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INDONESIA
Biomedical Journal of Indonesia
Published by Universitas Sriwijaya
ISSN : 24077097     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Biomedical Journal of Indonesia is an open access, peer-reviewed journal that focus on basic medical sciences, emphasizing on providing the molecular studies of biomedical problems and molecular mechanisms to integrate researches in all aspects of human health. BJI is dedicated to publishing original research and review articles covering all aspects of biomedical sciences.
Arjuna Subject : Kedokteran - Anatomi
Articles 392 Documents
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Cytotoxicity Effects of Benalu Tea Extract (Scurrula oortina) on Hella cells Kusumo Hariyadi; Fatmawati; Subandrate; Fahira Aninditia; Dazakiah
Biomedical Journal of Indonesia Vol. 6 No. 2 (2020): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

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Abstract

Tea garden waste has been investigated in the form of parasite tea Squrula oortina SpeciesFamily: Loranthaceae from the Dempo Pagar Alam tea plantation, Lahat Regency, South Sumatra.Stem and leaf samples are then dried and powdered, then isolated with 70% water-ethanolsubfraction. The extract was then dried by vacuum distillation at 70 o C until a concentrated extractwithout ethanol was obtained. The results of the study were tea parasite extract, and the extractwas tested for phytochemicals (monounsaturated fatty acids and double, theobromine derivates,quercetin derivates and Epicatekin derivates). Next, it would be taken to the Laboratory ofBiological Sciences at Gajah Mada University to be tested for cytotoxic effects on Hella cells,with control positive doxorubicin. The results of the research were tea leaves extract IC50 = 2538ug/mL and the standard of doxorubicin IC50 = 0.88 ug/mL so that it could be concluded that theparasite of the tea parasite had cytotoxic and proliferative effects.
Immunology Aspects in Tension-Type Headache Chronicity Restu Susanti
Biomedical Journal of Indonesia Vol. 6 No. 2 (2020): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

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Abstract

Tension-Type Headache (TTH) headache is a type of primary headache which mostlycomplained by patients. The pain often ignored due to low mortality rates. Inadequatemanagement makes the pain becoming chronic and causing a high disability rate. Many factorsinvolved in transforming infrequent tension-type headache to chronic tension-type headache.A deeper understanding of the immune system's role in the pathophysiological process andmodulation of chronic pain could be a potential target for developing therapies in managingchronic pain.
Covid-19 Infection in Elderly with Comorbids Yudistira, Edo; Roza Mulyana
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.376

Abstract

The senior population has a higher risk of contracting Covid-19 and is at risk ofdeveloping more severe disease. This is due to physiological changes in old age,which causes a decrease in immune function accompanied by an increase incomorbid disorders such as diabetes, hypertension, heart disease, lung disease,and dementia. WHO reports that the mortality rate for Covid-19 patients in theelderly above 80 years in China is around 21.9%, Italy is about 89% at the ageabove 70 years, and the United States is 85% at the age of 65 years and over.Delirium syndrome often appears as the primary complaint or infrequently; itoccurs on the first day the patient is treated and shows fluctuating symptoms.Symptoms of delirium, such as disorientation, difficulty concentrating, andinattention, often occur in the elderly and are associated with a poor prognosis.Management of geriatric patients with covid 19 must be carried out thoroughlyand completely, especially in geriatric patients with comorbidities. Managementincludes primary diseases, namely Covid-19 infection, delirium, nutritionaltherapy, blood sugar, family education for patient assistance, maintaining thepatient's body and environment cleanliness, oral hygiene, and, last but not least,moral support from the family for the patient. With complete management, elderlypatients with various comorbid can survive the Covid-19 infection.
The Effectiveness of The Combination of Nanoparticles from Carica papaya L. Leaf and Chitosan 1% Against Fibroblasts in The Tooth Socket of Wistar Rats. Sim, Mellisa; Helen Theresia Nauli; Dang Phuong Khanh; Novelya; Felice Florencia Nicoline
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.378

