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All Journal Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan IJOEP : International Journal of Ecophysiology Journal of Pharmaceutical and Sciences. Asian Multidisciplinary Research Journal of Economy and Learning
Meiva Amelia Lubis
Institut Kesehatan Helvetia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Hepatoprotective effects of ethanol extract of mobe leaves/eeml (artocarpus lacucha buch-ham.) against carbon tetrachloride induced hepatotoxicity in rats: English Lubis, Meiva Amelia; Dalimunthe, Aminah; Sitorus, Panal; Satria, Denny
International Journal of Ecophysiology Vol. 6 No. 2 (2024): International Journal of Ecophysiology
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijoep.v6i2.17505

Abstract

This study evaluates the protective effects of ethanol extract of mobe leaves (Artocarpus lacucha Buch-Ham.) on ALT, AST, and bilirubin levels in rats induced with carbon tetrachloride (CCl4) on Liver. The ethanol extract was prepared by maceration using 96% ethanol. Results showed that administering 400 mg/kg BW of the extract significantly reduced total bilirubin, ALT, and AST levels in CCl4-induced rats. Phytochemical screening revealed bioactive compounds like flavonoids, alkaloids, tannins, saponins, triterpenoids, and glycosides, which are potential antioxidants and hepatoprotective agents. The study concludes that mobe leaf extract has potential as a therapeutic agent to protect the liver from toxic damage. The significant contribution of this research is providing a scientific basis for using mobe leaf extract as a natural hepatoprotective agent, highlighting its potential for safe and effective herbal medicine. Further research and clinical trials are recommended.
The Effect of Ethanol Extract of Mobe Leaves (Artocarpus lacucha Buch-Ham.) on Caspase-3 Expression in Liver Tissue Rats Induced by Carbon Tetrachloride: English Lubis, Meiva Amelia; Indah Pertiwi; Damayanti
Asian Multidisciplinary Research Journal of Economy and Learning Vol. 2 No. 7 (2025): July 2025
Publisher : CV. ARGA FARMA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70471/nvgf9h70

Abstract

Carbon tetrachloride (CCl₄) is a commonly used hepatotoxic agent to induce liver injury via oxidative stress and the activation of hepatocyte apoptosis. One hallmark of apoptosis is the increased expression of Caspase-3, a key executor enzyme in the programmed cell death pathway. The ethanol extract of Mobe leaves (Artocarpus lacucha Buch-Ham.) is known to contain bioactive compounds such as flavonoids and triterpenoids, which have demonstrated hepatoprotective potential. This study investigates the hepatoprotective effects of ethanol extract of Mobe leaves (EEML) on Caspase-3 expression in the liver tissues of rats induced by carbon tetrachloride. This experimental study utilized 30 male rats randomly assigned into six groups. The negative control group received CCl₄ - and CMC-Na 1%, while the positive control group received silymarin and CCl₄. Four treatment groups received oral doses of EEML at 50, 100, 200, and 400 mg/kg body weight for 15 days with CCl₄ induction. Caspase-3 expression in liver tissue was analyzed using the immunohistochemistry (IHC) method and quantified based on the number of positively stained cells across five microscopic fields. The results showed a significant reduction in Caspase-3 expression (p<0.05) in the EEML-treated groups compared to the negative control, with the 400 mg/kg dose achieving an effect comparable to silymarin. These findings suggest that EEML possesses hepatoprotective properties through apoptosis inhibition, evidenced by decreased Caspase-3 expression in CCl₄ injured liver tissue.
Hepatoprotective Activity of Ethanol Extract of Mobe Leaves (Artocarpus lacucha Buch-Ham.) on Total Bilirubin, ALT, and AST Levels, and Macropathology of Liver in Rats Induced by Carbon Tetrachloride Meiva Amelia Lubis; Aminah Dalimunthe; Panal Sitorus; Denny Satria; Arga Lubis
Viva Medika Vol 17 No 3 (2024)
Publisher : LPPM Universitas Harapan Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35960/vm.v17i3.1490

