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All Journal The Indonesian Biomedical Journal Jurnal Gizi Klinik Indonesia Andalas obstetrics and gynecology journal Jurnal Pengabdian Inovasi dan Teknologi Kepada Masyarakat Jurnal Riset Ilmiah Jurnal Sains, Teknologi dan Kesehatan Jurnal Kesehatan
Defrin, Defrin
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PERBEDAAN LUARAN MATERNAL ANTARA IBU PREEKLAMSIA BERAT DENGAN DAN TANPA SINDROM HELLP DI RSUP DR. M.DJAMIL PADANG Mufiidah, Muthia; Defrin, Defrin; Rusjdi, Selfi Renita
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 2 No. 1 (2025): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, Maret 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v2i1.987

Abstract

Background: Preeclampsia is a new onset of hypertensive disorder that occurs after 20 weeks of gestation. Based on the degree of severity, preeclampsia is divided into two categories: mild preeclampsia and severe preeclampsia. Patients with severe preeclampsia can have some complications, one of them is HELLP syndrome (haemolysis, elevated liver enzymes, low platelet count). HELLP syndrome can further affect maternal mortality and morbidity rates.  Objective: This study aims to determine whether there are differences in maternal outcomes in severe preeclampsia with HELLP syndrome and severe preeclampsia without HELLP syndrome. Methods: The type of this research is observational analytic with a case-control approach using data from medical records. This research was conducted in July 2022–January 2023 at Dr. M. Djamil Padang Hospital. The samples were selected using simple random sampling technique and obtained a total of 78 samples. obtained. Bivariate analysis in this study was conducted using Chi-square test. Results: Patients with severe preeclampsia with and without HELLP syndrome were dominated by the low risk age group (20-35 years). Based on the number of pregnancies, the highest frequency was found in the multigravida group. The results of blood pressure and urine protein measurements in the two subjects were not much different. LDH and SGPT levels increased and platelet count decreased in severe preeclampsia with HELLP syndrome. Conclusion: There was no significant difference between the maternal outcomes in severe preeclampsia with HELLP syndrome and severe preeclampsia without HELLP syndrome (p>0.05)
KARAKTERISTIK GEJALA KLINIS IBU HAMIL DENGAN INFEKSI COVID-19 DI RSUP DR. M. DJAMIL PADANG Milano, Ryan Suheil; Defrin, Defrin; Firdawati, Firdawati; Aladin, Aladin; Russilawati, Russilawati; Revilla, Gusti
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 2 No. 1 (2025): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, Maret 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v2i1.1018

Abstract

Background: The SARS-CoV-2 virus easily spreads globally in a short period. Pregnant women are one of the vulnerable groups who can be infected with COVID-19, they have a risk of complications during pregnancy Objective: This research aims to identify the traits of expectant mothers with COVID-19 infection at Dr. M. Djamil Padang. Methods: This form of research uses retrospective descriptive approach, utilizing a comprehensive sampling and relying on secondary data sources. The research was conducted at Dr. M. Djamil Padang Hospital by taking data on pregnant women with confirmed COVID-19 infection in 2020-2021. Samples that met the inclusion and exclusion criteria were 302 cases Result: The results of this study showed the most gestational age was 3rd trimester (96.0), no clinical symptoms (58.6%), with the highest pregnancy outcomes being mature (72.5%), the highest birth weight babies being 2500-4000 grams (81,1%) and the highest maternal and infant outcomes being live mothers and babies ( 87.7%). Conclusion: This study concludes is that most pregnant women with COVID-19 infection at Dr. M. Djamil Padang in 2020-2021 with characteristics of third trimester gestational age, no clinical symptoms, mature pregnancy outcome, weight normal birth and high maternal and infant survival rates
PERBANDINGAN FAKTOR RISIKO DAN MANIFESTASI KLINIS HPV 16 DENGAN HPV 18 PADA PENDERITA KARSINOMA SERVIKS Anavelda, Aura Putri; Putra, Andani Eka; Defrin, Defrin; Suharti, Netti; Antonius, Puja Agung; Elmatris, Elmatris
SINERGI : Jurnal Riset Ilmiah Vol. 2 No. 4 (2025): SINERGI : Jurnal Riset Ilmiah, April 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/sinergi.v2i4.1114

