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INDONESIA
Biomedical Journal of Indonesia
Published by Universitas Sriwijaya
ISSN : 24077097     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Biomedical Journal of Indonesia is an open access, peer-reviewed journal that focus on basic medical sciences, emphasizing on providing the molecular studies of biomedical problems and molecular mechanisms to integrate researches in all aspects of human health. BJI is dedicated to publishing original research and review articles covering all aspects of biomedical sciences.
Arjuna Subject : Kedokteran - Anatomi
Articles 392 Documents
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EVOLUSI KARDIOLOGI SEBAGAI ILMU PENGETAHUAN: TINJAUAN PUSTAKA Alexander Edo Tondas; Chairil Anwar; Rolando Agustian Halim
Biomedical Journal of Indonesia Vol. 5 No. 3 (2019): Vol 5, No 3, 2019
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v5i3.9790

Abstract

Ilmu pengetahuan adalah usaha-usaha sadar untuk menyelidiki, menemukan dan meningkatkan pemahaman manusia dari berbagai segi kenyataan dalam alam manusia. Jumlah ilmu spesialisasi kedokteran pun masih terus bertambah hingga membentuk cabang-cabang lebih kecil lagi yang dikenal sebagai sub-spesialisasi. Salah satu jenis spesialisasi dalam ilmu kedokteran adalah spesialisasi ilmu kardiologi, yaitu ilmu yang memfokuskan diri untuk mempelajari organ jantung. Perkembangan ilmu kardiologi tidak dapat dilepaskan dari sejarah yang melatarbelakanginya. Kemajuan ilmu kardiologi sampai ke titik ini adalah sebuah perjalanan kontinu yang saling berkait. Setiap pelajaran di masa lalu akan menjadi modal untuk pengalaman di masa depan, begitu pula dengan ilmu kardiologi, di mana tiap-tiap fase nya menjadi fondasi untuk perkembangan di waktu mendatang.
Efek Ekstrak Buah Ciplukan (Physallis peruvenia) Pada Kadar T4 Tikus Putih Nita Parisa
Biomedical Journal of Indonesia Vol. 5 No. 3 (2019): Vol 5, No 3, 2019
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v5i3.9872

Abstract

Hipertiroid adalah suatu kondisi dimana terjadi peningkatan sintesis dan sekresi hormon tiroid sehingga kadar hormon tiroid dalam darah meningkat. Pada tahun 2013 didapatkan data 0,4% penduduk Indonesia mengalami hipertiroid. Buah ciplukan (Physalis peruviana) merupakan herba Indonesia yang diduga memiliki efek terhadap hormon tiroid. Jenis penelitian adalah eksperimental in vivo dengan subyek penelitian berupa tikus putih galur Wistar berjumlah 30 ekor yang dibagi menjadi 5 kelompok yaitu kontrol negatif (Akuades), kontrol positif (PTU 100 mg/kgBB), kelompok 3, 4, dan 5 ekstrak buah Ciplukan dengan dosis 250 mg, 500 mg, dan 1000 mg per kilogram berat badan. Hasil pemeriksaan menunjukkan terjadi penurunan kadar T4 pada perlakuan dengan kontrol positif dan pemberian eksrak buah ciplukan. Terdapat perbedaan penurunan kadar T4 untuk kelompok pemberian ekstrak buah ciplukan dosis 1, 2, dan 3 (p<0,05). Dapat disimpulkan bahwa ekstrak buah Ciplukan dengan dosis 250 mg/kgBB, 500 mg/kgBB, dan 1000 mg/kgBB memiliki potensi sebagai anti hipertiroid.
Efek Ekstrak Daun Jati Belanda terhadap Kadar Myeloperoxidase Jaringan Paru Tikus Putih Wistar Model Kontusio Pulmonum Nia Savitri Tamzil; Evi Lusiana; Desi Oktarina
Biomedical Journal of Indonesia Vol. 5 No. 3 (2019): Vol 5, No 3, 2019
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v5i3.10009

