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INDONESIA
IDJP (Indonesian Journal of Pharmaceutics)
Published by Universitas Padjadjaran
ISSN : -     EISSN : 25978748     DOI : -
Core Subject :
The Indonesian Journal of Pharmaceutics (IdJP) is an established international journal for pharmaceutical scientists concerned in all fields of pharmaceutical sciences, including pharmaceutical preformulation, formulation, manufacturing technologies, drug delivery systems, biopharmaceutics, and pharmacokinetics for drugs, vaccines and biologicals. IdJP also includes pharmaceutical engineering and industrial pharmacy topics.
Arjuna Subject : -
Articles 101 Documents
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Review: Mesoporous Silica Formulation in Biopharmaceutical Classification System (BCS) Class II Drug Development Ayodduki, Zahra Noor Silmi Hermawan; Anggi, Joseph Fide; Nurulaini, Siti Nunung; Budiman, Arif; Aulifa, Diah Lia
Indonesian Journal of Pharmaceutics Vol 7, Issue 1, Jan - April 2025
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v7i1.62641

Abstract

About 40% of approved drugs and nearly 90% of drug candidates have low aqueous solubility which limits their bioavailability resulting in suboptimal pharmacological activity. According to the Biopharmaceutical Classification System (BCS), drugs with low solubility and high permeability are categorized as BCS Class II, where the dissolution rate becomes a key factor in gastrointestinal absorption. One approach to increasing its solubility is the formation of an amorphous state, which lowers lattice energy and enhances dissolution. However, the amorphous form tends to be unstable and prone to recrystallization. Mesoporous silica has been developed as a drug delivery system capable of maintaining the stability of the amorphous form through molecular interactions with silanol groups and the nano-confinement effect that suppresses crystal growth. With a high surface area and tunable pore structure, mesoporous silica enhances the dissolution rate and bioavailability of BCS Class II drugs, ultimately contributing to improved pharmacological activity. This review summarizes the development of mesoporous silica formulations in drug delivery systems for BCS Class II drugs to enhance their pharmacological efficacy.
Solubility Enhancement Methods Of Efavirenz : A Review febryanto, hery diar; Eryani, Mikhania Christiningtyas; Husni, Patihul
Indonesian Journal of Pharmaceutics Vol 6, Issue 3, Sept - Dec 2024
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v6i3.64166

Abstract

Human Immunodeficiency Virus (HIV) is a global public health concern due to its progression to acquired immunodeficiency syndrome (AIDS) and the associated high morbidity and mortality rates. Efavirenz (EFV), an antiretroviral drug, is widely used to manage HIV/AIDS. However, EFV exhibits poor aqueous solubility and variable bioavailability, necessitating techniques to enhance its solubility and dissolution for improved therapeutic efficacy. This study reviewed methods to enhance EFV solubility using data from research published between 2019 and 2023. Various approaches, including Nano Micelles, Wet Milling, Co-crystals, Physical Mixtures, Nanocrystals, Dry Milling, and Liquisolid techniques, were analysed. The results demonstrated significant solubility enhancements. For instance, Fuentes (2024) achieved a 50% dissolution efficiency using Nano Micelles, while wet milling by Prado (2024) increased dissolution from 83.48% to 99.10% over 150 minutes. Co-crystals, such as those studied by Gowda (2022), improved solubility from 94.16 µg/mL (pure EFV) to 197.32 µg/mL (EFV-DL-Alanine). Sartori's (2022) Nanocrystals technique demonstrated a dissolution efficiency of 98.41%. Furthermore, physical mixtures like Nel's (2022) combination of EFV with pea protein isolate achieved a solubility increase from 1.00 mg/mL to 2.30 mg/mL. These methods highlight advancements in solubility enhancement techniques that improve EFV’s pharmacokinetic profile. These findings can guide the development of more effective pharmaceutical formulations, improving treatment outcomes for individuals living with HIV/AIDS.
 Risk Management in the Pharmaceutical Industry Supply Chain at the Pharmaceutical Wholesaler Level Evi, Sylvia; Sriwidodo, Sriwidodo; Masrahman, Roestan
Indonesian Journal of Pharmaceutics Vol 7, Issue 1, Jan - April 2025
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v7i1.62708

