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INDONESIA
Biomedical Journal of Indonesia
Published by Universitas Sriwijaya
ISSN : 24077097     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Biomedical Journal of Indonesia is an open access, peer-reviewed journal that focus on basic medical sciences, emphasizing on providing the molecular studies of biomedical problems and molecular mechanisms to integrate researches in all aspects of human health. BJI is dedicated to publishing original research and review articles covering all aspects of biomedical sciences.
Arjuna Subject : Kedokteran - Anatomi
Articles 392 Documents
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Hepatitis Lupus in Systemic Lupus Erythematosus in Male Patients Putra, Andikha; Raveinal
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.517

Abstract

Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease characterized by autoantibodies against the cell nucleus and involves many organ systems in the body with unknown etiologies and various clinical manifestations, disease course and prognosis. SLE can be found at all ages, generally appearing at age 9-58 years with a peak at age 28 years. It is more common in women with a ratio of women to men 15: 1 to 22: 1. The highest incidence and prevalence of SLE was found in North America 23.2 / 100.000 population / year and 241 / 100.0000 population. In Indonesia, there has been an increase in visits to SLE patients from 17.9-27.2% in 2015 to 30.3-58% in 2017. One of the manifestations of SLE is hepatitis lupus, which is inflammation of the liver tissue. Lupus hepatitis can occur in 20-50% of patients with SLE. It was reported that a 20-year-old man presented with complaints of pain in the joints of the right and left hands which increased since 1 week. The patient also complained of reddish patches on the face, hair loss and mouth sores. Physical examination revealed anemic eye conjunctiva, malar rash, oral ulcer. During the joint examination, there was tenderness in bilateral MCP and PIP. The abdominal examination revealed hepatomegaly. Investigations revealed anemia, thrombocytopenia, increased liver function. Abdominal ultrasound revealed hepatomegaly. ANA profile examination was positive for anti RNP, anti-sm, and anti- ribosomal protein antibodies. The patient was diagnosed with Systemic Lupus Erythematosus with lupus hepatitis according to the ACR (American College of Rheumatology) criteria in which the patient had 6 criteria. The patient was given therapy with 2x125 mg of intravenous methyl prednisolone for 3 days and hydroxychloroquine 1x200 mg orally and other symptomatic drugs.
The Hepatoprotective Effects of Basil Leaf (Ocimum sanctum L.) Extract on Paracetamol Induced Liver Damage in Male Rat Panggabean, Ronaldo; Nofita; Ade Maria Ulfa
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.518

Abstract

Basil leaf have antioxidants such as flavonoids, so it is thought to have a hepatoprotective effect. This study aims to investigate the effect of basil leaf extract on SGOT and SGPT levels in male rats induced by paracetamol. Basil leaf extract was carried out by the percolation method using ethyl acetate solvent, Some 20 male sprague dawley rats were randomly divided into 5 groups. Basil leaf extract (400 mg/kgBB and 600 mg/kgBB) and sylimarin (100 mg/kgBB) were carried out every day for 28 days, paracetamol was induced 24 hours after giving the last day of basil leaf extract. The parameters measured were SGOT and SGPT level to assess the effect of basil leaf extract on liver damage caused by paracetamol. The results showed that basil leaf extract (400 mg/kgBB dan 600 mg/kgBB) showed that the activities of SGOT and SGPT levels were statistically significant (p<0,05) to negative control. Basil leaf extract shows the effect of hepatoprotector on liver induced by paracetamol, however the effect given was not able to equate with positive control.
Antiviral Therapy in Corona Virus Disease-19 (Covid-19) Azka, Laisa; Irvan Medison; Dessy Mizarti
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.520

