peran adhesin A. actinomycetemcomitans di tikus Wistar. Hasil: Hasil analisis menunjukkan adanya aktivitas MMP-8 yang meningkat bermakna di kelompok kontrol dibandingkan dengan kelompok dengan induksi A. actinomycetemcomitans, A. actinomycetemcomitans + adhesin dan adhesin. Hal ini menunjukkan bahwa A. actinomycetemcomitans berkemampuan melakukan adesi, kolonisasi dan invasi pada host dalam patogenesis periodontitis agresif. Kesimpulan: Induksi protein adhesin A. actinomycetemcomitans dengan berat molekul 24 kDa meningkatkan aktivitas MMP-8 pada patogenesis periodontitis agresif.

Novel development of carbonate apatite-chitosan scaffolds based on lyophilization technique for bone tissue engineering Maretaningtias Dwi Ariani
Dental Journal (Majalah Kedokteran Gigi) Vol. 45 No. 3 (2012): September 2012
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: The natural biopolymer chitosan (Ch) is currently regarded as a candidate for bone tissue engineering. However, Ch is poor for cell adhesion and low bone formation ability. In order to enhance cell adhesion and bone formation ability, combination of Ch with carbonate apatite (CA) was developed. Purpose: The aim of this study was to make carbonate apatite-chitosan scaffolds (CAChSs) and evaluate its osteoconductivity in terms of cell proliferation. Methods: Chitosan scaffolds (ChSs) were made by the following procedure. Twenty-five, 50, 100, 200 and 400 mg Ch was dissolved into 5 ml of 2% acetic acid (CH3COOH), shaked for 15 min and neutralized with 15 ml of 0.1 M sodium hydroxide (NaOH) solution. After centrifugation, Ch gel was packed into the molds then frozen at -80°C for 2h and dried in a freeze dry machine for 24h. The sponges were subjected to UV radiation for 2h. To make CA-ChSs, 200 mg Ch was selected. After neutralization, 50 mg of 0.06 M CA were added into the 200 mg Ch gel. The structure of CA-ChSs was observed by scanning electron microscope (SEM). Mouse osteoblast-like cell (MC3T3-E1) proliferation in these scaffolds was investigated at 1, 7, 14 and 21 days. Results: Three dimensional porous structures of CA-ChSs were clearly observed by SEM. Proliferated cell numbers in CA-ChSs was significantly higher than those in ChSs (control) at each stage (p<0.05). Conclusion: It can be concluded that newly developed CA-ChSs had three-dimensional interconnected porous structure, good handling property and supporting ability of proliferation of osteoblasts. It is suggested that newly developed CA-ChSs could be considered as a scaffolds material for bone tissue enginearing.Latar belakang: Kitosan yang merupakan biopolimer alami dianggap sebagai salah satu kandidat untuk rekayasa jaringan tulang. Namun, kitosan memiliki kelemahan terhadap adhesi sel dan kurang mampu membentuk tulang yang cukup. Untuk meningkatkan adhesi sel dan kemampuan pembentukan tulang, telah dikembangkan suatu scaffolds yang menggabungkan kitosan dengan carbonate apatite (CA). Tujuan: Penelitian ini bertujuan untuk membuat carbonate apatite-chitosan scaffolds (CA-ChSs) serta mengevaluasi osteokonduktivitas CA-ChSs dari sudut pandang proliferasi sel. Metode: Chitosan scaffolds (ChSs) dibuat dengan prosedur berikut ini. Dua puluh lima, 50, 100, 200 dan 400 mg bubuk kitosan dilarutkan dalam 5 ml asam asetat (CH3COOH) 2%, dikocok selama 15 menit dan dinetralkan dengan 15 ml 0,1 M larutan sodium hidroksia (NaOH). Setelah sentrifugasi, gel kitosan dikemas ke dalam cetakan teflon kemudian dibekukan pada suhu -80°C selama 2 jam dan dikeringkan dalam mesin beku kering pada suhu -54°C selama 24 jam. Selanjutnya dilakukan radiasi ultraviolet pada ChSs selama 2 jam. Untuk membuat CA-ChSs, dipilih ChSs yang berisi 200 mg bubuk kitosan. Setelah dinetralisir, 50 mg dari 0.06 M CA ditambahkan ke dalam kitosan gel yang berisi 200 mg bubuk kitosan. Struktur CA-ChSs diamati dengan scanning electron microscope (SEM). Proliferasi mouse osteoblast-like cell (MC3T3-E1) dalam ChSs dan CA-ChSs dievaluasi pada hari ke-1, 7 dan 14. Hasil: CA-ChSs dengan struktur tiga dimensi yang berpori dapat diamati dengan jelas menggunakan SEM. Jumlah pertumbuhan dan perkembangan sel pada CA-ChSs secara signifikan lebih banyak dibandingkan pada ChSs (kontrol) pada setiap tahap pengamatan di hari ke-1, 7, 14 dan 21 (p<0.05). Kesimpulan: Dapat disimpulkan bahwa CA-ChSs mempunyai struktur tiga dimensi dengan pori-pori yang saling berhubungan satu sama lain dan dapat meningkatkan proliferasi osteoblast. Hal ini menunjukkan bahwa CA-ChSs adalah kandidat untuk rekayasa jaringan tulang.

