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INDONESIA
Biomedical Journal of Indonesia
Published by Universitas Sriwijaya
ISSN : 24077097     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Biomedical Journal of Indonesia is an open access, peer-reviewed journal that focus on basic medical sciences, emphasizing on providing the molecular studies of biomedical problems and molecular mechanisms to integrate researches in all aspects of human health. BJI is dedicated to publishing original research and review articles covering all aspects of biomedical sciences.
Arjuna Subject : Kedokteran - Anatomi
Articles 392 Documents
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The Effectiveness Test of Bangun-Bangun Leaves Extract (Plecthranthus Ambonicus) Against Streptococcus Pyogenes and Salmonella Typhi Bacteria Windi Anggriani; Stella Retta Marina; Ayu Hasanah; OK Yulizal
Biomedical Journal of Indonesia Vol. 6 No. 3 (2020): Vol 6, No 3, 2020
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i3.240

Abstract

Background Bangun-bangun leaves (Plectranthus amboinicus) are part of theLamiaceae family. (1) (1) Bangun-bangun leaves have a characteristic aromatic leavesaroma used as a medicinal plant (2). According to research conducted by (Dalimunthe et al., 2016) to find the use of this plant as an antibacterial because it contains compounds such as flavonoids, tannins, tripenoids, saponins, and essential oils. On the bangun-bangun leaves there is carvacrol, which is an essential component that has antibacterial activity in positive or negative gram bacteria. streptococcus pyogenes bacteria are vectors of suppurative infectious diseases and other diseases such as pharyngitis. While salmonella typhi bacteria is a vector of the disease which is usually called typhus and the medical language is typhoid fever. The purpose of this study was to determine that the bacteria salmonella typhi and streptococcus pyogenens can be inhibited by the leaves extract. The benefit of this research is to increase public understanding and knowledge in the use of bangun-bangun leaves. The method used in this study is an experimental method and post test only controlled group design. For the concentration used, namely 5%, 10%, 15%, 20%, 25% and this strength test is done by inserting the extract into a petri dish that has a bacterial culture. Data processing uses one-way ANOVA with the aim of comparing each variable. To see the extract against bacteria. The results showed that there were variations in the diameter of the inhibition zone formed by the concentration of the extract. And the most effective concentration to inhibit streptococcus pyogenes bacteria was a concentration of 25%, the inhibition zone diameter was 19.5mm, while salmonella typhi bacteria had a concentration of 25% and the inhibition zone diameter was 37.7m.
Relationship Between The Level of Alcohol Consumption to The Depression of Multiple Substance Users in Sleman Yogyakarta Andrian Fajar Kusumadewi; Pambayung Cesaria Tiara Daniswara; Silas Henry Ismanto; Afkar Aulia
Biomedical Journal of Indonesia Vol. 6 No. 3 (2020): Vol 6, No 3, 2020
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i3.245

Abstract

Introduction: The problem of using addictive substances, especially alcohol in Indonesia, is still a serious health problem. Since 2013, data on the proportion of alcoholic drink consumption in Indonesia has been found to have increased in 32 provinces in Indonesia. Alcohol consumption not only causes physical problems, but also mental disorders, triggers acts of violence, and disturbs other aspects of life. One of the psychiatric disorders that arise due to the abuse of alcoholic beverages is depression. If not treated immediately, depression can lead to suicidal thoughts that threaten the individual and have an impact on those around him. The aim of this study was to examine the level of alcohol consumption and its relationship to the level of depression. Methods: This study is an analytical study with a quantitative crosssectional survey design. The sampling technique was carried out by purposive sampling using the AUDIT questionnaire for the level of alcohol consumption, and BDI-II for the level of depression. Results: The research sample was obtained as many as 30 respondents. The results of the two-variable analysis using the somer test showed that there was no significant relationship between the level of alcohol use and the level of depression. Conclusion: In this study, there was no statistically significant relationship between the level of alcohol use and the level of depression in individuals who used multiple substances.
Use of 99mTc in The Field of Radiofarmation: A Review Faruk Jayanto Kelutur; Holis Abdul Holik
Biomedical Journal of Indonesia Vol. 7 No. 1 (2021): Vol 7, No 1, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i1.241

