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Majalah Kedokteran Sriwijaya
Published by Universitas Sriwijaya
ISSN : 08523835     EISSN : 26850486     DOI : https://doi.org/10.36706/mks.v52i4
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health
Majalah Kedokteran Sriwijaya (MKS) is published by Fakultas Kedokteran Universitas Sriwijaya since 1962. MKS is a peer-reviewed, multidisciplinary and scientific journal which publishes all areas regarding medical sciences. The covered research areas as follows : Microbiology Pathology Surgery Ophthalmology Gynecology and Obstetrics Psychiatry Anesthesia Pediatrics Orthopedics Anatomy Physiology Biochemistry Pharmacology Biophysics Endocrine and Metabolism Mental Health Forensic Medicine Medical Education Research Methodology Medical Ethics Nursing Community Medicine Public Health
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 229 Documents
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CORRELATION BETWEEN ETHAMBUTOL THERAPY DURATION AND ZINC SERUM LEVEL WITH COLOUR VISION DEFICIENCY IN TUBERCULOSIS PATIENTS Devi Azri Wahyuni; Mira Retna Tetiana; Mgs Irsan Saleh; Ahmad Rasyid
Majalah Kedokteran Sriwijaya Vol 52, No 2 (2020): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v52i2.11975

Abstract

Tuberculosis is one of the most common disease in Indonesia. Ethambutol is one of the main regiment therapy for patient with tuberculosis. Duration of ethambutol therapy depends on what category of tuberculosis patient. Ethambutol intake can cause optic neuropathy with colour vision deficiency as an early symptom. Ethambutol therapy can also cause decrease of zinc serum level and it is cause by zinc chelate that can be found in ethambutol. The purpose of this study was to determine the correlation between duration of ethambutol therapy and zinc serum level with colour vision deficiency which examined with Farnsworth Munsell 100 Hue in tuberculosis patients. This is an observational explorative study. Colour vision is xamined with Farnsworth Munsell 100 Hue and zin serum level is detected by blood sample. Data was analyzed by correlation study. Correlation statistic between ethambutol therapy duration with colur vision using Spearman coreelation study found that r = 0,5 and p = 0,00, whereas in correlation between zinc serum level with colour vision found that r = 1,68 and p = 0,32. There is significant correlation and positive direction between ethambutol therapy duration with colour vision deficiency. Even though there is no significant correlation between zinc serum level with colour vision deficiency, there is a strong correlation.
Profile of Coagulation Marker and The Influence Factors in Central Nervous System Tumor Yunni Diansari; Mediarty Syahrir; Sri Novianty Yusuf
Majalah Kedokteran Sriwijaya Vol 51, No 4 (2019): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v51i4.10071

Abstract

Brain tumors have the highest percentage of thrombosis compared to other types of malignancies. Hypercoagulation is a risk for thromboembolic events in patients with malignancy. Hypercoagulation conditions are frequentlyfound in patients with malignancy arising from the aptitudeof tumor cells to activate the coagulation system. This condition can be detected through coagulation markers in the blood. This marker isPT, APTT, INR, Fibrinogen and D-Dimer.This research is a descriptive analytic study using secondary data from medical records of patients with central nervous system (CNS) tumors. The inclusion criteria were CNS tumor patients> 18 years old and had been diagnosed with CNS tumor. Coagulation markers are recorded based on the results of the initial laboratory examination upon entering the hospital, consisting of D-Dimer, PT, APTT, Fibrinogen, INR.There were 124 researchsubjects, consisting of 60 men and 64 women. Most research subjects are in the age range of 40-49 years (54.8%). Hypercoagulation conditions were found in 92.74% of study subjects. The most common accompanying conditionwas hypertension (22.6%). There were no significant differences in the hypercoagulable conditions in groups with and without accompanying conditions.Hypercoagulation was found in most research subjects. There are no factors that influence the hypercoagulation condition in this study.
HUBUNGAN TIPE MALFORMASI ANOREKTAL, KELAINAN KONGENITAL PENYERTA, SEPSIS, DAN PREMATURITAS DENGAN MORTALITAS PASIEN MALFORMASI ANOREKTAL Bima Indra; Shalita Dastamuar; Rahmadr Hidayat
Majalah Kedokteran Sriwijaya Vol 50, No 1 (2018): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v50i1.8535

