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All Journal e-Journal Pustaka Kesehatan STOMATOGNATIC- Jurnal Kedokteran Gigi SOSIOLOGI NUSANTARA UNEJ e-Proceeding Dental Journal (Majalah Kedokteran Gigi) Journal Of Vocational Health Studies Majalah Biomorfologi (Biomorphology Journal) Denta: Jurnal Kedokteran Gigi Cakradonya Dental Journal
Atik Kurniawati
Department Of Oral Biology, Faculty Of Dentistry, Universitas Jember
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Library & Information Science Medicine & Pharmacology Neuroscience Public Health Social Sciences

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MINIMUM INHIBITORY CONCENTRATION OF PURPLE LEAF EXTRACT (GRAPTOPHYLLUM PICTUM L. GRIFF) AGAINST LACTOBACILLUS ACIDOPHILUS ATCC 4356 Indriyani Chusnadia, Shafira; Kurniawati, Atik; Setyaningsih, Sari; Wulandari, Erawati; Astuti, Pudji
Journal of Vocational Health Studies Vol. 7 No. 2 (2023): November 2023 | JOURNAL OF VOCATIONAL HEALTH STUDIES
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jvhs.V7.I2.2023.115-120

Abstract

Background: Dental caries is an oral cavity disease that affects most Indonesians. Lactobacillus acidophilus (L. acidophilus) is one of the bacteria that causes dental caries. Control of bacteria in the form of antibacterial agents is needed to suppress the growth of L. acidophilus. Purple leaves (Graptophyllum pictum L. Griff) are a medicinal plant with antibacterial compounds, namely flavonoids, alkaloids, saponins, and tannins. Purpose: Determine the Minimum Inhibitory Concentration (MIC) of purple leaves extract on the growth of L. acidophilus. Method: The sample consisted of seven groups, including positive control (chlorhexidine 0.2%), negative control (BHI-B), and purple leaves extract with concentrations of 25%, 12.5%, 6.25%, 3.12%, and 1.56%. The antibacterial activity of purple leaves extract was carried out quantitatively using a spectrophotometer with a wavelength of 600 nm. After that, it was incubated at 37°C for 48 hours, followed by absorbance measurement. The absorbance results were then analyzed using the Paired T-Test (before and after incubation). Result: Purple leaves extract concentrations of 6.25%, 12.5%, and 25% had an inhibitory effect on L. acidophillus. Conclusion: Minimum Inhibitory Concentration (MIC) of purple leaves extract on the growth of L. acidophilus was 6.25%
POTENSI EKSTRAK DAUN UNGU DALAM MENURUNKAN JUMLAH SEL OSTEOKLAS TIKUS YANG DIINDUKSI PORPHYROMONAS GINGIVALIS Atik Kurniawati; Melok Aris Wahyukundari; Syafira Dwi Astuti
Cakradonya Dental Journal Vol 12, No 2 (2020): Agustus 2020
Publisher : FKG Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/cdj.v12i2.18436

Abstract

Periodontitis merupakan penyakit inflamasi pada jaringan periodontal. Porphyromonas gingivalis merupakan salah satu bakteri patogen pemicu periodontitis. Respons awal inflamasi dipicu oleh faktor virulen P.gingivalis antara lain lipopolisakarida (LPS) yang berlanjut pada kerusakan ligamen periodontal sehingga memicu resorpsi tulang alveolar yang diperankan oleh sel osteoklas. Ekstrak daun ungu (Graptophyllum pictum L. Griff) diketahui dapat menghambat P.gingivalis secara in vitro, namun kemampuannya sebagai antiinflamasi dalam menurunkan jumlah sel osteoklas pada kejadian periodontitis belum diketahui. Penelitian ini bertujuan untuk mengevaluasi potensi ekstrak daun ungu (EDU) dalam menurunkan jumlah sel osteoklas pada tikus wistar yang diinfeksi dengan P.gingivalis. Penelitian dilakukan pada tikus wistar yang terdiri atas 6 kelompok. Masing-masing kelompok terdiri dari 5 tikus wistar. Enam kelompok yang terdiri dari kelompok normal (KN): tanpa perlakuan, kelompok kontrol negatif (K-): diinfeksi P.gingivalis (Pg), kelompok kontrol positif (K+): Pg + Tantum Verde, dan 3 kelompok perlakuan yaitu: KP2,5% (Pg + EDU 2,5%), KP5% (Pg + EDU 5%) serta KP10% (Pg + EDU10%). Pemeriksaan histologi dengan pengecatan Haematoxylin-Eosin (HE), jumlah sel osteoklas pada jaringan gingiva, ditentukan dengan menghitung jumlah rata-rata dari 3 lapang pandang tiap potongan jaringan. Analisis data dengan One Way Anova dilanjutkan LSD. Kesimpulan penelitian ini adalah ekstrak daun ungu berpotensi menurunkan jumlah sel osteoklas pada jaringan gingiva tikus wistar (p0,05).
PERAN EKSTRAK DAUN WUNGU (GRAPTOPHYLLUM PICTUM L. GRIFF) TERHADAP ADHESI STREPTOCOCCUS MUTANS PADA NEUTROFIL Atik Kurniawati; Sulistiyani -; Arina Nur Rahmah
Cakradonya Dental Journal Vol 11, No 2 (2019): Agustus 2019
Publisher : FKG Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/cdj.v11i2.16156