Abstract

Nanoparticles size can make easier for drugs to enter and react quickly to the body.In this study, nanoparticles Carica papaya L. leaf were used and combined withchitosan 1%. The aim of this study was to measure the effectiveness of thecombination of nanoparticles from Carica papaya L. leaf and chitosan 1% againstfibroblasts in the tooth socket of Wistar rats. Carica papaya L. leaf extract wasmade by maceration method and converted into a concentration of 25%, 50%, 75%and 100%, then made into nanoparticles using the nanoemulsion method. Chitosan1% was made using Na-TPP solvent using the ionic gelation method with a ratio of2:1 and after that it was mixed with nanoparticles of Carica papaya L. leaf thenmade into a gel preparation. The ANOVA statistical test shows a significant numberof p <0.05, so it can be ignored that the increase in the number of fibroblast cellsproduced by the nano gel extract is 25%, 50%, 75% and 100%, its 138, 173, 177.4and 328. Thus, the combination of 100% Carica papaya L. leaf nanoparticle extractand 1% nanocitosan was the most effective in increasing fibroblast cells on Wistarrat tooth socket.
Effectiveness of Tamarillo Skin Extract (Solanum betaceum Cav.) with Sealer Combination in Inhibiting Growth of Enterococcus faecalis E.Y, Siregar; Novelya; Susanto C
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.380

Abstract

Introduction : Caries is a growth medium for pathogenic micro-organisms an inflammatory process can occur which can cause damage to the tooth pulp. Enterococcus faecalis one of the Gram-positive facultative anaerobes which causes failure after endodontic treatment. In the field of dentistry, herbal ingredients can be used as alternative medicinal ingredients because the ingredients is tamarillo skin which contains flavonoids, terpenoids, saponins and phenol compounds. In addition to herbal alternatives, endodontic filling also uses ingredients that have antibacterial potential that can kill and prevent reproduction in the root canals, one of which is the zinc oxide eugenol sealer which is usually applied together with gutta percha. Research objective: to determine the effectiveness of the extract of tamarillo (Solanum betaccum Cav.) skin sealer combination in inhibiting the growth of Enterococcus faecalis. Method: The research was conducted in an experimental laboratory post test only control group design. Results : a sealer made from zinc oxide-eugenol had the largest diameter compared to the combination group of 100%, 75%, 50%, 25% tamarillo skin extract with sealer, and aquadest. Based on the One Way Anova test, there was a significant difference in the mean diameter of the inhibition zone (p <0.05) and the Post Hoc LSD analysis test showed that the sealer was the best group to kill the Enterococcus faecalis bacteria. Conclusion : sealers have a good effect on inhibiting Enterococcus faecalis bacteria as a cause of failure in endodontic treatment.
Activity of Averrhoa Bilimbi L Leaf Extract as Denture Cleaner Towards The Number of Colonies of Candida Albicans in Heat Cured Resin with a 30 Minutes Period Idamawati; M. Simanjuntak, Rouli Natasia; Molek; Listyaning Kartiko Kinasih
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.381

Abstract

Denture stomatitis is a chronic inflammatory condition of the oral mucosa thatgenerally occurs in users of removable dentures. The cause is multifactorialbut is often associated with the presence of Candida albicans. The mucosawhich is covered by the denture base also reduces the function of saliva whichfunctions as a cleanser for the oral cavity and results in food wasteaccumulating and microorganisms such as Candida albicans can increase innumber. Candida albicans is a normal flora of the oral cavity which is anopportunistic pathogen. The starfruit plant (Averrhoa billimbi l) is a naturalingredient that can be used as an antifungal agent. The aim was to determinethe ratio of the effectiveness of starfruit leaf extract (Averrhoa billimbi) betweenthe concentrations of 12.5%, 25%, 50%, 100%, control + (Clorhexidine) andcontrol - (Aquadest) in reducing the number of Candida albicans colonies. Thetest method used the dilution method, the colony count of Candida albicansusing a spectrophotometer. The results of the one way ANOVA statistical testresulted in a significance value of p = 0.000 (p <0.05) which means that thereis a difference in the average concentration of Candida albicans between theextract concentrations of 12.5%, 25%, 50%, 100%, control + and control. -namely 6.78 ± 0.35, 6.27 ± 0.21, 4.89 ± 0.29, 1.01 ± 0.18, 0.59 ± 0.19 and 9.13± 2.28 in inhibiting growth Candida albicans and this was confirmed by theTukey HSD posthoc test. The conclusion of this study is that there is adifference between the antifungal effectiveness of starfruit leaf extract(Averrhoa billimbi) concentrations of 12.5%, 25%, 50% and 100% in inhibitingthe growth of Candida albicans colonies.
Correlations Between Mandibular Third Molars to Inferior Alveolar Nerve Locations in Vietnamese Population Pham Ngoc Anh Thu; Tran Nhut Thao Trang; Florenly; Novelya
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.382

