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All Journal Prosiding Seminar Nasional Sains Dan Teknologi Fakultas Teknik Majalah Farmaseutik Jurnal Farmasi Indonesia JKPK (Jurnal Kimia dan Pendidikan Kimia) Jurnal Insan Farmasi Indonesia
Muhamad Ansory, Hery
Fakultas Farmasi, Universitas Setia Budi Surakarta Jl. Letjend Sutoyo Mojosongo, Surakarta.
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Engineering Immunology & microbiology Medicine & Pharmacology Physics

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The Analysis of Nutmeg Mace Essential Oil Compound Using GC-MS and Antibacterial Activity Test Toward Ecschericia coli and Staphylococcus aureus Nur ‘Aini Hidayah; Hery Muhamad Ansory; Prietta Khania Kusuma Putri; Anita Nilawati
Majalah Farmaseutik Vol 13, No 2 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (530.428 KB) | DOI: 10.22146/farmaseutik.v13i2.40915

Abstract

Isolation of essential oil from nutmeg mace by using water distillation method had been done. The content analysis of the nutmeg mace essential oil compound was done by using GC-MS. The analysis result shows that there are 4 dominant compounds they are α-pinene, sabinene, 2-β-pinen, and myristicin. The quality of nutmeg mace essential oil is seen from the ratio of oil resulted from isolation with the SNI standard. Nutmeg mace essential oil does not fulfill the SNI standard in term of specific weight. However, it contains a relatively high among of myristicin which is 30.82%. According to Agusta (2000), essential oil is a good antibacterial. The antibacterial activity test was done by using the dilution and diffusion method. The result of the dilution test could not conclude the value of KHM and KBM. The diffusion test result shows that nutmeg mace essential oil with 7.5% concentration is able to inhibit the growth of Stapylococus aureus with the average inhibition zone diameter of 9.25 mm. While on the Ecschericia coli bacteria, it has the average inhibition zone diameter of 7.375 mm.
Studi Docking Molekuler Senyawa Dalam Minyak Atsiri Pala (Myristica fragrans H.) Dan Senyawa Turunan Miristisin Terhadap Target Terapi Kanker Kulit Alfian Bagas Pratama; Rina Herowati; Hery Muhamad Ansory
Majalah Farmaseutik Vol 17, No 2 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v17i2.59297

Abstract

Kanker kulit adalah penyakit di mana kulit kehilangan kemampuannya untuk regenerasi dan tumbuh secara normal. Penyebab umum terjadinya kanker kulit adalah intesitas paparan sinar UVB. Penelitian terdahulu telah membuktikan kandungan senyawa di dalam minyak atsiri pala (Myristica fragrans H.) khususnya miri stsin memiliki khasiat sebagai antioksidan dan efek cytotoxic. Telah dilakukan skrining target molekuler dari kandungan kimia minyak atsiri pala beserta turunan miristisin-nya terhadap target molekuler antikanker kulit antara lain Heat Shock Protein 90 (HSP90A), Prostaglandin Synthase 2 (PTGS2) dan Dihydroorotate Dehidrogenase (DHODH), dan memprediksi interaksi senyawa dari ke 61 ligan uji dengan target molekuler tersebut, kemudian dilakukan docking molekuler menggunakan perangkat lunak PyRx 0.8. Hasil penelitian menunjukkan bahwa senyawa dalam minyak atsiri pala yaitu Guanicin memiliki nilai ΔGbind yang baik pada  HSP90A dengan nilai -8,2 kkal/mol. Hasil docking antara protein PTGS2 dan DHODH dengan ligan baik dari senyawa dalam minyak atsiri pala maupun senyawa turunan miristisin menunjukkan bahwa hampir semua ligan dapat berinteraksi dengan kedua target dengan ligan yang nilai ΔGbind paling kecil dan memiliki model interaksi terbaik dari senyawa minyak atisi pala adalah asam dihidroguaiaretik, dengan nilai ΔGbind secara berurut-urut sebesar  -8,1 kkal/mol dan -9,3 kkal/mol.
Potency and Stability Emulgel of Ethanol Extract Strawberry Leaf (Fragaria x ananassa var Duchesne) as a Sunscreen Detyari Faza Auliya; Hery Muhamad Ansory; Suhartinah Suhartinah
Majalah Farmaseutik Vol 18, No 4 (2022): in press
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v18i4.73909

