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INDONESIA
IDJP (Indonesian Journal of Pharmaceutics)
Published by Universitas Padjadjaran
ISSN : -     EISSN : 25978748     DOI : -
Core Subject :
The Indonesian Journal of Pharmaceutics (IdJP) is an established international journal for pharmaceutical scientists concerned in all fields of pharmaceutical sciences, including pharmaceutical preformulation, formulation, manufacturing technologies, drug delivery systems, biopharmaceutics, and pharmacokinetics for drugs, vaccines and biologicals. IdJP also includes pharmaceutical engineering and industrial pharmacy topics.
Arjuna Subject : -
Articles 97 Documents
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 Antioxidant Potential of Usnea spp. Extract with Lysozyme Conjugation for the Prevention of Chronic Kidney Disease Progression Junior, Darren; Dewi, Luh Putu Widya Amritha; Indratmo, Novea; Indrayani, Agung Wiwiek
Indonesian Journal of Pharmaceutics Vol 6, Issue 1, Jan - April 2024
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v6i1.57697

Abstract

The prevalence of chronic kidney disease worldwide has been reported to increase every year with hypertension serving as the leading cause. The recommended treatment for chronic kidney disease patients with a history of hypertension is antihypertensive medications, which could cause side effects from prolonged use. Hence, the authors sought out a possible novel modality by implementing antioxidant properties from beard lichen (Usnea spp.) extract. Literature search was conducted on trusted scientific databases, including Google Scholar, PubMed, DOAJ, and Cochrane. The pathophysiology of hypertension in the progression of chronic kidney disease could mainly be attributed to the presence of inflammation and oxidative stress, which could be attenuated by the use of antioxidants. Lichens are a class of complex living organisms resulting from a symbiosis that allows them to synthesize various beneficial phytochemicals. Usnic and stictic acid derived from Usnea spp. are part of phenolic compounds that display strong antioxidant activities. In order for these antioxidants to have a focused effect on the kidneys, a kidney-targeted drug delivery system should be considered with lysozyme conjugation being the most studied method. The combination of Usnea spp. extract’s antioxidant capabilities with lysozyme conjugation could serve as a potential novel modality in the specific prevention of chronic kidney disease progression.                 Keywords: antioxidant; chronic kidney disease; lysozyme conjugation; Usnea                       spp. 
 A Comparative Study on The Therapeutic Effect of pH, Temperature Triggered, and Ion Activated In Situ Gelling System For Ocular Delivery Kurniawansyah, Insan Sunan; Farisa Desy Arya, Insi; Budiman, Arif; Zubaidah, and
Indonesian Journal of Pharmaceutics Vol 6, Issue 2, May - August 2024
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v6i2.52695

Abstract

One of the most popular pharmaceutical preparations for the eyes today is in situ gel. The in situ gel system is a system that is liquid at room temperature but will form a gel when it comes into contact with the body or undergoes a change in pH. The form of the drug delivery system is in-situ is a type of mucoadhesive drug delivery system. Gel formation depends on several factors such as temperature modulation, pH changes, the presence of ions, ultra-violet irradiation, electrical sensitivity, and the enzyme by which the active substance is released. The purpose of this study is to compare the therapeutic efficacy of in situ gel medicines on pH, temperature triggered, and ion activated gelling systems. A drug in situ gel is a drug delivery device that transforms into a gel after being applied to the body. The findings revealed that the pH, temperature triggered, and ion activated gelling system factors had a substantial influence on the extended release medicines that affect the therapeutic effect of in situ gel medications. This comparative investigation demonstrates that the pH, temperature triggered, and ion activated gelling system factors have significant implications on the therapeutic benefits of in situ gelled medicines. A deeper knowledge of the relationships between these variables and in situ gel drug delivery methods can lead to the development of more effective and dependable medication compositions. These findings could aid in the development of improved gel in situ drug delivery systems to improve therapeutic benefits in the treatment of a variety of medical disorders.  Keywords: in situ gel, pH triggered, temperature triggered, ion activated, therapeutic effect.
A Literature Review Of Nanocarrier Development Through Emulsification Diffusion Method (Edm) arafat, Md yeasin; Nijhu, Rajia Sultana
Indonesian Journal of Pharmaceutics Vol 6, Issue 1, Jan - April 2024
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v6i1.55950