Abstract

Kontusio pulmonum adalah cedera pada parenkim paru yang sering terjadi akibat trauma tumpul pada dinding dada. Cedera ini akan mengaktivasi respon inflamasi yang dapat menghasilkan efek stres oksidatif sehingga akhirnya terjadi kerusakan jaringan paru. Beberapa studi mengindentifikasi efek ekstrak daun jati belanda terkait proses inflamasi dan efeknya sebagai antioksidan. Penelitian ini merupakan studi eksperimental secara in vivo dengan pendekatan preposttest with control group design yang bertujuan mengetahui efektivitas ekstrak daun jati belanda (Guazuma ulmifolia) dalam proteksinya terhadap sel alveolar paru dengan praperlakuan kontusio pulmonum. Subyek penelitian ini ialah tikus putih (Rattus norvegicus) galur Wistar yang terbagi menjadi 5 kelompok yaitu kontrol positif, kontrol negatif, ekstrak daun jati belanda 125 mg/kgBB, 250 mg/kgBB dan 500 mg/kgBB. Tikus diinduksi dengan menjatuhkan beban seberat 400 gram setinggi 50 cm. Hasil penelitian Ekstrak Daun jati belanda (EDJB) semua dosis dan kontrol positif dapat menurunkan kadar ekspresi myeloperoksidase secara signifikan (p<0.05). Oleh karena itu, dapat disimpulkan ekstrak daun jati belanda (Guazuma ulmifolia) semua dosis efektif dalam menurunkan ekspresi myeloperoxidase pada jaringan pulmo tikus putih Wistar yang diinduksi kontusio pulmonum.
Hubungan Pola Asuh Dengan Delinkuensi Siswa SMP Syarifah Aini; Khairina Rina; Margarita M. Maramis
Biomedical Journal of Indonesia Vol. 5 No. 3 (2019): Vol 5, No 3, 2019
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v5i3.10120

Abstract

Delinkuensi atau kenakalan remaja merupakan masalah serius di semua negara. Remaja yang terlibat kenakalan berpotensi terlibat tindak kriminalitas yang lebih serius. Banyak faktor yang diduga merupakan penyebab kenakalan remaja, salah satunya adalah keluarga. Pola asuh merupakan cara orang tua dalam mendidik anak, terutama dalam memberikan nilai dan norma yang berpengaruh pada tahap perkembangan anak selanjutnya, termasuk perilaku antisosial yang kerap dihubungkan dengan kenakalan. Penelitian ini bertujuan untuk menganalisis hubungan antara pola asuh dengan kenakalan remaja siswa sebuah SMP swasta di Surabaya. Penelitian ini merupakan studi analitik observasional bersifat cross-sectional yang menghubungkan antara pola asuh dengan kenakalan remaja siswa sebuah SMP di Surabaya. Teknik pengambilan sampel menggunakan cluster random sampling. Untuk mengetahui pola asuh orangtua digunakan kuisioner pola asuh Alabama (Parental Authoritory Questionaire). Kenakalan remaja dinilai dengan kuisioner Self-Report Delinquincy. Didapatkan 70% subyek penelitian yang terlibat kenakalan dengan 52,63% mengalami pengasuhan ibu yang otoritatif dan 66,18% mengalami pengasuhan ayah yang otoritatif. Tidak didapatkan hubungan bermakna antara pola asuh ibu dengan kenakalan remaja. Didapatkan hubungan bermakna antara pola as
Relationship of Mutation of Codon S 315 T KatG Mycobacterium Tuberculosis Gene with The Incidence of Multidrug Resistance Tuberculosis in South Sumatra Diah Syafriani; Rouly Pola Pasaribu; Zen Ahmad; Erial Bahar
Biomedical Journal of Indonesia Vol. 6 No. 1 (2020): Vol 6, No 1, 2020
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i1.10187

Abstract

MDR TB is the condition of M. tuberculosis (Mtb) that is resistant to at least isoniazid (INH) and rifampisin. This condition caused by certain genomic mutation in some Mtb spesific gene. Some gene that had role in INH mutation are katG, inhA, ahpC, ndh and kasA gene. The most common gene that mutates is katG gene, around 50-80 %, and the most mutation(64%) found in codon S 315T. Aim to know the correlation between Mtb codon S 315 T katG gene mutation and prevalence of multidrug resistance tuberculosis in South Sumatera This observational study with cross sectional approach was conducted in RSMH Palembang collaborated with Clinical Microbiology Laboratory Faculty of Medicine Universiats Sriwijaya from January to July 2019. The MDR TB group was 50 subjects the drug sensitive TB group was 21 subjects. Mtb katG codon S 315 T gene was isolated from each subjects using the PCR-RFLP method with the Mspl enzyme. KatG codon S 315 T gene in this study was visualized in 40 subjects only 26 subjects of MDR TB and 14 subjects of drug sensitive TB group. Result the frequency distribution genetic of MDR TB group was 65.38% wildtype and 34.62% mutant; in drug sensitive TB group was 92.86% wildtype and 7.14% mutant. The codon S 315 T katG gene mutation in this study was not correlated with the incidence of MDR TB (p = 0.07, OR = 6.8 (0.77 - 61.40, 95% CI)).Conclusion the codon S 315 T katG Mtb gene mutation was found in 34,62% subjects, but not significantly related to the incidence of MDR TB in South Sumatra.
Factors Influence Carotid Intima Thickening Media Thickness in Chronic Kidney Disease Patients Ade Yonata; Zulkhair Ali; Taufik Indrajaya; Ian Effendi; Novadian Suhaimi; Suprapti; Erial Bahar
Biomedical Journal of Indonesia Vol. 6 No. 1 (2020): Vol 6, No 1, 2020
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i1.10539

