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INDONESIA
IDJP (Indonesian Journal of Pharmaceutics)
Published by Universitas Padjadjaran
ISSN : -     EISSN : 25978748     DOI : -
Core Subject :
The Indonesian Journal of Pharmaceutics (IdJP) is an established international journal for pharmaceutical scientists concerned in all fields of pharmaceutical sciences, including pharmaceutical preformulation, formulation, manufacturing technologies, drug delivery systems, biopharmaceutics, and pharmacokinetics for drugs, vaccines and biologicals. IdJP also includes pharmaceutical engineering and industrial pharmacy topics.
Arjuna Subject : -
Articles 97 Documents
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Review: Increased Oral Bioavailability of Atorvastatin Calcium With Various Encapsulation Methods Murad, Nabil Arvel
Indonesian Journal of Pharmaceutics Vol 5, Issue 1, Jan - April 2023
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v5i1.40867

Abstract

Atorvastatin calcium is statin class dyslipidemia drug which belongs to the class 2 bioclassification system (BCS) drug, namely drugs that have high permeability and low water solubility. Low solubility in water makes atorvastatin calcium also has low bioavailability (12%). Encapsulation method as a drug delivery system enable bioavailability enhancement of a drug. The aim of this literature review is to discover encapsulation method that can enhance oral bioavailability of atorvastatin calcium in recent research and to explain how obtained encapsulation method could enhance the bioavailability of atorvastatin calcium. The obtained research article from PubMed database. Several forms of encapsulation showed an enhancement in bioavailability, namely nanoparticles, and nanocrystals, nanosponges, nano lipid carrier (NLC), micro and nanoemulsions, and inclusion complexes. The highest increase in oral bioavailability of atorvastatin calcium was obtained by the formation of nanosponges using β-cyclodextrin material with the condensation-polymerization preparation method succeeded in increasing oral bioavailability by 14 times when compared to pure calcium atorvastatin formulations.Keywords: Atorvastatin calcium, Bioavailability, Encapsulation
Article Review: Testing for Detection of Low Pig (Porcine) DNA in Cosmetic Products and Health Supplements Indah Puspita Syafitri, Raden; Fil Ayatil Karimah, Naqiyyah; Ratnawulan Mita, Soraya
Indonesian Journal of Pharmaceutics Vol 5, Issue 1, Jan - April 2023
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v5i1.44156

Abstract

The increase in the Muslim population worldwide has led to rapid growth in the halal product industry. Currently, halal food holds the largest proportion in the global market for halal products, followed by cosmetics and health supplements as one of the main sectors. In the raw materials used for capsule shells and the manufacture of cosmetics, many ingredients come from non-halal sources, such as gelatin, fatty acids, glycerin, and collagen, which are derived from pigs. However, the presence of pork ingredients in cosmetic products and health supplements is prohibited in certain religions, such as Islam. Therefore, the detection of lard in cosmetic and pharmaceutical products plays a crucial role for the benefit of Muslim consumers. Many methods have been developed to detect pork content in highly processed products, one of which is the DNA-based method. This literature review was conducted to explain DNA isolation methods and detection techniques that can be used for pig DNA analysis. A literature search was performed through online databases, and 14 research journals were found that met the inclusion criteria. Based on the collected research, DNA-based methods, including the Polymerase Chain Reaction (PCR) and its modifications, have demonstrated the ability to detect porcine DNA in products like cosmetics and health supplements. The selection of DNA detection and isolation methods depends on the type of sample under examination, thus enhancing the accuracy and success of porcine DNA detection.Keywords: DNA analysis, Pig DNA, Pig Content, Cosmetics, PCR, Health Supplements.
Risk of Falls with Benzodiazepine Receptor Agonists in Combination with Novel hypnotics. Higuchi, Yuya; Ishikawa, Yuya; Araki, Takuya; Ohshima, Yukina; Yashima, Hideaki; Yamamoto, Koujirou
Indonesian Journal of Pharmaceutics Vol 5, Issue 2, May - August 2023
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v5i2.52528