Abstract

Background: High-risk Human Papillomavirus (hrHPV) infection causes 99.7% of cervical carcinoma cases. Among the thirteen types of hrHPV, types 16 and 18 have a strong correlation with- cervical carcinoma. HPV 16 infection makes the immune system in the cervix hyporesponsive compared to HPV 18 infection. Objective: This study aims to compare the risk factors and clinical manifestations of HPV 16 with HPV 18 in cervical carcinoma patients. Method: This is an analytic study with a retrospective cohort approach using secondary data from the research of Dr. dr. Andani Eka Putra, M.Sc and dr. Syandrez Prima Putra which has been collected into a research master table. The sampling technique was non-probability sampling with convenience sampling on 38 respondents whose specimens were stored at the Central Laboratory of Diagnostics and Research on Infectious Diseases, Faculty of Medicine, Andalas University. Data analysis was carried out using Fisher's Exact test. Results: The results of statistical tests on the comparison of marriageable age between patients with HPV 16 and HPV 18 types showed a value of p = 0.038 (p <0.05). In this study, women who are > 45 years old, married early (<20 years), have a low level of education, work as housewives, and have a multiparity history are at high risk of cervical carcinoma. Patients with HPV 16 and 18 had risk factors and clinical manifestations were not much different (p>0.05). Conclusion: There is no significant comparison of the risk factors and clinical manifestations of HPV 16 with HPV 18 in patients with cervical carcinoma.
Relationship Between Placenta Accreta Index Score and Management in Placenta Accreta Patients in RSUP Dr. M. Djamil Padang Azhari, Nabilah; Defrin, Defrin; Nurhayati, Nurhayati
Andalas Obstetrics And Gynecology Journal Vol. 9 No. 1 (2025)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.9.1.124-133.2025

Abstract

Introduction : Placenta acreta index is a scoring system using ultrasound parameters used to diagnose placenta accreta. Parameters included are the number of previous caesarean section, location of the placenta, grading of lacunae, presence of bridging blood vessels, thickness of the myometrium. The management of placenta accreta is conservative and definitive management, where the definitive management performed is hysterectomy. The purpose of this study was to determine the relationship between PAI score and placenta accreta management in patients with placenta accreta at Dr. M. Djamil Hospital Padang. Method : This type of research was observational analytic with cross sectional research design. This study was conducted in the medical record section uses a total sampling technique of 184 patients. Data analysis used univariate analysis, bivariate with Chi square test. Result : The results of this study showed that 67.9% of patients with PAI≥4 scores, 56.5% of patients who underwent hysterectomy, and after the statistical test obtained a p value <0.001, then H0 was rejected, meaning that there was a relationship between placenta accreta index scores and placenta accreta management. Conclusion : It is conclude from the results of this study there is a significant relationship between PAI score and placenta accreta management (P<0.05) in placenta accreta patients. Keywords: Hysterectomy, placenta accreta, PAI score
PREVALENSI ANEMIA PADA KEHAMILAN : SEBUAH TINJAUAN LITERATUR SISTEMATIS Azmira, Nazurah; Defrin, Defrin; Burhan, Ida Rahmah; Rustam, Erlina; Antonius, Puja Agung; Yusri, Elfira
SINERGI : Jurnal Riset Ilmiah Vol. 2 No. 9 (2025): SINERGI : Jurnal Riset Ilmiah, September 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/sinergi.v2i9.1374

