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INDONESIA
IDJP (Indonesian Journal of Pharmaceutics)
Published by Universitas Padjadjaran
ISSN : -     EISSN : 25978748     DOI : -
Core Subject :
The Indonesian Journal of Pharmaceutics (IdJP) is an established international journal for pharmaceutical scientists concerned in all fields of pharmaceutical sciences, including pharmaceutical preformulation, formulation, manufacturing technologies, drug delivery systems, biopharmaceutics, and pharmacokinetics for drugs, vaccines and biologicals. IdJP also includes pharmaceutical engineering and industrial pharmacy topics.
Arjuna Subject : -
Articles 97 Documents
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Optimization of Propolis and Vegetable Oils-based Soap Formulation to Enhance Product Quality and Antioxidant Properties Rahadatul 'Aisy; Efri Mardawati; Desy Nurliasari; Hana Nur Fitriana; Awaly Ilham Dewantoro; Desy Nurliasari
Indonesian Journal of Pharmaceutics Vol 4, Issue 2, May - August, 2022
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v4i2.41229

Abstract

Consumers demanded the quality of solid soap for the bath were having a solid texture, high foam stability, and fulfillment of the national quality standard in SNI 3522:2021. Soap characteristics and quality are affected by soap bases and the existence of natural additive matter with antioxidant properties such as propolis extracts. The study aims to determine an optimum formula for soap production using Response Surface Methodology (RSM) with Box-Behnken experimental design. The research conducted in several stages, its consist to propolis extraction, soap formulation and production, RSM analysis towards predetermined responses, model validation, and products characterization (in optimum formulation). Optimized factors consist of the content of propolis extracts, coconut oils, palm oils, and olive oils, while the response was moisture content, foam stability, and antioxidant inhibition. The results showed each response has a significant model to get an optimum formula for propolis extracts soap production. The optimum formula for soap production requires 1.545 g propolis extracts, 13.097 g coconut oils, 29.629 g palm oils, and 29.809 g olive oils with the model validation for each response were 95.5% moisture content, 96.5% foam stability, and 97.5% antioxidant inhibition. Soap characterization in the optimum formula fulfilled the quality standard requirement in SNI 3522:2021 its consists of 20.24% moisture content, 2.22% insoluble ingredients in ethanol, and 0.07% free alkali content. Keywords: Box-Behnken Design, Formula Optimization, Propolis Extracts, RSM, Solid Soap.
Evaluation of Shampoo by Quality Control: Review Arnita Annisanur; Ida Musfiroh
Indonesian Journal of Pharmaceutics Vol 4, Issue 2, May - August, 2022
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v4i2.40492

Abstract

Shampoo is a product that is used to clean hair from dirts and also for specific therapeutic objectives such as conquering dandruff and hair loss. Product evaluation is a step that cannot be avoided to ensure product quality, including shampoo. As stated in the Good Manufacturing Practice guidelines, in the process of releasing product, the quality control in pharmaceutical industry must guarantee that the appropriate tests have been performed. The purpose of this review is to determine what attributes need to be evaluated in shampoo preparations. Datas for this review were obtained from national and international scientific publications published in the last 10 years using websites such as PubMed, Science Direct, and Springer. The keywords used in the search process are shampoo, evaluation of shampoo, types of shampoo. Final number of articles that used are 50 articles. Based on the search results, it is concluded that the evaluation of shampoo preparations consisted of testing physical appearance, homogeneity test, pH, solid content, viscosity, cleansing ability, and others. Keywords: Shampoo, quality control, products evaluation.
Approaches for Drug Design and Discovery Karyn Elizabeth; Eri Amalia
Indonesian Journal of Pharmaceutics Vol 4, Issue 2, May - August, 2022
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v4i2.41005