Abstract

Several risk factors for falls during hospitalization have been reported, of which hypnotics have a major influence. Insomnia is often intractable, and many cases are treated with two or more hypnotics; however, there is concern about the increased risk of falls due to the use of multiple hypnotics. Therefore, we aimed to clarify the effects of combining conventional and new hypnotics on the risk of falls. The impact of the concomitant use of hypnotics on the occurrence of fall events was evaluated retrospectively in patients 20 years of age and older received acute care medicine in an university hospital between January 2013 and August 2022. The survey items included age, sex, drug prescription status, whether a fall accident had occurred, and its circumstances. Of the 47,236 eligible patients, 976 experienced a fall accident during hospitalization (fall rate, 2.07%). Logistic regression analysis of the patient population not taking benzodiazepine receptor agonists showed that age (odds ratio [OR], 1.04), sex (OR, 0.84), and ramelteon use (OR, 3.06) independently contributed to falls. In contrast, in the patient population taking benzodiazepine receptor agonists, logistic regression analysis showed that only age (odds ratio [OR]: 1.03) and sex (OR: 0.76) independently contributed to falls. This suggests that ramelteon, suvorexant, and lemborexant, in combination with benzodiazepines, may not increase the risk of falls. Hypnotics with novel mechanisms of action may not increase the risk of fall when combined with benzodiazepine receptor agonists.
Applcation of Red Dragon Fruit Extract (Hylocereus polyrhizus) as an Antioxidant in Lip Cream Preparation Suharyani, Ine; Rindiyani, Rindiyani; Senja, Rima Yulia; Nurdianti, Lusy; Falya, Yuniarti
Indonesian Journal of Pharmaceutics Vol 5, Issue 1, Jan - April 2023
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v5i1.44548

Abstract

Later, women cannot separated from cosmetics, such as lip cream. However, many lip creams contains synthetic dye that sometime harmful for our body. Therefore red dragon fruit (Hylocereus polyrhizus) can  used as natural dyes in a  lip cream preparation. In addition, red dragon fruit contains anthocyanins, a group of flavonoid, that has efficacy as an antioxidants. This study aim to develope lip cream as cosmetic preparation containing of red dragon fruit for antioxidant. The extraction was done by Microwave Assisted Extraction (MAE) using ethanol 95%:aquadest (4:1).  Lip cream preparations were made in 3 formulas with varying concentrations of extract, 5% (LCE5), 10% (LCE10) and 15% (LCE 15). The extraction uasing MAE method was yielded the rendemen of 44,12%. Evaluation of the preparations carried out included organoleptic, pH, homogeneity, and spreadability, while antioxidant activity were carried out using spectrophotometry UV-Vis with the DPPH (2,2-diphenyl-1-picrylhidrazyl) method. The results showed that all lip cream formulas fulfill the requirement i.e organoleptic, pH, homogeneity, and spreadability. The antioxidant activity of LCE5, LCE10 and LCE15 were 195.26 ± 0.40, 174.94 ± 0,63, and 168.27 ± 0.60, respectively. All the preparation has medium antioxidant activity but LCE15 has a stronger antioxidant activity due to the smallest IC50 compared to LCE5 and LCE10. This result underlying the application of red dragon fruit extract as an antioxidant agent in lip cream preparation.
Comparative Dissolution Formulation and Test Simvastatin Ko-Crystal Tablets With Isonicotinamide As Coformer Sopyan, Iyan; Novianti, Ina; Abdassah Bratadiredja, Marline; Salsabila Hapsari, Raira; Setiawati, Ervina
Indonesian Journal of Pharmaceutics Vol 6, Issue 2, May - August 2024
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v5i3.55250

