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ISOLATION OF AMNIOTIC FLUID MESENCHYMAL STEM CELLS (AF MSCs) OBTAINED FROM CAESAREAN SECTIONS Utama, Bobby Indra
Andalas Obstetrics And Gynecology Journal Vol. 2 No. 1 (2018)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.2.1.1-9.2018

Abstract

Amniotic fluid is a liquid that fills the amniotic cavity which has defense and nutritional functions in fetal development. Human aterm amniotic fluid can be an ideal alternative as a source of mesenchymal stem cells, originating from the neonate. Preclinical studies of second and third trimester amnion fluid cells confirmed the number of potential donors from this wasted material. In several studies, AF-MSCs express mesenchymal markers such as CD90, CD73 (SH3, SH), CD105 (SH2), CD29, CD166, CD49e, CD58 and CD44 (MHC class I). These cells also express HLA-ABC antigens, CD 34, CD 45 which are hematopoietic markers, and endothelial CD31 markers. There is no expression of CD10, CD11b, CD14, CD34, CD117, EMA and HLA-DR, DP, DQ antigens. Most of AF-MSCs have pluripotent properties which are characterized by the discovery of octamer binding protein 3/4 (Oct-3/4), transcription factors Nanog (Nanog), and stage-specific embryonic antigen 4 (SSEA-4) on RT-PCR examination. From this study, 8 million cells was isolated. These cells will be used for research on pelvic organ prolapse therapy by using AF-MSCs. AF-MSCs isolation totally takes 6 weeks. From 1 flask, 2 million of stem cells was obtained. Keywords: amniotic fluid, AF-MSCs
UTERUS BIKORNU Marni, Herti; Ferry, Ferdinal; Utama, Bobby Indra
Andalas Obstetrics And Gynecology Journal Vol. 2 No. 2 (2018)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.2.2.115-118.2018

Abstract

Background : Uterus bicornis subseptum is a deformity of the uterus such as the shape of the heart, the fundus appears to be curved inward, and has a barrier or wall inside to the uterine cavity. This abnormality occurs due to failure of the fusion of the left and right mullerian ducts. If pregnant, women who have this form of the uterus will usually experience a location abnormality, in which the fetus is often transverse or breech. However, women who have this disorder sometimes find it difficult to get pregnant so they experience infertility. In addition, there is usually a disturbance in the formation of the kidneys, but in this patient there was no abnormality in the urinary tract. In cases where the patient does not have children and a bicornu uterine abnormality is found, uterine repair is performed and it is hoped that with the uterine anatomy returning to normal, the patient can become pregnant.Objective : Discuss the management of cases of congenital abnormalities of the internal genital organs in patients with a bicornu uterus.Method : Case Report.Case : Reported a patient aged 25 years with primary infertility 4 years and a bicornu uterus. In patients, chromotubation was performed first, after chromotubation, the patient was performed metrosplasty to remove the bulkhead in the uterus and to repair the uterus. During the post-op follow-up at the hospital the patient did not show any signs of infection or acute abdomen, then the patient was discharged on day 5. The patient was advised to go to the OBGYN polyclinic regularly for further follow-up to the success of his uterine repair. Assessment can be done in several ways including transvaginal ultrasound to assess whether there is adhesions to the endometrium from the results of uterine repair, HSG, SIS or hysteroscopy can also be done in assessing the success of metroplasty in this patient.Conclusion : After metrosplasty in a patient with a bicornu uterus, further follow-up is required to determine the success of this procedure by performing a follow-up ultrasound.Keywords: Bicornu uterus, metroplasty
SEPTUM VAGINA TRANSVERSA Utama, Bobby Indra; Ermawati, Ermawati
Andalas Obstetrics And Gynecology Journal Vol. 1 No. 2 (2017)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.1.2.80-85.2017