Abstract

An overview of the development of nanocarriers is presented in this work using the practical technique of the Emulsification Diffusion Method (EDM). The field of nanomedicine, which combines nanotechnology and medicine, involves creating new therapeutic and diagnostic modalities by employing precisely designed substances with this range of lengths. Many medicinal products and diagnostic tools based on nanoparticles have been developed. The emulsification-diffusion method (EDM) was utilized to prepare nanometer-sized particles, which are commonly used as polymeric carriers. The process involves emulsifying a drug and polymer solution in an aqueous phase that has been saturated with stabilizers and then adding an excessive amount of water.  Investigations into how process variables affect the average size of nanoparticles have been carried out. It was made apparent that the kind and concentrations of stabilizer, the speed at which the magnetic stirrer homogenizes, and the polymer concentration all affected the size of the nanoparticles. Additionally, the medications integrated into nanocarriers have a longer half-life in circulation, which boosts their effectiveness and allows for a lower application dose. Because of their small size and high surface area, drug nanocarriers are also more bioavailable and soluble, which allows their many atoms and high surface energy to act as catalysts. Keywords: Nanocarrier,Diffusion,Bioavailability,Solubility,Catalysts.
Towards Standardized Hydration Testing Protocols for Natural Product-Based Nanoemulgel Moisturizers: A Systematic Review Iskandar, Benni; Eka Saputri Nst, Sandry; Inggrid. P, Debora; Ami Sari, Rosi; Pulpa Susila, Afriani
Indonesian Journal of Pharmaceutics Vol 6, Issue 1, Jan - April 2024
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v6i1.59266

Abstract

The growing complexity of moisturizer formulations, particularly those incorporating natural product-based nanoemulgels, highlights an urgent need for standardized efficacy evaluation methods. This systematic review critically examines hydration testing methodologies used for natural ingredient-based nanoemulgel moisturizers, with a focus on their validity, reliability, and practical application. Through a comprehensive analysis of 32 peer-reviewed articles published between 2000 and 2023, this study identified several key limitations in current practices, including inconsistent testing conditions, the absence of standardized protocols for assessing natural ingredients, and variability in reporting methods. The findings emphasize the necessity of developing robust, standardized hydration testing protocols tailored specifically for natural product-based nanoemulgels. By addressing these challenges, this study lays the groundwork for optimizing nanoemulgel formulations, ensuring reliable efficacy assessments, and enhancing consumer trust in natural-based skincare products. Keyword: Moisturizer, Nanoemulgel, Natural Product 
Topical Formulation of Herbal Nanocosmetics for Anti-Aging Husni, Patihul; Eryani, Mikhania Christiningtyas
Indonesian Journal of Pharmaceutics Vol 6, Issue 2, May - August 2024
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v5i2.56857

Abstract

Skin aging is a biological process that involves a decline in skin function. Regarding prevention and inhibition of skin aging, use of cosmetic products is an option to avoid skin aging because it can improve texture and function of skin. Recently, development of a topical formulation of herbal nanocosmetics for anti-aging has grown increasingly popular. This review is aimed to summarize and describe topical formulation of herbal nanocosmetics for anti-aging application. In addition, this review also shows several studies performed by researchers in development of topical formulation of herbal nanocosmetics for anti-aging. The data were collected from published journals in the range of 2011-2023. Study result showed that nanoemulsion, nanostructured lipid carriers (NLC), solid lipid nanoparticles (SLN), niosomes, liposomes, ethosomes, and transfersomes are nanotechnology methods used to prepare herbal nanocosmetics for anti-aging in the cream or gel dosage form. In conclusion, herbal nanocosmetics combine the benefits of herbal extracts with nanotechnology which can be used to enhance the effectiveness of natural ingredients for anti-aging effect. Keywords: topical, herbal, nanocosmetics, anti-aging
Increasing Solubility of Simvastatin Via Salting Form Using Isonicotinamide As Co-Formers Sopyan, Iyan; Puspa, Inge; Salsabila Hapsari, Raira
Indonesian Journal of Pharmaceutics Vol 6, Issue 2, May - August 2024
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v6i2.60538