Abstract

Chronic kidney disease (CKD) is associated with high mortality rates related to cardiovascular complications. Atherosclerosis, arteriosclerosis and vascular calcification conditions are often found in CKD patients. Carotid intima media thickness (cIMT) thickening is one of the parameters of vascular disorders. a cross sectional study was conducted on patients with chronic kidney disease in the Mohammad Hoesin hospital Palembang. Blood samples were examined in the hospital laboratory. CIMT thickening was examined using echocardiography. 55 patients with stage 3-5 of chronic kidney disease were examined. The median cIMT was 0.8 (0.6-1.45) mm. Spearman's correlation analysis showed a significant correlation between triglyceride levels and thickening of cIMT (r = 0.303, p = 0.025). A significant correlation was also shown between phosphate levels and cIMT thickening (r = 0.290, p = 0.032). There were significant correlations of triglyceride levels and phosphate levels on the thickening of cIMT in chronic kidney disease patients at Mohammad Hoesin Hospital Palembang.
Correlation of Serum Sclerostin Levels with Carotid Intima Media Thickness in Chronic Kidney Disease Patients with Hemodialysis Adhi Permana; Ian Effendi; Taufik Indrajaya; Erial Bahar
Biomedical Journal of Indonesia Vol. 6 No. 1 (2020): Vol 6, No 1, 2020
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i1.10185

Abstract

Chronic kidney disease is associated with high mortality rates mainly to cardiovascular disease related with mineral and bone disorders. Sclerostin is an inhibitor of Wnt signaling which has the effect of increasing vascular calcification in patients with chronic kidney disease. There are several studies that show different results. Carotid intima media thickness ultrasound examination is a tool to identify atherosclerosis which is part of vascular calcification. The purpose of this study is to look at the correlation of sclerostin with carotid intima media thickness (CIMT) in patients with chronic kidney disease undergoing maintenance hemodialysis. In this cross-sectional study, the sclerostin concentration was measured by an enzymed linked immunosorbent assay. CIMT measurement by ultrasound mode B examination. There were 40 patients in this study. The mean sclerostin level was 256.68 ± 127.76 pg / ml. Sclerostin levels are considered high above 162 pg / ml, there are 30 people. CIMT thickening was present in 11 patients. There was no significant correlation of serum sclerostin with CIMT in patients with chronic kidney disease undergoing maintenance hemodialysis (r-0.32 p0,847). In multivariate linear regression, hemodialysis vintage is an independent factor that is significantly significant with CIMT. There was no significant correlation of serum sclerostin with CIMT in patients with chronic kidney disease undergoing hemodialysis.
Effectiveness of Garlic Water Extract Gel (Allium sativum. L) Against Necrotic Factor Alfa (TNF-α) Tumors and Mouth Ulcer Diameter in Rats Dian Anggraeni; H.M.T. Kamaluddin; Theodorus
Biomedical Journal of Indonesia Vol. 6 No. 1 (2020): Vol 6, No 1, 2020
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i1.7970