Abstract

Simvastatin is a statin drug used to lower plasma cholesterol in all types of hyperlipidemia. Simvastatin is included in BCS class II with poor solubility.  One of the efforts made to increase the solubility of simvastatin is the formation of co-crystals. Co-crystal is a modified type of crystal habit, which consists of two or more molecules in the same crystal lattice. The purpose of this study was to obtain the best excipient combination formula on the simvastatin co-crystalline tablet with isonicotinamide as a coformer and its comparable dissolution test results. The excipient combination optimization was carried out using a two-level factorial method. The optimized Avicel pH 102 and Primogel produced four combination designs on ready-made formulas, namely F1 Avicel pH 102: Primogel (79:2), F2 Avicel pH 102: Primogel (79:8), F3 Avicel pH 102: Primogel (85: 2) and F4 Avicel pH 102: Primogel (85: 8). The evaluation includes evaluating the mass of the print and the quality of the tablets. The excipient combination design solution in the best formula is Avicel pH 102 and Primogel with a ratio (79: 8). The method used in a comparable dissolution test is to compare the values of F1 (difference factor) and F2 (similarity factor) using BootStrap software. The F2 values observed were 50.3 at pH 1.2, 56.09 at pH 4.5, and 59.23 at pH 6.8, which indicates that the simvastatin co-crystalline tablet has similarities with the innovator tablet. The excipient combination design solution in the best formula is Avicel pH 102 and Primogel with a ratio (79: 8). The method used in a comparable dissolution test is to compare the values of F1 (difference factor) and F2 (equation factor) using BootStrap software. The F2 values observed were 50.3 at pH 1.2, 56.09 at pH 4.5, and 59.23 at pH 6.8, which indicates that the simvastatin co-crystalline tablet has similarities with the innovator tablet.Keywords: Simvastatin, co-crystal, two-stage factorial, comparable dissolution                     test.
Risk of Falls with Benzodiazepine Receptor Agonists in Combination with Novel hypnotics. Higuchi, Yuya; Ishikawa, Ph.D, Yuya; Araki, Ph.D, Takuya; Ohshima, Ph.D, Yukina; Yashima, Ph.D., Hideaki; Yamamoto, Ph.D., Koujirou
Indonesian Journal of Pharmaceutics Vol 5, Issue 1, Jan - April 2023
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v5i1.41451

Abstract

Several risk factors for falls during hospitalization have been reported, of which hypnotics have a major influence. Insomnia is often intractable, and many cases are treated with two or more hypnotics; however, there is concern about the increased risk of falls due to the use of multiple hypnotics. Therefore, we aimed to clarify the effects of combining conventional and new hypnotics on the risk of falls. The impact of the concomitant use of hypnotics on the occurrence of fall events was evaluated retrospectively in patients 20 years of age and older received acute care medicine in a university hospital between January 2013 and August 2022. The survey items included age, sex, drug prescription status, whether a fall accident had occurred, and its circumstances. Of the 47,236 eligible patients, 976 experienced a fall accident during hospitalization (fall rate, 2.07%). Logistic regression analysis of the patient population not taking benzodiazepine receptor agonists showed that age (odds ratio [OR], 1.04), sex (OR, 0.84), and ramelteon use (OR, 3.06) independently contributed to falls. In contrast, in the patient population taking benzodiazepine receptor agonists, logistic regression analysis showed that only age (OR: 1.03) and sex (OR: 0.76) independently contributed to falls. This suggests that ramelteon, suvorexant, and lemborexant, in combination with benzodiazepines, may not increase the risk of falls. Hypnotics with novel mechanisms of action may not increase the risk of fall when combined with benzodiazepine receptor agonists. evaluasi. Keywords: fall risk, hypnotics, acute care hospitals
Review: Management Technology Transfer in the Indonesian Pharmaceutical Industry Sumayyah, Shofiah; Resca Harda, Adila; Aliza Putriana, Norisca
Indonesian Journal of Pharmaceutics Vol 5, Issue 1, Jan - April 2023
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v5i1.40898

Abstract

Thisreviewarticlefocusesontechnologytransferinthepharmaceuticalindustry,specifically discussingits importance,guidelines, process, and documentation intheIndonesiancontext.Thepurposeis toprovideadetailedunderstandingoftechnologytransfer from drug discovery to product development, including the reasons for its utilizationanditssignificanceinthepharmaceuticalsector.Themethodologyemployedforthisreview involvedsearching onlineliterature throughplatformssuchasScienceDirectandGoogleScholarusingkeywordslike"TransferTechnology"and "Pharmaceutical Development." Thefindings of the primary sources emphasizethecrucialroleoftechnologytransferinfacilitatingthegrowth ofthepharmaceuticalindustry. Itenables theavailabilityof essential technologiesin developing countries,promotingaccessibilityandaffordability.Threekeyfactorscontributetoeffectivetechnologytransfer:properplanning,involvementofcapableindividuals,andawell-definedprocess.Successintechnologytransfernecessitatesacomprehensiveunderstandingoftheprocessandtheabilitytopredictitsfutureperformanceaccurately.Furthermore,thearticleemphasizestheimportanceofensuringrobustandeffectivemanufacturingprocessesfordrugsubstancesanddrugproducts.Thisincludesproducingthesesubstancesandproductsincompliancewithregisteredspecifications and adhering to Good Manufacturing Practices Keywords: Transfer technology, Pharmaceutical development, Research and development, Pharmaceutical industry.
Article Review: Testing for Detection of Low Pig DNA (Porcine) in Cosmetic Products and Health Supplements Syafitri, Raden Indah Puspita; Karimah, Naqiyyah Fil Ayatil; Mita, Soraya Ratnawulan
Indonesian Journal of Pharmaceutics Vol 5, Issue 2, May - August 2023
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v5i2.47259