Abstract

The pharmaceutical industry in Indonesia faces several challenges in risk management, particularly in stakeholder management, which includes the government, healthcare providers, distributors, and the public. The complexity of regulations, market fluctuations, and changes in healthcare policies necessitate the implementation of effective risk management strategies in interactions with stakeholders. This study aims to analyze the implementation of risk management in stakeholder management within Indonesia’s pharmaceutical industry, identify key risks that may impact business sustainability, and evaluate the mitigation approaches employed. A qualitative case study, incorporating in-depth interviews with key industry stakeholders, revealed that the primary risks include regulatory uncertainty, supply chain disruptions, and challenges in stakeholder communication and compliance. Effective mitigation strategies involve the adoption of adaptive compliance systems, strengthened communication and collaboration with regulators, and digitization of supply chains to enhance transparency and efficiency. This study underscores the importance of a risk-based approach in stakeholder management to ensure the sustainability and competitiveness of Indonesia’s pharmaceutical industry.
 New Drug Delivery Systems in Livestock Animals Herdiana, Yedi
Indonesian Journal of Pharmaceutics Vol 6, Issue 3, Sept - Dec 2024
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v6i3.62570

Abstract

The development of animal husbandry in Indonesia has seen positive progress through government initiatives to increase productivity and efficiency. The field of veterinary medicine plays a vital role in maintaining the health and productivity of livestock, which ultimately impacts the productivity and quality of animal products. However, areas still require improvement, particularly infrastructure, technology, and management. Pharmaceutical science, specifically veterinary pharmacy, focuses on treating animals using different drug delivery systems due to physiological differences. Significant modification in livestock drug delivery involves adjusting medication based on animal needs to improve health and reduce the risk of overmedication and antibiotic resistance. Advancements in technology and medical developments are continuously being reviewed and studied to improve veterinary medicine.
Impact of Sample Preparation Methods on LC-MS/MS Analysis of Molecular Targeted Drugs Tanaka, Yusuke; Araki, Takuya; Yashima, Hideaki; Yamamoto, Koujirou
Indonesian Journal of Pharmaceutics Vol 7, Issue 1, Jan - April 2025
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v7i1.60748

Abstract

The therapeutic efficacy of molecular targeted drugs (MTD)s and the risk of certain adverse drug effects are closely related to their blood concentrations, highlighting the importance of optimizing dosage based on therapeutic drug monitoring. In this study, we compared four pretreatment methods for the analysis of 15 MTDs by LC-MS/MS: protein precipitation (PPT), solid-phase extraction (SPE) using a reversed-phase (RP) column, SPE using a mixed-mode cation-exchange RP column, and supported liquid extraction (SLE), and evaluated their effects on recovery rates and matrix effects. While PPT showed high recovery rates (>80%) for 8 out of 15 compounds, certain highly polar MTDs exhibited significant peak intensity decreases with repeated analyses, indicating potential issues with ion suppression due to impurities. SPE using a reversed-phase column (HLB) resulted in low recovery rates for 12 out of 15 compounds. In contrast, SPE using an MCX column yielded high recovery rates (>80%) for 14 out of 15 compounds but exhibited substantial matrix effects for 9 out of 15 compounds (matrix factors >2). Addressing these matrix effects required sample dilution, and achieving higher sensitivity would necessitate extensive method adjustments tailored to each compound. SLE demonstrated the most favorable results, with the largest number of compounds showing acceptable recovery rates and minimal matrix effects. In conclusion, these findings, based on standard protocols from product manuals, suggest that while method optimization could improve performance for specific compounds, SLE appears to be the most suitable first-choice pretreatment method for the LC-MS/MS analysis of MTDs due to its balance of recovery and matrix effect control.
Review: Isolation of Gelatin from Several Types of Fish Suryaman, Ine Suharyani; Sulastri, Lela; Astuti, Enih Nindi; Delviyanti, Elis; Senja, Rima Yulia; Tomi, Tomi
Indonesian Journal of Pharmaceutics Vol 7, Issue 1, Jan - April 2025
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v7i1.58575