Abstract

Oral ulcer is a pathological condition characterized by loss of epithelial tissue which causes inflammation. During inflammation, inflammatory mediators such as TNF-α will increase. Therefore, drugs are needed to suppress TNF-α levels to reduce inflammation. One of the herbal that can reduce inflammation is garlic. Experimental study, In vivo, pre-post system. The samples used were 36 male white wistar rats which were divided into 6 groups (6 individuals / groups) namely the group without treatment (as pre-treatment data), the negative control group was the HPMC gel base, positive controls were given benzydamine, the group treatment I was given 20% garlic aqueous extract gel, the treatment group II was given 40% garlic aqueous extract gel, the treatment group III was given 80% garlic aqueous extract gel. Administration of the drug was given topically 2 times a day for 4 days. Making oral ulcers was done by placing filter paper which had been soaked in 50% acetic acid solution in the labial area of the lower gingival tissue. Oral ulcer measurements were carried out on the 1st day after making oral ulcers and on day 5. On the 5th day all rats were sacrificed to take gingival tissue and TNF-α levels were measured using ELISA. Data analysis using SPSS version 24 and One Way Anova test with 5% specifications followed by Post Hoc Test using LSD and Games Howell test.Analyzed with One Way Anova showed that there were significant differences in TNF-α levels and oral ulcer diameter (p <0.05) which indicated that garlic aqueous extract gel applied in the area of oral ulcers affected TNF-α levels and diameter of mouth ulcer. The LSD test results showed that 80% garlic water extract gel was effective to reduce TNF-α levels (p <0.05). The Games Howell test results showed that garlic aqueous extract gel 20%, 40% and 80% had the same effectiveness as benzydamine in reducing the diameter of oral ulcers.Garlic aqueous extract gel (Allium sativum. L) concentration of 80% is more effective than benzydamine in decreasing levels of TNF-α. Garlic aqueous extract gel (Allium sativum. L) concentrates 20%, 40% and 80% as effective as benzydamine in terms of reducing the diameter of oral ulcers in male white wistar rats.
IFN-γ and IL-4 Secretion after Stimulation of EC610 Fusion Antigens (ESAT-6-CFP-10) in Patients With Active Pulmonary TB and Latent TB Wina Safutri; Eddy Mart Salim; Kemas Ya'kub Rahadiyanto; Muhammad Irsan Saleh; Nova Kurniati; Rachmat Hidayat; Fransisca Srioetami Tanoerahardjo
Biomedical Journal of Indonesia Vol. 6 No. 1 (2020): Vol 6, No 1, 2020
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i1.9087

Abstract

Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis (M.tb) and is still a major health problem in the world. Immunity against tuberculosis is very complex because it involves almost all components of the immune system. One of the cells that are responsible for cell-mediated immunity are lymphocytes, especially T helper lymphocytes are divided into Th1 (proinflammatory cytokines IFN-γ) and Th2 (anti-inflammatory cytokine IL-4). EC610 fusion antigens (ESAT-6-CFP-10) is a peptide containing a specific antigen M.tb. Order to determine the differences between the secretion of IFN-γ and IL-4 after stimulation EC610 fusion antigens (ESAT-6-CFP-10) in patients with active pulmonary TB and latent TB.Research with a quasi-experimental design in laboratory in vitro in patients with active pulmonary tuberculosis group of 21 samples and 28 samples of latent TB. Venous blood sampling in vitro anticoagulants heparin and PBMCs isolated using a Ficoll-Paque ™, then cultured with antigen fusion EC610 for 24-72 hours with a CO2 incubator at a temperature of 370 C. The levels of IFN-γ and IL-4 by ELISA method. Statistical analysis with alternative test non-parametric Mann Whitney. IFN-γ secretion in patients with active pulmonary TB group (6700 pg / ml) was higher than the latent (6000 pg / ml) after stimulation by antigen fusion EC610, but not significant (p = 0.769). While the secretion of IL-4 levels (180 and 60 pg / ml) there was a significant difference between the groups (p = 0.000).
The Topical Effect of Binahong Fraction Leaves [Anredera Cordifolia (Ten.) Steenis] on Increased Epithelization and Hydroxyproline Level at Incision Wound in Rats Meriyanti P.S.; M.T. Kamaluddin; Theodorus
Biomedical Journal of Indonesia Vol. 6 No. 1 (2020): Vol 6, No 1, 2020
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i1.10590

Abstract

Binahong leaves [Anredera cordifolia (Ten.) Steenis] are easily found in Indonesia, efficacious and had been used as a wound-healing herbal medicine. This research aimed to assess the effectiveness of acetate ethyl fraction in binahong leaves [Anredera cordifolia (Ten.) Steenis] as a topical agent to the histopathology changes including increased epithelization and histochemistry examination by assessing hydroxyproline level in the acute incision wound healing process in Sprague Dawley rats. An in vivo laboratory experiment, using the Pre and Post Test Only Control Group Design. The subject was Sprague Dawley white male rats, randomly divided into 5 (five) treatment groups, a negative control group (gel-based), positive control group (Bioplacenton), 1% concentration of acetate ethyl fraction from binahong leaves group (FADB 1%), 2% concentration of acetate ethyl fraction from binahong leaves (FADB 2%) and 4% concentration of acetate ethyl fraction from binahong leaves (FADB 4%). The collected data was analyzed using SPSS programme version 21.0 with homogeneity test, normality test, Wilcoxon test, Mann Whitney test, Independent T-test, and Post Hoc confirmation using LSD test. In 4th-day skin tissue examination, the effectiveness of 4% concentration of acetate ethyl fraction from binahong leaves was not significantly different from Bioplacenton effectiveness in increasing epithelization and hydroxyproline level in the 10th-day skin tissue examination.

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