Abstract

Anorectal malformations are a broad spectrum of anal and rectal disorders ranging from stenosis to anorectal agenesis. The incidence of mortality in cases of anorectal malformations is influenced by many factors, including the type of anorectal malformation, associated congenital anomalies, sepsis, and prematurity as investigated in this study. This study aims to identify the association between anorectal malformation type, associated congenital anomalies, sepsis, and prematurity with mortality on anorectal malformation patient. This research is an observational analytic study with cross sectional study design. Secondary data collection was obtained from eighty-two medical records of anorectal malformation patients in Dr. Mohammad Hoesin Hospital Palembang from January 2015 to June 2017 that meets the inclusion criteria. Of the eighty-two cases of anorectal malformations, nineteen cases of mortality (23.2%) were obtained. Of the four risk factors studied, two risk factors were found to significantly affect the mortality of anorectal malformation patients, they are anorectal malformation type (p value = 0.036) and sepsis (p value = 0.049). Factors that have significant correlation to mortality of patients with anorectal malformations are the type of anorectal malformations and sepsis, whereas associated congenital anomalies and prematurity have no effect on the mortality of patients with anorectal malformations.
The Correlation Between Limited Range of Movement And Functional Ability of Frozen Shoulder Patient at Medical Rehabilitation Department RSUPDr Mohammad Hoesin Palembang Ine Santia; Nyimas Fatimah; Tri Suciati
Majalah Kedokteran Sriwijaya Vol 51, No 1 (2019): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v51i1.8559

Abstract

Frozen shoulder is the inflammation of shoulder joint,  marked by a painful, adhesive, atrophic and shortened joint capsule. As a result, movement range of the joint becomes limited. In frozen shoulder patients, the limitation can affect and lessen functional ability. Therefore, this study is aimed to analyze the correlation between the limited range of movement of shoulder joint and the functional ability of frozen shoulder patients in Department of Medical Rehabilitation of RSUP Dr. Mohammad Hoesin Palembang.  This study is an observational analysis using correlation test with cross-sectional design. Twenty nine frozen shoulder patients in Department of Medical Rehabilitation of RSUP Dr. Mohammad Hoesin Palembang in November 2018 that met the inclusion criteria were taken as subjects of this study by using consecutive sampling technique. Functional ability was assessed with quickDASH questionnaire while shoulder joint range of movement with goniometry. Data analysis was conducted subsequent to the assessments. The result of correlation test between functional ability and shoulder joint range of movement is significant. The study findings include active flexion (p=0,000; r=-0,669), active extension (p=0,004; r=-0,520), active abduction (p=0,000; r=-0,663), active adduction (p=0,022; r=-0,423), passive flexion (p=0,001; r=-0,589), extension passive (p=0,002; r=-0,543), passive abduction (p=0,000; r=-0,676) and passive adduction (p=0,038; r=-0,388).There is a significant correlation between limited range of movement and functional ability in frozen shoulder patients from Department of Medical Rehabilitation of RSUP Dr. Mohammad Hoesin Palembang.
Hubungan Antara Ekspresi Cyclooxygenase-2 Dengan Derajat Histopatologi dan Invasi Limfovaskular Karsinoma Sel Skuamosa Serviks Listinawati Listinawati; Henny Sulastri; Wresnindyatsih Wresnindyatsih; Mutiara Budi Azhar
Majalah Kedokteran Sriwijaya Vol 46, No 3 (2014): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v46i3.2707