Abstract

Indonesia is a country with the largest fishery waste, one of which is fish bones as a source of gelatin. Gelatin is the main protein that makes up skin and bone tissue in animals. This review was compiled to compare the results of isolating gelatin from bone waste in various types of fish. Articles were collected from the website https://scholar.google.co.id/ with "gelatin, gelatin content, gelatin in fish bones, viscosity, pH" in the 2015–2022 period, and 11 journals were obtained. In this literature study, a method for isolating gelatin from fish bone waste will be discussed, followed by an evaluation of the gelatin obtained, including its yield and its physical properties. It is hoped that the results of this review will provide information regarding a new source for gelatin isolation so that gelatin can be widely used by the food, pharmaceutical, cosmetic, and photographic industries, particularly in the pharmaceutical and food industries, which currently require gelatin as a stabilizer and emulsifier so that it can make and maintain the emulsion system.
Standardized vs. manufacturer leaflet techniques for inhalation devices: A randomized controlled trial Takahashi, Emiri; Saito, Yurina; Maeda, Eri; Okada, Yuko; Takahashi, Yuta; Doi, Nobuyuki; Horie, Takeo; Araki, Takuya; Obayashi, Kyoko; Suzuki, Asuka
Indonesian Journal of Pharmaceutics Vol 7, Issue 1, Jan - April 2025
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v7i1.61601

Abstract

Variations in inhaler leaflet information may affect the understanding of inhalation techniques.We aimed to determine the effectiveness of standardized and package leaflets in describing correct inhaler usage and to identify any existing pitfalls. This prospective, randomized, open-labeled, blinded endpoint study with a 2 × 2 factorial design was conducted in August2019. We included 38 pharmacy students who did not use inhalers and allocated them into 4 groups:  2 groups used standardized leaflets (with 1 and  2 devices, respectively),  while the other  2 groups used package leaflets (with 1 and  2 devices, respectively). The participants were instructed on the essential techniques of using each inhaler and asked to practice using the assigned leaflets until the procedures were completely learned. The primary outcome was evaluated the following day as the score rate (%) of the technique. The effectiveness of leaflets stratified by the number of devices was  tested using a two-way analysis of variance with an interaction term. We compared techniques with different implementation rates between groups to identify potential pitfalls. The differences and 95% confidence interval in the score rate (%) between the groups using standardized or package leaflets were significantly different in the two-device group analysis. The implementation rate of certain instructions between the two-device groups was higher when using standardized leaflets for both devices. Standardized leaflets enhanced the comprehension of inhalation techniques for multiple devices due to their normalized wording. These findings may help improve package leaflets and healthcare professionals' instructions, thereby promoting appropriate inhaled medication use.
Unlocking the Secrets to Truly Healthy Facial Skin: A Comprehensive Review of Its Influences Huang, Stella Aurelia; Fauziyyah, Rasya Salma; Aurelia, Khanna Ragita; Amalia, Eri
Indonesian Journal of Pharmaceutics Vol 7, Issue 2, May - August 2025
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v7i2.69755

