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All Journal Jurnal Farmasi Sains dan Komunitas JRST (Jurnal Riset Sains dan Teknologi) Indonesian Journal for Health Sciences (IJHS) Jurnal Ilmu Kefarmasian Indonesia Prima Abdika: Jurnal Pengabdian Masyarakat Journal of Fundamental and Applied Pharmaceutical Science Jurnal Locus Penelitian dan Pengabdian JRKN Jurnal Farmasi Indonesia Journal of Urban Health Research BATOBO: Jurnal Pengabdian Kepada Masyarakat Mitramas Jurnal Pengabdian dan Pemberdayaan Masyarakat Mitramas Jurnal Pengabdian dan Pemberdayaan Masyarakat

Pretty Falena Atmanda Kambira

Department Of Pharmacy, School Of Medicine And Health Sciences, Atma Jaya Catholic University Of Indonesia

Author-ID : 10705732

Aerospace Engineering Arts Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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PENGUJIAN AKTIVITAS ANTIOKSIDAN MAKRO ALGA SUMBAWA DALAM HUBUNGANNYA DENGAN KANDUNGAN SENYAWA BIOAKTIF DAN EFEK FARMAKOLOGI Erlia Anggrainy Sianipar; Natasha Satriawan; Juliana Sumartono; Pretty Falena Atmanda Kambira
Jurnal Riset Kesehatan Nasional Vol. 6 No. 2 (2022)
Publisher : Institute Teknologi dan Kesehatan (ITEKES) Bali

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37294/jrkn.v6i2.457

Abstract A popular natural resource of Sumbawa Island is macroalgae. Chlorophyta, Phaeophyta, and Rhodophyta are types of macroalgae that have been cultivated and utilized by the local community. However, its potential to treat many diseases is still under-explored. Based on the content of bioactive compounds, macroalgae is believed to have antioxidant activity that could scavenge free radicals and thus potentially prevent and treat various diseases caused by excessive free radicals. This study aimed to analyze the antioxidant activity of Sumbawa macroalgae in various solvent fractions. Samples were macerated in n-hexane, ethyl acetate, and ethanol solvents. Antioxidant activity was tested using 1,1-Diphenyl-2-picryl Hydrazil (DPPH) method and ascorbic acid as a positive control. The percentage yield of extracts from various solvent fractions varied between 0.25% to 0.62%. The result of antioxidant activity testing showed that the IC50 (Inhibition Concentration) value of macroalgae extract was moderate to weak in the range of 108.1 ± 1.068 to 665.2 ± 0.479 g/mL and positive control was 6.156 ug/mL ±0.563g/mL. The relationship between antioxidant activity and the content of bioactive compounds and their pharmacological effects were discussed in this study. This study concluded that the ethyl acetate fraction of macroalgae had higher antioxidant activity than the n-hexane and ethanol fractions. Further analysis was needed to determine the composition of the bioactive compounds and identify their pharmacological effects at the molecular level. Keywords: Macroalgae, antioxidant, Sumbawa, bioactive compounds, pharmacological effects Abstrak Sumber daya alam yang populer di Pulau Sumbawa adalah makroalga. Chlorophyta, Phaeophyta dan Rhodophyta merupakan jenis makroalga yang telah dibudidayakan dan dimanfaatkan oleh masyarakat setempat. Namun, potensinya dalam hal pengobatan penyakit masih kurang tereksplorasi. Berdasarkan kandungan senyawa bioaktifnya, makroalga diyakini memiliki aktivitas antioksidan yang dapat menangkap radikal bebas sehingga berpotensi mencegah dan mengobati berbagai penyakit akibat radikal bebas yang berlebihan. Penelitian ini bertujuan untuk menganalisis aktivitas antioksidan makroalga Sumbawa dalam berbagai fraksi pelarut. Sampel dimaserasi dalam pelarut n-heksan, etil asetat, dan etanol. Aktivitas antioksidan diuji dengan metode 1,1-Diphenyl-2-picryl Hydrazil (DPPH) dan asam askorbat sebagai kontrol positif. Hasil persentase rendemen ekstrak dari berbagai fraksi pelarut cukup bervariasi berkisar antara 0,25% hingga 0,62%. Hasil pengujian aktivitas antioksidan menunjukkan nilai IC50 (Inhibition Concentration) ekstrak makroalga tergolong sedang hingga lemah yang berada dalam rentang 108,1 ± 1,068 hingga 665,2 ± 0,479 µg/mL dan kontrol positif sebesar 6,156 ug/mL ±0,563g/mL. Hubungan aktivitas antioksidan dengan kandungan senyawa bioaktif dan efek farmakologinya dibahas dalam penelitian ini. Penelitian ini menyimpulkan bahwa fraksi etil asetat makroalga memiliki aktivitas antioksidan yang lebih tinggi dibandingkan fraksi n-heksan dan etanol. Analisis lebih lanjut diperlukan untuk mengetahui komposisi senyawa bioaktif dan mengidentifikasi efek farmakologinya pada tingkat molekuler. Kata Kunci: Makroalga, Antioksidan, Sumbawa, Senyawa Bioaktif, Efek farmakologi