Abstract

One of the probable complications in mandibular third molar extraction is thedamage to the inferior alveolar nerve (IAN). Calculating the distance between IANand third mandibular can decrease the complication risk. In this study, cone beamcomputed tomography (CBCT) scans were used to evaluate several factors relatedto the positional relationship between mandibular third molar and IAN in theVietnamese population. One-hundred-seventy-eight CBCT scans were collectedfrom dental clinics at Ho Chi Minh City, from 1st January 2018 to 28th February2021. Only 100 scans were included in this study, 55 scans of female and 45 scansof male patients. The age of the patients ranged from 19 to 59 years old. From thisstudy, the most common location of IAN relative to the roots of the mandibularthird molar was on the apical side (60.5%), followed by the buccal side (21.5%), thelingual side (16%), and the least common located between the roots (2%). Overall,the mean distance between mandibular third molar roots to IAN was 3.19±1.85mm. There was a significant correlation between the left and right sides ofthe IAN location, indicating symmetry. Moreover, there is no association was foundbetween gender and the location of IAN
Effectivity of Jatropha multifida L. Leaves Extract as Antibacterial on Streptococcus mutans using In Vitro Testing Methods Kinasih, Listyaning Kartiko; Idamawati Nababan; Suci Erawati; Rouli Natasia M Simanjuntak
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.384

Abstract

Intoduction: Health is the condition of the entire body and body parts of an individual who is free from disease both physically, mentally and socially, thus enabling the individual to be able to carry out daily activities more productively. However, many people neglect their own health, especially in the field of dental and oral health. Caries is one of the most common oral and dental problems. The prevalence of dental caries in Indonesia is high, namely 88.8%. Dental caries is caused by Streptococcus mutans bacteria which plays a role in the conversion of sucrose to lactic acid. Infection due to Streptococcus mutans bacteria can be treated by taking antibiotics. Apart from drugs, antibiotics can also be obtained from natural ingredients, one of which is the tintir castor plant (Jatropha multifida Linn) or commonly known as the betadine. Objective: To see the effect of the antibacterial content of tintir leaves against Streptococcus mutans bacteria and to determine the differences in the antibacterial effect of betadine leaf extract (Jatropha multifida L.) from a concentration of 25%, 50%, 75%, and 100% against Streptococcus mutans. Methods: The type of research used in this study was a laboratory experimental study with a post-test-only control group design as the research design and to test the sensitivity of bacteria using the paper disc diffusion test. Data analysis using One-Way ANOVA. Result: The results of this study indicate the effect of tintir castor leaf extract (Jatropha multifida L.) in inhibiting the growth of Streptococcus mutans bacteria.
The Effect of Pure Garlic (Allium Sativum L.) Juice on The Color Stability of Heat Polymerized Acrylic Resin Denture Base Tumara, Herlin Nadya; Mourent Miftahullaila; Sopan Sinamo; Yohana Aprilia Saragih; Silvia Giovani
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.385

Abstract

Intoduction : PMMA or acrylic resin is a necessary material in dentistry for denture bases, one of which is often used is heat cured acrylic resin or heat polymerized acrylic resin. Garlic juice is a denture cleaner to inhibit bacteria and is also an extrinsic factor that causes discoloration. Purpose: To determine the duration of immersion in pure garlic juice which can cause discoloration of the acrylic resin. Methods: laboratory experiments with posttest only control group design research. Results: The mean ± SD change in color of hot polymerized acrylic resin after immersing in garlic juice for 2, 4, 6, 8 hours was 0.67 ± 0.22; 0.91 ± 0.31; 1.22 ± 0.32; and 1.56 ± 0.25. Conclusion: There is an effect of soaking time with garlic juice on the base of denture acrylic resin on discoloration.
Severe Anemia in Non Suicide Self Injury as a Complication of Major Depression Disorder Mardi, Tris; Arina Widya Murni
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.516

Abstract

Non suicide self injury (NSSI) is a rare case in adults. Non suicide self injury is an act of hurting himself such as cutting, burning, punching without intending to commit suicide. NSSI itself is a complication of major depression that is not treated properly from the onset of symptoms. Severe depression that lasts for a long time, can aggravate illnesses such as the appearance of symptoms of psychosis and have an impact on various complications such as NSSI and somatic complications that can reduce the patient's health condition. Reported a case of a 22 year old woman with severe anemia due to chronic bleeding. It is known that chronic bleeding in the patient is the result of habitual cutting, in which the patient slashes her left forearm. Cutting habitualis is part of the action of NSSI where the management must be holistic and sustainable, the management of patients consists of psychotherapy as starting from dialectical behavior therapy is a form of cognitive therapy that can help a person adapt to activities that can pass through distress. Psychodynamic therapy is to help someone form new habits that previously could cause pleasure to the patient. Psychotherapy accompanied by psychopharmaceuticals can accelerate improvement in patient.

Page 18 of 40 | Total Record : 392

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