Abstract

Background : Anemia has become a public health problem that bring many potencial danger to both maternal and neonatal side. Many studies show that there are significant correlation between maternal mortality and anemia during pregnancy.Objective: This review is done to determine the prevalence and risk factors of anemia among pregnant women Methods : This study is a systematic literature review focused on the prevalence of anemia during pregnancy from 2011-2020. Literature search on Pubmed and Proquest databases was carried out to identify studies included in inclusion criteria related to prevalence of anemia during pregnancy. In this review, 60 articles were reviewed after 4105 articles found in both databases were screened using PRISMA guidelines. A total of 49589 participants from 20 developing countries were included. Results : The results showed that the rate of anemia in pregnancy range from 7,4% to 90%, with an average of 36,2%. The most reported risk factors are low economic level/ household income (10,2%), maternal age (9,6), rural residence (7,8%), educational status of the mother (7,2%)and less consumption of iron/folic acid (7,2%). Conclusion : Based on the review, available evidence suggest that prevalence of anemia remain high especially in low and middle income countries. Maximum efforts need to be initiated to help prevent anemia during pregnancies. Public should be educated on early initiation of antenatal care to enhance surveillance, identification and treatment of anemia
PERBANDINGAN ANTARA KADAR VITAMIN C PLASMA DARAH HAMIL ATERM PADA KETUBAN PECAH DINI DENGAN HAMIL ATERM TANPA KETUBAN PECAH DINI Defrin, Defrin; Rasyid, Rosfita
Andalas Obstetrics And Gynecology Journal Vol. 2 No. 2 (2018)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.2.2.101-108.2018

Abstract

Premature rupture of membranes is the most common complication of pregnancy. The incidence of premature rupture of membranes in pregnancy ranged from 6% to 10%, and 20% of these cases occur before 37 weeks gestation. The incidence of premature rupture of membranes in Indonesia ranges from 4.5% to 7.6% of all pregnancies. This research was conducted to determine the cross-sectional differences in the blood plasma levels of vitamin C in term pregnancy premature rupture of membranes with blood plasma levels of vitamin C in term pregnancy without premature rupture of membranes in M. Jam- il Padang hospital, Achmad Muchtar Bukittinggi hospital, and Pariaman Hospital. There are significant differences in vitamin C blood plasma levels in term pregnancy with premature rupture of membranes and term pregnancy without premature rupture of membranes ( P < 0.05). Mean levels of vitamin C in blood plasma at term pregnancy with premature rupture of membranes lower than in the blood plasma levels of vitamin C in term pregnancy without premature rupture of membranes.Keywords: Premature rupture of membrane in aterm, blood plasma levels of vitamin C
Deteksi Dini Kehamilan Risiko Tinggi di Wilayah Kerja Puskesmas Pegambiran Kota Padang Tahun 2022 Yusrawati, Yusrawati; Desmawati, Desmawati; Amir, Arni; Serudji, Joserizal; Basyir, Vaulinne; Defrin, Defrin; Karmia, Hudilla Rifa; Ayunda, Aldina Ayunda Insani; Safaringga, Miranie; Evareny, Lisma; Agus, Meilinda
JDISTIRA - Jurnal Pengabdian Inovasi dan Teknologi Kepada Masyarakat Vol. 3 No. 1 (2023)
Publisher : Yayasan Rahmatan Fidunya Wal Akhirah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58794/jdt.v3i1.429