Abstract

Technetium-99m (99mTc) has been applied in nuclear medicine as a radiopharmacyfor both diagnosis and therapy. 99mTc is obtained from a 99Mo/99mTc (half-life 66 h) generator in the form of sodium pertechnetate (Na[99mTcO4]) by decaying to 99Tc for 6 hours and emitting gamma energy rays (Eɤ = 140 keV). This radionuclide has an electron configuration of 4d5 5s2, which will form complexes with different ligands and have oxidation rates from +1 to +7. The coordinated complex of technetium-99m has been utilized in nuclear medicine in tissues and organs (thyroid, red and white blood cells, kidneys, brain, myocardial, and bone). The resulting kit production must have based on Good Manufacturing Practice, which consists of batch planning, washing, sterilization of glassware and stopper, starting material, preparation of large quantities of the solution, sterile filtration, dispensing, crimping, a summary of process control, quarantine, packaging and leaving the production premises.
Relationship between Prostate Volume and International Prostate Symptom Score (IPSS) Degree of Tamed Prostate Enlargement on Transabdominal Ultrasonography (TAUS) and Transrectal Ultrasonography (TRUS) Examination Eriawan Agung Nugroho; Abu Azhar; Ezra Endria Gunadi
Biomedical Journal of Indonesia Vol. 7 No. 1 (2021): Vol 7, No 1, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i1.259

Abstract

Introduction: IPSS is the gold standard in measuring clinical symptoms of BPH.1Prostate volume has been said to have a close relationship with the development of BPH.9 The aim of this study was to determine the relationship between prostate volume as measured by transabdominal ultrasonography (TAUS) and transrectal (TRUS) to the degree of IPSS. Methods: An analytic observational study with a cross sectional design was carried out on 303 BPH patients at the General Hospital of Kariadi Hospital, Semarang. The data obtained from the TAUS, TRUS and IPSS prostate volume were obtained from medical records for the period 2015 - 2020. The data were then analyzed by using the chi square test. Results: Patients with BPH have a TAUS prostate volume in classification I of 0 people 0%, classification II of 16 people (5.3%), classification III of 96 people (31.7%), classification IV of 102 people (33.7%) and classification V of 89 people (29.4%). While TRUS in classification I was 0% (0 people), classification II was 11 people (3.6%), classification III was 92 people (30.4%), classification IV was 110 people (36.3%) and classification V of 90 people (29.7%). IPSS obtained severe IPSS degrees, namely 192 people (63.4%), moderate degrees of 111 people (36.6%), and mild degrees 0% (0 people). The results of the Chi Square test obtained a p-value of 0.000 (p <0.05), indicating that there was a significant relationship between prostate volume, whether examined by transabdominal or transrectal ultrasound, and the degree of IPSS. The correlation coefficient r = 0.925 indicates a very strong relationship between prostate volume as measured by both transabdominal and transrectal ultrasound with the degree of IPSS, a positive result shows that the increase in prostate volume, the degree of IPSS will also increase. Conclusion: There is a significant relationship between prostate volume as measured by both TAUS and TRUS and the degree of IPSS.
Molahidatidosa from Pathophysiology to Clinical: Literature Review Rachmat Hidayat; Irawan Sastradinata
Biomedical Journal of Indonesia Vol. 7 No. 1 (2021): Vol 7, No 1, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i1.260

Abstract

Hydatidiform is a gestational trophoblast disease which is histopathologically characterized by the proliferation of avascular trophoblast cells and corial villi and undergoing hydrophic degeneration. The proliferation of trophoblast cells in hydatidiform moles can be in the form of cytotrophoblast, syncytiotrophoblast or intermediate trophoblast proliferation.
Sarcopenia from Pathophysiology to Clinical : Literature Review Rachmat Hidayat; Nur Riviati
Biomedical Journal of Indonesia Vol. 7 No. 1 (2021): Vol 7, No 1, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i1.261

Abstract

The causes of sarcopenia are thought to be multifactorial including: environmental factors, illness, activation of inflammatory pathways, mitochondrial dysfunction, loss of neuromuscular junctions, reduced number of satellite cells and changes in the quality of hormonal function. The mechanism of sarcopenia occurs because the aging process coupled with reduced physical activity can cause the formation of cytokines to increase so that inflammation is easy, insulin resistant, anabolic resistance and neuromuscular impairments.
Omega-3 as an Anti-Inflammatory Modality: Literature Review Rachmat Hidayat; Nur Riviati
Biomedical Journal of Indonesia Vol. 7 No. 1 (2021): Vol 7, No 1, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i1.262

Abstract

Omega-3 fatty acids are polyunsaturated fatty acids that have multiple double bonds, the first double bond is located on the third carbon atom of the omega-methyl group, the next double bond is located at the third carbon atom from the previous double bond. The methyl omega group is the last group in the fatty acid chain. Omega-3 fatty acids are nutrients that play a vital role in the growth and development process of brain neuron cells for the intelligence of the born baby.
Bioethical Principles of Use of Experimental Animals in Biomedical Research Rachmat Hidayat; Patricia Wulandari
Biomedical Journal of Indonesia Vol. 7 No. 1 (2021): Vol 7, No 1, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i1.267