Genotoxicity test of propolis extract, mineral trioksida aggregat, and calcium hydroxide on fibroblast BHK-21 cell cultures Ceples Dian Kartika W.P; Sri Kunarti; Ari Subiyanto
Dental Journal (Majalah Kedokteran Gigi) Vol. 48 No. 1 (2015): March 2015
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Health industry has always used natural products as an alternative. Propolis, a natural antibiotic, is a resinous yellow brown or dark brown substance derived from honey bees (Apis mellifera). The main chemical compounds contained in propolis are flavonoids, phenolics and other various aromatic compounds. Flavonoids are well known plant compounds that have antibacterial, antifungal, antiviral, antioxidant and anti-inflammatory proprieties. Propolis is expected to be an alternative used for root canal treatment with lower toxicity compared to calcium hydroxide (Ca(OH)2 . Over the last decade, a new material, mineral trioxide aggregate (MTA) was developed, and has been used as the gold standard. All materials used in mouth should be biocompatible. The initial level of material biocompatibility evaluation involves toxicity and genotoxicity tests. Purpose: This research is aimed to conduct comparison test of genotoxicity effect of propolis extract, MTA and Ca(OH)2 on fibroblast BHK-21 cell culture. Methods: This research was conducted with single-cell gel electrophoresis method. Results: The results indicate that propolis extract cannot cause DNA damage, while MTA can cause apoptosis and Ca(OH)2 can cause neucrosis. Conclusion: It can be concluded that propolis extract has genotoxicity effect lower than MTA and Ca(OH)2 , but MTA has lower effect on fibroblast BHK-21 cell culture.