Abstract

This study evaluates the hepatoprotective effects of ethanol extract of mobe leaves (Artocarpus lacucha Buch-Ham.) in rats induced with carbon tetrachloride (CCl4). The objective was to determine the extract's efficacy in reducing liver damage markers, specifically total bilirubin, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels, and to assess liver macropathology. The ethanol extract was prepared by maceration using 96% ethanol. Results showed that administering 400 mg/kg body weight (BW) of the extract significantly reduced total bilirubin, ALT, and AST levels in CCl4-induced rats. Additionally, liver macropathology observations indicated improved liver conditions in the treatment group. Phytochemical screening revealed bioactive compounds like flavonoids, alkaloids, tannins, saponins, triterpenoids, and glycosides, which are potential antioxidants and hepatoprotective agents. The significant contribution of this research is providing a scientific basis for using mobe leaf extract as a natural hepatoprotective agent, highlighting its potential for safe and effective herbal medicine. Further research and clinical trials are recommended to validate these findings and explore the extract's therapeutic applications.
Formulasi Dan Evaluasi Sediaan Sabun Cair Scrub Dari Sari Buah Melon (Cucumis melo L.) Ervina Syahfitri Lubis; Indah Pertiwi; Meiva Amelia Lubis
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1745

Abstract

Melon fruit (Cucumis melo L.) contains bioactive compounds such as vitamin C, β-carotene, flavonoids, polyphenols, pectin, and superoxide dismutase (SOD) enzyme that theoretically have potential antioxidant and skin care benefits in topical preparations. This study aimed to formulate and evaluate the physical quality of liquid scrub soap from melon fruit juice at varying concentrations of 0% (F0/blank), 5% (F1), 10% (F2), and 15% (F3), using coffee grounds as a natural exfoliating agent. Physical quality evaluations included organoleptic testing, foam height and stability, pH, and viscosity according to SNI 06-4085-1996. Data were analyzed using One-Way ANOVA followed by Tukey HSD post-hoc test (α=0.05). Organoleptic results showed all formulas were white, liquid, melon-scented, and contained brown scrub granules. One-Way ANOVA showed that melon fruit juice concentration significantly affected all tested parameters (p<0.05). The average pH of F1, F2, and F3 were 8.53±0.06ᵇ, 9.17±0.12ᶜ, and 9.77±0.06ᵈ, meeting SNI requirements (pH 8–11). Average foam heights of F1, F2, and F3 were 105.00±1.00ᵇ mm, 125.67±1.53ᶜ mm, and 154.00±2.65ᵈ mm, with foam stability of 82.27±1.76ᵃᵇ%, 85.13±0.32ᵇᶜ%, and 87.03±1.47ᶜ%, all meeting SNI standards (13–220 mm) and stability threshold ≥70%. Viscosity of F1, F2, and F3 were 1,633±57.74ᵇ cP, 2,000±100.00ᶜ cP, and 2,567±57.74ᵈ cP, within the acceptable range (400–4,000 cP). Tukey HSD confirmed significant differences among all formulas for pH, foam height, and viscosity parameters. It was concluded that melon fruit juice can be successfully formulated into a liquid scrub soap and all formulas met the established physical quality requirements. Formula F3 at 15% concentration produced the best results. Further research is needed to evaluate the biological activity of the preparation, including antioxidant testing, exfoliation efficacy, and skin irritation studies.
Tren Penelitian Pengobatan Herbal untuk Penyakit Radang Usus: Analisis Bibliometrik dengan Penekanan pada Kolitis Ulseratif Muhammad Amin Nasution; Muhammad Andry; Sry Ulina Karo-Karo; Indah Pertiwi Nasution; Meiva Amelia Lubis; Damayanti S Damayanti S
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1538