Abstract

The increase in the Muslim population in the world has made the halal product industry grow rapidly. Currently, halal food has the largest proportion in the global market for halal products, followed by cosmetic and pharmaceutical products as the main sector. In the raw materials used for capsule shells and the manufacture of cosmetics, many ingredients come from non-halal sources, for example gelatin, fatty acids, glycerin, and collagen that come from pigs. However, the presence of pork ingredients in medicines, health supplements and cosmetics is prohibited in certain religions such as Islam, therefore the detection of lard in cosmetic products and other pharmaceutical products plays an important role for the benefit of Muslim consumers. Many methods have been developed to detect pork content in highly processed products, one of which is the DNA-based method. This literature review was created based on the aforementioned reason to explain DNA isolation methods and detection that can be used for pig DNA analysis. A literature search was carried out through online databases and 14 research journals were found that met the inclusion criteria. From the research data, it is proven that DNA-based methods such as Polymerase Chain Reaction and its modifications can detect the presence of porcine DNA in products such as cosmetics and food supplements. The selection of DNA detection and isolation methods is based on the type of sample being tested.
Review Article: Advancing Cancer Treatment With Mesoporous Silica Nanoparticle-Based Theranostics Wirawan, Delphine; Hulwana, Alfa Fildzah; Herdiana, Yedi
Indonesian Journal of Pharmaceutics Vol 5, Issue 3, Sept - Dec 2023
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v5i2.56808

Abstract

Cancer is a major cause of death globally. It is often detected at a late stage, whileconventional treatments are more effective during the early and middle stages.These traditional treatments also cause many side effects due to the lack oftargeted delivery. Nanotechnology, particularly mesoporous silica nanoparticles(MSNs), has been investigated for cancer treatment and diagnosis. Theranostics,which combine therapy and diagnostics, can provide simultaneous treatment anddetection, potentially lowering mortality rates. A literature review was conductedusing keywords such as mesoporous silica nanoparticles, cancer, diagnosis, andtherapy in online databases like PubMed. The results of this review were analyzedand compared with existing literature, aiming to provide a comprehensiveoverview of mesoporous silica nanoparticles as current cancer treatment anddiagnosis.Keywords: MSNs, cancer, theranostic, therapy, literature.
Optimization Matrix Formulas Using Hypromellose and Carboxymethylcellulose Sodium for Metformin HCl Extended Release Caplets Andrie, Agus; Kurniawan Syah, Insan Sunan; Chaerunisaa, Anis Yohana
Indonesian Journal of Pharmaceutics Vol 5, Issue 3, Sept - Dec 2023
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v5i3.53135

Abstract

The first-line pharmacological therapy in type II diabetes patients in people who are overweight and have normal kidney function is metformin. However, metformin with immediate release has been found to have some weaknesses, namely that a maximum dose of 2,000 mg/day requires use 2 to 3 times a day, which leads to a potential patient's non-compliance, in addition to causing disorders in the intestinal tract. To overcome this problem, a formulation was developed that was modified with extended release using the direct compressed method. This study aims to determine the influence of variations in the concentration of hypromellose and carboxymethylcellulose natrium (Na-CMC) matrices in the extended-release of metformin HCl 500 mg to obtain an optimal and similar extended-release system capsule formula to the originator drug, as well as to prove the quality of the selected formula through stability monitoring. This research is expected to produce the optimum formula for metformin HCl capsules extended release and can be applied in the pharmaceutical industry into commercial products.Keywords: Diabetes, Metformin HCl, Extended release, Direct compressed,                     Hypromellose, Carboxymethylcellulose natrium.

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