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All Journal Prosiding Seminar Nasional Sains Dan Teknologi Fakultas Teknik Majalah Farmaseutik Jurnal Farmasi Indonesia Jurnal Insan Farmasi Indonesia Open Access Health Scientific Journal Advance Sustainable Science, Engineering and Technology (ASSET)
Muhamad Ansory, Hery
Fakultas Farmasi, Universitas Setia Budi Surakarta Jl. Letjend Sutoyo Mojosongo, Surakarta.
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Dentistry Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Nursing Physics Public Health Veterinary

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Uji Aktivitas Antidepresan Minyak Atsiri Pala Tanpa Miristisin Dengan Metode Open Field Test dan Forced Swimming Test Wangu, Chelsy Fauziah; Ansory, Hery Muhamad; Hanifah, Inaratul Rizkhy
Majalah Farmaseutik Vol 21, No 1 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v21i1.81518

Abstract

Minyak atsiri pala dilaporkan memiliki aktivitas antidepresan, zat aktif yang berperan dalam aktivitas antidepresan tersebut adalah miristisin, akan tetapi senyawa tersebut juga dilaporkan  bersifat halusinogen dan toksik yang dapat menyebabkan keracunan pada dosis berlebih. dalam penelitian ini diujikan aktivitas minyak atsiri pala tanpa miristisin sebagai antidepresan dan menjadi kebaruan dari penelitian. Dalam penelitian ini digunakan 6 kelompok hewan uji yaitu kelompok kontrol normal, kontrol positif, kontrol negatif, dosis 5; 10; 20 mg/kgBB dan menggunakan metode open field test, forced swimming test dan tail suspension test. Analisis data normalitas menggunakan Shapiro Wilk setelah itu akan dilanjutkan melihat perbedaan signifikan dengan One Way ANOVA. Hasil penelitian menunjukkan minyak atsiri pala tanpa miristisin tidak memiliki aktivitas antidepresan yang dilihat pada parameter penurunan immobility time dan peningkatan lokomotor. Hasil analisis menggunakan post hoc  LSD menunjukkan tidak ada kelompok yang berbeda secara signifikan saat dibandingkan dengan kontrol positif amitriptilin 3,25 mg/KgBB sig. p(<0,05).
Microencapsulation of Phycocyanin from Spirulina platensis by Freeze-Drying: Optimization of Maltodextrin–Soy Protein Matrices for Enhanced Stability and Antioxidant Functionality Dian Marlina; Ryan Werytama Saputra; Takad Bagas Aji Prasetyo; Hery Muhamad Ansory; Siti Aisiyah; Desi Purwaningsih
Advance Sustainable Science Engineering and Technology Vol. 8 No. 2 (2026): February-April
Publisher : Science and Technology Research Centre Universitas PGRI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26877/asset.v8i2.2726

Abstract

Phycocyanin, a natural blue pigment from Spirulina platensis, exhibits strong antioxidant activity but is highly unstable under light, heat, and pH variations, limiting its practical applications. This experimental study addresses the lack of systematic optimization data on maltodextrin–soy protein isolate (SPI) wall matrices for phycocyanin microencapsulation via freeze-drying. Phycocyanin was extracted using phosphate buffer and encapsulated at different maltodextrin:SPI ratios (9:1, 8:2, and 7:3). Each formulation was analyzed in triplicate (n = 3) for encapsulation efficiency (EE), phycocyanin retention, moisture content, particle size, and antioxidant activity (DPPH assay). The 8:2 ratio exhibited the best performance with EE of 88.5%, phycocyanin content of 0.710 mg·mL⁻¹, and particle size of 70.2 µm. Moderate antioxidant activity was observed (IC₅₀ = 102.29 ppm). ANOVA confirmed that the polymer ratio significantly affected all parameters (p < 0.05). Overall, the optimized maltodextrin–SPI microcapsules enhanced the stability and antioxidant functionality of phycocyanin under laboratory conditions, supporting their potential application as bioactive ingredients in functional food and pharmaceutical formulations.
Formulation and Characterization of Myricetin Solid Lipid Nanoparticles (SLNs) via Ultrasonication Method Dewi Zulfa Rosida; Muhammad Dzakwan; Hery Muhamad Ansory
Open Access Health Scientific Journal Vol. 7 No. 2 (2026): August 2026
Publisher : Griya Eka Sejahtera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55700/oahsj.v7i2.235