Abstract

The vagina is a membranous muscular tube that connects the vulva and uterus. Congenital or congenital abnormalities in the form of complete or partial absence of the vagina (vaginal agenesis). Patients who experience vaginal agenesis have less frequency, namely 1 in 4000 births, 1 in 4000 to 10,000 births (ACOG). Meanwhile in Dr. Cipto Mangunkusumo Jakarta from 1995 to 1999, an average of 10-12 cases per year. It has been reported the case of a female patient aged 14 years who entered the Gynecology Ward Dr. M. Djamil Padang on January 25, 2014 at 11.00 WIB with a delivery from the RSMJ gyn clinic with a diagnosis of transverse vaginal septum + hematometra + hematotrachelos + hematokolpos planned for a septal incision. After performing the operative action, ± 500 cc of blackish brown liquid was successfully removed.Keywords: Agenesis Vagina, TVS, Tranverse Septum Vagina, Case Report
PERBEDAAN LEVEL RERATA KEKUATAN OTOT DASAR PANGGUL SEBELUM DAN SETELAH PERSALINAN SPONTAN PADA KELOMPOK INKONTINENSIA URIN DAN KELOMPOK NORMAL Utama, Bobby Indra; Sari, Hasni Kemala; Bachtiar, Hafni
Andalas Obstetrics And Gynecology Journal Vol. 1 No. 1 (2017)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.1.1.7-14.2017

Abstract

Trauma to the pelvic floor during delivery is now recognized as a major etiological factor against PFM disorders such as urinary incontinence, pelvic organ prolapse and fecal incontinence. This study was conducted to analyze the differences in mean levels of differences of pelvic muscle strength before and after spontanous labor between stress urinary inconti-nence group and normal group. This research was done using analytic method with cross sectional design in 13 women with stress urinary incontinence, and 17 women with normal group. Subjects were collected in hospitals of Pariaman, Padang from May to December 2014. Examination of the pelvic floor muscle strength was performed with a perineometer. Differences between the mean difference in the strength of the pelvic floor muscles before and after spontaneous delivery between the two groups were analyzed using independent t test. The mean difference between the strength of the pelvic floor muscles before and after spontaneous labor in stress urinary incontinence group was larger than normal group (3.85 + 1.281 cmH2O vs 2,00 + 1.173 cmH2O, p = 0.000). The mean difference between the strength of the pelvic floor muscles before and after spontaneous labor in stress urinary incontinence group was significantly greater than the normal group.Keywords: Pelvic Floor Muscle, Urinary Incontinence, Spontaneous Labor
The Incidence of Overactive Bladder in KIA Poly Patients at Pauh Health Center in Padang City Using Overactive Bladder Symptoms Score Utama, Bobby Indra; Widayat, Widayat; Arwan, Berriandi
Andalas Obstetrics And Gynecology Journal Vol. 3 No. 2 (2019)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.3.2.83-89.2019

Abstract

Objective : This study looked at the incidence of overactive bladder (OAB) in KIA poly patients at Pauh Health Center in Padang City using Overactive Bladder Symptomps Score (OABSS).Method : This research is descriptive. The sampling technique was purposive sampling by considering inclusion and exclusion criteria. The inclusion criteria were women of ideal reproductive age (20-35 years) who had given birth spontaneously, were not pregnant, did not suffer from neurological disorders, diabetes, post bladder surgery and or urinary tract infections and were not treated with Overactive Bladder (OAB), while the exclusion criteria are not willing to take part in the study. The study was carried out at the KIA Poly of Pauh City Health Center in Padang during January 2019. The variable in this study was Overactive Bladder (OAB).Result : In this study, 97.22% of respondents experienced complaints of overactive bladder (OAB), (97.14%) experienced an urgent complaint, and only a small percentage (2.86%) of respondents experienced urinary incontinence. The results of this study indicate that respondents who did not experience complaints of overactive bladder (OAB) were respondents with the smallest parity (parity 1). Conclusion : Most respondents experienced complaints of overactive bladder (OAB) and urgency, and only a small proportion of respondents experienced urinary incontinence. The results of this study indicate that respondents who did not experience complaints of overactive bladder (OAB) were respondents with the smallest parity (parity 1).Keywords: overactive bladder (OAB), Urgensi,inkontinensia urin, Overactive Bladder Symptom Scores (OABSS)
Correlation of Colony Lactobacillus spp. with The Incident of Overactive Bladder with OBSS Score at Pauh Primary Health Center Padang Gumilar, Rimbun Wahyu; Utama, Bobby Indra; Bachtiar, Hafni
Andalas Obstetrics And Gynecology Journal Vol. 5 No. 1 (2021)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.5.1.56-62.2021