Abstract

Drug discovery in general requires high costs and especially a very long time, which is around 11-16 years. This is because drug development must go through a complete series of research processes to obtain comprehensive data. However, in line with the community's need for the availability of quality drugs, having good efficacy and safety, the development of drug development technology using a computing system is carried out. This is in line with the development of science and collaboration between various disciplines. Approaches that can be used for computational drug discovery include Structure-Based Drug Design and Ligand Based Drug Design which are proven to accelerate and increase the possibility of finding new drugs. This article aims to provide an overview of several approaches to drug discovery development, especially the benefits of computational. The data were collected from 28 primary published journals and 28 supporting literatures. This article discusses the two computational methods, especially from the application aspect which is expected to be useful in the field of drug discovery and development to be more efficient in terms of time and cost. The traditional approach to new drug development takes about 11-16 years but using computational methods can shorten the drug discovery stage to 9-13 years. Keywords: Drug Discovery, Ligand Based CADD, Structure-Based CADD
Hospitalized patients on orexin receptor antagonists have a lower risk of falls Yukina Ohshima; Takuya Araki; Hideaki Yashima; Noriyuki Nakayama; Koujirou Yamamoto
Indonesian Journal of Pharmaceutics Vol 4, Issue 2, May - August, 2022
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v4i2.44186

Abstract

Falls and fall-related injuries remain a major safety concern in many hospitals and nursing homes. Although many studies have examined the relationship between accidents and sedating medications, further analysis is needed of the association between falls and individual hypnotics. The aim of this study was to clarify the association between hypnotics and the risk of falls in hospital. The impact of hypnotics on fall events was retrospectively evaluated in patients aged 20 years or older who were admitted to Gunma University Hospital between January 2013 and March 2022. Logistic regression analysis was performed with age, sex, and drug prescription status as the independent variables and fall events as the dependent variable. Of the 54,019 patients included in the study, 1,460 experienced a fall during hospitalization (incidence, 2.7%). The hypnotics prescribed included orexin receptor antagonists, melatonin receptor agonists, and benzodiazepine receptor agonists. Logistic regression analysis showed that age (odds ratio [OR] 1.04), male sex (OR 1.14), estazolam (OR 2.99), flunitrazepam (OR 2.34), brotizolam (OR 1.65), diazepam (OR 3.34), lorazepam (OR 2.93), alprazolam (OR 1.91), ethyl loflazepate (OR 2.81), zolpidem (OR 1.40), eszopiclone (OR 1.87), clonazepam (OR 1.94), and ramelteon (OR 2.15) independently contributed to falls. Short-acting benzodiazepine receptor agonists tended to have smaller ORs for fall risk. Orexin receptor antagonists were not associated with falls. Therefore, orexin receptor antagonists and short-acting benzodiazepine receptor agonists are likely safer than intermediate-acting and long-acting benzodiazepines. Keywords: fall risk, hypnotics, acute care hospitals
Review: Solubility And Bioavailability Enhancement Of Carvedilol Using Multicomponent Crystal Method Nadiyah Salma Athaya; Iyan Sopyan
Indonesian Journal of Pharmaceutics Vol 4, Issue 2, May - August, 2022
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v4i2.44137

Abstract

Carvedilol is included in the BCS class 2 classification, drugs that have low solubility and high permeability. Drugs with low solubility pose a major challenge for oral drugs in achieving the desired systemic circulation. Moreover, carvedilol is indicated for the treatment of cardiovascular disease and hypertension which requires a rapid pharmacological response. A way to increase drug solubility is by forming multicomponent crystals, including solvates, cocrystals, and salts. Cocrystal and salt formation methods are the most frequently used methods in the pharmaceutical field. The multicomponent crystal approach is a process of combining active drug ingredients with other compounds known as coformers which then interact through molecular bonds. Multicomponent crystals provide benefits to improve the physicochemical properties of drugs without affecting their pharmacological properties. In this review, we discuss the multicomponent crystal approach as an effort to increase the solubility and bioavailability of carvedilol. The main reference data used in this review are research journals published in the last 10 years (2012-2022) using the keywords carvedilol, multicomponent crystal, solubility, bioavailability, and using Google Scholar as a database. There is also a discussion on regulation of cocrystals, methods for forming multicomponent crystals, and characterization of multicomponent crystals. The multicomponent crystal approach has promising benefits in increasing the solubility and bioavailability of carvedilol in the body. Keywords: Carvedilol, multicomponent crystal, solubility, bioavailability
Drug Delivery System in Feline Herdiana, Yedi; Wilar, Gofarana; Sofian, Ferry Ferdiansyah; Pitaloka, Annisa Dyah; Nurhijriah, Yasinta; Safira, Rayhan Zarra; Salsabila, Annisa Siti; Z, Maziyatunisa
Indonesian Journal of Pharmaceutics Vol 4, Issue 3, Sep - November, 2022
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v4i3.44274