Abstract

Background: Myricetin is a flavonol flavonoid with promising neuroprotective and antioxidant activities. However, its therapeutic application is severely limited by poor water solubility and a low dissolution rate. This study aimed to enhance the solubility and formulation stability of myricetin by developing a Solid Lipid Nanoparticle (SLN) delivery system.Methods: Myricetin-SLNs were prepared via the ultrasonication method using Tween 80 as a nonionic surfactant. Lipid screening was conducted using Imwitor 491, Dynasan 118, and Apifil at concentrations of 2%, 4%, and 6%. The selected lipid (Apifil at 2%, 3%, 4%, and 5%) was melted at 100 °C, homogenized with the aqueous phase using a magnetic stirrer at 2000 rpm for 1 hour, cooled to 35 °C, and subjected to probe ultrasonication at 35 kHz for 5 minutes. The SLNs were characterized using a particle size analyzer and a UV-Vis spectrophotometer to evaluate storage stability, particle size, polydispersity index (PDI), entrapment efficiency, zeta potential, and DPPH free radical scavenging activity.Results: Lipid screening revealed that Apifil-based formulations provided superior physical stability compared to Imwitor 491 and Dynasan 118. The optimized formulation, F7 (containing 2% Apifil), yielded the smallest particle size of 105.5±0.70 nm, a highly homogeneous PDI of 0.232, a zeta potential of -20.52 mV, and the highest entrapment efficiency at 73.56%. Furthermore, F7 demonstrated strong antioxidant activity with an IC50 value of 38.77 ppm, compared to pure myricetin (14.44 ppm).Conclusion: The formulation of myricetin into Solid Lipid Nanoparticles using 2% Apifil via ultrasonication effectively minimizes particle size and maximizes entrapment efficiency. Although it exhibits lower long-term storage stability at room temperature, it successfully preserves potent antioxidant activity, offering a promising approach for health sciences and advanced drug delivery applications
Co-Authors Afif Meilana Sindani Putri Ahmad Ferdinansyah Rafsanjani Alfian Bagas Pratama Anita Nilawati Argo Khoirul Anas Bambang Purwono Desi Purwaningsih Detyari Faza Auliya Dewi Zulfa Rosida Ghani Abhi Majid Hafidh Al Azzhar Hardjono Sastrohamidjojo Ika Nur Fitriani Ika Nur Fitriani Inaratul Rizkhy Hanifah Ines Tri Hastuti Keswara, Yane Dila Laksmiari Sekar Nirwani Mardiyono Mardiyono Marlina, Dian Mira Dia Nofia Muhammad Dzakwan Nilawati, Anita Nur &#039;Aini Hidayah Nur ‘Aini Hidayah Nur ‘Aini Hidayah Nuraini Harmastuti Nuraini Harmastuti Nurrohmah Dwi Mahesti Nurrohmah Dwi Mahesti Petrick Gilang Pambudi Prietta Khania Kusuma Putri Prietta Khania Kusuma Putri Prietta Khania Kusuma Putri Putri, Clara Prasidya Maharani Rina Herowati Rinda Binugraheni, Rinda Ryan Werytama Saputra Sasqia Indri Maharani Siti Aisiyah Suhartinah Suhartinah Suhartinah Takad Bagas Aji Prasetyo Tiara Dwi Ayunani Wangu, Chelsy Fauziah Windia Wulantika