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All Journal Klinikal Sains (Jurnal Analis Kesehatan) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Ira Pangesti
Program Studi Sarjana Terapan Teknologi Laboratorium Medis, Fakultas Farmasi, Sains dan Teknologi, Universitas Al-Irsyad Cilacap
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology

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Uji Aktivitas Antibiofilm Ekstrak Daun Binahoang (A. Cordifolia) Terhadap Bakteri Staphylococcus Aureus Niki Vina Ngaeni; Yusuf Eko Nugroho; Ira Pangesti
Klinikal Sains : Jurnal Analis Kesehatan Vol. 13 No. 1 (2025): Juni
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikalsains.v13i1.5671

Abstract

One of the natural ingredients that is utilized as a medicinal ingredient is the binahoang plant. Binahoang has roots, leaves, tubers, stems, flowers that contain active compounds namely flavonoids, alkaloids, torpenoids, and saponins. The purpose of this research is to determine whether binahoang leaf extract can inhibit the growth of Staphylococcus aureus bacterial biofilm. The research method used is True Experimental Design. This research design uses Posttest Only Control Deisgn. Where there are three groups, namely the treatment group, positive control group and negative control group. The data obtained will be tested statistically using the JASP v.18 analysis of variance method and followed by the Paired Sample T-test parametric test. The results of this research obtained that binahoang leaf extract is able to inhibit biofilm against Staphylococcus aureus bacteria with an average value in the biofilm formation inhibition activity test in 3 treatments namely 0.372; 0.441; 0.314 and positive control 0.610. So it can be stated that the results of bacterial growth in the treatment have a smaller value than the positive control of tetracycline 0.03 mg/ml. The conclusion of this research is that binahoang (A. cordifolia) leaf extract can inhibit biofilm growth against Staphylococcus aureus bacteria.
POTENSI AKAR BURDOCK SEBAGAI BENTUK PROTEKTIF RADIKAL BEBAS PADA SALURAN PERNAPASAN PEROKOK AKTIF STUDY IN-VIVO PADA TIKUS JANTAN Imam Agus Faizal; Frinsisca Octaviany; Ira Pangesti; Dini Puspodewi; Arina Lis Sa'adah
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2561

Abstract

Exposure to cigarette smoke is known to trigger oxidative stress and trigger an inflammatory response in lung tissue. Lung organs are highly susceptible to damage due to continuous exposure to pollutants, especially free radicals. This condition has the potential to cause pathological changes in the structure of lung cells. This study aimed to evaluate the difference in histological changes in rat lungs between the group not exposed to conventional cigarette smoke (control group) and the group exposed to cigarette smoke accompanied by the administration of burdock root extract, ethanol solvent, methanol, and vitamin E. Exposure was carried out 7 times for 14 days, using one cigarette for each treatment session. The results of the observation showed that all the groups that received exposure had lung tissue damage. Based on the average histopathological score, the rate of lung damage was grouped as follows: K1 (negative control) of 4.6; K2 (positive control) of 7; P1 (treatment with ethanol) of 5.6; P2 (treatment with methanol) of 8.6; and P3 (treatment with vitamin E) by 6.6. The group with the highest level of damage was P2 (methanol) which fell into the severe damage category, while the lowest level of damage was found in P1 (ethanol), which fell into the light category.
Co-Authors Arina Lis Sa'adah Dini Puspodewi Frinsisca Octaviany Imam Agus Faizal Niki Vina Ngaeni Yusuf Eko Nugroho