Abstract

Angka Kematian Ibu (AKI) Indonesia secara Nasional tahun 2017 dan 2019 tidak mengalami perubahan yaitu 305 per-100.000 kelahiran hidup. Menurut data Rakernas 2019, ibu hamil meninggal akibat komplikasi kebidanan yang tidak ditangani dengan baik dan tepat waktu, 15% mengalami komplikasi, dan 85% normal. Penyebab utama kematian ibu akibat hipertensi (33,07%), perdarahan obstetrik (27,03%), komplikasi non-obstetrik (15,7%), komplikasi obstetrik lainnya (12,04%), infeksi pada kehamilan (6,06%), dan penyebab lainnya (4,81%). Kelainan saat kehamilan akan berpengaruh terhadap pertumbuhan dan perkembangan janin. Akibatnya, janin mengalami gangguan hingga pertumbuhan dan perkembangan nantinya saat lahir dan masa lima tahunnya (balita). Tindakan promotif dan preventif agar masalah ini teratasi sangatlah penting. Salah satunya kolaborasi Bidan dan dokter kandungan melakukan tindakan promotif dan preventif khususnya pada deteksi dini kehamilan risiko tinggi. Kegiatan dilakukan pada ibu hamil di wilayah kerja Puskesmas Pegambiran, meliputi pemeriksaan tanda-tanda vital, penyuluhan nutrisi ibu hamil dan tanda bahaya pada kehamilan serta Pemeriksaan USG. Didapatkan hasil 3,8% ibu hamil dengan plasenta previa, 3,8% ibu hamil dengan fetal distress, dan terdapat peningkatan pengetahuan ibu hamil terkait nutrisi dan tanda bahaya pada kehamilan. Ibu hamil dengan risiko tinggi pada kehamilan dilakukan rujukan ke fasilitas lebih lengkap. Diharapkan adanya pendampingan dan selalu menggalakkan kebiasaan untuk nutrisi seimbang dan selalu melakukan pemeriksaan (antenatal care).
Asupan zat besi, kadar hepsidin, dan kadar hemoglobin pada mahasiswi obesitas dan normal Putri, Fonny Kurnia; Desmawati, Desmawati; Defrin, Defrin
Jurnal Gizi Klinik Indonesia Vol 20, No 2 (2023): Oktober
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.79076

Abstract

Fe intake, hepcidin levels, and hemoglobin levels in obese and normal female studentsBackground: The most common anemia is related to problems with nutritional status. Obesity increases the risk of anemia because of the accumulation of fat in adipose tissue that triggers inflammation which can lead to anemia.Objective: This study aims to determine differences in iron (Fe) intake, hepcidin levels, and hemoglobin (Hb) levels in obese and normal female students.Methods: This research is an observational study with a comparative cross-sectional research design. Sampling was done by systematic random sampling. Data assessment of Fe intake, hepcidin levels, and Hb levels was carried out by SQ-FFQ interview, ELISA method, and cyanmethemoglobin method. Normality test and data analysis were performed using the Shapiro-Wilk test, independent t-test, Mann-Whitney, and Chi-Square.Results: The mean intake of Fe in obesity was 14.39±6.87 mg higher than the normal female students' 14.14±7.50 mg (p=0.726). The median hepcidin level in obesity was 322.32 pg/mL higher than normal female students 315.67 pg/mL (p=0.677). The mean hemoglobin level in obesity was 11,2±1,1 g/dL lower than normal female students 12,1±1,09 g/dL (p=0.001).Conclusions: There was no significant difference in Fe intake and hepcidin levels in the obese and normal female students. However, there was a significant difference in hemoglobin levels in obese and normal female students.
Perbandingan Nilai Risk Malignancy Index Kanker Ovarium Tipe Serosum dan Musinosum RSUP Dr. M. Djamil Padang pada Tahun 2017 Luhuria, Frita Dwi; Defrin, Defrin; Friadi, Andi
Andalas Obstetrics And Gynecology Journal Vol 4, No 1 (2020)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.4.1.87-94.2020