Abstract

Karsinoma sel skuamosa (KSS) serviks merupakan karsinoma invasif yang terdiri dari sel-sel dengan diferensiasi skuamosa. Berdasarkan derajat histopatologinya KSS serviks dibagi menjadi derajat 1 (diferensiasi baik), derajat 2 (diferensiasi sedang) dan derajat 3 (diferensiasi buruk). Banyak faktor yang berperan dalam karsinogenesis KSS serviks, antara lain cyclooxygenase-2, enzim kunci dalam sintesis prostaglandin, namun hubungan antara COX-2 dengan derajat histopatologi KSS serviks masih menjadi kontroversi. Penelitian ini bertujuan untuk mengetahui hubungan antara ekspresi COX-2 dengan derajat histopatologi dan invasi limfovaskular KSS serviks dengan pemeriksaan immunohistokimia. Penelitian ini adalah penelitian potong-lintang. Lima puluh slaid sampel diambil dengan cara simple random sampling dari arsip Patologi Anatomi RSUP Dr. Mohammad Hoesin Palembang dari Januari sampai Desember 2013. Dilakukan pulasan menggunakan antibodi COX-2 dan dianalisis hubungan ekspresi tersebut dengan derajat histopatologi dan invasi limfovaskular KSS serviks. Hasil penelitian didapatkan derajat histopatologi terbanyak adalah derajat atau diferensiasi buruk (derajat 2 dan 3) sebesar 78%, diikuti derajat atau diferensiasi baik (22%). Terdapat hubungan yang bermakna antara ekspresi COX-2 dengan derajat histopatologi KSS serviks (p=0,046). Invasi limfovaskular dijumpai pada 78% kasus, tetapi tidak berhubungan dengan positifitas ekspresi COX-2 (p=0,618). Didapat juga temuan lain yaitu sebukan atau infiltrasi sel radang yang padat pada 72% kasus dan adanya hubungan yang bermakna dengan positifitas ekspresi COX-2 (p=0,020). Disimpulkan bahwaekspresi COX-2 paling tinggi terdapat pada KSS serviks dengan derajat atau diferensiasi buruk dan semakin menurun pada derajat atau diferensiasi baik. Invasi limfovaskular tidak berhubungan dengan ekspresi COX-2.
Pirani Score Difference in CTEV Patients Treated with Ponseti’s Serial Cast in RSUP dr. Mohammad Hoesin Palembang Davin Caturputra Setiamanah; Nur Rachmat Lubis; Indri Seta Septadina
Majalah Kedokteran Sriwijaya Vol 52, No 1 (2020): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v52i1.11427

Abstract

Congenital talipes equinovarus (CTEV) is a congenital deformity involving calcaneo-navicular complex. It is best understood with mnemonic CAVE which includes cavus, adduction, varus, and equinus of the foot. Ponseti’s method, the gold standard of treating CTEV, includes strapping and tapping technique, manipulation, serial casting, and functional therapy. The purpose of this study is proving that there is a significant Pirani score difference in CTEV patients treated with Ponseti’s serial casts. It is an observational study with time series design. Observation and evaluation to the CTEV patients were conducted during the period of August-December 2017 at The Orthopedics Clinic in RSUP dr. Mohammad Hoesin Palembang. All the data were analyzed with Wilcoxon test using IBM SPSS version 24. Total 14 CTEV feet were treated with Ponseti method. From all of the 7 patients, four were females (57.1%) and three were males (42.9%). Every patient had bilateral deformity and less than a year in age. Mean Pirani score of the study group after the second plaster cast were 3.78 ± 2.05 for the left feet and 4.07 ± 1.66 for the right feet. Mean post-treatment Pirani score of the study group, respectively left and right feet, were 0.57 ± 0.60 and 0.28 ± 0.39. Total 92% of the feet were treated successfully by Ponseti’s serial casts. There is a significant difference in Pirani score before and after the treatment of CTEV using Ponseti’s serial casts (p < 0.05).
Hubungan Infeksi Soil Transmitted Helminths (STH) dengan Prestasi Belajar pada Siswa SDN 169 di Kelurahan Gandus Kecamatan Gandus Kota Palembang Dwi Handayani; Muhaimin Ramdja; Indah Fitri Nurdianthi
Majalah Kedokteran Sriwijaya Vol 47, No 2 (2015): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v47i2.2750