Abstract

Background : Overactive bladder (OAB) is a group of urgent symptoms, with or without urgent incontinence. Research shows that some Lactobacillus spp. can be a sign of a women bladder’s good health; and found a decrease number of Lactobacillus spp. in patients with OAB. This study aims to assess the correlation of Lactobacillus spp. colony with OAB using the OABSS score at Pauh Primary Health Center, Padang.Method : This research is an analytic study with a cross sectional comparative design. The research was conducted from December 2019 to February 2020 at Pauh Primary Health Center. All women aged 20-40 years who came to Pauh Primary Health Center during the study period were included in the study. Pregnant women, having pelvic abnormalities and a history of other urinary tract diseases or having a history of hypertension and diabetes mellitus were excluded in the study. Numerical data are presented in the form of central tendency. Bivariate analysis was performed using the t-independent test if the data distribution was normal and the Kolmogorov-Smirnov test if the distribution of the data was not normally distributed.Result: There were 42 samples consisting of 21 OAB respondents and 21 normal respondents. The age of the respondents in the OAB group was 28 ± 6.8 years, while the normal group was 32 ± 7.3 years (p> 0.05). The number of Lactobacillus spp colonies in the normal group was higher than the OAB group, namely 16,389,670 ± 74,380,427.9 CU / ml compared to 15,229,634 ± 67,553,932.9 CU / ml (p> 0.05).Conclusion: There was no correlation between the number of Lactobacillus Spp colonies and the incidence of Overactive Bladder. It is necessary to do further research regarding other risk factors associated with the incidence of OAB and the causes of the decrease number of Lactobacillus spp colonies in OAB patients and the presence of other microorganisms, especially pathogenic microorganisms. Keywords: overactive bladder, Lactobacillus, OABSS score
Relationship between Serum Magnesium Status and the Incidence of Preeclampsia at 8 Padang Primary Health Care Fajriati, Hifzhillah; Utama, Bobby Indra; Nurhayati, Nurhayati
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 1 (2024)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.1.586-593.2024

Abstract

Introduction: Preeclampsia is one of the main causes of maternal morbidity and mortality, with its etiology and pathophysiology not fully understood. Several studies have shown that magnesium plays an important role in preeclampsia. Magnesium plays a role in modulating endothelial function. Decreased serum magnesium levels in pregnancy can trigger endothelial dysfunction that has an impact on the occurrence of preeclampsia.Objective: Determine the relationship between serum magnesium status with incidence of preeclampsia in pregnant women at 8 Padang Primary Health Care.Method: An observational analytic with cross-sectional design. Sampling was carried out using total sampling technique from research master data at 8 Padang Primary Health Care for period June 2019 – May 2020. The total sample was 45 pregnant women who met the inclusion and exclusion criteria. Data were analyzed using Fisher’s.Result: The serum magnesium status of pregnant women in the 8 Padang Primary Health Care was dominated by normal serum magnesium status (91.1%) and only 8.9% of pregnant women had preeclampsia. Fisher’s test showed that there was a significant relationship between serum magnesium status and the incidence of preeclampsia (p-value = 0,034).Conclusion: There is a significant relationship between serum magnesium status and preeclampsia (with overlook the factors of previous preeclampsia history, family history of preeclampsia, and magnesium intake during pregnancy). Hypomagnesemia status in pregnant women can exacerbate the occurrence of preeclampsia.
Comparison of womwne's quality of life post abdominal and vaginal hysterectomy F, Fauzan; Utama, Bobby Indra; Firdawati, Firdawati
Andalas Obstetrics And Gynecology Journal Vol. 6 No. 1 (2022)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.6.1.35-41.2022

Abstract

Introduction:Hysterectomy is the most common major surgical procedure in gynecology. Approximately 90% of hysterectomies are performed on indications of benign gynecological disease. The number of women affected by hysterectomy is relatively low, but the impact of these complications often changes the quality of life. There are several types of hysterectomy, from partial/supravaginal, complete/total, to radical. Hysterectomy with any surgical technique can cause complications. This can be minimized by careful surgical planning and preparation before surgeryAssessing changes in quality of life after surgery is important for patient decision making and for health care evaluation, as health care becomes more standardized. Objective: This study aims to determine the difference in quality of life between women who have undergone abdominal hysterectomy surgery and women who have undergone vaginal hysterectomy surgery.Methods: This research is an analytic observational study with a cross sectional comparative study approach which was conducted on 54 women who had undergone hysterectomy at Dr. RSUP. M. Djamil, Padang. 27 of them underwent abdominal hysterectomy, and 27 others underwent vaginal hysterectomy. All patients were interviewed using the Short Form-36 (SF-36) questionnaire. The assessment is carried out with a scoring system where a score of 0 is the lowest value, and 100 is the highest value.Results: The average quality of life of the woman's post abdominal and vaginal hysterectomy was 91.71 ± 6.73 and 99.07 ± 1.66 respectively. There is a difference in the mean value of quality of life of women and post abdominal and vaginal hysterectomy (p<0.05).Conclusion: There was a significant difference between the quality of life of women after hysterectomy, where women who underwent vaginal hysterectomy had a higher quality of life than women who underwent abdominal hysterectomyKeywords: Hysterectomy, Abdominal, Vaginal, Quality of life
Analysis of the stress level of resident physician education program specialist in Obstetrics and Gynecology Andalas University in 2020 Fajri, Ari Fuad; Utama, Bobby Indra; Hardisman, Hardisman
Andalas Obstetrics And Gynecology Journal Vol. 6 No. 1 (2022)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.6.1.65-71.2022