Abstract

Simvastatin is a drugs used to lower plasma cholesterol. Simvastatin is a class II BCS drug that has low solubility and high permeability. One of the efforts made to increase the solubility of simvastatin is the formation of multicomponent crystals (co-crystals and salts). The purpose of this study was to determine the solubility and dissolution profile of multicomponent crystal simvastatin with the best co-former candidate from the in silico test. Simvastatin-co-former multicomponent crystal were prepared using solvent drop grinding method with a mol ratio of 1:1 ; 1:2 and 2:1. Based on the result of value of binding affinity and ability to form hydrogen bonds, isonicotinamide was chosen as the co-former in this research. Evaluation of multicomponent crystals was carried out by solubility and dissolution tests. The evaluation results showed an increase in the solubility and dissolution of the simvastatin-isocotinamide multicomponent crystal with the highest increase occurring in the simvastatin-isocotinamide multicomponent crystal with a mol ratio of 1:2. Multicomponent crystal characterization was carried out to determine physicochemical characteristics. The results of characterization using infrared spectrophotometry showed a spectrum shift. The results of the Differential Scanning Calorimetry (DSC) analysis show a decrease in the melting point. The results of Powder X-ray diffraction analysis showed that there were differences in the shape of the crystals indicated by the formation of new peaks on the diffractogram. So, it can be concluded that simvastatin-isocotinamide multicomponent crystals are able to increase solubility and dissolution compared to pure simvastatin.
Development of Foundation Formulation From Eggshells as Anti UV Agent Putri, Salsa Davincy; Mardhiani, Yanni Dhiani; Adiyati Rum, Ira
Indonesian Journal of Pharmaceutics Vol 6, Issue 1, Jan - April 2024
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v6i1.58955

Abstract

Foundation often contains anti-UV filters whether synthetic or natural. One of the natural ingredients that can be used as an anti-UV agent is eggshells because they contain calcium carbonate. This study aim to develop foundation as cosmetic preparation containing of duck eggshells and Moringa seed oil (Moringa oleifera Lam.)  for anti-UV agent. The combination of duck eggshell and moringa seed oil is carried out with the hypothesis can increase the ability of the preparation to protect the skin from exposure to solar radiation. Foundation preparation were made in 6 formulas with varying concentrations of duck eggshells and moringa seed oil. Evaluation of the preparations carried out included organoleptic test, homogeneity, pH, viscosity, spreadability, and color dispersion for 28 days at room temperature, freeze thaw stability test for 6 cycles, and anti-UV activity were carried out using spectrophotometry UV-Vis. The results of the evaluation were analyzed using One-Way ANOVA method. Based on the results of physical evaluation analysis, all formulas showed stable foundation preparations.  All preparations showed a non-irritative category after an irritation test on test animals (albino rabbits). Anti-UV activity with an average SPF value for F0 was 4,2±0,29 (minimal category), F1 was 18.75±1.41 (ultra category), F2 13.68±0.73 (maximum category), F3 14.00±0.46 (maximum category), F413.02±0.47 (maximum category), and F5 18.14±0.31 (ultra category). Keywords: Eggshells, moringa seed oil, cosmetic foundation, SPF
 A Concise ReviewThe Ph Triggered Concept In Situ Ophthalmic Gel Of Sodium Cromoglycate, Diclofenac Sodium and Aceclofenac Kurniawansyah, Insan Sunan; Farisa Desy Arya, Insi; Sopyan, Iyan
Indonesian Journal of Pharmaceutics Vol 6, Issue 3, Sept - Dec 2024
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v6i3.52748