Seroprevalence of Herpes Simplex virus types 1 and 2 and their association with CD4 count among HIV-positive patients Irna Sufiawati; Sunardhi Widyaputra; Tony S. Djajakusumah
Dental Journal (Majalah Kedokteran Gigi) Vol. 45 No. 2 (2012): June 2012
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Herpes simplex virus (HSV) is a common cause of viral opportunistic infections among HIV-positive patients. Frequent, more severe and prolonged episodes of recurrent HSV infection can be a source of significant morbidity and mortality among HIV-positive patients with advanced immunosuppression, reflected by low CD4 count. However, conflicting results have also been reported. Purpose: The aim of this study was to investigate the seroprevalence of HSV type 1 (HSV-1) and type 2 (HSV-2) in HIV-positive patients compare with the rate in HIV-negative patients, and to evaluate their association with CD4 count. Methods: A cross sectional study was conducted among 145 subjects consisting of 80 HIV-positive and 65 HIV-negative patients attending the top referral hospital in Bandung, West Java, Indonesia. The serum obtained was assayed for the presence of HSV-1 and HSV-2 IgG antibodies using ELISA kits. Data were analyzed using a Chi-square test, t-tests and analysis of variance (ANOVA). Results: There were no significant differences in HSV-1 seroprevalence between HIV-positive patients (71%) and HIV-negative patients (66%). HSV-2 seroprevalence was significantly higher in HIV-positive patients (30%) than HIV-negative patients (5%). The titers of HSV-1 IgG antibodies in HIV-positive patients (mean 24.63 ± 19.06 IDU) were significantly lower than those of HIV-negative patients (mean 44.62 ± 33.22 IDU). In contrast, HSV-2 IgG antibody titers in HIV-positive patients (mean 13.31 ± 20.28 IDU) were significantly higher than HIV-negative patients (mean 4.42 ± 10.99 IDU). There was no significant correlation between HSV-1 and HSV-2 seropositivity and CD4 count among HIV-positive patients. However, most of HSV-2 seropositive patients had CD4 count < 200 cells/mm3. Conclusion: Seroprevalence of HSV-1 and HSV-2 among HIV-positive patients was high with no correlation with CD4 count.Latar belakang: Herpes simplex virus (HSV) adalah penyebab infeksi virus oportunistik yang paling umum pada pasien HIVpositif. Infeksi HSV rekuren yang sering terjadi, lebih berat, dan episode yang berkepanjangan dapat menjadi penyebab morbiditas dan mortalitas yang signifikan pada pasien HIV-positif dengan imunosupresi lanjut, ditandai dengan jumlah CD4 yang rendah. Namun, hasil yang bertentangan juga telah dilaporkan. Tujuan: Penelitian ini bertujuan untuk mengetahui seroprevalensi HSV tipe 1 (HSV-1) dan tipe 2 (HSV-2) pada pasien HIV-positif dibandingkan dengan pasien HIV-negatif, dan untuk mengevaluasi hubungannya dengan jumlah CD4. Metode: Penelitian potong lintang ini dilakukan pada 145 subjek yang terdiri dari 80 pasien HIV-positif dan 65 pasien HIV-negatif yang berkunjung ke rumah sakit pusat rujukan di Bandung, Jawa Barat, Indonesia. Antibodi IgG HSV-1 dan HSV-2 di dalam serum diperiksa dengan menggunakan ELISA. Data dianalisis dengan uji Chi-square, t-test dan ANOVA, nilai p < 0.05 dianggap signifikan secara statistik. Hasil: Seroprevalensi antibodi IgG HSV-1 pada pasien HIV-positif (71%) tidak berbeda secara signifikan dengan pasien HIV-negatif (66%). Namun, seroprevalensi HSV-2 secara signifikan lebih tinggi pada pasien HIV-positif (30%) dibandingkan dengan pasien HIV-negatif (5%). Titer antibodi IgG HSV-1 pada pasien HIV-positif (mean 24.63 ± 19.06 IDU) secara signifikan lebih rendah dibandingkan pasien HV-negatif (mean 44.62 ± 33.22 IDU). Sedangkan, titer antibodi IgG HSV-2 pada pasien HIV-positif (mean 13.31 ± 20.28 IDU) secara signifikan lebih tinggi dibandingkan pasien HIV-negatif (mean 4.42 ± 10.99 IDU). Tidak ada hubungan yang signifikan antara seropositivitas HSV-1 dan -2 dengan jumlah CD4. Namun, sebagian besar pasien seropositif HSV-2 memiliki jumlah CD4 < 200 sel/mm3. Kesimpulan: Seroprevalensi HSV-1 dan HSV-2 pada pasien HIV-positif adalah tinggi, tetapi tidak berkorelasi dengan jumlah CD4.