Abstract

Coronavirus disease 2019 (COVID-19) is a disease caused by a new coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, previously known as 2019-nCoV), which was first identified in Wuhan City, Hubei Province, PRC. The total number of COVID-19 cases worldwide has reached 102 million cases with 54 million cases recovered and 2.3 million cases dead. Handling for this pandemic is still being carried out. In Indonesia, the antiviral drugs used are those that meet the Emergency Use Authorization (EUA) requirements, and are included in the COVID-19 management guidelines issued by the Ministry of Health. Antiviral options used are Oseltamivir, Favifirapir, Remdesivir. Until now, the use of antivirus is still being researched regarding the effectiveness and security of the antivirus used. Oseltamivir is used as an antiviral for COVID-19 with a mild clinical course, Favifirapir is used for mild to moderate clinical cases of COVID-19. For the use of remdesivir in COVID-19 patients with severe and critis clinical conditions.
Characteristics of Calvaria Depression Fractures Patients in Dr. Kariadi General Hospital, Semarang Hengky, Tan; Erie B. P. Setya Budi Andar
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.524

Abstract

Introduction. Head injury is one of trauma cases with high morbidity and mortality, with an incidence of 7.3 to 811 cases per 100.000 individuals per year and mortality ratio varying from 5.2 to 80.73 cases per 100.000 cases. Calvaria fractures that result from head injuries are often associated with risk of post-traumatic morbidity and mortality, where the incidence of post-trauma calvaria fractures is about 25% of all cases and around 10% of calvaria fractures are depressed calvaria fractures. This study was aimed to identify the characteristics of patients with depressed calvaria fractures at Dr. Kariadi General Hospital in 2020. Methods. This research is a descriptive study using secondary data from medical records. There were 30 patients with depressed calvaria fractures in January - December 2020 at Dr. Kariadi Hospital. The data is then presented in tabular form. Results. Depressed calvaria fractures in the period 2020 at Dr. Kariadi General Hospital was dominated by male (76.7%), mainly age 12-45 years old with a mean of 25.73 years old. The most common cause of depressed calvaria fractures is high velocity trauma. Minor head injury is the most common type of head injury. Depressed calvaria fractures of the frontal bone predominate in 80% of cases, with fracture depth > 1 tabula. Conclusion. There were no cases of posttraumatic infection. There were 16.7% of cases with neurological deficits at the time of discharge. There were 73.3% cases with other intracranial disorders associated with depressed calvaria fractures. Operative management is the main choice of management with most cases length of stay are 5-10 days.
The Effectiveness of Giving Growth Hormone to Children with Chronic Kidney Disease: Systematic Literature Review Afdhila , Irhamni Nur; Fitrisia Amelin; Gardenia Akhyar
Biomedical Journal of Indonesia Vol. 7 No. 3 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i3.537

Abstract

Chronic Kidney Disease (CKD) can cause growth problems in children. This condition will affect children’s social life and increase morbidity and mortality. Growth hormone (GH) is one of medication that has been used for treatment of impaired growth in children with chronic kidney disease. In Indonesia, this management has not been provided, because it is expensive and its effectiveness is uncertain. This research was conducted to determine the effectiveness of growth hormone in increasing linear growth in children with CKD. This study is a systematic review of the Randomized Controlled Trial (RCT) study to determine the effectiveness of growth hormone as a treatment for children with CKD. Literature search was conducted using five databases, namely Pubmed, Google Scholar, DOAJ, BMC and CENTRAL that matched the inclusion and exclusion criteria. The guide used in the literature selection was the PRISMA flow chart. A Total of 10 studies were included in the systematic review. Growth hormone is effective in increasing linear growth in children with CKD. Generally there was a significant increase in height (standard deviation (SD)), high velocity (SD or cm) in the therapy group compared to the control group. The dose of growth hormone that is given varies, but the most is 4 IU / m2 / day, once a day, by subcutaneous injection. The duration of growth hormone administration varied from 6 months to 5 years with an average of 1.7 years. Growth hormone did not aggravate kidney problems in children with CKD and can increase important factors in bone formation, namely alkaline phosphatase and osteocalcin.
Nurse Index Satisfaction at Hospital with Nurse Profession, Training, Nurse Assessment and Ethic Implementation in Pandemic Situation Suhardhi, Erick Prawira; Ascobat Gani
Biomedical Journal of Indonesia Vol. 7 No. 3 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i3.538