Abstract

Introduction:The Specialist Doctor Education Program (PPDS) is one of the academic education of general practitioners and is known as a resident doctor to become a specialist and is at the forefront ofhealth services. Resident doctors are expected to be flexible clinicians, educators, researchers, andadministrators by the end of their residency training. It often requires stressful hard work, and is oftenreported as a cause of burnout, anxiety, depression, anger, irritability, anxiety, sleep deprivation,fatigue, substance abuse, and psychosocial problems. One of the problems that often occurs with residents is long working hours. Based on the working hours regulation adopted in the UK since 1998, namely the European Working Time Directive (EWTD) and a policy change in 2007 and 2009 called The New Deal, the working hours of resident doctors to achieve optimal performance is 56 hours per week. In the initial survey of 10 PPDS Obgin Unand residents, network station residents still had to carry out their duties 24 hours a day for 1 month in the hospital. Except for applying for certain permits. If you add up, the average working hours in 1 week is more than 60 working hours. Objective: This study aims to determine the stress level of resident doctors in the Education Program of  Obstetric and Gynecology Specialist, Andalas University in 2020Methods: This research is a quantitative study followed by qualitative method using an explanatory design. Data was taken using the triangulation method. The data was taken from questionnaires, Focus Group Discussion (FGD), and document review from Obstetric and Gynecology residents of all semester at Andalas University.Results: The highest stress level in the Obstetric and Gynecology residents of Andalas University in 2020 was 60.3% at moderate level, there was a relationship between stress levels with graduation and semester. The highest stress domain is ARS (Academic Related Stressor) and SRS (Social Related Stressor).Conclusion: the stress level in the Obstetric and Gynecology residents of Andalas University in 2020 is at a moderate level, and the highest stress domain is ARS (Academic Related Stressor) and SRS (Social Related Stressor).Keywords: Resident Doctor; Obstetric and Gynecology; stress
Adult Women with Congenital Adrenal Hyperplasia (CAH) Setiawan, Muhammad Rudi; Arif, Ichsan; Utama, Bobby Indra
Andalas Obstetrics And Gynecology Journal Vol. 6 No. 1 (2022)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.6.1.110-115.2022

Abstract

Introduction : Congenital Adrenal Hyperplasia (CAH) is the most common cause of ambiguous genitalia. It is a genetic disorder that occurs due to failure or disruption of the formation of enzymes which play a role in the production of cortisol and aldosterone and can cause fusion of the labia, clitoromegaly, and a fusion of the vagina and distal urethra.Case Reports:A 32-year-old patient, unmarried, came to the urogynecology department complaining of thickening of the upper genitalia that resembles male genitalia. This problem has been known to the patient since she was 16 years old and was brought to the doctor at the age of 21 and diagnosed with congenital adrenal hyperplasia. The patient has had menstruation since she was 14 years old, but it is irregular. Since 8 years ago, the patient has been regularly taking hydrocortisone from an internal medicine specialist but has never been to the obstetrics and gynecology department for 8 years, now the patient comes to the urogynecology department because she wants to get married. When the patient was in school, she grew up like a normal woman and have good academic abilities. In the family history, there was no family history of congenital abnormalities. From physical examination, her height is 150 cm. She shows the habitus of external body like a woman. On genital examination found no formation of labia, clitoromegaly. Karyotype 46, XX. Ultrasonography found uterus and ovaries within normal limits.Conclusion:Counseling, both surgical and non-surgical treatment with a multidisciplinary approach, will give good results in patients with CAH. Rapid diagnosis and treatment will provide good management for patients with CAH. Surgery in the form of reducing the size of the clitoris (while maintaining the function of sensation), as well as expanding the vaginal opening can help in these patients to improve the patient's quality of life.Keywords: Congenital Adrenal Hyperplasia; clitoromegaly; unmarried