Abstract

Strawberry leaf extract (Fragaria x ananassa var Duchesne) was reported to have good sunscreen activity. A good dosage formulation is necessary for the next stage. The purpose of this study was to formulate emulgel from the ethanol extract of strawberry leaves using physical quality tests, stability tests, and SPF value test.                 The strawberry leaves were extracted by the reflux method using 96% ethanol as solvent. The extract was analyzed for chemical content by TLC. The emulgel preparation is formulated with a concentration of 0,25%; 0,50% and 1%. The preparations were tested for physical quality, stability, and sunscreen activity using in vitro and in vivo. In vitro test using UV-Vis spectrophotometry and in vivo with experiments on human skin.The results showed that the yield of ethanol extract of strawberry leaves was 20,5% and the TLC test showed positive content of flavonoids and tannins. The emulgel formula had the best effectiveness as a barrier was formula with an extract concentration of 1%. The 1% ethanol extract concentration of strawberry leaves an emulgel resulted in SPF value of 59,94 ± 0,260.
UJI AKTIVITAS ANTIDEPRESAN ISOMIRISTISIN TERHADAP IMMOBILITY TIME MENCIT PUTIH JANTAN (MUS MUSCULUS) Sasqia Indri Maharani; Hery Muhamad Ansory; Inaratul Rizkhy Hanifah
Jurnal Insan Farmasi Indonesia Vol 6 No 1 (2023): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v6i1.1279

Abstract

Isomyristicin results from myristicin isomerization and is reported to have the same biological activity as myristicin, an antidepressant. Myristicin at a specific dose causes toxicity, so it is necessary to study isomyristicin, which is estimated to have the same biological activity as myristicin. However, there has been no test related to isomyristicin having antidepressant activity. Therefore, this study aimed to determine the antidepressant activity and the optimum dose of isomyristicin to decrease the immobility time of male white mice (Mus musculus). This study used 30 male white mice divided into six groups: positive control, negative control, normal control, and isomyristicin dose 1.5 mg/Kg BW, 3 mg/Kg BW, and 6 mg/Kg BW mice. The method to measure the immobility time of male white mice is the Forced Swimming Test (FST) and Tail Suspension Test (TST) to induce depression. To analyze the normality data using a Shapiro Wilk and a one-way ANOVA to analyze the significant difference in the data. The result showed all doses of isomyristicin have the ability to antidepressant, and the optimal dose was 1,5 mg/kg BW mice with 82 % as the decrease percentage and proved by post hoc with sig. p (<0,05).
Peningkatan Aktivitas Antioksidan pada Ekstrak Daun Kelor (Moringa oleifera) melalui Fermentasi: Studi Perbandingan Kandungan Fenolik dan Aktivitas Antioksidan Hery Muhamad Ansory; Nuraini Harmastuti; Windia Wulantika; Afif Meilana Sindani Putri
Jurnal Farmasi Indonesia Vol 20 No 1 (2023): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v20i1.1652

Abstract

This study aimed to investigate the effect of fermentation on the antioxidant activity and phenolic content of 96% ethanol extract from Moringa oleifera leaves. While the antioxidant potential of Moringa leaves has been recognized, this research introduces a novel concept of utilizing fermentation to enhance the levels of active compounds. The state of the art in antioxidant activity and fermentation is used to validate the significant improvement in antioxidant activity. The findings provide new insights into utilizing Moringa leaves as a natural antioxidant source obtained through fermentation. The research methodology involved fermenting the 96% ethanol extract from Moringa leaves using Lactobacillus B bacteria for 24, 48, and 72 hours. The phenolic content was measured using the Folin-Ciocalteu method, while the antioxidant activity was evaluated using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method. The results demonstrated a significant increase in phenolic content after the fermentation process. The phenolic content of the fermented Moringa leaf extract was 86.133±5.925 mgGAE/gram after 24 hours, increased to 91.244±7.374 mgGAE/gram at 48 hours, and reached 122.578±9.576 mgGAE/gram at 72 hours. Additionally, the antioxidant activity also increased with fermentation time. The IC50 values for samples fermented for 24, 48, and 72 hours were 60.887 µg/ml, 58.742 µg/ml, and 53.169 µg/ml, respectively. These results indicate that fermentation of Moringa leaf extract can significantly enhance phenolic content and antioxidant activity.
Inovasi Fermentasi: Meningkatkan Kandungan Antioksidan pada Bekatul Menggunakan Aspergillus Oryzae Hafidh Al Azzhar; Mardiyono Mardiyono; Hery Muhamad Ansory
Jurnal Farmasi Indonesia Vol 20 No 2 (2023): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v20i2.2234

