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INDONESIA
Biomedical Journal of Indonesia
Published by Universitas Sriwijaya
ISSN : 24077097     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Biomedical Journal of Indonesia is an open access, peer-reviewed journal that focus on basic medical sciences, emphasizing on providing the molecular studies of biomedical problems and molecular mechanisms to integrate researches in all aspects of human health. BJI is dedicated to publishing original research and review articles covering all aspects of biomedical sciences.
Arjuna Subject : Kedokteran - Anatomi
Articles 392 Documents
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Immunology Aspects in Tension-Type Headache Chronicity Restu Susanti
Biomedical Journal of Indonesia Vol. 6 No. 2 (2020): Vol 6, No 2, 2020
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i2.11764

Abstract

Tension-Type Headache (TTH) headache is a type of primary headache which mostly complained by patients. The pain often ignored due to low mortality rates. Inadequate management makes the pain becoming chronic and causing a high disability rate. Many factors involved in transforming infrequent tension-type headache to chronic tension-type headache. A deeper understanding of the immune system's role in the pathophysiological process and modulation of chronic pain could be a potential target for developing therapies in managing chronic pain.
mRNA NFATC1 Expression in Genu Osteoarthritis with Effusion Muhammad Reagan; Hermansyah; Rachmat Hidayat; Surya Darma; Putri Muthia
Biomedical Journal of Indonesia Vol. 6 No. 2 (2020): Vol 6, No 2, 2020
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i2.10418

Abstract

Based on a study conducted by the WHO Global Burden of Disease in 2010 stated, OA ranks 11th, the cause of disability in the world, and ranks 6th in East Asia and the Asia-Pacific countries, ranked 10th in North America, ranked 7th in Eastern Europe , and ranked 13th in Western Europe. Pathogenesis of osteoarthritis (OA) as degenerative joint disease that was once thought caused by a mechanical process. The prevalence, etiology, pathogenesis and progression of OA are still not understood until now, mainly because of the many influencing factors. This type of research is a analytic study. It was conducted in Rheumatology Polyclinic Dr. Mohammad Hoesin Palembang from February to December 2019. Affordable research population is all genu osteoarthritis sufferers with effusion who go to Dr. RSUP Mohammad Hoesin Palembang as 80 samples. Comparison of NFATC1 mRNA levels in genu osteoarthritis patients with effusion shows that there is no difference in gender and history of diabetes, whereas hypertension history and degree of osteoarthritis based on Lawrence Kalgren shows significantly different expression of NFATC1 mRNA. Age with NFATC1 mRNA expression showed no significant correlation, in contrast to BMI, Stroke Test and joint effusion volume showed a weak significant correlation, even though the direction of the correlation was negative on Stroke Test and joint effusion volume.
Dry Needling Can Be an Alternative Treatment for Hemifacial Spasm Marisdina S.; Sugiharto H.; Pradian A.
Biomedical Journal of Indonesia Vol. 6 No. 2 (2020): Vol 6, No 2, 2020
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i2.11802

Abstract

Treatment with botulinum toxin injections is preferred to microvascular decompression surgery therapy, but this injection is only effective in a few months and quite expensive. This study is the first study to assess the effectiveness of dry needling on clinical improvement of hemifacial spasm compared to standard therapy of botulinum toxin injection. The study design was quasi experimental. Total of 24 subjects were divided into two groups. The first group underwent dry needling intervention while the other had botulinum injection. Clinical severity before and after treatment in both groups was assessed using Jankovic and HFS7 scores. In dry needling group there were significant differences between Jankovic and HFS7 score at baseline and at week 1, 2, 3 and 4. While in botox group significant differences were also Jankovic and HFS7 score at baseline and at weeks 2 and 4. There were also a significant difference of Jankovic and HFS7 score when we compared dry needling group to botulinum toxin group. Dry needling can be an alternative treatment for hemifacial spasm, although clinical improvements based on Jankovic and HFS7 scores in dry needling group were not as effective as those with botulinum toxin injections.
IFN-γ and IL-2 Secretion after ESAT-6-CFP-10 (EC-610) Fusion Antigen Stimulation from Patients with Active Lung Tuberculosis and Latent Lung Tuberculosis Bastian; Nova Kurniati; Kemas Ya'kub Rahadiyanto; M.Irsan Saleh; Zen Hafy; Fransisca Srioetami Tanoerahardjo; Jusak Nugraha; Eddy Mart Salim
Biomedical Journal of Indonesia Vol. 6 No. 2 (2020): Vol 6, No 2, 2020
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i2.10741