Effect of Robusta coffee beans ointment on full thickness wound healing Yorinta Putri Kenisa; Istiati Istiati; Wisnu Setyari J
Dental Journal (Majalah Kedokteran Gigi) Vol. 45 No. 1 (2012): March 2012
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Traumatic lesions, whether chemical, physical, or thermal in nature, are among the most common lesion in the mouth. Wound healing is essential for the maintenance of normal structure, function, and survival of organisms. Experiments of Robusta coffee powder on rat-induced alloxan incision wound, clinically demonstrated similar healing rate with the povidone iodine 10%. No studies that look directly the effect of coffee extract in ointment form when viewed in terms of histopathology. Robusta coffee bean (Coffea canephora) consists of chlorogenic acid (CGA) and caffeic acid which are belived to act as antioxidant and take part in wound healing process. Purpose: The aim of this study was to identify the enhancement of healing process of full-thickness skin wound after Robusta coffee beans extract ointment application. Methods: Sample consisted of 20 Cavia cabaya treated with full-thickness with wounds and was given Robusta coffee beans extract ointment concentration range of 22.5%, 45%, and 90% except the control group which was given ointment base material. Animals were then harvested on the fourth day and made for histopathological preparations. Data were calculated and compared by one-way ANOVA test and LSD test. Results: The study showed that Robusta coffee bean extract ointment can increase the number of lymphocytes, plasma cells, macrophages, fibroblasts, and blood vessels by the presence of chlorogenic acid (CGA) and Caffeic acid. Conclusion: In conclusion Robusta coffee bean extract ointment enhance the healing process of fullthickness skin wound of Cavia cabaya.Latar belakang: Lesi traumatik, baik akibat rangsang kimia, fisik, atau termal, merupakan lesi yang paling umum terjadi di dalam rongga mulut. Penyembuhan luka yang terjadi ini penting untuk pemeliharaan struktur normal, fungsi, dan kelangsungan hidup organisme. Percobaan pemberian bubuk kopi Robusta terhadap luka sayatan pada tikus yang diinduksi aloksan, secara klinis menunjukkan tingkat penyembuhan yang sama dengan povidone iodine 10%. Namun belum ada penelitian yang melihat secara langsung pengaruh ekstrak kopi dalam bentuk salep bila dilihat dari segi histopatologi. Biji kopi Robusta (Coffea canephora) terdiri dari chlorogenic acid (CGA) dan caffeic acid yang dipercaya berperan sebagai antioksidan dan mengambil bagian dalam proses penyembuhan luka. Tujuan: Tujuan penelitian ini adalah untuk mengidentifikasi peningkatan proses penyembuhan luka full-thickness pada kulit setelah pengaplikasian salep ekstrak biji kopi Robusta. Metode: Sampel terdiri dari 20 Cavia cabaya yang diberi perlakuan berupa luka sayat full-thickness pada kulit punggung dan diberi salep ekstrak biji kopi Robusta dengan beberapa konsentrasi, yaitu 22,5%, 45%, dan 90%, sedangkan kelompok kontrol hanya diberi bahan dasar salep. Binatang coba kemudian dieksekusi pada hari keempat dan dibuat sediaan histopatologinya. Data dihitung dan dibandingkan dengan uji One-Way ANOVA dan uji LSD. Hasil: Hasil penelitian menunjukkan bahwa salep ekstrak biji kopi Robusta dapat meningkatkan jumlah limfosit, sel plasma, makrofag, fibroblas, dan pembuluh darah yang dipengaruhi oleh chlorogenic acid (CGA) dan caffeic acid. Kesimpulan: Disimpulkan bahwa salep ekstrak biji kopi Robusta memiliki efek dapat meningkatkan proses penyembuhan luka full-thickness pada kulit Cavia cabaya.

Daya hambat xylitol dan nistation terhadap pertumbuhan Candida albicans (in vitro) (Inhibition effect of xylitol and nistatin combination on Candida albicans growth (in vitro)) Sarah Kartimah Djajusman; Udijanto Tedjosasongko; Irmawati Irmawati
Dental Journal (Majalah Kedokteran Gigi) Vol. 47 No. 3 (2014): September 2014
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: The growth of Candida albicans can be controlled by using antifungal such as nystatin. These days we found that using antifungal is not enough to control Candida albicans, we also have to control the intake of sugar by using xylitol. Purpose: Purpose of the study was to determine the optimal inhibitory concentration of xylitol-nystatin in the Candida albicans growth. Methods: This was an in-vitro study using an antimicrobial test of serial dilution with xylitol-nystatin and sucrose–nystatin consentration of 1%, 3%, 5%, 7%, 9%, and 10%.Growth inhibition of C. albicans was determined by the inhibition zone of xylitol + nystatin on C. albicans culture media (in vitro) Results: The result of study was the inhibitory consentration of xylitol-nystatin to inhibit Candida albicans growth was 3%-10%. Conclusion: The study showed that combination of xylitol and nystation could inhibit the growth of Candida albicans.Latar belakang: Pertumbuhan Candida albicans dapat dikontrol dengan menggunakan antijamur seperti nistatin. Penggunakan antijamur saja tidak cukup untuk mengontrol Candida albicans, namun perlu pula mengontrol asupan gula dengan menggunakan xylitol. Tujuan: Tujuan dari penelitian ini adalah untuk menentukan konsentrasi hambat optimal xylitol-nistatin dalam pertumbuhan Candida albicans. Metode: Penelitian ini merupakan penelitian in vitro menggunakan uji antimikroba pengenceran serial dengan xylitol-nistatin dan nystatin-sukrosa konsentrasi 1%, 3 %, 5 %, 7%, 9%, dan 10%. Daya hambat pertumbuhan C. albicans diukur dari zona hambat xylitol + nistatin pada media kultur C. albicans (in vitro) Hasil: Konsentrasi penghambatan xylitol-nistatin untuk menghambat pertumbuhan Candida albicans adalah 3-10%. Simpulan: Hasil penelitian menunjukkan bahwa kombinasi xylitol dan nystation bisa menghambat pertumbuhan Candida albicans.