COMBINATION UV-VIS SPECTROSCOPY AND PARTIAL LEAST SQUARE FOR DETECTING ADULTERATION PARACETAMOL AND PIROXICAM IN TRADITIONAL MEDICINES Pretty Falena Atmanda Kambira; Dion Notario; Untung Gunawan; Sherina Dhamayanti; Raymunanda Widya Kimla Ningrum; Sondang G.O. Ambarita; Grafty Polin
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 17, No 1 (2020)
Publisher : Sanata Dharma University

An analytical method based on combination UV-Vis spectroscopy and chemometric was developed for detecting commonly listed adulterants such as paracetamol and piroxicam simultaneously in traditional medicines. No complex sample preparation and separation are required except grinding, dissolving, and filtering. The spectral interferences were resolved by multivariate techniques. Wavelengths selection and number of components optimization were performed by a combination of Genetic Algorithm and Partial Least Square (GA-PLS) followed by backward elimination through Jack-Knife Partial Least Square Regression (JK-PLSR). The capability PLSR model for quantitative analysis was assessed from the coefficient of determination (R2) and root mean square of error prediction/cross-validation (RMSEP/RMSECV) dan predicted residual sum of square (PRESS). Classification performance of PLS Discriminant Analysis (PLS-DA) was evaluated from the area under the receiver operating characteristic curve (AUROCC). For ensuring the sensitivity of the method, the detection limits from the two pseudo-univariate lines were estimated. The R2, RMSEP, RMSECV, AUROCC, and detection limit obtained from the selected models of paracetamol and piroxicam were 0.999, 0.25 mg/L, 0.15 mg/L, 100%, and 0.4 mg/L respectively. Therefore, the proposed method is suitable for the rapid screening of adulterated herbal medicine.

Aktivitas antibakteri dan antivirus dari minyak kayu putih: Sistematik review Pretty Falena Atmanda Kambira; Merry Liliana; Laurentine Belinda Arfenda; Sherleen Marcella
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 12 No. 2 (2020): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Tujuan: Eucalyptus sp. adalah anggota keluarga Myrtaceae, dan minyaknya telah digunakan secara komersial dalam industri makanan, kosmetik, dan sediaan farmasi. Ketenaran minyak kayu putih naik selama pandemi COVID-19 karena beberapa klaim memiliki aktivitas antivirus terhadap virus corona (1). Namun demikian, klaim ini tidak terbukti secara ilmiah dan dapat menimbulkan misinformasi kepada publik. Minyak kayu putih diketahui memiliki aktivitas antibakteri terhadap bakteri gram positif dan gram negatif (2). Namun, sejauh mana efektivitasnya hampir tidak diketahui. Oleh karena itu, penelitian ini bertujuan untuk menilai aktivitas antibakteri dan antivirus minyak kayu putih menggunakan tinjauan sistematis Cochrane. Metode: Studi yang termasuk dalam tinjauan sistematis diambil dari database PubMed dan Science Direct. Kata kunci pencarian adalah ("Eucalyptus oil" OR "Eucalyptol") AND ("Antibacterial" OR "Antiviral" OR "MIC"). Hasil: Ada 114 artikel yang diidentifikasi dari strategi pencarian, dan tambahan empat artikel ditemukan dari sitasi. Setelah duplikasi, 83 artikel tersisa. Namun, 61 artikel dikeluarkan karena tidak melaporkan aktivitas antimikroba dari minyak kayu putih. Dua puluh dua artikel diskrinig pembacaan teks lengkap, dan enam belas dikeluarkan karena tidak memenuhi kriteria inklusi. Akhirnya, enam belas artikel dimasukkan dalam sistematik review ini. Kesimpulan: Minyak kayu putih memiliki aktivitas antibakteri dan antivirus yang bergantung pada komposisi kimia dan strain mikroba. Oleh karena itu, menjadikannya kandidat unggulan sebagai senyawa antimikroba dan desinfektan. Namun, studi klinis masa depan tentang mekanisme kerjanya diperlukan.