Abstract

This study aims to assess the antioxidant activity of fermented rice bran extract as an innovative approach to enhance the content of bioactive compounds. Although rice bran is known for its richness in phenolic compounds and γ-oryzanol, the use of enzymatic fermentation to increase its bioactivity remains limited. The research explores the antioxidant activity of fermented rice bran extract, providing fresh insights into harnessing the untapped potential of natural antioxidants. Rice bran was fermented with Aspergillus oryzae for 7, 14, and 21 days. The fermented product was then extracted using 70% ethanol, and its antioxidant activity was determined in vitro using the DPPH method. The results indicated that a 14-day fermentation exhibited the highest antioxidant activity (AAI 1.47), categorized as strong antioxidant activity. For non-fermented rice bran and 7-day fermentation, AAI values were 1.09 and 1.05, respectively. Fermentation for 21 days showed the lowest antioxidant activity (AAI 0.55), which was categorized as moderate. These findings contribute to understanding the impact of fermentation duration on the antioxidant activity of rice bran, supporting its potential as a valuable source of antioxidants.
Pengujian Toksisitas Akut Minyak Atsiri Biji Pala pada Mencit Jantan (Mus musculus) Ghani Abhi Majid; Yane Dila Keswara; Hery Muhamad Ansory
Jurnal Farmasi Indonesia Vol 20 No 2 (2023): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v20i2.2263

Abstract

Nutmeg seed essential oil works as an antibacterial, antioxidant, antifungal and anti-inflammatory. It is not yet known the safety of using nutmeg seed essential oil as a medicine so it is necessary to carry out safety tests, namely acute toxicity tests. The purpose of this study was to determine the safety of nutmeg seed essential oil and determine the LD50 value, influence on body weight, behavioral changes and macropathology of mouse organs. Isolation of nutmeg seed essential oil using the steam distillation method. Nutmeg seed essential oil was analyzed using GS-MS. Acute toxicity test in this study used fixed dose method. The test animals used 30 male white mice were divided into 6 test groups, namely the placebo control group and the treatment group given nutmeg essential oil doses of 5, 50, 300, 2000 and 5000 mg / KgBB. The observation parameters of test animals include toxic symptoms, body weight, and organ macropathology. The analysis method used is one way ANOVA followed by Tukey's Post-Hoc test. The results showed that after giving nutmeg seed essential oil there were no significant toxic effects but could affect the body weight of mice. Macropathological observation of mouse organs in all groups looked normal and no damage to mouse organs resulted from the administration of test preparations. Thus, the LD50 essential oil of nutmeg seeds is pseudo ≥ 5000 mg/KgBB, including the classification of practically non-toxic.
Uji Toksisitas Akut Miristisin Terhadap Mencit Putih Betina (Mus musculus) Putri, Clara Prasidya Maharani; Ansory, Hery Muhamad; Hanifah, Inaratul Rizkhy
Majalah Farmaseutik Vol 20, No 2 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v20i2.81477

Abstract

Miristisin memiliki aktivitas antidepresan, antioksidan, dan antibakteri, namun sampai saat ini belum ada data ilmiah mengenai toksisitas dari senyawa miristisin. Uji toksisitas akut oral dilakukan untuk mendeteksi efek toksik yang muncul dalam waktu singkat setelah pemberian sediaan uji.Tujuan penelitian ini adalah mengetahui toksisitas akut miristisin dari tanaman pala (Myristica fragrans) terhadap mencit putih betina (Mus musculus). Metode yang digunakan adalah fixed dose berdasarkan Organization for Economic Co-Operation and Development (OECD). Sampel pada penelitian ini adalah miristisin dari minyak pala dengan dosis 5, 50, 300 dan 2000 mg/KgBB. Hasil penelitian menunjukkan hingga dosis 2000 mg/KgBB tidak terdapat kematian namun pada dosis tersebut terdapat gejala toksisitas berupa grooming, lemas, dan nafas abnormal pada sebagian hewan uji sehingga miristisin dikatakan tidak toksik. Hasil analisis paired t test menunjukkan bahwa terdapat bermakna pada perubahan berat badan mencit antar kelompok pada hari pertama dan hari ke-3 pengamatan (p<0,05) yang diduga karena berkurangnya nafsu makan.
COMPARISON OF ESSENTIAL OILS QUALITY FROM PARTS OF NUTMEG BASED ON MYRISTICINE LEVELS Hery Muhamad Ansory; Hardjono Sastrohamidjojo; Bambang Purwono; Nurrohmah Dwi Mahesti
Jurnal Farmasi Indonesia Vol 12 No 2 (2015): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1087.705 KB) | DOI: 10.31001/jfi.v12i2.291