Abstract

The Secretion of IFN-γ and IL-2 After ESAT-6-CFP-10 Fusion Antigen Stimulation in Active and Latent TB Patients. This study held to discover how immune responses work and to know the pathogenesis of active TB and latent TB patients. This study used PBMC to stimulate T Cells with ESAT-6 and CFP-10 antigen fusion, and measure the level of IFN-γ and IL-2 with ELISA antibody sandwich (U-Cytech). 16 ml of blood were drawn to 5 tubes. ESAT-6 CFP-20 inducted one tube with QuantiFERON for IFN-γ assay. The other four tubes were PBMC isolated using Ficoll-Paque, and pre-incubated with stimulation of ESAT-6 CFP-10 fusion antigen for 24-72 hours at 370 C and measured using T-Spot and ELISA reader. We got from this study that there are no significant differences in IFN-γ levels for both groups with active TB and latent TB. Measurement of IL-2 levels showed significant differences between the two group.
Cytotoxicity Effects of Benalu Tea Extract (Scurrula oortina) on Hella cells Kusumo Hariyadi; Fatmawati; Subandrate; Fahira Aninditia; Dazakiah
Biomedical Journal of Indonesia Vol. 6 No. 2 (2020): Vol 6, No 2, 2020
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i2.10281

Abstract

Tea garden waste has been investigated in the form of parasite tea Squrula oortina Species Family: Loranthaceae from the Dempo Pagar Alam tea plantation, Lahat Regency, South Sumatra. Stem and leaf samples are then dried and powdered, then isolated with 70% water-ethanol subfraction. The extract was then dried by vacuum distillation at 70oC until a concentrated extract without ethanol was obtained. The results of the study were tea parasite extract, and the extract was tested for phytochemicals (monounsaturated fatty acids and double, theobromine derivates, quercetin derivates and Epicatekin derivates). Next, it would be taken to the Laboratory of Biological Sciences at Gajah Mada University to be tested for cytotoxic effects on Hella cells, with control positive doxorubicin. The results of the research were tea leaves extract IC50 = 2538 ug/mL and the standard of doxorubicin IC50 = 0.88 ug/mL so that it could be concluded that the parasite of the tea parasite had cytotoxic and proliferative effects.
The Effect Of Giving Red Dragon Fruit (Hylocereus polyrhizus) Extract On Spermatozo Motility In White Rats (Rattus norvegicus) Wistar Line With High Fat Induction Kirani Nuranisa; Cut Fauziah; Yuli Suciati
Biomedical Journal of Indonesia Vol. 6 No. 3 (2020): Vol 6, No 3, 2020
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i3.232

Abstract

Hyperlipidemia is a condition when high level of blood lipids and causes morphological changes in spermatozoa. Red dragon fruit (Hylocereus Polyrhizus) is one of the plants as a source of antioxidants and has unsaturated fat content that is needed in the spermatozoa maturation process. The aims of this the study is to determine the benefits of red dragon fruit extract on the motility of white rat spermatozoa (Rattus norvegius) induced by high-fat diet. The study is design by true experimental research and research only testing group design. This research conducted in the Pharmacology and Therapy Laboratory, Padjajaran University Education Hospital, in January 2020 using white rats, male . ± 8 weeks wistar strains weighing ± 200-250. The study sample was divided into several groups such group I as a control, group II as a negative control, group III as positive group with simvastatin dose 0.72 mg / day, group IV as research group 1 using red dragon fruit extract dose of 60 mg / 200 grBB / day for 52 days, and group V as group 2 therapy using dragon fruit extract dose of 60 mg / 200grBB / day for 104 days. The results showed that the mean percentage of motility of rat spermatozoa increased in the relief group with the supplement of red dragon fruit extract by dosing of 60 mg / 200 grBB / day for 104 days, or 51, 2%. This study conclude that red dragon fruit has a superior effectivity better than simvastatin in increasing the motility of spermatozoa.
The Effectiveness Of Moringa oleifera L (Moringa oleifera L) Fraction On The Improvement Of Hemoglobine Levels Of Betinine Rat (Rattus norvegicus) Anemia Model Of Iron Deficiency Winda Ricika
Biomedical Journal of Indonesia Vol. 6 No. 3 (2020): Vol 6, No 3, 2020
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i3.233