Abstract

Introduction. Pandemic Covid-19 situation in Indonesia since March 2021, make hospitals to have adaption with condition. Therefore, there is un satisfaction for nurse profession, training, nurse assessment and ethical in emergency, this is known by pre survei in emergency. This research was aimed to study about nurse satisfaction in pandemic area, and see pandemic effect to nurse satisfaction, topic research is satisfaction for nurse profesion, training, nurse assesment and ethical nurse. Methods. Research method for this research is descriptive quantitative, where research use fact, situation and variable happen when the research on going. instrument used in this research is quisoner, sample used is nurse which work in Hospital X, Tangerang district with total sample 151 nurses. Results. Nurse satisfaction preview in hospitals X, Tangerang district is more than 90% nurses satisfied with profession of nurses, training more than, nurse assessment and ethical of nurse. Conclusion. All the nurse satisfied with their profession, training, assesment and ethical implementation, there is improvement room to reduce blame culture in nurse division and implement just culture in nurse division.
Effect of Artemisia vulgaris Extract for Increasing IL-12 and Granzyme Expression (Study on Mammary Adenocarcinoma C3H Mice Given Adriamycin- Cyclophosphamide Chemotherapy Regimen) Hardanto, Gery Rifano; Selamat Budijitno
Biomedical Journal of Indonesia Vol. 7 No. 3 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i3.539

Abstract

Background: The incidence of breast cancer worldwide is still high. Surgery remains the top choice with other modalities of chemotherapy, radiation, and immunotherapy such as Artemisia vulgaris (AV). The study was aimed to demonstrate that administration of AV extract increased p53 expression and the apoptotic index in mammary adenocarcinoma. Methods: This study used a "Post-test only control group design" on 24 females C3H mice that were randomly selected and divided into four groups: group K (control), P1 (chemotherapy), P2 (extract), and P3 (combination). Mammary adenocarcinoma comes from the inoculation of donor mice. Chemotherapy of Adriamycin 0,18 mg and Cyclophosphamide 1,8 mg were given in 2 cycles. AV 13 mg (0.2 ml) was given once daily orally. IL-12 and granzyme expression were evaluated by immunohistochemical staining. Results : Mean of IL-12 and Granzyme expression were found in groups K, P1, P2, P3 were 50,40 ± 1,56, 60,28 ± 1,54, 53,48 ± 1,35, 75,40 ± 1,46 dan 14,96 ± 0,61, 24,86 ± 1,21, 17,14 ± 1,02, 26,62 ± 0,70. The statistical analysis showed that there were significant differences in the IL-12 between groups of K vs P1 (0,001), P1 vs P2 (0,001), K vs P2 (0,028), P1 vs P3 (0,001), K vs P3 (0,001), P2 vs P3 (0,001) and in granzyme expression between groups of K vs P1 (0,001), P1 vs P2 (0,001), K vs P2 (0,010), P1 vs P3 (0,047), K vs P3 (0,001), P2 vs P3 (0,001). Correlation analysis between IL-12 and Granzyme expression were found significant correlation (p = 0,001 and r = -0,911). Conclusion: Artemisia vulgaris can improve the effectivity of Adriamycin-Cyclophosphamide chemotherapy on C3H mice with mammary adenocarcinoma in terms of elevated IL-12 and Granzyme expression.
Malignant Brain Lymphoma Based on Age, Gender, Symptoms, Imaging Modality, Hiv Examination, And Histopathology at Dr. Kariadi Central General Hospital Semarang From January 2016 to December 2018 Kemara, Selly Adyta; Krisna Tsaniadi Prihastomo
Biomedical Journal of Indonesia Vol. 7 No. 3 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i3.540