The effectiveness of Nigella sativa seed extract in inhibiting Candida albicans on heat cured acrylic resin Hanoem EH; Imam B; Kartika Purnama Pranoto
Dental Journal (Majalah Kedokteran Gigi) Vol. 44 No. 3 (2011): September 2011
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Indonesia has a variety of plants that can be used for medicines. One of the medicinal plants is Nigella sativa. Nigella sativa has been used for medicinal purposes, both as medicinal herb and as medicinal oil. It contains saponin and atsiri oils that have antifungal, antimicrobial and antibacterial effects. Nigella sativa has been suggested as denture cleansers since it can inhibit the growth of Candida albicans (C. albicans) on heat cured acrylic resin. Purpose: The aim of this research is to know the effectiveness of Nigella sativa seed extract in inhibiting the growth of C. albicans on heat cured acrylic resin. Methods: Eighteen acrylic samples were divided into three groups. Group I was control group, only contaminated with C. albicans without immersing in any solution. Group II was acrylic sample immersed in sterile aquades for one hour. Group III was acrylic sample immersed in Nigella sativa seed extract for one hour. Results: There were significant differences of C. albicans (p < 0.05) among the three groups. The number of Candida albicans was significantly higher in Group I, while that in group II was lower than that in group I, and that in group III was the lowest. Conclusion: Nigella sativa seed extract was effective in inhibiting the growth of C. albicans on heat cured acrylic resin.Latar belakang: Indonesia memiliki berbagai tanaman yang dapat dipakai sebagai obat, salah satu tanaman tersebut adalah jinten hitam (Nigella sativa). Pada beberapa negara jinten hitam telah digunakan untuk berbagai tujuan, baik sebagai obat herbal maupun sebagai minyak. kandungan jinten hitam adalah saponin dan minyak atsiri yang mempunyai efek anti jamur dan anti mikroba. Jinten hitam disarankan sebagai pilihan pembersih gigi tiruan yang dapat menghambat pertumbuhan Candida albicans (C. albicans) pada resin akrilik heat cured. Tujuan: Tujuan penelitian ini adalah mengetahui efektivitas dari ekstrak biji jinten hitam dalam menghambat pertumbuhan C. albicans pada resin akrilik heat cured. Metode: Delapan belas sampel akrilik heat cured dibagi dalam tiga kelompok, kelompok I sebagai kelompok kontrol, lempeng akrilik tanpa direndam dalam bahan apapun selama 1 jam. Kelompok perlakuan II, lempeng akrilik direndam dalam aquades steril selama 1 jam. Kelompok perlakuan III, lempeng akrilik direndam dalam ekstrak biji jinten hitam selama 1 jam. Hasil: Ada perbedaan yang bermakna dari C. albicans (p < 0,05) pada ketiga kelompok tersebut. Jumlah C. albicans lebih banyak secara bermakna pada kelompok I, pada kelompok II lebih sedikit daripada kelompok I dan kelompok III paling sedikit. Kesimpulan: Ekstrak biji jinten efektif dalam menghambat pertumbuhan C. albicans pada resin akrilik heat cured.

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Home Page

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Abstract

Abstract

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Contact Name
Saka Winias

Contact Email
saka.winias@gmail.com

Phone
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Journal Mail Official
dental_journal@yahoo.com

Editorial Address
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Location
Kota surabaya,

Jawa timur

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