Abstract

The iron deficiency anemia is kind of anemia because the less of iron that make the function to tie oxygen is down. Young girl is one of sufferer group who’s prone to get anemia. The long consequence of anemia for the young girl will disturb fatal function of some organ in their body. In general arise of headache symptoms and pain in the centre of head. And the in pregnancy will increase some complication risk such as maternal death. Premature born and perinatal death. One of nature ingredients (herbal) which is reported to have high iron content is kelor leaf (Moringa oleifera L) for about 28, 29 mg/100 g kelor. The purpose of this research is to know the effectivenessof Kelor leave fraction ((Moringa oleifera L) to increase hemoglobin grade with preclinical. Experimental research with complete random design (RAL) has been done in February till April 2019 in medical faculty laboratory of universitas sriwijaya Palembang. Sample of the research is female rat that has inclusion criteria as much 30 rats. Divided into 5 group. That is negative control group. Positive control (ferrous fumarate 60%), n-heksan fraction, ethyl acetate, and 1% concentration of kelor leave ethanol, the data of Hb all of subject before and after treatment from subject of iron deficiency anemia has collected by using Easy Touch GCHb tool. The analysis data of this research used SPSS 2.2 version. The result of the research said that the hemoglobin grade before and after treatment showed significant increasing(p<0,05) for n – hexane fraction and acetate ethyl >45%. While ethanol fraction only 32%.
Regulation of Cell Cycle Rachmat Hidayat; Lusia Hayati
Biomedical Journal of Indonesia Vol. 6 No. 3 (2020): Vol 6, No 3, 2020
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i3.236

Abstract

The cell cycle is a vital process in the life of every organism. Normally, the cell cycle results in cell division. Cell division consists of 2 main processes, namely DNA replication and chromosome division that has been duplicated into 2 daughter cells. Cyclin is expressed periodically so that the cyclin concentration varies at each phase of the cell cycle. Cdks are threonine or serine protein kinases which must bind to cyclin for its activation. The concentration of Cdks is relatively constant during the cell cycle. Cyclin-dependent kinase inhibitor (CKI) is a protein that can inhibit Cdk activity by binding to Cdk or the cyclin-Cdk complex
Electroencephalography (EEG) Features in Patients with Primary Headache at Neurology Polyclinic of Dr. M. Djamil Padang Hospital Restu Susanti
Biomedical Journal of Indonesia Vol. 6 No. 3 (2020): Vol 6, No 3, 2020
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i3.238

Abstract

Headache is one of the most common neurological complaints. The InternationalHeadache Society (IHS) classification divides headaches into a primary and secondary headache. The cause or type of headache can be determined from the history of the disease and physical examination. Neurophysiological tests are used in establishing a differential diagnosis of headache. There are several neurophysiological methods used in the diagnosis of headaches, one of them is electroencephalography. This study aims to look at the most frequent EEG picture in cases of a primary headache without focal neurological deficits in the Neurology Polyclinic of Dr. M. Djamil Padang Hospital from January 2019 to December 2019. This research used a descriptive method. The study population was all patients who underwent an EEG examination in the Integrated Diagnostic Installation (IDT) of Dr. M. Djamil Padang Hospital from January 2019 to December 2019. Subjects were patients who had a chief complaint of headache who had been subjected to an EEG examination. Statistical analyzes were performed computerized using IBM SPSS Statistics version 23.0 for Windows. From this study, the most common chronic headache is migraine, and the most common EEG feature is normal. EEG can be used as a modality for investigating chronic headaches without focal neurological deficits.
Effect Of Lavender Oil Aromaterapy On Menstrual Pain In Students AT SMPN18 PESAWARAN In 2020 Eby Juliana Sabrina; Riona Sanjaya; Surmiasih; Yona Desni Sagita
Biomedical Journal of Indonesia Vol. 6 No. 3 (2020): Vol 6, No 3, 2020
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i3.239

Abstract

The problem of primary dysmenorrhoea is largely overcome by resting and taking medication. Many ways to eliminate or reduce dysmenorrhea both pharmacologically and non-pharmacologically. Management of menstrual pain can also be managed nonpharmacologically, such as giving aromatherapy, aromatherapy administration techniques can use a variety of aromatherapy such as lavender. The purpose of this study was to determine the effect of Lavender Oil Aromatherapy on Menstrual Pain in Students at SMP N 18 Pesawaran in 2020. This type of quantitative research design is quasy experimental design research with one grub pretest and posttest approach. The population in this study were all students. Samples taken in this study were 31 students who experienced disminore when the study took place. Analysis of the data used using the Wilcoxon test. The results of data analysis and processing found that there was an effect of Lavender Oil Aromatherapy on Menstrual Pain in Junior High School 18 Pesawaran in 2020 with a p-value of 0,000 <0.05. Respondents can increase their knowledge about handling disminorea by searching for information via the internet or reading books, so that respondents are not dependent on pharmacological treatment alone.

Page 26 of 40 | Total Record : 392

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