Abstract

Inflammatory bowel disease (IBD), particularly ulcerative colitis (UC), is a chronic gastrointestinal disorder that significantly affects quality of life. Despite advances in conventional therapy, some patients experience adverse effects, relapse, high treatment burden, or inadequate response, contributing to interest in complementary approaches, including herbal medicine. This study aims to map the development of herbal medicine research in IBD, specifically UC, by examining publication trends, key contributors, collaboration patterns, and emerging themes. This study analyzed 518 English-language journal articles indexed in Scopus from 2016 to 2025. VOSviewer (version 1.6.20) and Biblioshiny (R package version 5.0) were used to analyze source productivity, country collaboration, citation relationships, and keyword co-occurrence. Among the ten most productive sources, the Journal of Ethnopharmacology (44 articles), Frontiers in Pharmacology (24), and Phytomedicine (22) contributed 90 of 160 articles (56.3%) in the top-ten-source subset; this percentage does not represent the entire 518-document corpus. Among records with identifiable corresponding-author countries, China contributed 46.0%, followed by India (11.1%) and South Korea (8.3%). The thematic structure centered on anti-inflammatory pathways, immune modulation, DSS-induced colitis, intestinal-barrier function, gut microbiota, and emerging systems approaches such as network pharmacology and metabolomics. The journal profile and keyword network suggest that the evidence base remains predominantly preclinical and translational. Clinical validation, extract standardization, safety reporting, and multinational collaboration are therefore priorities before wider clinical adoption
Efek Ekstrak Etanol Daun Mobe (Artocarpus lacucha Buch-Ham.) terhadap Histopatologi Hati Tikus Diinduksi Karbon Tetraklorida Meiva Amelia Lubis; Aminah Dalimunthe; Panal Sitorus; Denny Satria; Indah Pertiwi; Damayanti S Damayanti S
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1432

Abstract

Background: Liver injury due to exposure to hepatotoxic chemicals remains a major problem in the medical and pharmaceutical fields. Carbon tetrachloride (CCl₄) is a classic hepatotoxic agent that induces oxidative stress, lipid peroxidation, and hepatocyte necrosis through free radical formation. Mobe leaves (Artocarpus lacucha Buch-Ham.) contain bioactive compounds, particularly flavonoids and phenolics, which possess antioxidant and anti-inflammatory properties with potential hepatoprotective effects. Objective: This study aimed to evaluate the effect of ethanol extract of mobe leaves (EEML) on the liver histopathology of rats induced with carbon tetrachloride. Methods: This experimental study used a post-test only control group design. Twenty-five male rats were divided into five groups: negative control (CMC-Na 1% + CCl₄), positive control (silymarin 100 mg/kgBW + CCl₄), and three treatment groups receiving EEML at doses of 50, 100, and 200 mg/kgBW + CCl₄. Hepatotoxicity was induced by intraperitoneal injection of CCl₄ (1 mL/kgBW) twice weekly for 14 days. Liver tissue was processed for hematoxylin-eosin staining, and histopathological changes (hepatocyte degeneration, necrosis, and inflammatory cell infiltration) were assessed semi-quantitatively using a scoring system (0-3). Results: CCl₄ induction caused severe liver damage in the negative control group, characterized by diffuse hydropic degeneration, extensive necrosis, and marked inflammatory infiltration (score 3 for all parameters). EEML administration significantly reduced liver injury in a dose-dependent manner. The 200 mg/kgBW dose showed the most pronounced hepatoprotective effect, with degeneration score 2, necrosis score 1, and inflammation score 2, approaching the protective effect of silymarin (score 1 for all parameters). Conclusion: Ethanol extract of mobe leaves demonstrated hepatoprotective activity against CCl₄-induced liver damage in rats, with the optimal effect at 200 mg/kgBW. These findings support the potential of mobe leaves as a natural hepatoprotective agent.
Co-Authors Aminah Dalimunthe Arga Lubis Damayanti Damayanti S Damayanti S Damayanti S Damayanti S Denny Satria Denny Satria Denny Satria, Denny Ervina Syahfitri Lubis Indah Pertiwi INDAH PERTIWI Indah Pertiwi Nasution Muhammad Amin Nasution Muhammad Andry Panal Sitorus Sitorus, Panal Sry Ulina Karo-Karo