Formulation of Hairspray from Cherry Leaves (Muntingia calabura L.) with Antimicrobial Properties Reynelda Juliani Sagala; Pretty Falena Atmanda Kambira; Karmil Tri Nanda
Journal of Urban Health Research Vol. 1 No. 2 (2023): Journal of Urban Health Research
Publisher : School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/juhr.v1i2.4286

Introduction: Indonesia is a tropical country with high temperatures and humidity. Poor personal hygiene can trigger bacteria to grow and multiply. According to research, bacteria that are usually found in skin and hair including Staphylococcus aureus (37%), followed by Escherichia coli (17%). Use of antibacterial hairspray is expected to inhibit the growth of pathogenic bacteria on the surface of the scalp and hair. Using natural ingredients, i.e., cherry (Muntingia calabura L.) leaves, in the form of antibacterial hairspray preparations, is expected not to irritate the scalp, be more eco-friendly, and the raw materials are easily obtained. Methods: The preparation of cherry (Muntingia calabura L.) leaves extract was carried out by maceration method with 70% ethanol (simplisia : solvent = 1:10). Furthermore, the extract was then evaluated for phytochemical content, formulation optimization, and antibacterial activity. Afterward, formulation and preparation, and lastly, its evaluation in the form of an organoleptic test, pH test, viscosity test, homogeneity test, spreadability test, adhesion test, and product stability test. Results: The results of phytochemical screening of flavonoid compounds and tannins from cherry (Muntingia calabura L.) leaves extract resulted in a positive reaction. The minimum inhibitory level of cherry (Muntingia calabura L.) leaves extract against Staphylococcus aureus and Escherichia coli bacteria was 40 mg/ml. Cherry (Muntingia calabura L.) leaves extract was then formulated into hairspray dosage forms with different concentrations of extract in Formula A (0.1%), Formula B (0.3%), and Formula C (0.5%). Conclusions: The hairspray formula that had the best stability after passing the freeze-thaw cycling test and physical evaluation of the preparation during storage for 28 days was Formula C. The parameters of the observed hairspray were organoleptic, pH, homogeneity, viscosity, spreadability, and adhesion. Keywords: Hairspray - Cherry Leaves – Stability - Antibacterial

The Effects of Heating Temperatures on Passion Fruit Juice's Ascorbic Acid and Total Phenol Levels Siswandi, Alodia Jeconiah; Prismawan, Deka; Kambira, Pretty Falena Atmanda
Journal of Fundamental and Applied Pharmaceutical Science Vol 4, No 1 (2023): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i1.18648

The Passiflora edulis f. flavicarpa, a yellow passion fruit, is known for its distinctive aroma and tart flavor. The pulp of the yellow passion fruit can be used to make tea, jam, and syrup commercially. Commercial items are processed using oven heating, which involves prolonged exposure to high temperatures. As a result, fruit content, particularly water content, may alter. The benefit of reducing the water content is that less microbial growth medium means the product has a longer shelf life. However, fruit flesh’s nutritional composition will also change due to the ascorbic acid and phenolic compounds' thermolability and other factors. In this study, the yellow passion fruit pulp juice is heated in a controlled manner at 60°C, 70°C, and 80°C for 7 hours using an oven. The purpose is to assess changes in the amounts of ascorbic acid and total phenol that occurred. A paired T-test was used to assess the association between weight loss, ascorbic acid levels, and phenolic levels in the control and treatment groups. The amount of ascorbic acid was determined using the 2.6 dichloroindophenol titrimetry method, and the amount of phenol was determined using the Folin-Cioceltau method and UV-Vis spectrophotometry. According to this study, increasing the temperature to 60 °C or 80 °C significantly reduces weight and ascorbic acid levels. Also, the heating temperature unaffected the amount of phenol in each group.