Abstract

Facial skin health results from a complex interaction between intrinsic biological processes and extrinsic environmental exposures, extending beyond the effects of topical skincare alone. This narrative review synthesizes evidence from original studies published between 2015 and 2025, retrieved from PubMed and Google Scholar using targeted search terms related to internal factors such as hydration status, hormonal regulation, and genetic variation, as well as external influences including ultraviolet radiation, air pollution, and light absorption. Eligible studies were full-text original articles in English or Indonesian that examined skin-active ingredients or physiological mechanisms affecting facial skin. The literature consistently identifies hydration as a fundamental determinant of skin elasticity, smoothness, and luminosity, mediated through corneocyte organization, lipid barrier integrity, and aquaporin-3–regulated water transport. Hormonal factors, particularly estrogen, play a critical role in maintaining dermal quality by stimulating collagen synthesis, enhancing skin thickness, and reducing oxidative damage. Genetic variability further contributes to individual differences in skin characteristics by influencing collagen density, antioxidant defense systems, pigmentation pathways, and inflammatory responses. External stressors significantly modulate these intrinsic processes, with ultraviolet radiation and air pollution accelerating skin aging through oxidative stress, collagen degradation, barrier disruption, and pigmentary alterations. In addition, light absorption and reflection at the skin surface, affected by sebum composition and optical properties of the stratum corneum, influence perceived skin tone and radiance. Collectively, the evidence underscores the importance of understanding how intrinsic and extrinsic factors interact to shape facial skin health. A holistic, evidence-based approach that integrates topical treatments with internal health optimization, hormonal balance, lifestyle modification, and personalized care strategies is essential for achieving and maintaining optimal facial skin condition.
 The Efficacy of Favipiravir Therapy in COVID-19 Patients: A Review Article Kurniawansyah, Insan Sunan; Amelia, Nisa Ayu
Indonesian Journal of Pharmaceutics Vol 7, Issue 2, May - August 2025
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v7i2.68959

Abstract

The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has resulted in a major global public health crisis. In the absence of a universally approved specific antiviral therapy, several existing antiviral agents have been repurposed, including favipiravir. Favipiravir is a purine nucleoside analog that inhibits RNA-dependent RNA polymerase (RdRp), an essential enzyme for viral RNA replication. This review aims to evaluate the clinical efficacy of favipiravir therapy in patients with COVID-19. A narrative literature review was conducted using databases such as PubMed and Google Scholar, including national and international peer-reviewed journals published between 2019 and 2021. Clinical trials, randomized controlled trials, and observational studies assessing favipiravir in COVID-19 patients were included, while articles lacking accessible full texts or reliable data were excluded. The reviewed studies indicate that favipiravir therapy is associated with improved clinical outcomes, including reduced duration of fever and cough and accelerated viral clearance within 7–14 days of hospitalization, particularly in patients with mild to moderate COVID-19. However, considerable variability in outcomes was observed due to differences in study design, sample size, dosing regimens, comparator therapies, and treatment duration. Overall, favipiravir demonstrates potential as an antiviral therapy for COVID-19; nevertheless, large-scale, well-designed randomized controlled trials are required to definitively confirm its efficacy and safety across different patient populations. 
Ternary Solid Dispersions for Improved Dissolution Profile of Poorly Water-Soluble Drugs: Insights from Recent Studies Amaliah, Salma; Aulifa, Diah Lia; Budiman, Arif
Indonesian Journal of Pharmaceutics Vol 7, Issue 2, May - August 2025
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v7i2.63625

Abstract

Enhancing the dissolution of poorly water-soluble drugs remains a major challenge in drug development. Binary solid dispersions (BSDs), composed of a drug and a hydrophilic polymer, have been employed to improve solubility primarily through amorphization. However, many BSD systems suffer from limited wettability and suboptimal dispersion, which reduce their effectiveness in promoting rapid and consistent drug release. Ternary solid dispersions (TSDs) introduce a functional third component, such as an additional polymer, surfactant, co-former, or other excipient, to overcome these limitations and further enhance dissolution performance. This review provides a concise summary of current advancements in TSD systems and their underlying mechanisms for improving drug dissolution. Relevant studies published between 2020 and 2025 were retrieved from Scopus, Google Scholar, and PubMed using the keywords "ternary solid dispersion" and "dissolution." Critical formulation strategies, excipient combinations, and manufacturing techniques were summarized to elucidate how TSDs improve dissolution by stabilizing the amorphous state, inhibiting nucleation and crystal growth, enhancing wettability, and preventing particle agglomeration. The selected preparation method was determined to significantly affect dissolution behavior. The compiled evidence supports TSD systems as a versatile and efficient strategy for improving the dissolution characteristics of poorly water-soluble drugs, offering substantial potential for advancing oral drug delivery.

Page 10 of 11 | Total Record : 101

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