Abstract

The Risk Malignancy Index (RMI) is one of the simplest assessments that can assist in diagnosing and determining the prognosis of benign and malignant adnexa masses. Epithelial carcinoma is the most common type of about 90% of ovarian cancers.  As many as 35-40% of the epithelial type are serous and 6-10% are musinosum.This study aims to compare the picture of RMI value on the incidence of ovarian cancer serosum and musinosum type. This study was cross sectinal comparative study from medical records of ovarian cancer patients at obstetrics and gynecology section in DR M Djamil Hospital Padang from January 1st, 2017 until December 31st, 2017. The population was found one hundred and forty of patients with ovarian cancer and only one hundred and twenty nine of patients met the inclusion criteria and there were no exclusion criteria. Next RMI value is calculated based on RMI 1 formula, result is described in tabular form and data processing with SPSS program. Conclucion of this study is there were no differences in age distribution, ascites occurrence and age of menopause in serous and musinosum ovarian cancer. There is a difference in Ca, 125 levels in serous with musinosum ovarian cancer which also contribute to the high value of RMI. The mean value of patients‘s RMI in serous type ovarian cancer is higher than the mean value of RMI in patients with type Musinosum ovarian cancer. Keywords: index of risk malignancy, menopause, ultrasonography, anatomic pathology, serous ovarian carcinoma
Amniotic Fluid Embolism in Post Caesarean Section Defrin, Defrin; Farnas, Heri
Andalas Obstetrics And Gynecology Journal Vol. 4 No. 2 (2020)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.4.2.161-166.2020

Abstract

Background: According to WHO, around 73% of maternal deaths globally are caused by direct obstetric causes. The amniotic fluid embolism is a life-threatening obstetric emergency characterized by sudden cardiopulmonary system failure and can be accompanied by Disseminated Intravascular Coagulation (DIC). The amniotic fluid embolism event usually occurs during labor and birth, but can also occur immediately in the post partum period or after pregnancy termination. About 56% of women will not survive for first 2 hours after the acute event. Amniotic fluid embolism is an unpredictable event, so that no prophylactic intervention can be carried out effectively and the handling and enforcement of a diagnosis that still debatable.Objective: To report maternal deaths due to amniotic fluid embolism post cesarean sectionMethod: Case ReportCase:  Reported case of a 30 years old woman with an initial diagnosis in emergency departement with decreased consciousness due to Severe hypoxia due to Pulmonary emboli due to Amniotic fluid emboli on P2A0L2 post Cesarean Section first day of puerperium. The patient experienced a sudden loss of consciousness accompanied by severe shortness of breath after 6 hours after cesarean section surgery in a private hospital. After initial examination and treatment by administering oxygen through the Nonrebreathing Mask, there was no improvement in the O2 saturation value and then the patient was intubated by the anesthetist. After intubation, the O2 saturation value still does not increase, then the patient suddenly experiences cardiac arrest and followed with cardiac resuscitation for 2 cycles accompanied by resuscitation drugs then the patient returns to spontaneous circulation. From the cardiology department, inotropic therapy was given and echocardiographic investigations were carried out. On echocardiographic examination, they found McConnel's sign which showed suspicios of pulmonary embolism. At the time the patient will be moved to the intensive care unit, the patient experiences a cardiac arrest for the second time, then resuscitation is performed again for 2 cycles, but it does not work and the patient is declared dead.Conclusion: Amniotic fluid embolism is an obstetric emergency condition that cannot be predicted and has a high mortality rate. Treatment is supportive to support the cardiopulmonary system and management of coagulopathy that may occur.Keywords: maternal mortality, amniotic fluid embolism 
Co-Authors Adang Bachtiar ALADIN ALADIN Anavelda, Aura Putri Andani Eka Putra Andi Friadi Antonius, Puja Agung Arni Amir Azhari, Nabilah Azmira, Nazurah Basyir, Vaulinne David Perdana Desmawati Desmawati Elmatris Sy Erlina Rustam Farnas, Heri Firdawati Firdawati Fridsto, Zeino Gusti Revilla Hardisman Hartanto, Boby Hema Malini, Hema Ida Rahmah Burhan Insani, Aldina Ayunda Karmia, Hudilla Rifa Lisma Evareny Luhuria, Frita Dwi Masrul Mayuliani, Mayuliani Meilinda Agus, Meilinda Milano, Ryan Suheil Miranie Safaringga Mudjiran Mufiidah, Muthia Netti Suharti, Netti Nurhayati Nurhayati Putri, Fonny Kurnia Rosfita Rasyid Russilawati, Russilawati Selfi Renita Rusjdi Sinambela, Megawati Utama, Try Genta Yusrawati Yusrawati Yusri, Elfira