Review Waktu Larut Mempengaruhi Kualitas Tablet Effervescent Sediaan Herbal Sagala, Reynelda Juliani; Rachmawati, Putriana; Kambira, Pretty F.A
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 13 No 2 (2021): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

The effervescent tablet is an alternative dosage form to deliver the active pharmaceutical ingredients or natural products for therapeutic effects. Moreover, this dosage form is also used in the food industry for nutritional drinks. The tablet is preferred because of its practicality, improve water solubility, refreshing taste, and more easily absorbed than the conventional tablet. Tablet’s water dissolving time in the medium will affect the rate and amount of active ingredients. The disintegrating time of effervescent tablets is affected by the concentration of both acid and base elements, the tablet binder’s concentration (PVP), the interaction between citric acid and tartaric acid, and the concentration of the base element, the water content over the tablet, and the lubricant’s variation. The acid will affect the disintegration time however its imbalance will decrease the freshness. Therefore, an optimal balance of the base and acid element is required to make an effervescent tablet with a good disintegration time and an appropriate refreshing taste.

A A LITERATURE REVIEW OF HERBAL SUNSCREEN’S DOSAGE FORM AND SPF VALUE CLAIM Rachmawati, Putriana; Sagala, Reynelda Juliani; Kambira, Pretty Falena Atmanda
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 13 No 1 (2021): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

The Indonesian government recommended sunbathing for 15 to 30 minutes in the morning to deal with the Covid-19 pandemic. Exposure to sunlight will activate the formation of vitamin D, which the body needs for defense against Covid-19 infection. However, excessive sun exposure will cause skin problems, including psoriasis, sarcoidosis, sunburn to skin cancer. One of the protections against sun exposure is the use of sunscreen. Sunscreen protects the skin from UV exposure by two mechanisms, namely, absorbing UV rays or reflecting UV rays. Currently, many sunscreens are developed with active substances derived from nature in various dosage forms. Sunscreen protection is stated using a photoprotector claim in the form of an SPF value or other supporting claims. This SPF value can be claimed using in vivo test, which previously could be predicted by on paper and in vitro approaches. Sunscreen safety is carried out by ensuring that the raw materials used comply with the requirements and penetration tests.

EFFECT OF EXTRACTION METHODS ON PHENOLIC CONTENT AND ANTIOXIDANT ACTIVITY OF BAJAKAH ROOT (Spatholobus littoralis) Agustin, Julia Then; Kambira, Pretty Falena Atmanda; Michael, Michael; Prismawan, Deka
Indonesian Journal of Health Science Vol 9 No 2 (2025): September
Publisher : Universitas Muhammadiyah Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24269/ijhs.v9i2.11683

The Bajakah root (Spatholobus littoralis), a native plant of Kalimantan, is recognized for its phenolic content and antioxidant activity. This study aims to compare the effects of three extraction methods—maceration, soxhlet, and reflux—on the total phenolic content and antioxidant activity of Bajakah root extracts. The plant material was extracted using 96% ethanol, followed by phenolic content analysis via the Folin-Ciocalteu method and antioxidant activity evaluation using the DPPH assay. Results revealed that the reflux method produced the highest phenolic content (17.6 ± 0.1 mg GAE/g extract) and the strongest antioxidant activity (IC50 of 26 ± 1 µg/mL). The soxhlet method yielded a phenolic content of 17.4 ± 0.2 mg GAE/g extract with an IC50 of 30 ± 0 µg/mL, while maceration resulted in the lowest phenolic content (14.6 ± 0.7 mg GAE/g extract) and an IC50 of 34 ± 2 µg/mL. The heating processes involved in the reflux and Soxhlet methods likely facilitated the degradation of glycosides, thereby enhancing phenolic content. All methods demonstrated exceptionally strong antioxidant activity (IC50 < 50 µg/mL). This study underscores the significant influence of extraction methods on the phenolic quality and antioxidant capacity of Bajakah root extracts.

Peningkatan Pengetahuan Kesehatan Kulit pada Siswa SMA Methodist Jakarta Utara Melalui Kegiatan Promosi Kesehatan Kambira, Pretty Falena Atmanda; Khosasi, Vanescia; Juwono, Jennifer; Yen, Yen; Meliana, Fransisca Novi; Limardi, Franca Claudia; Fernandes, Febri Dansen
Mitramas: Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol. 2 No. 1 (2024)
Publisher : Universitas Katolik Indonesia Atma Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/mitramas.v2i1.5100