Abstract

The drug delivery system is an attractive field of study since it has several applications in veterinary and human medicine. In the realm of veterinary medicine, the discovery of new routes of administration or new delivery systems to regulate the release of medications is of great importance. Due to the high number of animals and the special issues related to the administration of drugs and their market potential is very large, it is necessary to modify the dosage form to produce an effective and practicable preparation. Cats are the most popular pet in the world, outnumbering dogs by a ratio of three to one. It is vital to understand the prevalent illness patterns and limits of traditional delivery systems to establish appropriate dosage forms for cats. We believe this publication will be of interest to veterinarians and pharmaceutical scientists working in the field.
Nanoparticle Drug Delivery System Afinasari, Auliya; Amalia, Eri
Indonesian Journal of Pharmaceutics Vol 4, Issue 3, Sep - November, 2022
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v4i3.44254

Abstract

Drug Delivery System is a method of drug formulation, which aims to deliver the active substance to achieve a therapeutic effect in the body. Along with the development of science in the field of drug manufacturing technology, drug delivery systems have evolved from conventional to targeted delivery systems and even nanorobots, gene therapy, biological products, and long-term delivery systems.Among the drug delivery systems that have been developed, nanotechnology has been applied as a targeted delivery system such as in cancer treatment. This review is focused on nanotechnology especially in nanoparticle dosage forms, including liposomes, dendrimers, niosomes, micelles, solid-lipid nanoparticles, nanospheres, nanocapsules, and gold nanoparticles. The data were collected from 41 primary published journals and 20 supporting literatures. The basic principles, strategies, and carrier systems used in the manufacture of each preparation will be presented in this article, including prospects in the future for SOPs.
Formulation and Evaluation of Sunscreen Gel Combination of Bisoctrizole and Gotu Kola Extract (Centella asiatica (L.) Urban) Mardhiani, Yanni Dhiani; Supriadi, Dadih; Islamiyah, Putri Hafisa Nur
Indonesian Journal of Pharmaceutics Vol 4, Issue 3, Sep - November, 2022
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v4i3.44919

Abstract

Gotu kola extract has antioxidant activity and contains flavonoids that can absorb maximum wavelengths of UV radiation. Bisoctrizole is a photoprotective agent to minimize sun damage. The Sun Protection Factor value of sunscreen can be increased by combining Bisoctrizole and Gotu kola extract as sunscreen in the form of a gel. This study aims to develop a sunscreen gel from a combination of Bisoctrizole UV filter material and Gotu kola extract which has good physical properties and sun protection efficacy. Gel evaluation was carried out on organoleptic, homogeneity, adhesion, dispersion, viscosity, syneresis, pH, irritation test, stability test, and in vitro test of SPF value (UV-Visible Spectrophotometry). The results showed that the combination sunscreen gel (F5-F7) had excellent physical appearance and homogeneity, no syneresis, pH 4.96±0.01 - 5.30±0.01, viscosity 5960±106 - 9240±173 cps, spreadability 5.75±0.05 - 6.38±0.03 cm, adhesion 1.24±0.20 - 2.89±0.12 seconds, and is non-irritating. The results of the measurement of sunscreen activity showed that the SPF value of the Bisoctrizole 5% gel added with Gotu kola extract 5% (F5); 7.5% (F6); and 10% (F7), respectively, were 27.73±0.04; 34.56±0.23; and 37.31±0.36. There was a significant difference (p<0.05) in the room temperature gel stability test and the cycling test on pH, viscosity, and spreadability.. The highest SPF value was found in the gel combination of Bisoctrizole 5% with Gotu kola extract 10% (F7) with an increase of 55.58%. Gotu kola extract can be formulated with Bisoctrizole into a sunscreen gel with ultra photoprotective activity (SPF>15).
Review: Preparation of Flavonoid Nanoparticles using the Nanoprecipitation Method Pratama, Rizky Farhan; Sopyan, Iyan; Rusdiana, Taofik
Indonesian Journal of Pharmaceutics Vol 4, Issue 3, Sep - November, 2022
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v4i3.40849