Abstract

Infeksi Soil Transmitted Helminths (STH) masih merupakan salah satu masalah kesehatan yang utama di Indonesia. Pada anak-anak sekolah dasar infeksi STH akan menghambat mereka dalam mengikuti pelajaran dikarenakan anak akan merasa cepat lelah, daya konsentrasi menurun, malas belajar dan pusing. Tujuan penelitian ini adalah untuk mengetahui hubungan infeksi STH dengan prestasi belajar pada siswa SDN 169 Kelurahan Gandus, Kecamatan Gandus, Kota Palembang. Jenis penelitian ini adalah penelitian observasional analitik dengan rancangan cross-sectional. Populasi penelitian ini adalah 334 siswa. Dengan proportionate stratified random sampling didapatkan sampel 73 anak.. Data yang dikumpulkan adalah nilai Ujian Tengah Semester (UTS) terakhir dan tinja yang diperiksa di Laboratorium Parasitologi Fakultas Kedokteran Universitas Sriwijaya menggunakan teknik Kato Katz dan Harada Mori modifikasi. Hasil yang diperoleh dianalisis menggunakan uji statistik Fisher’s Exact Text. Prevalensi infeksi STH pada siswa SDN 169 Kelurahan Gandus Kecamatan Gandus Kota Palembang adalah 6,8% dengan perbandingan laki-laki 1,3% dan perempuan 5,5%. Kelompok usia 7-8 tahun paling banyak terinfeksi (4,1%). Prestasi belajar yang didapat masih banyak siswa dengan prestasi belajar kurang yaitu 65,8% dengan perbandingan laki-laki 39,8% dan perempuan 26,0%. Hasil uji statistik Fisher Exact diperoleh nilai p = 0,365 (p > 0,05).  Tidak terdapat hubungan antara prestasi belajar dan kejadian infeksi STH pada siswa SDN 169 di Kelurahan Gandus.
PENGARUH TERAPI SENAM OTAK TERHADAP TINGKAT KOGNITIF LANSIA YANG MENGALAMI DEMENSIA DI PANTI SOSIAL TRESNA WERDHA WARGA TAMA INDERALAYA Raden Surahmat; Novitalia Novitalia
Majalah Kedokteran Sriwijaya Vol 49, No 4 (2017): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v49i4.8525

Abstract

Penurunan kemampuan daya ingat, daya pikir, dan penurunan kemampuan tersebut menimbulkan gangguan terhadap fungsi kehidupan sehari- hari bagi lansia. Salah satu upaya untuk mencegah  dan  memperbaiki daya ingat  salah  satunya  yaitu  senam otak. Tujuan penelitian ini untuk mengetahui pengaruh terapi senam otak terhadap lansia yang mengalami demensia di Panti Sosial Tresna Werdha Werdha Warga Tama Indralaya. Desain penelitian yang digunakan Pra-Eksperimen dengan menggunakan metode one- group pretest-posttest design. Populasi dalam penelitian ini berjumlah 33 orang. Metode pengambilan sampel yang  digunakan  adalah  total  sampling.  Sampel  dalam  penelitian  ini  yaitu  lansia  yang  berumur  60-70  tahun.  Alat pengumpulan data yang digunakan kuesioner Mini Mental State Examination (MMSE). Analisis statistik menggunakan uji Paired t-test. Penelitian ini dilakukan pada tanggal 11 sampai 24 April 2016. Hasil uji statistik didapatkan p value = 0,000 dengan nilai ? = 0,05 (p < 0,05), yang berarti bahwa ada pengaruh pemberian terapi senam otak terhadap tingkat kognitif lansia demensia.Dengan demikian dapat disimpulkan bahwa senam otak dapat meningkatkan fungsi kognitif lansia yang mengalami demensia. Peneliti menyarankan petugas panti dapat menerapkan terapi senam otak ini untuk penanganan pada lansia yang mengalami demensia. Sehingga kesehatan maupun daya ingat pada lansia dapat terjaga.
Inflammatory Bowel Disease Pada Anak Deny Salverra Yosy; Hasri Salwan
Majalah Kedokteran Sriwijaya Vol 46, No 2 (2014): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v46i2.2698