Kegiatan promosi kesehatan kulit pada siswa SMA Methodist, Jakarta Utara yang dilaksanakan pada tanggal 20 Juli 2023 berhasil meningkatkan pengetahuan siswa tentang kesehatan kulit. Hal ini terlihat dari peningkatan nilai rata-rata pengetahuan siswa dari 4,42 menjadi 9,49. Kegiatan ini juga mendapatkan umpan balik yang sangat baik dari peserta. Secara keseluruhan, 95,16% peserta menyatakan puas dengan kegiatan ini. Kegiatan ini menggunakan metode ceramah, workshop, dan pemberian flyer. Ceramah disampaikan oleh dosen farmasi dari Universitas Katolik Indonesia Atma Jaya, sedangkan workshop pembuatan masker peel-off dipandu oleh mahasiswa/i program studi Farmasi, FKIK Universitas Katolik Indonesia Atma Jaya. Flyer kesehatan kulit yang disusun secara sistematis, singkat, dan padat juga diberikan kepada peserta. Selain itu, kegiatan ini juga menghasilkan satu series video edukasi dengan topik ‘Perawatan Kulit Wajah’ yang terdiri dari tiga video pendek berdurasi tidak lebih dari 4 menit. Ketiga video ini diunggah di platform media sosial Instagram agar dapat menjangkau masyarakat yang lebih luas tidak hanya peserta seminar dan workshop. Kegiatan promosi kesehatan kulit ini diharapkan dapat meningkatkan kesadaran masyarakat, khususnya remaja, tentang pentingnya perawatan kulit yang aman dan sesuai dengan kebutuhan kulit.

Jeruk Nipis Sebagai Tanaman Obat Keluarga (TOGA) untuk Swamedikasi dan Peningkatan Kesejahteraan di Desa Wates Jaya Kambira, Pretty Falena; Tatsbita, Masyitha; Margaretha, Louisa; Buyung, Angeline L.; Aurelia, Cindy; Panjaitan, Sarah L.
Mitramas: Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol. 2 No. 2 (2024)
Publisher : Universitas Katolik Indonesia Atma Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/mitramas.v2i2.5594

Kegiatan pengabdian masyarakat berupa workshop budidaya dan pemanfaatan jeruk nipis sebagai Tanaman Obat Keluarga (TOGA) telah berhasil meningkatkan pengetahuan anggota Kelompok Wanita Tani (KWT) di Desa Wisata Wates Jaya, Bogor. Desa ini, yang terletak di lereng Gunung Pangrango, memiliki potensi pertanian yang belum dimanfaatkan secara optimal. Jeruk nipis dipilih sebagai fokus kegiatan karena manfaatnya bagi kesehatan, potensi ekonominya, dan kemudahan budidayanya di lahan terbatas. Kegiatan ini melibatkan 21 anggota KWT dan mencakup materi komprehensif tentang manfaat kesehatan, aplikasi industri, potensi ekonomi, dan teknik budidaya jeruk nipis, termasuk pembibitan, penanaman, dan perawatan tanaman. Hasil evaluasi menunjukkan peningkatan pengetahuan peserta, terutama terkait teknik budidaya. Pemberian bibit jeruk nipis diharapkan dapat menjadi stimulus bagi anggota KWT untuk memulai budidaya secara mandiri, meningkatkan pendapatan ekonomi, dan memperbaiki kesehatan keluarga. Dukungan berkelanjutan, pelatihan lanjutan, dan pengembangan produk olahan jeruk nipis menjadi rekomendasi untuk keberlanjutan program ini, sehingga dapat memberikan dampak positif yang lebih luas bagi masyarakat desa.

Co-Authors Agustin, Julia Then Aurelia, Cindy Auren Liu Brian Tinanto Buyung, Angeline L. Deka Prismawan Dion Notario Dwi Arymbhi Sanjaya Erlia Anggrainy Sianipar Fernandes, Febri Dansen Grafty Polin Gwyneth Yovela Gunawan Irawan, Alvin Juliana Sumartono Juwono, Jennifer Karmil Tri Nanda Khosasi, Vanescia Lapian, Kristin Fransiska Laurentine Belinda Arfenda Limardi, Franca Claudia Lusy Noviani Margaretha, Louisa Mathias Lourdion Kusnaman Meliana, Fransisca Novi Merry Liliana Michael Michael Michael Michael Natasha Satriawan Ni Kadek Refi Mariska Panjaitan, Sarah L. Putriana Rachmawati Raymunanda Widya Kimla Ningrum Reynelda Juliani Sagala Sherina Dhamayanti Sherleen Marcella Siswandi, Alodia Jeconiah Sondang G.O. Ambarita Tatsbita, Masyitha Untung Gunawan Yen Yen Yohanes Eko Adi Prasetyanto

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