Abstract

The ophthalmic solutions have a major problem that is the poor bioavailability, such as the attainment of optimal drug concentration at the site of action, which is compromised mainly due to precorneal loss resulting in only small fraction of the drug being ocularly absorbed. This is overcome by developing an in situ ophthalmic gel which increases the retention time of the drug. The present review describes the formulation and evaluation of in situ gel-forming ophthalmic drug delivery system of an anti allergy drug sodium cromoglycate, an anti-inflammatory drug diclofenac sodium and aceclofenac based on the pH triggered concept in situ gelation. All the formulations varies in concentration and the content used. Based on the results obtained, Sodium cromoglycate which has been formulated with gelrite and HPMC E15LV has the highest ocular residence time compared to the other two formulations.Keywords: Ophthalmic in situ gel,sodium cromoglycate, diclofenac sodium,                      aceclofenac, gelrite, HPMC E15LV
Lip Balm Formulation and Physical Properties Evaluation Of Yellow Pumpkin Fruit (Cucurbita Moschata Duchesne) Ethanol Extract with Cera Alba Variation Concentration Christiningtyas Eryani, Mikhania; Risky Ayu Paramita, Denok; Ayuning Trias, Diah; Husni, Patihul
Indonesian Journal of Pharmaceutics Vol 6, Issue 3, Sept - Dec 2024
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v6i3.60617

Abstract

Lip balm is a cosmetic product generally used to care for, moisturize, decorate, and protect lips from environmental influences. This study aims to determine the effect of variations inconcentration of cera alba as base on the lip balm physical properties of yellow pumpkin fruit (Cucurbita moschata Duchesne)ethanol extract. The experimental design used was a pre-experimental one-shot case study. This study employed three formulas with varying concentrations of Cera alba, namely 10% (F1), 15% (F2), and 20% (F3). The physical properties of the lip balm under investigation included homogeneity, pH, adhesion, and hardness. The results showed that the variation concentration of cera alba had affect on adhesion and hardness, while not affect the homogeneity of physical properties and pH. Keywords : Yellow pumpkin, cera alba, lip balm
Determination of Hydroquinone and Retinoic Acid in Whitening Creams in Ujung Berung Market Bandung, Using UV-Visible Spectrophotometry Shalihat, Ayu; Putri, Syakira Dwi; Fadhilah, Khusnul
Indonesian Journal of Pharmaceutics Vol 6, Issue 3, Sept - Dec 2024
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v6i3.63939

Abstract

Whitening creams are cosmetic products applied to the skin to brighten or alter skin tone. The use of retinoic acid and hydroquinone without medical supervision is prohibited under Indonesian Food an Drug Authority (BPOM) regulations, as these are classified as prescription drugs that may cause harmful side effects with long-term use, such as skin irritation, dryness, burning sensation, and teratogenic effects. Unfortunately, these substances are still misused in some facial whitening products. This study aimed to identify the presence and determine the concentration of retinoic acid and hydroquinone in facial whitening creams sold in Ujung Berung Market, Bandung City. Samples were selected using purposive sampling with the criteria of being low-cost and without a registration number. A total of four cream samples were analyzed qualitatively using Thin Layer Chromatography (TLC) with a mobile phase of acetone:n-hexane (4:6), and quantitatively using UV-Visible spectrophotometry. Absorbance measurements for retinoic acid and hydroquinone were performed at wavelengths of 324 nm and 300 nm, respectively. TLC results showed that two samples, B and D, tested positive for retinoic acid with Rf values of 0.52 and 0.55, respectively, exhibited dark blue spots similar to the standard. The result of hydroquinone analysis using TLC was unidentified. Quantitative analysis revealed that sample B contained the highest retinoic acid concentration (0.077% w/w), while sample A had the highest hydroquinone concentration (0.604% w/w). These findings suggest that some facial whitening creams sold in Ujung Berung Market still contain unauthorized levels of retinoic acid and hydroquinone, highlighting the need for stricter regulation and public awareness.

Page 9 of 10 | Total Record : 97

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