Abstract

Streptococcus mutans (S. mutans) merupakan bakteri utama penyebab karies gigi yang mampu mendemineralisasi email, menginvasi dentin yang dapat berlanjut menjadi inflamasi pulpa (pulpitis). Streptococcus mutans menginvasi inang diawali dengan melakukan adhesi (perlekatan). Proses ini merupakan langkah awal dalam proses inflamasi. Oleh karena itu, adhesi Streptococcus. mutans pada sel inang perlu dicegah agar tidak terjadi infeksi oleh bakteri. Neutrofil merupakan sel pertahanan pertama yang datang pada proses inflamasi. Salah satu upaya untuk mencegah terjadinya adhesi tersebut bisa menggunakan bahan alami yang bersifat anti-inflamasi, salah satunya yaitu daun wungu. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak daun wungu (EDW) terhadap adhesi bakteri Streptococcus. mutans pada neutrofil dan perbedaan indeks adhesi dalam berbagai konsentrasi dengan eksperimental laboratoris menggunakan the post test only control group design. Sampel terbagi menjadi 5 kelompok (klp): klp I/kontrol (tanpa inkubasi EDW), klp II (EDW 3,125%), klp III (EDW 6,25%), klp IV (EDW 12,5%), dan klp V (EDW 25%). Isolat neutrofil diinkubasi dengan EDW selama 3 jam, kemudian dipapar S. mutans selama 4 jam. Indeks adhesi dihitung berapa rata-rata jumlah S. mutans yang menempel pada 100 neutrofil. Simpulan penelitian menunjukkan bahwa ekstrak etanol daun wungu berpotensi menurunkan indeks adhesi Streptococcus mutans. Kata kunci: adhesi, S. mutans, neutrophil, daun wungu
Efektivitas Ekstrak Biji Kakao (Theobroma Cacao L.) terhadap Penyembuhan Luka Pencabutan Gigi pada Sel Makrofag Atik Kurniawati; Zainul Cholid; Melati Harum Pertiwi
Denta Journal Kedokteran Gigi Vol 13 No 2 (2019): Agustus
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

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Abstract

Background: Tooth extraction is a choice procedure that is often carried out in the field of dentistry. Tooth extraction can cause a cavity in the form of a tooth socket and tooth extraction wounds on the tissue around the socket followed by the body's response through wound healing. One of the process of wound healing namely the inflammatory phase. Macrophages are the most dominant cells in inflammation with the highest number on days 2 to 3. Polyphenols in cocoa beans have an active compound in the form of anti-inflammatory and antioxidants that are effective in accelerating the healing of wounds. Purpose: To determine the effect of giving the cocoa bean extract gel to the number of macrophage cells in the socket after tooth extraction male wistar rat on the 1st, 3th and 5th day. Material and method: This type of research is experimental laboratories. The samples used were 24 male Wistar rats which were then divided into 2 groups, namely the control group (sockets not given any treatment) and treatment groups (sockets were given 8% cocoa bean extract) on the 1st, 3th and 5th day post tooth extraction will be carried out decaputation. Results: The 8% cocoa bean extract gel had the potential to influence the number of macrophage cells in the socket after the tooth extraction of male Wistar rat on the 1st, 3th and 5th day caused an active compound in the cocoa Conclusions: the most effectiveness of the cocoa bean extract gel toward tooth extraction healing on the number of macrophage cells on the 3ath day
The Influence of Ethanol Extract Graptophyllum pictum L. Griff toward Phagocytic Activity of Monocyte Exposed by Candida albicans Atik Kurniawati
Denta Journal Kedokteran Gigi Vol 12 No 2 (2018): Agustus
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