Abstract

Background: Primary CNS Lymphoma (PCNSL) is rare cancer from the brain or spinal cord lymphatic tissue. The incidence increased in patients over 60 years, with an incidence rate of 0.5/100,000 per year. PCNSL associated with poor survival. The aim of the study was to determine the incidence of Brain Malignant Lymphoma based on age, gender, symptoms, imaging modalities, HIV examination, and histopathological results at dr. Kariadi Semarang. Methods: This is a retrospective descriptive study. We collected brain malignant lymphoma patient’s medical records who came to the ER and the Neurosurgery Polyclinic of Dr. Kariadi Semarang from period January 2016-December 2018. Results: There were 1,012 brain tumor patients, 6 patients were brain malignant lymphoma with the highest prevalence in the age range of 45-65 years (5 patients) and 66.67% male. The most common symptom was blurred vision 23.07%. The imaging modalities showed lesions on: right parietal lobe 14.29%, sella region 14.29%, parasella region 14.29%, cerebellum 14.29%, IV ventricle 14.29%, vertebrae sacrum 2-5 14.29 %, and the fronto-temporo-parietal region 14.29%. No HIV test data were obtained. According to histopathology, Diffuse large B cell Lymphoma Malignant non Germinal Center (DLBCL) and High grade, B cell Non Hodgkin Lymphoma (small type) each were 33.33%. Conclusions: The prevalence of malignant brain lymphoma cases was highest in the 45–65 year age group and male, with blurred vision. Most of the results of imaging modalities show an even distribution of brain malignant lymphomas and generally do not do HIV testing. The most common histopathological diagnosis was DLBCL.
The Formulation and Physical Evaluation Tests of Ethanol in Telang Flower (Clitoria ternatea L.) Extract Losio Form as Antioxidant Jayanti, Merly; Ade Maria Ulfa; Angga Saputra Yasir
Biomedical Journal of Indonesia Vol. 7 No. 3 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i3.543

Abstract

Background. Antioxidants are defined as compounds that are able to delay, slow down, or inhibit oxidation reactions. One of the plants that has the potential as natural antioxidants is the telang flower. The purpose of this study was to determine whether the ethanol extract of telang flower (Clitoria ternatea L.) can be formulated in a losion form that meets the requirements of the physical evaluation test and to determine the ethanol extract of telang flower (Clitoria ternatea L.) has antioxidant activity. Methods. The extraction using maceration techniques with 96% ethanol solvent. The yield obtained from the maceration technique was 29.16%. Phytochemical analysis of telang flowers contains alkaloids, flavonoids, polyphenols, saponins and tannins. Determination of the levels of flavonoids obtained levels of 10.05% and for polyphenols of 15.33%. Results. Telang flower extract (Clitoria ternatea L.) can be formulated into losions and meets the requirements of the physical evaluation test in the extract concentration of 0.1%. The losion of telang flower extract (Clitoria ternatea L.) with a concentration of 0.1% telang flower extract has very strong antioxidant activity because it has an IC50 value <50 ppm, and the IC50 yield of a losion with a concentration of 0.1% telang flower extract (Clitoria ternatea L.) of 37.92 ppm which means that it has very strong antioxidant activity. Conclusion. The formula of the telang flower extract lotion has strong antioxidant activity and protects the skin from free radicals.
Management of Jakarta Metropolitan Medical Center Hospital in Preventing Burnout in Nurses during the Covid-19 Pandemic Chintia, Amelia; Ede Surya Darmawan
Biomedical Journal of Indonesia Vol. 7 No. 3 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i3.581

Abstract

Introduction. The COVID-19 pandemic has caused considerable losses to the health care system in Indonesia. The Indonesian Doctors Association (IDI) noted that as of October 3, 2020, 130 doctors, nine dentists, and 92 nurses died due to COVID-19. The problems that caused the death of health workers during the COVID-19 pandemics included the lack of PPE, inadequate patient screening in health facilities, and fatigue of medical personnel due to the increasing number of COVID-19 patients as long working hours and psychological pressure. Of course, this condition can disrupt the quality of life and work productivity in the health series. Therefore, the hospital needs to make various efforts to prevent burnout in health workers during the COVID-19 pandemic. Methods. This research was a descriptive method with quantitative and qualitative approaches. The researcher revealed the facts that occurred when the study was running and presented them as they were. The research respondents were nurses who were in the isolation room and ICU COVID-19 at MMC Hospital Jakarta. Researchers used the Maslach Bach Inventory (MBI) questionnaire instrument to 43 respondents via the Google form. Researchers also conducted interviews with the Head of Nursing and several COVID-19 nurses who had filled out questionnaires. Results: The majority of COVID-19 nurses at MMC Hospital had moderate burnout levels. MMC Hospital Jakarta has made various efforts to prevent burnout in nurses. Conclusion: Management of MMC Hospital in preventing burnout in nurses was good enough, but several points can be improved to make it better.

Page 19 of 40 | Total Record : 392

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