Abstract

Inflammatory bowel disease (IBD) menunjukkan sekelompok gangguan yang ditandai oleh peradangan usus kronis dengan etiologi yang tidak diketahui. IBD meliputi penyakit Crohn (PC) dan kolitis ulseratif (KU). Definisi dari KU dan PC didasarkan pada lokasi dan karakteristik dari proses peradangan pada saluran cerna. IBD dapat terjadi pada semua usia tetapi jarang terjadi pada masa bayi. IBD merupakan hasil dari interaksi yang kompleks antara faktor lingkungan, genetik, dan kekebalan tubuh. KU dan PC berhubungan dengan manifestasi intra dan ekstraintestinal. Gejala umum dari KU adalah adanya diare dan perdarahan rektal. Gejala yang paling sering terjadi pada penyakit Crohn adalah nyeri perut. Diagnosis IBD didasarkan pada gejala klinis, endoskopi, radiologis dan histologis. Pengobatan IBD meliputi pemberian 5-aminosalicylates (5-ASA), kortikosteroid, antibiotik, immune modifier, metotreksat, terapi nutrisi, terapi probiotik, dan pembedahan. Hanya 1% dari pasien dengan PC paling tidak mengalami satu kali kekambuhan setelah diagnosis dan terapi awal. Terdapat risiko yang bermakna untuk berkembangnya kanker pada penyakit usus kronis, dan pasien yang menderita PC tampaknya memiliki risiko yang sama dengan yang menderita KU.
Comparison of Cardiac Size in Posteroanterior Chest X-Ray and Echocardiography Agustining Rahayu; Bachtiar Murtala; Sri Asriyani; Andi Alfian Zainuddin; Muzakkir Muzakkir; Nikmatia Latief
Majalah Kedokteran Sriwijaya Vol 51, No 4 (2019): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v51i4.10238

Abstract

Cardiac size is important to determine the presence of cardiac enlargement caused by left ventricular enlargement or right ventricular enlargement. Although echocardiography is considered to be the gold standard for cardiac enlargement, its availability is limited, expensive and requires trained experts. The posteroanterior (PA) chest X-ray (CXR) is the most common imaging used as a reliable alternative. The aim of this study was to compare cardiac size using cardiothoracic ratio (CTR) and transverse left cardiothoracic ratio (TL-CTR) in PA chest X-ray and echocardiography. This cross- sectional study involved 88 inclusion sample, aged 20-60 years. On the basis of provisional clinical diagnosis, the patients were divided three groups, consist of: (i) Group with normal cardiac size, (ii) Group with left ventricular enlargement (LVE) dan (iii) Group with right ventricular enlargement (RVE). All patients underwent PA CXR and M-Mode echocardiography examinations. The results of the two modalities were compared. CTR and TL-CTR, transverse diameter (TD) and transverse left (TL) in PA chest X-ray showed a strong positive correlation with total ventricular dimension (TVD) and left ventricular internal dimension (LVID) in echocardiography. CTR, TL-CTR, TD and TL in the PA chest X-ray are very good indicators for TVD and LVID in echocardiography. Chest X-ray is a reliable alternative for the diagnosis of cardiomegaly/cardiac enlargement in the absence of echocardiography. 

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