Abstract

Flavonoids are polyphenolic compounds that have 15 carbon chains, 2 benzene rings and a heterocyclic pyran ring. From the literature study, it is known that flavonoids have various pharmacological activities such as anticancer, antimicrobial, antiviral, antiangiogenic, antimalarial, antioxidant, neuroprotective, antitumor, and antiproliferative agents. However, flavonoids have limited oral bioavailability which may be due to their poor solubility, low permeability, and low stability, which impair their effectiveness as therapeutic agents. One of the efforts to increase solubility is nanoparticle technology where the active compound particles are reduced to the nanometer scale, usually up to 100 nm. Nanoprecipitation is a method of preparing nanoparticles by dissolving the active drug substance and polymer into an organic solvent and then adding an anti-solvent such as water. The advantages of this method are the production is relatively fast, inexpensive, does not require a lot of energy, and does not require emulsion precursors. The purpose of this literature review is to examine the technique of making flavonoid nanoparticles using the nanoprecipitation method, the results of their characterization and evaluation. Based on a literature review that has been carried out on 30 journals, there are 20 flavonoid secondary metabolites that have been prepared into nanoparticles using the nanoprecipitation method. Some of the polymers used were effective in achieving satisfactory particle size, polydispersity index (PDI), Zeta potential and Encapsulation Efficiency (EE%). Thus, the nanoprecipitation method can be used to make flavonoid nanoparticles with optimal formulations to improve the physicochemical properties of flavonoids for drug development in the future.
Tableting Turmeric Rhizome (Curcuma domestica Val.) and Mangosteen Peel (Garcinia mangostana L.) Extract as Antioxidant Supplement Reyhani, Amalia; Sriwidodo, Sriwidodo; Chaerunisa, Anis Yohana; Umar, Abd. Kakhar; Sylvia Nurrasjid, Evi; Rahman Roestan, Mas
Indonesian Journal of Pharmaceutics Vol 4, Issue 3, Sep - November, 2022
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v4i3.39667

Abstract

Free radicals are unstable molecules that lose electrons in their outer orbitals. These compounds can be toxins for the human body and cause various degenerative diseases. To avoid this, we need antioxidants. Examples of common sources of antioxidants are turmeric (Curcuma domestica Val.) and mangosteen rind (Garcinia mangostana L.). Both of these plants have very strong antioxidant activity but have a less favorable taste for consumption. This study aimed to obtain tablets containing turmeric rhizome and mangosteen rind extract that can cover the taste with a variety of binders. Subsequently, we observed the antioxidant  activity of two extracts before and after preparation. The tableting method was wet granulation and the characterization included the physical properties of the tablets. The levels of curcumin, alpha mangosteen, and total polyphenols were also checked. The antioxidant activity was measured using the DPPH method. Based on the characterization results, NaCMC 5% was the best binder for preparing tablets containing turmeric rhizome and mangosteen rind extract with a flow rate of 11.434 g/s, repose’s angle of 29.39ᵒ, loss on drying of 2.65%, carr’s index of 15.22, hardness of 43N, friability of 0.926%, and disintegration time of 16.44 minutes. The antioxidant test result showed that the combination of turmeric extract and mangosteen rind extract with a ratio of 1:2 had the best antioxidant activity with an IC50 value of 31.01 µg/ml, alpha mangosteen level of 29.77%, and curcumin level of 27.22%. The antioxidant activity of the preparation was not changed significantly after tableting. Based on the findings, it can be concluded that the tablet formulation of turmeric rhizome and mangosteen rind extract using 5% NaCMC can be potentially used as an antioxidant supplement.

Page 6 of 10 | Total Record : 97

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