Abstract

Telah dilakukan isolasi minyak atsiri dari daging buah, fuli dan biji buah pala denganmenggunakan metode distilasi uap. Analisis kadar senyawa miristisin sebagai indikator darikualitas minyak pala dilakukan dengan menggunakan kromatografi gas dan spektrometer massa.Isolasi senyawa miristisin dilakukan dengan metode distilasi fraksinasi pengurangan tekanan.Analisis kemurnian miristisin dari hasil isolasi dilakukan dengan menggunakan kromatografi gas.Analisis struktur miristisin hasil isolasi dilakukan dengan menggunakan spektrofotometer inframerah dan 1H NMR.Hasil isolasi minyak pala dengan metode distilasi uap dari daging buah pala didapatkan0,75% dengan kadar miristisin 10,54%, fuli pala didapatkan 4,77% dengan kadar miristisin 38,45%dan biji pala didapatkan 6,62% dengan kadar miristisin 9,24%. Hasil isolasi senyawa miristisin dariminyak pala dengan metode distilasi fraksinasi pengurangan tekanan didapatkan dengan kadar92,13%.Kualitas minyak atsiri dari bagian fuli pala memiliki kualitas yang lebih baik dengankandungan miristisin sebesar 38,45%.
Pemanfaatan Limbah Belimbing Wuluh, Kulit Jeruk, dan Bayam sebagai Sumber Asam Organik: Studi Konsentrasi Asam dan Potensi sebagai Agen Reduktor Nurrohmah Dwi Mahesti; Hery Muhamad Ansory
Jurnal Farmasi Indonesia Vol 21 No 2 (2024): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v21i2.2630

Abstract

Fruit and vegetable waste contains organic acids that can still be utilized, offering new potential as reducing agents in environmentally friendly chemical applications. The samples used in this study include Averrhoa bilimbi, orange peel, and spinach waste, known to contain organic acids. This study aims to optimize the extraction process of organic acids from these samples and identify their potential as reducing agents. The method involves drying and dissolving the waste samples, which were dried at 60°C and then disbanded in aquabidest with varying times and temperatures. The concentration of organic acids was analyzed using alkalimetry and permanganometry to measure total acids and reduce acids. The results show that variations in dissolution time and temperature influence the concentration of dissolved organic acids in the waste samples. The highest concentration was achieved at a dissolution time of 90 minutes and a temperature of 60°C, with concentrations decreasing at longer times and higher temperatures. Qualitative identification indicates that Averrhoa bilimbi and spinach contain oxalic and ascorbic acids, while orange peel contains citric and ascorbic acids. These findings highlight the potential of these samples as reducing agents, especially under optimal dissolution conditions.
Co-Authors Afif Meilana Sindani Putri Ahmad Ferdinansyah Rafsanjani Alfian Bagas Pratama Anita Nilawati Argo Khoirul Anas Bambang Purwono Detyari Faza Auliya Ghani Abhi Majid Hafidh Al Azzhar Hardjono Sastrohamidjojo Ika Nur Fitriani Ika Nur Fitriani Inaratul Rizkhy Hanifah Ines Tri Hastuti Keswara, Yane Dila Laksmiari Sekar Nirwani Mardiyono Mardiyono Mira Dia Nofia Nilawati, Anita Nur &#039;Aini Hidayah Nur ‘Aini Hidayah Nur ‘Aini Hidayah Nuraini Harmastuti Nuraini Harmastuti Nurrohmah Dwi Mahesti Nurrohmah Dwi Mahesti Petrick Gilang Pambudi Prietta Khania Kusuma Putri Prietta Khania Kusuma Putri Prietta Khania Kusuma Putri Putri, Clara Prasidya Maharani Rinda Binugraheni, Rinda Sasqia Indri Maharani Suhartinah Suhartinah Suhartinah Tiara Dwi Ayunani Wangu, Chelsy Fauziah Windia Wulantika