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Abstract

Background: Candidiasis is one of oral infectious disease caused by Candida albicans.The role of C. albicans as pathogen opportunistic in oral infection can affected by immune system. Phagocytosis has contributed in immune system against C. albicans infection, which is the role of monocytes. Grapthophyllum L. Griff has been proved to increase macrophage’s phagocytic activity, but the effect of violet leaves ethanol extract (EEDU) to increase monocyte’s phagocytic activity on C. albicans is unknown. Objectives: To determine the effect of violet leaves extract on monocyte’s phagocytic activity on C. albicans. Methods: This research was acted in vitro on human monocyte cell culture. There was 5 groups: negative control group, positive control group (incubated in Isoprinosine) and treatment groups was incubated in EEDU 2,5%, 5%, 10%. The percentage of activated monocytes was counted. Result: The result showed that incubation of EEDU 2,5%, 5% and 10% could increase monocyte’s phagocytic activity significantly (p<0,05) compared to control groups. The number of monocyte’s phagocytosis on C. albicans incubated with EEDU 2,5%, 5% and 10% is 65%, 60,5%, and 58,75%. The optimal concentration of EEDU to increase monocyte’s phagocytic activity was 2,5%. Conclusion: The study showed that EEDU can increase monocyte’s phagocytic activity on C. albicans.
Peran Perempuan dalam Pembangunan Daerah di Kalurahan Dadapayu, Kapanewon Semanu, Kabupaten Gunungkidul, Provinsi Daerah Istimewa Yogyakarta, Indonesia: Peran Perempuan dalam Pembangunan Daerah di Kalurahan Dadapayu, Kapanewon Semanu, Kabupaten Gunungkidul, Provinsi Daerah Istimewa Yogyakarta, Indonesia Marista Christina Shally Kabelen; Meila Riska Fitri; Atik Kurniawati
Jurnal Sosiologi Nusantara Vol 10 No 1 (2024)
Publisher : UNIB Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/jsn.10.1.188-203

Abstract

This research discusses the development of the role of women in the public domain, particularly in village governance in Kalurahan Dadapayu, Kapanewon Semanu, Gunungkidul Regency. The current development of women's roles not only involves dual roles within the household and workplace but also encompasses multiple roles within society, which is an evolving aspect consistently linked to gender equality issues. The aim of this study is to describe the enhancement of women's roles and the development of gender equality in the roles of women in Kalurahan Dadapayu. Additionally, challenges and efforts to strengthen women's presence are also examined in this research. There has been a lot of research conducted that examines gender and patriarchal culture, but the relationship to the role of women in the public sphere is an interesting thing in this research. The research employs a descriptive research method, with sample data selection carried out through purposive sampling. The research findings conclude that there has been progress in empowering women and their roles in public development. Some women have taken on strategic roles, and there are provisions supporting decision-making. Gender equality has been adequately accommodated through the division of domestic roles between spouses in all the sources interviewed.
EFFECTS OF PURPLE LEAF EXTRACT ON NEUTROPHILS AND MACROPHAGES IN TOOTH EXTRACTION WOUNDS Atik Kurniawati; Zainul Cholid; Budi Yuwono; Nadie Fatimatuzzahro; Putri Fajrin Widyatami; Neriza Ayuni Sunaryo
Journal of Vocational Health Studies Vol. 10 No. 1 (2026): July 2026 | JOURNAL OF VOCATIONAL HEALTH STUDIES
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jvhs.V10.I1.2026.47-55

Abstract

Background: Tooth extraction induces trauma to the tissue and triggers an inflammatory response as part of the wound healing process. The early inflammatory phase is characterized by the accumulation of neutrophils and macrophages at the wound site. A prolonged inflammatory phase can result in excessive tissue damage. The purple leaf (Graptophyllum pictum L.Griff) extract (PLE) has been suggested to possess anti-inflammatory properties. Purpose: This study aims to analyze the effect of PLE on the number of neutrophils and macrophages in tooth extraction wounds. Method: This study employed a laboratory experimental design using a Post-Test-Only Control Group Design. A total of 32 male Wistar rats were divided into four control groups receiving distilled water and four treatment groups receiving 10% PLE administered by nasogastric on days 1, 3, 5, and 7. Following euthanasia, tissue samples were processed and stained using Haematoxylin-eosin. Neutrophils and macrophages were observed and quantified. The data were tabulated and analyzed statistically. Result: There was a significant difference (p-value < 0.05) between the control group and the treatment group. The 10% PLE treatment group showed a lower mean number of neutrophils and a higher mean number of macrophages than the control group on days 1,3,5, and 7. Conclusion: PLE affects the number of neutrophils and macrophages in tooth extraction wounds.
Co-Authors Arina Nur Rahmah Budi Yuwono Budi Yuwono Desy Sofyah Hartina Erawati Wulandari Falah, Pilar Menara Indriyani Chusnadia, Shafira Mangestuti Agil Marista Christina Shally Kabelen Meila Riska Fitri Melati Harum Pertiwi Melok Aris Wahyukundari Nadie Fatimatuzzahro Neriza Ayuni Sunaryo Ni Made Mertaniasih Pertiwi, Melati Harum PUDJI ASTUTI Pudji Astuti Putri Fajrin Widyatami Resti Ayu Indriana Sari Setyaningsih Savira Aulia Rachim Sulistiyani . Syafira Dwi Astuti Yani Corvianindya Rahayu Yudha Nurdian Zainul Cholid Zainul Cholid Zainul Cholid