Abstract

Research is an activity carried out based on scientific principles and methods systematically to obtain information, data, and information from related subjects, with understanding the theory and proving assumptions and / or hypotheses. The resultsobtained are conclusions that can be applied or become additional knowledge for the advancement of science. However, research activities must still respect the rights and dignity of research subjects. Health research includes biomedical, epidemiological, social, and behavioral research. Some health research can be done in vitro, using mathematical models, or computer simulations.
Relationship of The Degree of Head Injury Based on Glasgow Coma Scale (GCS) with the Arrival of Acute Post Concussion Syndrome (PCS) Onset in Post-Head Injury Patients in General Hospital Dr.M.Djamil Padang Muhammad Reza Azriyantha; Syaiful Saanin; Hesty Lidya Ningsih
Biomedical Journal of Indonesia Vol. 7 No. 1 (2021): Vol 7, No 1, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i1.273

Abstract

Background: Traumatic brain injury is the main cause of death in the population under the age of 45 years, and the fourth leading cause of death in the entire of population. Based on the degree of traumatic brain injury, it is commonly categorized based on the Glasgow Coma Scale (GCS). Post-Concussion Syndrome (PCS) is the set of somatic, emotional / behavioral and cognitive symptoms that occur after a traumatic brain injury. The aim of this study was to find out the prevalence and correlation of the degree of traumatic brain injury based on the Glasgow Coma Scale (GCS) and the emersion of Post-Concussion Syndrome (PCS) acute onset in patients with head injuries Method: This study was a cross-sectional analytic study of patients who experienced Post-Concussion Syndrome (PCS) after traumatic brain injury at DR. M. Djamil Hospital Padang in 2020 from June to November 2020. Data were collected by filling in a questionnaire (The Rivermead Post Concussion Symptoms Questionnaire) and medical record data of neurosurgical patients that met the inclusion and exclusion criteria. Result: : It indicated that 70 patients were included in the inclusion criteria of this study. A total of 38 (54.3) respondents did not undergo the acute onset of PCS, meanwhile respondents who experienced acute onset of PCS were 32 (45.7) respondents. The results showed that 25 (67.6%) respondents with mild traumatic brain injury had PCS acute onset, while 4 (17.4%) respondents with moderate degree of traumatic brain injury had PCS acute onset, and 4 (17.4%) respondents had PCS acute onset PCS 3 (30%) respondents experienced severe traumatic brain injury with acute onset PCS and statistically the difference in the proportion of data from each of these variables was significant with a p-value of 0.0001. The results of statistical tests showed that p value> 0.05 on the correlation between PCS and GCS, thus, it can be concluded that there was no correlation between the direction of the relationship between PCS and GCS. Conclusion There was no correlation between the degree of traumatic brain injury based on GCS and the incidence of PCS acute onset, either it was unidirectional or vice versa in patients with head injuries at RSUP M. Djamil Padang.
Comparison of Lymphocyte Neutrophil Ratio in Head Injury Patients with Blood and without Intracranial Bleeding in Dr. M. Djamil Hospital Muhammad Zaki Abdul Hafiz; Syaiful Saanin; Hesty Lidya Ningsih
Biomedical Journal of Indonesia Vol. 7 No. 1 (2021): Vol 7, No 1, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i1.275

Abstract

Background: Head injuries occur every 15 seconds worldwide, with patientsdying every 12 minutes. The value of the Neutrophil Lymphocyte Ratio (NLR) is afactor that influences the assessment and prognostic value of patients withintracranial hemorrhage and without intracranial hemorrhage in head injury.The aim of this study was to determine the relationship between increased NLRbased on the severity of head injury patients with or without intracranialhemorrhage. M ethods: This study is a retrospective cross sectional study of headinjury patients with hemorrhage and without intracranial hemorrhage who weretreated at Dr. M. Djamil Hospital Padang in 2020 from May to December 2020.Data was collected in the Medical Records Department of Dr. M. Djamil HospitalPadang who met the inclusion and exclusion criteria. Results : A total of 92patients were included in the inclusion criteria for this study. The results showe dthat the mean NLR value in head injury patients was 11.72 with a variation of7.31. The mean NLR level based on the severity of mild head injury was 10.15with a variation of 6.38. The mean NLR level of moderate head injury severity was12.70 with a variation of 7.09. The mean NLR level of severe head injury, was14.69 with a variation of 9.30. The results showed that there was no difference inthe mean of NLR levels in mild head injury patients with hemorrhage and withoutintracranial hemorrhage. The results showed that there was a significantrelationship between NLR levels in moderate head injury patients withhemorrhage (14.20) and without intracranial hemorrhage (7.20) (p value = 0.029),whereas in severe head injury it could not be assessed because there was nosample without hemorrhage. Conclusion: There is an association betweenincreased NLR and intracranial bleeding in moderate head injury patients.

Page 27 of 40 | Total Record : 392

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